PPR_long domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pentatricopeptide repeat domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B2P6_LEIMU

TriTrypDb:

LmxM.31.1210

Length:

801

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B2P6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2P6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	301	303	PF00675	0.478
CLV_NRD_NRD_1	381	383	PF00675	0.731
CLV_NRD_NRD_1	453	455	PF00675	0.592
CLV_PCSK_KEX2_1	101	103	PF00082	0.555
CLV_PCSK_KEX2_1	301	303	PF00082	0.485
CLV_PCSK_KEX2_1	490	492	PF00082	0.446
CLV_PCSK_KEX2_1	5	7	PF00082	0.634
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.555
CLV_PCSK_PC1ET2_1	490	492	PF00082	0.446
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.658
CLV_PCSK_SKI1_1	101	105	PF00082	0.524
CLV_PCSK_SKI1_1	476	480	PF00082	0.434
CLV_PCSK_SKI1_1	491	495	PF00082	0.478
CLV_PCSK_SKI1_1	552	556	PF00082	0.486
CLV_PCSK_SKI1_1	619	623	PF00082	0.492
CLV_PCSK_SKI1_1	709	713	PF00082	0.443
CLV_PCSK_SKI1_1	771	775	PF00082	0.502
CLV_PCSK_SKI1_1	780	784	PF00082	0.468
DEG_APCC_DBOX_1	770	778	PF00400	0.538
DEG_APCC_KENBOX_2	123	127	PF00400	0.579
DEG_Nend_Nbox_1	1	3	PF02207	0.625
DEG_SPOP_SBC_1	377	381	PF00917	0.576
DOC_CKS1_1	495	500	PF01111	0.535
DOC_CKS1_1	783	788	PF01111	0.630
DOC_CYCLIN_RxL_1	777	785	PF00134	0.536
DOC_MAPK_gen_1	454	460	PF00069	0.612
DOC_MAPK_gen_1	489	495	PF00069	0.364
DOC_MAPK_gen_1	5	13	PF00069	0.701
DOC_PP1_RVXF_1	474	481	PF00149	0.558
DOC_PP1_SILK_1	728	733	PF00149	0.451
DOC_PP4_FxxP_1	23	26	PF00568	0.689
DOC_PP4_FxxP_1	783	786	PF00568	0.523
DOC_USP7_MATH_1	377	381	PF00917	0.670
DOC_USP7_MATH_1	387	391	PF00917	0.754
DOC_USP7_MATH_1	65	69	PF00917	0.660
DOC_USP7_MATH_1	756	760	PF00917	0.564
DOC_WW_Pin1_4	494	499	PF00397	0.555
DOC_WW_Pin1_4	604	609	PF00397	0.435
DOC_WW_Pin1_4	782	787	PF00397	0.612
LIG_14-3-3_CanoR_1	105	112	PF00244	0.516
LIG_14-3-3_CanoR_1	145	149	PF00244	0.364
LIG_14-3-3_CanoR_1	375	384	PF00244	0.649
LIG_14-3-3_CanoR_1	83	91	PF00244	0.530
LIG_Actin_WH2_2	223	238	PF00022	0.535
LIG_Actin_WH2_2	464	481	PF00022	0.366
LIG_APCC_ABBA_1	112	117	PF00400	0.407
LIG_APCC_ABBA_1	224	229	PF00400	0.464
LIG_APCC_ABBA_1	353	358	PF00400	0.509
LIG_APCC_ABBAyCdc20_2	66	72	PF00400	0.651
LIG_BIR_III_4	767	771	PF00653	0.568
LIG_Clathr_ClatBox_1	466	470	PF01394	0.531
LIG_FHA_1	187	193	PF00498	0.471
LIG_FHA_1	221	227	PF00498	0.395
LIG_FHA_1	325	331	PF00498	0.344
LIG_FHA_1	361	367	PF00498	0.584
LIG_FHA_1	44	50	PF00498	0.551
LIG_FHA_1	536	542	PF00498	0.414
LIG_FHA_1	559	565	PF00498	0.541
LIG_FHA_1	574	580	PF00498	0.418
