DUF4709 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2P7_LEIMU

TriTrypDb:

LmxM.31.1220

Length:

797

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2P7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2P7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.534
CLV_C14_Caspase3-7	490	494	PF00656	0.513
CLV_C14_Caspase3-7	579	583	PF00656	0.543
CLV_NRD_NRD_1	10	12	PF00675	0.610
CLV_NRD_NRD_1	104	106	PF00675	0.470
CLV_NRD_NRD_1	147	149	PF00675	0.444
CLV_NRD_NRD_1	269	271	PF00675	0.513
CLV_NRD_NRD_1	320	322	PF00675	0.425
CLV_NRD_NRD_1	361	363	PF00675	0.632
CLV_NRD_NRD_1	54	56	PF00675	0.376
CLV_NRD_NRD_1	763	765	PF00675	0.615
CLV_NRD_NRD_1	771	773	PF00675	0.674
CLV_NRD_NRD_1	777	779	PF00675	0.679
CLV_PCSK_FUR_1	8	12	PF00082	0.579
CLV_PCSK_KEX2_1	10	12	PF00082	0.610
CLV_PCSK_KEX2_1	104	106	PF00082	0.470
CLV_PCSK_KEX2_1	146	148	PF00082	0.427
CLV_PCSK_KEX2_1	269	271	PF00082	0.518
CLV_PCSK_KEX2_1	361	363	PF00082	0.574
CLV_PCSK_KEX2_1	715	717	PF00082	0.527
CLV_PCSK_KEX2_1	771	773	PF00082	0.672
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.520
CLV_PCSK_PC1ET2_1	715	717	PF00082	0.616
CLV_PCSK_PC1ET2_1	771	773	PF00082	0.654
CLV_PCSK_PC7_1	143	149	PF00082	0.318
CLV_PCSK_SKI1_1	143	147	PF00082	0.480
CLV_PCSK_SKI1_1	160	164	PF00082	0.538
CLV_PCSK_SKI1_1	185	189	PF00082	0.533
CLV_PCSK_SKI1_1	259	263	PF00082	0.511
CLV_PCSK_SKI1_1	322	326	PF00082	0.430
CLV_PCSK_SKI1_1	346	350	PF00082	0.528
CLV_PCSK_SKI1_1	563	567	PF00082	0.509
CLV_PCSK_SKI1_1	587	591	PF00082	0.656
CLV_PCSK_SKI1_1	76	80	PF00082	0.529
CLV_PCSK_SKI1_1	781	785	PF00082	0.524
CLV_Separin_Metazoa	358	362	PF03568	0.483
DEG_APCC_DBOX_1	155	163	PF00400	0.588
DEG_APCC_DBOX_1	345	353	PF00400	0.527
DEG_SPOP_SBC_1	646	650	PF00917	0.736
DOC_CYCLIN_RxL_1	320	328	PF00134	0.539
DOC_CYCLIN_RxL_1	560	571	PF00134	0.518
DOC_CYCLIN_RxL_1	709	723	PF00134	0.539
DOC_MAPK_gen_1	321	329	PF00069	0.422
DOC_MAPK_gen_1	361	367	PF00069	0.568
DOC_MAPK_MEF2A_6	321	329	PF00069	0.422
DOC_MAPK_NFAT4_5	322	330	PF00069	0.421
DOC_PP1_RVXF_1	232	238	PF00149	0.561
DOC_PP1_RVXF_1	362	368	PF00149	0.471
DOC_PP1_RVXF_1	689	695	PF00149	0.453
DOC_USP7_MATH_1	42	46	PF00917	0.581
DOC_USP7_MATH_1	426	430	PF00917	0.714
