Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2P4_LEIMU

TriTrypDb:

LmxM.31.1190

Length:

563

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2P4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2P4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	384	388	PF00656	0.578
CLV_NRD_NRD_1	332	334	PF00675	0.591
CLV_NRD_NRD_1	437	439	PF00675	0.624
CLV_NRD_NRD_1	441	443	PF00675	0.608
CLV_NRD_NRD_1	514	516	PF00675	0.629
CLV_NRD_NRD_1	67	69	PF00675	0.609
CLV_NRD_NRD_1	98	100	PF00675	0.693
CLV_PCSK_KEX2_1	332	334	PF00082	0.591
CLV_PCSK_KEX2_1	437	439	PF00082	0.624
CLV_PCSK_KEX2_1	441	443	PF00082	0.608
CLV_PCSK_KEX2_1	512	514	PF00082	0.673
CLV_PCSK_KEX2_1	67	69	PF00082	0.593
CLV_PCSK_KEX2_1	97	99	PF00082	0.699
CLV_PCSK_PC1ET2_1	512	514	PF00082	0.673
CLV_PCSK_PC7_1	437	443	PF00082	0.691
DOC_ANK_TNKS_1	207	214	PF00023	0.620
DOC_CKS1_1	76	81	PF01111	0.530
DOC_MAPK_gen_1	475	485	PF00069	0.618
DOC_MAPK_gen_1	487	495	PF00069	0.566
DOC_MAPK_gen_1	53	60	PF00069	0.611
DOC_MAPK_MEF2A_6	262	271	PF00069	0.676
DOC_MAPK_MEF2A_6	53	60	PF00069	0.679
DOC_PP1_RVXF_1	213	220	PF00149	0.607
DOC_PP1_RVXF_1	489	496	PF00149	0.601
DOC_PP2B_LxvP_1	325	328	PF13499	0.672
DOC_PP2B_LxvP_1	407	410	PF13499	0.624
DOC_USP7_MATH_1	182	186	PF00917	0.599
DOC_USP7_MATH_1	294	298	PF00917	0.660
DOC_USP7_MATH_1	306	310	PF00917	0.507
DOC_USP7_MATH_1	410	414	PF00917	0.666
DOC_USP7_MATH_1	443	447	PF00917	0.587
DOC_USP7_MATH_1	464	468	PF00917	0.587
DOC_USP7_MATH_1	520	524	PF00917	0.683
DOC_USP7_MATH_1	85	89	PF00917	0.579
DOC_USP7_UBL2_3	487	491	PF12436	0.533
DOC_WW_Pin1_4	125	130	PF00397	0.592
DOC_WW_Pin1_4	164	169	PF00397	0.776
DOC_WW_Pin1_4	220	225	PF00397	0.588
DOC_WW_Pin1_4	261	266	PF00397	0.673
DOC_WW_Pin1_4	285	290	PF00397	0.635
DOC_WW_Pin1_4	302	307	PF00397	0.576
DOC_WW_Pin1_4	415	420	PF00397	0.673
DOC_WW_Pin1_4	429	434	PF00397	0.592
DOC_WW_Pin1_4	460	465	PF00397	0.533
DOC_WW_Pin1_4	524	529	PF00397	0.518
DOC_WW_Pin1_4	75	80	PF00397	0.635
LIG_14-3-3_CanoR_1	119	129	PF00244	0.551
LIG_14-3-3_CanoR_1	218	226	PF00244	0.604
LIG_14-3-3_CanoR_1	299	304	PF00244	0.553
LIG_14-3-3_CanoR_1	307	317	PF00244	0.504
LIG_14-3-3_CanoR_1	321	325	PF00244	0.624
LIG_14-3-3_CanoR_1	519	528	PF00244	0.510
LIG_BRCT_BRCA1_1	129	133	PF00533	0.628
LIG_BRCT_BRCA1_1	193	197	PF00533	0.643
LIG_BRCT_BRCA1_1	424	428	PF00533	0.634