LIG_FHA_1	758	764	PF00498	0.460
LIG_FHA_1	773	779	PF00498	0.442
LIG_FHA_1	93	99	PF00498	0.420
LIG_FHA_2	111	117	PF00498	0.522
LIG_FHA_2	280	286	PF00498	0.377
LIG_FHA_2	37	43	PF00498	0.681
LIG_FHA_2	731	737	PF00498	0.546
LIG_GBD_Chelix_1	317	325	PF00786	0.454
LIG_LIR_Apic_2	20	26	PF02991	0.668
LIG_LIR_Gen_1	113	123	PF02991	0.245
LIG_LIR_Gen_1	134	142	PF02991	0.375
LIG_LIR_Gen_1	161	171	PF02991	0.435
LIG_LIR_Gen_1	206	215	PF02991	0.371
LIG_LIR_Gen_1	229	239	PF02991	0.445
LIG_LIR_Gen_1	241	249	PF02991	0.266
LIG_LIR_Gen_1	256	265	PF02991	0.308
LIG_LIR_Gen_1	275	283	PF02991	0.198
LIG_LIR_Gen_1	44	55	PF02991	0.534
LIG_LIR_Gen_1	519	527	PF02991	0.536
LIG_LIR_Gen_1	557	567	PF02991	0.533
LIG_LIR_Gen_1	57	65	PF02991	0.347
LIG_LIR_Gen_1	690	699	PF02991	0.497
LIG_LIR_Gen_1	93	103	PF02991	0.396
LIG_LIR_LC3C_4	316	319	PF02991	0.228
LIG_LIR_Nem_3	113	118	PF02991	0.223
LIG_LIR_Nem_3	134	139	PF02991	0.373
LIG_LIR_Nem_3	161	166	PF02991	0.467
LIG_LIR_Nem_3	169	175	PF02991	0.346
LIG_LIR_Nem_3	206	210	PF02991	0.379
LIG_LIR_Nem_3	229	235	PF02991	0.459
LIG_LIR_Nem_3	241	245	PF02991	0.255
LIG_LIR_Nem_3	256	262	PF02991	0.308
LIG_LIR_Nem_3	275	280	PF02991	0.198
LIG_LIR_Nem_3	350	356	PF02991	0.476
LIG_LIR_Nem_3	44	50	PF02991	0.551
LIG_LIR_Nem_3	515	520	PF02991	0.468
LIG_LIR_Nem_3	57	63	PF02991	0.359
LIG_LIR_Nem_3	673	679	PF02991	0.490
LIG_LIR_Nem_3	689	695	PF02991	0.439
LIG_LIR_Nem_3	93	99	PF02991	0.398
LIG_NRBOX	463	469	PF00104	0.502
LIG_PALB2_WD40_1	628	636	PF16756	0.537
LIG_PCNA_TLS_4	130	137	PF02747	0.382
LIG_PCNA_yPIPBox_3	728	738	PF02747	0.249
LIG_Pex14_1	331	335	PF04695	0.475
LIG_PTB_Apo_2	147	154	PF02174	0.553
LIG_Rb_pABgroove_1	109	117	PF01858	0.493
LIG_REV1ctd_RIR_1	618	628	PF16727	0.553
LIG_SH2_CRK	156	160	PF00017	0.433
LIG_SH2_CRK	172	176	PF00017	0.269
LIG_SH2_CRK	207	211	PF00017	0.380
LIG_SH2_CRK	242	246	PF00017	0.343
LIG_SH2_CRK	277	281	PF00017	0.308
LIG_SH2_CRK	47	51	PF00017	0.563
LIG_SH2_CRK	614	618	PF00017	0.462
LIG_SH2_CRK	656	660	PF00017	0.427
LIG_SH2_CRK	727	731	PF00017	0.371
LIG_SH2_CRK	743	747	PF00017	0.563
LIG_SH2_CRK	784	788	PF00017	0.643
LIG_SH2_CRK	96	100	PF00017	0.388
LIG_SH2_GRB2like	232	235	PF00017	0.483
LIG_SH2_GRB2like	716	719	PF00017	0.291
LIG_SH2_NCK_1	149	153	PF00017	0.427
LIG_SH2_NCK_1	567	571	PF00017	0.541
LIG_SH2_NCK_1	669	673	PF00017	0.511
LIG_SH2_NCK_1	784	788	PF00017	0.643
LIG_SH2_PTP2	136	139	PF00017	0.229
LIG_SH2_SRC	47	50	PF00017	0.443
LIG_SH2_STAP1	220	224	PF00017	0.399
LIG_SH2_STAP1	255	259	PF00017	0.308
LIG_SH2_STAP1	56	60	PF00017	0.425
LIG_SH2_STAP1	560	564	PF00017	0.490
LIG_SH2_STAP1	567	571	PF00017	0.532