DOC_USP7_MATH_1	442	446	PF00917	0.477
DOC_USP7_MATH_1	473	477	PF00917	0.748
DOC_USP7_MATH_1	499	503	PF00917	0.761
DOC_USP7_MATH_1	514	518	PF00917	0.695
DOC_USP7_MATH_1	527	531	PF00917	0.541
DOC_USP7_MATH_1	577	581	PF00917	0.683
DOC_USP7_MATH_1	748	752	PF00917	0.618
DOC_USP7_UBL2_3	185	189	PF12436	0.533
DOC_USP7_UBL2_3	679	683	PF12436	0.583
DOC_WW_Pin1_4	455	460	PF00397	0.727
DOC_WW_Pin1_4	462	467	PF00397	0.673
DOC_WW_Pin1_4	476	481	PF00397	0.692
DOC_WW_Pin1_4	569	574	PF00397	0.562
DOC_WW_Pin1_4	642	647	PF00397	0.659
DOC_WW_Pin1_4	720	725	PF00397	0.579
DOC_WW_Pin1_4	735	740	PF00397	0.634
LIG_14-3-3_CanoR_1	104	112	PF00244	0.463
LIG_14-3-3_CanoR_1	16	23	PF00244	0.569
LIG_14-3-3_CanoR_1	234	238	PF00244	0.459
LIG_14-3-3_CanoR_1	252	262	PF00244	0.334
LIG_14-3-3_CanoR_1	299	307	PF00244	0.410
LIG_14-3-3_CanoR_1	362	368	PF00244	0.452
LIG_14-3-3_CanoR_1	472	480	PF00244	0.698
LIG_14-3-3_CanoR_1	484	488	PF00244	0.743
LIG_14-3-3_CanoR_1	500	506	PF00244	0.581
LIG_14-3-3_CanoR_1	8	14	PF00244	0.636
LIG_Actin_WH2_2	330	345	PF00022	0.600
LIG_BIR_II_1	1	5	PF00653	0.652
LIG_BRCT_BRCA1_1	113	117	PF00533	0.455
LIG_BRCT_BRCA1_1	636	640	PF00533	0.643
LIG_BRCT_BRCA1_1	733	737	PF00533	0.511
LIG_BRCT_BRCA1_1	99	103	PF00533	0.456
LIG_BRCT_BRCA1_2	636	642	PF00533	0.643
LIG_CaM_IQ_9	135	150	PF13499	0.543
LIG_CaM_IQ_9	671	687	PF13499	0.489
LIG_FHA_1	104	110	PF00498	0.444
LIG_FHA_1	2	8	PF00498	0.511
LIG_FHA_1	354	360	PF00498	0.605
LIG_FHA_1	423	429	PF00498	0.537
LIG_FHA_1	47	53	PF00498	0.488
LIG_FHA_1	530	536	PF00498	0.426
LIG_FHA_1	687	693	PF00498	0.537
LIG_FHA_1	91	97	PF00498	0.478
LIG_FHA_2	190	196	PF00498	0.436
LIG_FHA_2	205	211	PF00498	0.474
LIG_FHA_2	304	310	PF00498	0.494
LIG_FHA_2	371	377	PF00498	0.476
LIG_FHA_2	531	537	PF00498	0.515
LIG_FHA_2	627	633	PF00498	0.658
LIG_FHA_2	646	652	PF00498	0.693
LIG_LIR_Gen_1	273	282	PF02991	0.515
LIG_LIR_Gen_1	290	300	PF02991	0.302
LIG_LIR_Gen_1	328	337	PF02991	0.525
LIG_LIR_Gen_1	45	54	PF02991	0.504
LIG_LIR_Gen_1	532	541	PF02991	0.453
LIG_LIR_Gen_1	635	640	PF02991	0.700
LIG_LIR_Gen_1	68	78	PF02991	0.556
LIG_LIR_Nem_3	114	120	PF02991	0.563
LIG_LIR_Nem_3	273	278	PF02991	0.537
LIG_LIR_Nem_3	290	296	PF02991	0.293
LIG_LIR_Nem_3	328	332	PF02991	0.558