LIG_BRCT_BRCA1_1	431	435	PF00533	0.596
LIG_BRCT_BRCA1_1	87	91	PF00533	0.613
LIG_FHA_1	111	117	PF00498	0.568
LIG_FHA_1	226	232	PF00498	0.608
LIG_FHA_1	380	386	PF00498	0.720
LIG_FHA_1	410	416	PF00498	0.717
LIG_FHA_1	88	94	PF00498	0.541
LIG_FHA_2	148	154	PF00498	0.628
LIG_FHA_2	351	357	PF00498	0.671
LIG_Integrin_RGD_1	208	210	PF01839	0.623
LIG_LIR_Gen_1	240	250	PF02991	0.588
LIG_LIR_Gen_1	297	306	PF02991	0.680
LIG_LIR_Nem_3	240	245	PF02991	0.450
LIG_LIR_Nem_3	297	303	PF02991	0.685
LIG_LIR_Nem_3	45	49	PF02991	0.461
LIG_SH2_CRK	300	304	PF00017	0.543
LIG_SH2_STAP1	300	304	PF00017	0.543
LIG_SH2_STAT3	313	316	PF00017	0.493
LIG_SH2_STAT5	189	192	PF00017	0.616
LIG_SH2_STAT5	313	316	PF00017	0.504
LIG_SH3_1	103	109	PF00018	0.628
LIG_SH3_3	103	109	PF00018	0.628
LIG_SH3_3	273	279	PF00018	0.490
LIG_SH3_3	466	472	PF00018	0.690
LIG_SH3_3	482	488	PF00018	0.561
LIG_SH3_4	487	494	PF00018	0.489
LIG_TRAF2_1	15	18	PF00917	0.576
LIG_TRAF2_1	23	26	PF00917	0.579
LIG_TRAF2_1	237	240	PF00917	0.579
LIG_TRAF2_1	477	480	PF00917	0.649
LIG_WRC_WIRS_1	226	231	PF05994	0.581
LIG_WW_3	470	474	PF00397	0.640
MOD_CDC14_SPxK_1	128	131	PF00782	0.633
MOD_CDK_SPK_2	302	307	PF00069	0.558
MOD_CDK_SPK_2	460	465	PF00069	0.515
MOD_CDK_SPxK_1	125	131	PF00069	0.637
MOD_CK1_1	120	126	PF00069	0.712
MOD_CK1_1	185	191	PF00069	0.612
MOD_CK1_1	220	226	PF00069	0.588
MOD_CK1_1	298	304	PF00069	0.590
MOD_CK1_1	305	311	PF00069	0.592
MOD_CK1_1	312	318	PF00069	0.587
MOD_CK1_1	429	435	PF00069	0.554
MOD_CK1_1	463	469	PF00069	0.631
MOD_CK1_1	474	480	PF00069	0.704
MOD_CK1_1	523	529	PF00069	0.578
MOD_CK2_1	147	153	PF00069	0.578
MOD_CK2_1	320	326	PF00069	0.564
MOD_CK2_1	350	356	PF00069	0.709
MOD_CK2_1	474	480	PF00069	0.669
MOD_GlcNHglycan	143	146	PF01048	0.591
MOD_GlcNHglycan	183	187	PF01048	0.613
MOD_GlcNHglycan	193	196	PF01048	0.652
MOD_GlcNHglycan	36	39	PF01048	0.471
MOD_GlcNHglycan	401	404	PF01048	0.672
MOD_GlcNHglycan	412	415	PF01048	0.595
MOD_GlcNHglycan	466	469	PF01048	0.648
MOD_GlcNHglycan	479	483	PF01048	0.667
MOD_GlcNHglycan	49	52	PF01048	0.472
MOD_GlcNHglycan	506	509	PF01048	0.762
MOD_GlcNHglycan	523	526	PF01048	0.559
MOD_GSK3_1	164	171	PF00069	0.602
MOD_GSK3_1	290	297	PF00069	0.598
MOD_GSK3_1	298	305	PF00069	0.618
MOD_GSK3_1	308	315	PF00069	0.666
MOD_GSK3_1	395	402	PF00069	0.495
MOD_GSK3_1	422	429	PF00069	0.629
MOD_GSK3_1	460	467	PF00069	0.567