LIG_SH2_STAP1	656	660	PF00017	0.487
LIG_SH2_STAT5	136	139	PF00017	0.357
LIG_SH2_STAT5	178	181	PF00017	0.475
LIG_SH2_STAT5	2	5	PF00017	0.620
LIG_SH2_STAT5	232	235	PF00017	0.573
LIG_SH2_STAT5	279	282	PF00017	0.368
LIG_SH2_STAT5	290	293	PF00017	0.378
LIG_SH2_STAT5	335	338	PF00017	0.492
LIG_SH2_STAT5	56	59	PF00017	0.435
LIG_SH2_STAT5	560	563	PF00017	0.496
LIG_SH2_STAT5	656	659	PF00017	0.400
LIG_SH2_STAT5	663	666	PF00017	0.359
LIG_SH2_STAT5	693	696	PF00017	0.398
LIG_SH2_STAT5	716	719	PF00017	0.393
LIG_SH2_STAT5	784	787	PF00017	0.607
LIG_SH3_3	27	33	PF00018	0.448
LIG_SH3_3	643	649	PF00018	0.391
LIG_SH3_3	783	789	PF00018	0.608
LIG_SUMO_SIM_par_1	465	470	PF11976	0.529
LIG_TRAF2_1	219	222	PF00917	0.518
LIG_TRAF2_1	572	575	PF00917	0.581
LIG_TRFH_1	163	167	PF08558	0.552
LIG_TYR_ITAM	229	245	PF00017	0.377
LIG_TYR_ITIM	154	159	PF00017	0.417
LIG_TYR_ITIM	230	235	PF00017	0.467
LIG_TYR_ITIM	725	730	PF00017	0.492
LIG_UBA3_1	111	119	PF00899	0.460
LIG_UBA3_1	230	236	PF00899	0.473
LIG_UBA3_1	730	738	PF00899	0.252
MOD_CK1_1	241	247	PF00069	0.396
MOD_CK1_1	378	384	PF00069	0.771
MOD_CK1_1	456	462	PF00069	0.591
MOD_CK1_1	550	556	PF00069	0.504
MOD_CK1_1	558	564	PF00069	0.478
MOD_CK1_1	591	597	PF00069	0.307
MOD_CK1_1	607	613	PF00069	0.369
MOD_CK1_1	688	694	PF00069	0.526
MOD_CK2_1	279	285	PF00069	0.429
MOD_CK2_1	65	71	PF00069	0.670
MOD_CK2_1	680	686	PF00069	0.584
MOD_CK2_1	730	736	PF00069	0.434
MOD_GlcNHglycan	216	219	PF01048	0.460
MOD_GlcNHglycan	297	300	PF01048	0.658
MOD_GlcNHglycan	447	452	PF01048	0.549
MOD_GlcNHglycan	455	458	PF01048	0.499
MOD_GlcNHglycan	472	475	PF01048	0.495
MOD_GSK3_1	291	298	PF00069	0.572
MOD_GSK3_1	32	39	PF00069	0.713
MOD_GSK3_1	456	463	PF00069	0.589
MOD_GSK3_1	600	607	PF00069	0.570
MOD_GSK3_1	726	733	PF00069	0.446
MOD_GSK3_1	772	779	PF00069	0.398
MOD_LATS_1	81	87	PF00433	0.564
MOD_N-GLC_1	125	130	PF02516	0.538
MOD_N-GLC_1	198	203	PF02516	0.269
MOD_N-GLC_1	460	465	PF02516	0.472
MOD_N-GLC_1	604	609	PF02516	0.548
MOD_NEK2_1	1	6	PF00069	0.735
MOD_NEK2_1	214	219	PF00069	0.444
MOD_NEK2_1	317	322	PF00069	0.349
MOD_NEK2_1	453	458	PF00069	0.544
MOD_NEK2_1	460	465	PF00069	0.418
MOD_NEK2_1	555	560	PF00069	0.429
MOD_NEK2_2	110	115	PF00069	0.539
MOD_NEK2_2	220	225	PF00069	0.404
MOD_NEK2_2	65	70	PF00069	0.651
MOD_PIKK_1	90	96	PF00454	0.576
MOD_PK_1	339	345	PF00069	0.508
MOD_PKA_1	101	107	PF00069	0.494
MOD_PKA_2	101	107	PF00069	0.550
MOD_PKA_2	144	150	PF00069	0.373
MOD_PKA_2	291	297	PF00069	0.567
MOD_PKA_2	300	306	PF00069	0.477
MOD_PKA_2	453	459	PF00069	0.606
MOD_PKA_2	634	640	PF00069	0.600
MOD_PKB_1	14	22	PF00069	0.607