LIG_LIR_Nem_3	37	43	PF02991	0.540
LIG_LIR_Nem_3	376	381	PF02991	0.626
LIG_LIR_Nem_3	45	51	PF02991	0.488
LIG_LIR_Nem_3	532	537	PF02991	0.459
LIG_LIR_Nem_3	635	639	PF02991	0.632
LIG_LIR_Nem_3	68	73	PF02991	0.536
LIG_LIR_Nem_3	74	78	PF02991	0.440
LIG_MLH1_MIPbox_1	113	117	PF16413	0.572
LIG_NRBOX	108	114	PF00104	0.474
LIG_PDZ_Class_3	792	797	PF00595	0.600
LIG_Pex14_1	386	390	PF04695	0.572
LIG_Pex14_2	117	121	PF04695	0.473
LIG_Pex14_2	636	640	PF04695	0.599
LIG_SH2_CRK	217	221	PF00017	0.490
LIG_SH2_CRK	40	44	PF00017	0.616
LIG_SH2_CRK	48	52	PF00017	0.589
LIG_SH2_CRK	70	74	PF00017	0.560
LIG_SH2_NCK_1	275	279	PF00017	0.503
LIG_SH2_NCK_1	390	394	PF00017	0.535
LIG_SH2_NCK_1	70	74	PF00017	0.476
LIG_SH2_SRC	171	174	PF00017	0.527
LIG_SH2_STAP1	48	52	PF00017	0.609
LIG_SH2_STAP1	699	703	PF00017	0.460
LIG_SH2_STAT3	335	338	PF00017	0.399
LIG_SH2_STAT5	390	393	PF00017	0.558
LIG_SH2_STAT5	48	51	PF00017	0.574
LIG_SH3_3	362	368	PF00018	0.488
LIG_SH3_3	475	481	PF00018	0.622
LIG_SUMO_SIM_anti_2	532	540	PF11976	0.416
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.515
LIG_SUMO_SIM_anti_2	93	100	PF11976	0.492
LIG_SUMO_SIM_par_1	563	568	PF11976	0.512
LIG_SUMO_SIM_par_1	93	100	PF11976	0.480
LIG_TRAF2_1	151	154	PF00917	0.433
LIG_TRAF2_1	310	313	PF00917	0.451
LIG_TRAF2_1	317	320	PF00917	0.428
LIG_TRAF2_1	629	632	PF00917	0.577
LIG_UBA3_1	314	323	PF00899	0.438
LIG_WRC_WIRS_1	531	536	PF05994	0.517
LIG_WRC_WIRS_1	72	77	PF05994	0.471
MOD_CDK_SPK_2	569	574	PF00069	0.553
MOD_CDK_SPxxK_3	462	469	PF00069	0.702
MOD_CDK_SPxxK_3	720	727	PF00069	0.581
MOD_CK1_1	476	482	PF00069	0.719
MOD_CK1_1	503	509	PF00069	0.657
MOD_CK1_1	517	523	PF00069	0.533
MOD_CK1_1	530	536	PF00069	0.471
MOD_CK1_1	568	574	PF00069	0.547
MOD_CK1_1	580	586	PF00069	0.576
MOD_CK1_1	60	66	PF00069	0.515
MOD_CK1_1	617	623	PF00069	0.658
MOD_CK1_1	635	641	PF00069	0.609
MOD_CK1_1	645	651	PF00069	0.680
MOD_CK2_1	147	153	PF00069	0.539
MOD_CK2_1	16	22	PF00069	0.709
MOD_CK2_1	189	195	PF00069	0.405
MOD_CK2_1	204	210	PF00069	0.500
MOD_CK2_1	240	246	PF00069	0.525
MOD_CK2_1	303	309	PF00069	0.484
MOD_CK2_1	47	53	PF00069	0.631
MOD_CK2_1	620	626	PF00069	0.741
MOD_CK2_1	645	651	PF00069	0.747
MOD_Cter_Amidation	267	270	PF01082	0.535
MOD_Cter_Amidation	8	11	PF01082	0.687
