ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania mexicana

UniProt:

E9B2P3_LEIMU

TriTrypDb:

LmxM.31.1180

Length:

660

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2P3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2P3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	348	352	PF00656	0.462
CLV_C14_Caspase3-7	508	512	PF00656	0.641
CLV_NRD_NRD_1	206	208	PF00675	0.631
CLV_NRD_NRD_1	225	227	PF00675	0.491
CLV_NRD_NRD_1	25	27	PF00675	0.426
CLV_NRD_NRD_1	441	443	PF00675	0.656
CLV_PCSK_KEX2_1	206	208	PF00082	0.633
CLV_PCSK_KEX2_1	221	223	PF00082	0.531
CLV_PCSK_KEX2_1	225	227	PF00082	0.489
CLV_PCSK_KEX2_1	25	27	PF00082	0.426
CLV_PCSK_KEX2_1	441	443	PF00082	0.656
CLV_PCSK_KEX2_1	648	650	PF00082	0.549
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.649
CLV_PCSK_PC1ET2_1	648	650	PF00082	0.549
CLV_PCSK_PC7_1	202	208	PF00082	0.694
CLV_PCSK_PC7_1	437	443	PF00082	0.611
CLV_PCSK_SKI1_1	121	125	PF00082	0.461
CLV_PCSK_SKI1_1	163	167	PF00082	0.565
CLV_PCSK_SKI1_1	249	253	PF00082	0.582
CLV_PCSK_SKI1_1	353	357	PF00082	0.495
DEG_Nend_UBRbox_3	1	3	PF02207	0.583
DEG_SCF_FBW7_1	541	548	PF00400	0.586
DEG_SPOP_SBC_1	151	155	PF00917	0.510
DEG_SPOP_SBC_1	311	315	PF00917	0.664
DOC_CYCLIN_yCln2_LP_2	156	162	PF00134	0.402
DOC_MAPK_MEF2A_6	255	263	PF00069	0.512
DOC_PP2B_LxvP_1	169	172	PF13499	0.621
DOC_PP2B_LxvP_1	288	291	PF13499	0.534
DOC_PP2B_LxvP_1	308	311	PF13499	0.501
DOC_USP7_MATH_1	151	155	PF00917	0.510
DOC_USP7_MATH_1	210	214	PF00917	0.523
DOC_USP7_MATH_1	236	240	PF00917	0.667
DOC_USP7_MATH_1	311	315	PF00917	0.646
DOC_USP7_MATH_1	368	372	PF00917	0.567
DOC_USP7_MATH_1	376	380	PF00917	0.560
DOC_USP7_MATH_1	409	413	PF00917	0.706
DOC_USP7_MATH_1	473	477	PF00917	0.534
DOC_USP7_MATH_1	556	560	PF00917	0.568
DOC_USP7_MATH_1	606	610	PF00917	0.581
DOC_USP7_MATH_1	655	659	PF00917	0.593
DOC_USP7_UBL2_3	346	350	PF12436	0.600
DOC_WW_Pin1_4	141	146	PF00397	0.550
DOC_WW_Pin1_4	155	160	PF00397	0.434
DOC_WW_Pin1_4	163	168	PF00397	0.560
DOC_WW_Pin1_4	206	211	PF00397	0.684
DOC_WW_Pin1_4	241	246	PF00397	0.527
DOC_WW_Pin1_4	322	327	PF00397	0.564
DOC_WW_Pin1_4	407	412	PF00397	0.724
DOC_WW_Pin1_4	419	424	PF00397	0.583
DOC_WW_Pin1_4	443	448	PF00397	0.658
DOC_WW_Pin1_4	467	472	PF00397	0.600
DOC_WW_Pin1_4	485	490	PF00397	0.774
DOC_WW_Pin1_4	497	502	PF00397	0.576
DOC_WW_Pin1_4	523	528	PF00397	0.704
DOC_WW_Pin1_4	537	542	PF00397	0.652
DOC_WW_Pin1_4	73	78	PF00397	0.312
LIG_14-3-3_CanoR_1	225	230	PF00244	0.518
LIG_14-3-3_CanoR_1	392	398	PF00244	0.595
LIG_14-3-3_CanoR_1	41	45	PF00244	0.388
LIG_14-3-3_CanoR_1	623	632	PF00244	0.708
LIG_Actin_WH2_2	110	126	PF00022	0.455
LIG_APCC_ABBA_1	282	287	PF00400	0.512
LIG_APCC_ABBAyCdc20_2	281	287	PF00400	0.539
LIG_BRCT_BRCA1_1	5	9	PF00533	0.489
LIG_BRCT_BRCA1_1	513	517	PF00533	0.506
LIG_deltaCOP1_diTrp_1	372	377	PF00928	0.558
LIG_deltaCOP1_diTrp_1	513	517	PF00928	0.567
LIG_eIF4E_1	11	17	PF01652	0.441