MOD_Plk_1	124	130	PF00069	0.516
MOD_Plk_1	143	149	PF00069	0.291
MOD_Plk_1	220	226	PF00069	0.419
MOD_Plk_1	255	261	PF00069	0.292
MOD_Plk_1	43	49	PF00069	0.628
MOD_Plk_1	460	466	PF00069	0.565
MOD_Plk_1	573	579	PF00069	0.489
MOD_Plk_1	588	594	PF00069	0.526
MOD_Plk_1	757	763	PF00069	0.549
MOD_Plk_4	132	138	PF00069	0.521
MOD_Plk_4	144	150	PF00069	0.542
MOD_Plk_4	171	177	PF00069	0.368
MOD_Plk_4	186	192	PF00069	0.392
MOD_Plk_4	209	215	PF00069	0.434
MOD_Plk_4	241	247	PF00069	0.393
MOD_Plk_4	317	323	PF00069	0.368
MOD_Plk_4	339	345	PF00069	0.392
MOD_Plk_4	555	561	PF00069	0.469
MOD_Plk_4	591	597	PF00069	0.564
MOD_Plk_4	655	661	PF00069	0.520
MOD_Plk_4	688	694	PF00069	0.556
MOD_Plk_4	726	732	PF00069	0.492
MOD_ProDKin_1	494	500	PF00069	0.548
MOD_ProDKin_1	604	610	PF00069	0.432
MOD_ProDKin_1	782	788	PF00069	0.622
MOD_SUMO_for_1	118	121	PF00179	0.455
MOD_SUMO_rev_2	116	120	PF00179	0.494
MOD_SUMO_rev_2	193	198	PF00179	0.521
MOD_SUMO_rev_2	473	481	PF00179	0.489
TRG_DiLeu_BaEn_1	134	139	PF01217	0.495
TRG_DiLeu_BaEn_1	161	166	PF01217	0.554
TRG_DiLeu_BaEn_4	193	199	PF01217	0.529
TRG_ENDOCYTIC_2	115	118	PF00928	0.405
TRG_ENDOCYTIC_2	136	139	PF00928	0.409
TRG_ENDOCYTIC_2	156	159	PF00928	0.197
TRG_ENDOCYTIC_2	172	175	PF00928	0.348
TRG_ENDOCYTIC_2	207	210	PF00928	0.365
TRG_ENDOCYTIC_2	232	235	PF00928	0.468
TRG_ENDOCYTIC_2	242	245	PF00928	0.296
TRG_ENDOCYTIC_2	277	280	PF00928	0.308
TRG_ENDOCYTIC_2	356	359	PF00928	0.403
TRG_ENDOCYTIC_2	442	445	PF00928	0.387
TRG_ENDOCYTIC_2	47	50	PF00928	0.591
TRG_ENDOCYTIC_2	520	523	PF00928	0.529
TRG_ENDOCYTIC_2	560	563	PF00928	0.415
TRG_ENDOCYTIC_2	614	617	PF00928	0.381
TRG_ENDOCYTIC_2	656	659	PF00928	0.406
TRG_ENDOCYTIC_2	669	672	PF00928	0.374
TRG_ENDOCYTIC_2	692	695	PF00928	0.407
TRG_ENDOCYTIC_2	727	730	PF00928	0.373
TRG_ENDOCYTIC_2	743	746	PF00928	0.445
TRG_ENDOCYTIC_2	96	99	PF00928	0.377
TRG_ER_diArg_1	13	16	PF00400	0.634
TRG_ER_diArg_1	301	304	PF00400	0.505
TRG_NES_CRM1_1	350	365	PF08389	0.262
TRG_Pf-PMV_PEXEL_1	732	736	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAW5	Leptomonas seymouri	57%	100%
A0A0S4JD08	Bodo saltans	32%	95%
A0A1X0NW71	Trypanosomatidae	40%	100%
A0A3S7X5H9	Leishmania donovani	90%	100%
A0A422P1H7	Trypanosoma rangeli	39%	100%
A4HKA8	Leishmania braziliensis	79%	100%
A4I7T8	Leishmania infantum	90%	100%
D0A9Z8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	97%
Q0WPZ6	Arabidopsis thaliana	21%	92%
Q4Q5G1	Leishmania major	90%	100%
Q76C99	Oryza sativa subsp. indica	20%	100%
Q9SH60	Arabidopsis thaliana	22%	100%
Q9SS81	Arabidopsis thaliana	20%	100%
V5BL80	Trypanosoma cruzi	42%	100%