MOD_GlcNHglycan	149	152	PF01048	0.475
MOD_GlcNHglycan	368	371	PF01048	0.539
MOD_GlcNHglycan	475	478	PF01048	0.569
MOD_GlcNHglycan	485	488	PF01048	0.733
MOD_GlcNHglycan	489	492	PF01048	0.636
MOD_GlcNHglycan	497	500	PF01048	0.636
MOD_GlcNHglycan	512	515	PF01048	0.593
MOD_GlcNHglycan	516	519	PF01048	0.471
MOD_GlcNHglycan	549	552	PF01048	0.399
MOD_GlcNHglycan	567	570	PF01048	0.593
MOD_GlcNHglycan	622	625	PF01048	0.659
MOD_GlcNHglycan	733	736	PF01048	0.824
MOD_GlcNHglycan	751	754	PF01048	0.486
MOD_GSK3_1	233	240	PF00069	0.474
MOD_GSK3_1	303	310	PF00069	0.497
MOD_GSK3_1	366	373	PF00069	0.527
MOD_GSK3_1	416	423	PF00069	0.672
MOD_GSK3_1	42	49	PF00069	0.375
MOD_GSK3_1	467	474	PF00069	0.782
MOD_GSK3_1	483	490	PF00069	0.608
MOD_GSK3_1	491	498	PF00069	0.630
MOD_GSK3_1	499	506	PF00069	0.537
MOD_GSK3_1	510	517	PF00069	0.496
MOD_GSK3_1	563	570	PF00069	0.525
MOD_GSK3_1	620	627	PF00069	0.709
MOD_GSK3_1	634	641	PF00069	0.542
MOD_GSK3_1	642	649	PF00069	0.621
MOD_GSK3_1	731	738	PF00069	0.736
MOD_GSK3_1	81	88	PF00069	0.531
MOD_LATS_1	418	424	PF00433	0.482
MOD_N-GLC_1	354	359	PF02516	0.468
MOD_N-GLC_1	370	375	PF02516	0.469
MOD_N-GLC_1	455	460	PF02516	0.461
MOD_N-GLC_1	624	629	PF02516	0.642
MOD_N-GLC_1	659	664	PF02516	0.608
MOD_NEK2_1	1	6	PF00069	0.709
MOD_NEK2_1	179	184	PF00069	0.539
MOD_NEK2_1	248	253	PF00069	0.445
MOD_NEK2_1	263	268	PF00069	0.419
MOD_NEK2_1	325	330	PF00069	0.443
MOD_NEK2_1	414	419	PF00069	0.559
MOD_NEK2_1	435	440	PF00069	0.506
MOD_NEK2_1	471	476	PF00069	0.617
MOD_NEK2_1	483	488	PF00069	0.551
MOD_NEK2_1	565	570	PF00069	0.571
MOD_NEK2_1	57	62	PF00069	0.569
MOD_NEK2_1	96	101	PF00069	0.455
MOD_NEK2_2	233	238	PF00069	0.509
MOD_NEK2_2	467	472	PF00069	0.609
MOD_PIKK_1	16	22	PF00454	0.556
MOD_PIKK_1	263	269	PF00454	0.547
MOD_PIKK_1	380	386	PF00454	0.475
MOD_PIKK_1	435	441	PF00454	0.656
MOD_PK_1	420	426	PF00069	0.477
MOD_PKA_1	147	153	PF00069	0.315
MOD_PKA_1	188	194	PF00069	0.524
MOD_PKA_2	103	109	PF00069	0.466
MOD_PKA_2	147	153	PF00069	0.315
MOD_PKA_2	233	239	PF00069	0.477
MOD_PKA_2	268	274	PF00069	0.605
MOD_PKA_2	298	304	PF00069	0.406
MOD_PKA_2	363	369	PF00069	0.550
MOD_PKA_2	471	477	PF00069	0.778
MOD_PKA_2	483	489	PF00069	0.637
MOD_PKA_2	499	505	PF00069	0.614