LIG_eIF4E_1	142	148	PF01652	0.414
LIG_FAT_LD_1	13	21	PF03623	0.329
LIG_FHA_1	101	107	PF00498	0.513
LIG_FHA_1	164	170	PF00498	0.651
LIG_FHA_1	394	400	PF00498	0.711
LIG_FHA_1	408	414	PF00498	0.696
LIG_FHA_1	480	486	PF00498	0.688
LIG_FHA_1	627	633	PF00498	0.436
LIG_FHA_2	295	301	PF00498	0.532
LIG_FHA_2	491	497	PF00498	0.636
LIG_FHA_2	546	552	PF00498	0.662
LIG_Integrin_RGD_1	575	577	PF01839	0.532
LIG_IRF3_LxIS_1	451	456	PF10401	0.508
LIG_LIR_Gen_1	329	340	PF02991	0.445
LIG_LIR_Gen_1	472	480	PF02991	0.526
LIG_LIR_Gen_1	6	17	PF02991	0.457
LIG_LIR_Nem_3	21	27	PF02991	0.382
LIG_LIR_Nem_3	329	335	PF02991	0.597
LIG_LIR_Nem_3	371	377	PF02991	0.713
LIG_LIR_Nem_3	472	477	PF02991	0.611
LIG_LIR_Nem_3	6	12	PF02991	0.479
LIG_MYND_1	541	545	PF01753	0.635
LIG_NRBOX	12	18	PF00104	0.423
LIG_PCNA_PIPBox_1	130	139	PF02747	0.323
LIG_Pex14_1	127	131	PF04695	0.362
LIG_RPA_C_Fungi	260	272	PF08784	0.532
LIG_SH2_CRK	142	146	PF00017	0.416
LIG_SH2_CRK	190	194	PF00017	0.509
LIG_SH2_CRK	58	62	PF00017	0.340
LIG_SH2_NCK_1	190	194	PF00017	0.509
LIG_SH2_NCK_1	359	363	PF00017	0.476
LIG_SH2_SRC	27	30	PF00017	0.461
LIG_SH2_STAP1	332	336	PF00017	0.457
LIG_SH2_STAP1	389	393	PF00017	0.606
LIG_SH2_STAT5	11	14	PF00017	0.448
LIG_SH2_STAT5	27	30	PF00017	0.336
LIG_SH2_STAT5	389	392	PF00017	0.590
LIG_SH3_2	201	206	PF14604	0.614
LIG_SH3_3	195	201	PF00018	0.630
LIG_SH3_3	320	326	PF00018	0.626
LIG_SH3_3	370	376	PF00018	0.556
LIG_SH3_3	87	93	PF00018	0.473
LIG_SUMO_SIM_par_1	14	22	PF11976	0.333
LIG_TRAF2_1	171	174	PF00917	0.635
LIG_TRAF2_1	251	254	PF00917	0.489
LIG_TRAF2_1	264	267	PF00917	0.560
LIG_TRAF2_1	527	530	PF00917	0.506
MOD_CK1_1	155	161	PF00069	0.552
MOD_CK1_1	239	245	PF00069	0.678
MOD_CK1_1	247	253	PF00069	0.565
MOD_CK1_1	294	300	PF00069	0.607
MOD_CK1_1	3	9	PF00069	0.548
MOD_CK1_1	40	46	PF00069	0.291
MOD_CK1_1	446	452	PF00069	0.714
MOD_CK1_1	592	598	PF00069	0.610
MOD_CK2_1	15	21	PF00069	0.434
MOD_CK2_1	247	253	PF00069	0.509
MOD_CK2_1	261	267	PF00069	0.564
MOD_CK2_1	294	300	PF00069	0.529
MOD_CK2_1	442	448	PF00069	0.685
MOD_CK2_1	545	551	PF00069	0.665
MOD_CK2_1	606	612	PF00069	0.508
MOD_DYRK1A_RPxSP_1	163	167	PF00069	0.493
MOD_GlcNHglycan	212	215	PF01048	0.578
MOD_GlcNHglycan	238	241	PF01048	0.580
MOD_GlcNHglycan	249	252	PF01048	0.633
MOD_GlcNHglycan	419	422	PF01048	0.597
MOD_GlcNHglycan	448	451	PF01048	0.745
MOD_GlcNHglycan	465	468	PF01048	0.508
MOD_GlcNHglycan	558	561	PF01048	0.665
MOD_GlcNHglycan	594	597	PF01048	0.795
MOD_GlcNHglycan	6	9	PF01048	0.515
MOD_GlcNHglycan	614	617	PF01048	0.480
MOD_GlcNHglycan	640	643	PF01048	0.580
MOD_GlcNHglycan	657	660	PF01048	0.479
MOD_GSK3_1	113	120	PF00069	0.558
MOD_GSK3_1	151	158	PF00069	0.585
MOD_GSK3_1	206	213	PF00069	0.576
MOD_GSK3_1	3	10	PF00069	0.506
MOD_GSK3_1	312	319	PF00069	0.618
MOD_GSK3_1	387	394	PF00069	0.600
MOD_GSK3_1	419	426	PF00069	0.596
MOD_GSK3_1	442	449	PF00069	0.754
MOD_GSK3_1	453	460	PF00069	0.601