MOD_GSK3_1	474	481	PF00069	0.749
MOD_GSK3_1	495	502	PF00069	0.713
MOD_GSK3_1	520	527	PF00069	0.587
MOD_GSK3_1	85	92	PF00069	0.568
MOD_LATS_1	216	222	PF00433	0.605
MOD_N-GLC_1	396	401	PF02516	0.626
MOD_N-GLC_1	457	462	PF02516	0.694
MOD_NEK2_1	1	6	PF00069	0.705
MOD_NEK2_1	295	300	PF00069	0.581
MOD_NEK2_1	320	325	PF00069	0.584
MOD_NEK2_1	385	390	PF00069	0.624
MOD_PIKK_1	120	126	PF00454	0.607
MOD_PIKK_1	218	224	PF00454	0.491
MOD_PIKK_1	312	318	PF00454	0.559
MOD_PIKK_1	444	450	PF00454	0.744
MOD_PIKK_1	506	512	PF00454	0.573
MOD_PKA_2	135	141	PF00069	0.610
MOD_PKA_2	191	197	PF00069	0.532
MOD_PKA_2	217	223	PF00069	0.601
MOD_PKA_2	298	304	PF00069	0.564
MOD_PKA_2	306	312	PF00069	0.513
MOD_PKA_2	320	326	PF00069	0.623
MOD_PKA_2	331	337	PF00069	0.619
MOD_PKA_2	474	480	PF00069	0.650
MOD_PKA_2	495	501	PF00069	0.603
MOD_PKA_2	503	509	PF00069	0.658
MOD_Plk_1	339	345	PF00069	0.576
MOD_Plk_1	396	402	PF00069	0.626
MOD_Plk_1	478	484	PF00069	0.569
MOD_Plk_4	110	116	PF00069	0.501
MOD_Plk_4	185	191	PF00069	0.704
MOD_Plk_4	299	305	PF00069	0.546
MOD_Plk_4	309	315	PF00069	0.689
MOD_Plk_4	320	326	PF00069	0.609
MOD_Plk_4	556	562	PF00069	0.550
MOD_ProDKin_1	125	131	PF00069	0.591
MOD_ProDKin_1	164	170	PF00069	0.777
MOD_ProDKin_1	220	226	PF00069	0.588
MOD_ProDKin_1	261	267	PF00069	0.668
MOD_ProDKin_1	285	291	PF00069	0.632
MOD_ProDKin_1	302	308	PF00069	0.569
MOD_ProDKin_1	415	421	PF00069	0.674
MOD_ProDKin_1	429	435	PF00069	0.597
MOD_ProDKin_1	460	466	PF00069	0.536
MOD_ProDKin_1	524	530	PF00069	0.518
MOD_ProDKin_1	75	81	PF00069	0.631
MOD_SUMO_rev_2	19	29	PF00179	0.551
TRG_ENDOCYTIC_2	300	303	PF00928	0.604
TRG_ER_diArg_1	100	103	PF00400	0.657
TRG_ER_diArg_1	332	335	PF00400	0.578
TRG_ER_diArg_1	344	347	PF00400	0.600
TRG_ER_diArg_1	41	44	PF00400	0.443
TRG_ER_diArg_1	436	438	PF00400	0.625
TRG_ER_diArg_1	472	475	PF00400	0.606
TRG_ER_diArg_1	513	515	PF00400	0.637
TRG_ER_diArg_1	52	55	PF00400	0.608
TRG_ER_diArg_1	58	61	PF00400	0.720
TRG_ER_diArg_1	67	69	PF00400	0.703
TRG_ER_diArg_1	97	99	PF00400	0.678
TRG_NLS_MonoCore_2	511	516	PF00514	0.706
TRG_NLS_MonoExtC_3	511	516	PF00514	0.639
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P995	Leptomonas seymouri	31%	100%
A0A3S7X5D7	Leishmania donovani	74%	99%
A4HKA6	Leishmania braziliensis	54%	98%
A4I7T6	Leishmania infantum	75%	99%
Q4Q5G3	Leishmania major	77%	100%