MOD_PKA_2	580	586	PF00069	0.552
MOD_PKA_2	708	714	PF00069	0.626
MOD_PKA_2	726	732	PF00069	0.783
MOD_PKA_2	748	754	PF00069	0.585
MOD_PKA_2	758	764	PF00069	0.503
MOD_PKA_2	767	773	PF00069	0.629
MOD_PKA_2	9	15	PF00069	0.594
MOD_Plk_1	25	31	PF00069	0.494
MOD_Plk_1	370	376	PF00069	0.538
MOD_Plk_1	624	630	PF00069	0.721
MOD_Plk_1	709	715	PF00069	0.555
MOD_Plk_2-3	71	77	PF00069	0.471
MOD_Plk_4	25	31	PF00069	0.602
MOD_Plk_4	303	309	PF00069	0.567
MOD_Plk_4	47	53	PF00069	0.651
MOD_Plk_4	530	536	PF00069	0.449
MOD_Plk_4	60	66	PF00069	0.467
MOD_Plk_4	635	641	PF00069	0.663
MOD_ProDKin_1	455	461	PF00069	0.728
MOD_ProDKin_1	462	468	PF00069	0.674
MOD_ProDKin_1	476	482	PF00069	0.692
MOD_ProDKin_1	569	575	PF00069	0.566
MOD_ProDKin_1	642	648	PF00069	0.661
MOD_ProDKin_1	720	726	PF00069	0.579
MOD_ProDKin_1	735	741	PF00069	0.636
MOD_SUMO_rev_2	490	497	PF00179	0.514
TRG_DiLeu_BaEn_1	108	113	PF01217	0.520
TRG_DiLeu_BaEn_1	786	791	PF01217	0.526
TRG_DiLeu_BaEn_2	556	562	PF01217	0.454
TRG_DiLeu_BaEn_4	154	160	PF01217	0.546
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.514
TRG_DiLeu_LyEn_5	108	113	PF01217	0.506
TRG_ENDOCYTIC_2	217	220	PF00928	0.453
TRG_ENDOCYTIC_2	275	278	PF00928	0.560
TRG_ENDOCYTIC_2	40	43	PF00928	0.580
TRG_ENDOCYTIC_2	48	51	PF00928	0.512
TRG_ENDOCYTIC_2	70	73	PF00928	0.571
TRG_ER_diArg_1	103	105	PF00400	0.471
TRG_ER_diArg_1	147	149	PF00400	0.411
TRG_ER_diArg_1	156	159	PF00400	0.484
TRG_ER_diArg_1	360	362	PF00400	0.625
TRG_ER_diArg_1	7	10	PF00400	0.634
TRG_NES_CRM1_1	108	123	PF08389	0.519
TRG_NES_CRM1_1	53	68	PF08389	0.525
TRG_NES_CRM1_1	543	557	PF08389	0.559
TRG_NLS_MonoExtN_4	143	150	PF00514	0.315
TRG_NLS_MonoExtN_4	768	775	PF00514	0.518
TRG_Pf-PMV_PEXEL_1	136	141	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	252	257	PF00026	0.378
TRG_Pf-PMV_PEXEL_1	778	782	PF00026	0.648

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICL4	Leptomonas seymouri	62%	100%
A0A1X0NVY2	Trypanosomatidae	40%	100%
A0A3S5ISI8	Trypanosoma rangeli	40%	100%
A0A3S7X5E6	Leishmania donovani	92%	100%
A4HKA9	Leishmania braziliensis	75%	100%
A4I7T9	Leishmania infantum	92%	100%
D0A9Z9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4Q5G0	Leishmania major	90%	100%