MOD_GSK3_1	463	470	PF00069	0.628
MOD_GSK3_1	479	486	PF00069	0.738
MOD_GSK3_1	537	544	PF00069	0.633
MOD_GSK3_1	98	105	PF00069	0.447
MOD_LATS_1	35	41	PF00433	0.451
MOD_N-GLC_1	368	373	PF02516	0.429
MOD_N-GLC_1	453	458	PF02516	0.658
MOD_NEK2_1	102	107	PF00069	0.432
MOD_NEK2_1	117	122	PF00069	0.394
MOD_NEK2_1	15	20	PF00069	0.325
MOD_NEK2_1	150	155	PF00069	0.539
MOD_NEK2_1	292	297	PF00069	0.648
MOD_NEK2_1	399	404	PF00069	0.670
MOD_NEK2_1	453	458	PF00069	0.696
MOD_NEK2_1	463	468	PF00069	0.563
MOD_NEK2_1	626	631	PF00069	0.580
MOD_NEK2_1	638	643	PF00069	0.484
MOD_NEK2_2	597	602	PF00069	0.623
MOD_NEK2_2	606	611	PF00069	0.563
MOD_PIKK_1	176	182	PF00454	0.539
MOD_PIKK_1	216	222	PF00454	0.588
MOD_PIKK_1	479	485	PF00454	0.527
MOD_PIKK_1	543	549	PF00454	0.591
MOD_PIKK_1	568	574	PF00454	0.650
MOD_PIKK_1	600	606	PF00454	0.625
MOD_PIKK_1	626	632	PF00454	0.517
MOD_PKA_1	225	231	PF00069	0.506
MOD_PKA_2	225	231	PF00069	0.506
MOD_PKA_2	391	397	PF00069	0.594
MOD_PKA_2	40	46	PF00069	0.388
MOD_PKA_2	612	618	PF00069	0.602
MOD_PKA_2	624	630	PF00069	0.480
MOD_PKA_2	638	644	PF00069	0.544
MOD_Plk_1	328	334	PF00069	0.600
MOD_Plk_4	113	119	PF00069	0.410
MOD_Plk_4	15	21	PF00069	0.328
MOD_Plk_4	312	318	PF00069	0.647
MOD_Plk_4	40	46	PF00069	0.312
MOD_Plk_4	409	415	PF00069	0.695
MOD_Plk_4	589	595	PF00069	0.506
MOD_ProDKin_1	141	147	PF00069	0.548
MOD_ProDKin_1	155	161	PF00069	0.434
MOD_ProDKin_1	163	169	PF00069	0.559
MOD_ProDKin_1	206	212	PF00069	0.685
MOD_ProDKin_1	241	247	PF00069	0.528
MOD_ProDKin_1	322	328	PF00069	0.562
MOD_ProDKin_1	407	413	PF00069	0.725
MOD_ProDKin_1	419	425	PF00069	0.579
MOD_ProDKin_1	443	449	PF00069	0.658
MOD_ProDKin_1	467	473	PF00069	0.600
MOD_ProDKin_1	485	491	PF00069	0.776
MOD_ProDKin_1	497	503	PF00069	0.572
MOD_ProDKin_1	523	529	PF00069	0.707
MOD_ProDKin_1	537	543	PF00069	0.654
MOD_ProDKin_1	73	79	PF00069	0.312
MOD_SUMO_rev_2	302	311	PF00179	0.613
TRG_DiLeu_BaEn_2	131	137	PF01217	0.314
TRG_DiLeu_BaEn_3	433	439	PF01217	0.666
TRG_DiLeu_BaEn_4	173	179	PF01217	0.654
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.548
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.615
TRG_DiLeu_BaLyEn_6	649	654	PF01217	0.437
TRG_DiLeu_BaLyEn_6	90	95	PF01217	0.517
TRG_ENDOCYTIC_2	190	193	PF00928	0.513
TRG_ENDOCYTIC_2	27	30	PF00928	0.461
TRG_ENDOCYTIC_2	332	335	PF00928	0.592
TRG_ENDOCYTIC_2	58	61	PF00928	0.388
TRG_ENDOCYTIC_2	634	637	PF00928	0.496
TRG_ER_diArg_1	206	208	PF00400	0.696
TRG_ER_diArg_1	24	26	PF00400	0.415
TRG_ER_diArg_1	440	442	PF00400	0.661
TRG_Pf-PMV_PEXEL_1	353	358	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	608	612	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	636	640	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9L2	Leptomonas seymouri	39%	100%
A0A3S7X5E8	Leishmania donovani	81%	100%
A4HKA5	Leishmania braziliensis	56%	100%
A4I7T5	Leishmania infantum	81%	100%
Q4Q5G4	Leishmania major	81%	100%