Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2P2_LEIMU

TriTrypDb:

LmxM.31.1170

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9B2P2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2P2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	321	325	PF00656	0.568
CLV_NRD_NRD_1	107	109	PF00675	0.466
CLV_NRD_NRD_1	131	133	PF00675	0.350
CLV_NRD_NRD_1	166	168	PF00675	0.531
CLV_NRD_NRD_1	271	273	PF00675	0.404
CLV_PCSK_KEX2_1	107	109	PF00082	0.466
CLV_PCSK_KEX2_1	131	133	PF00082	0.416
CLV_PCSK_KEX2_1	165	167	PF00082	0.534
CLV_PCSK_KEX2_1	271	273	PF00082	0.403
CLV_PCSK_SKI1_1	166	170	PF00082	0.527
CLV_PCSK_SKI1_1	271	275	PF00082	0.448
CLV_PCSK_SKI1_1	287	291	PF00082	0.361
DEG_APCC_DBOX_1	164	172	PF00400	0.397
DEG_Nend_UBRbox_4	1	3	PF02207	0.391
DOC_CKS1_1	236	241	PF01111	0.383
DOC_CYCLIN_RxL_1	161	174	PF00134	0.378
DOC_CYCLIN_RxL_1	268	276	PF00134	0.568
DOC_MAPK_FxFP_2	395	398	PF00069	0.239
DOC_MAPK_gen_1	131	138	PF00069	0.596
DOC_MAPK_gen_1	165	171	PF00069	0.335
DOC_MAPK_gen_1	48	55	PF00069	0.346
DOC_MAPK_HePTP_8	128	140	PF00069	0.432
DOC_MAPK_MEF2A_6	131	140	PF00069	0.517
DOC_PP2B_LxvP_1	10	13	PF13499	0.355
DOC_PP2B_LxvP_1	22	25	PF13499	0.328
DOC_PP4_FxxP_1	193	196	PF00568	0.268
DOC_PP4_FxxP_1	395	398	PF00568	0.239
DOC_SPAK_OSR1_1	189	193	PF12202	0.393
DOC_USP7_MATH_1	198	202	PF00917	0.505
DOC_USP7_MATH_1	237	241	PF00917	0.420
DOC_USP7_MATH_1	277	281	PF00917	0.674
DOC_USP7_MATH_1	282	286	PF00917	0.682
DOC_USP7_MATH_1	64	68	PF00917	0.429
DOC_USP7_MATH_1	83	87	PF00917	0.332
DOC_WW_Pin1_4	232	237	PF00397	0.407
DOC_WW_Pin1_4	322	327	PF00397	0.602
DOC_WW_Pin1_4	358	363	PF00397	0.732
DOC_WW_Pin1_4	8	13	PF00397	0.384
LIG_14-3-3_CanoR_1	151	156	PF00244	0.303
LIG_14-3-3_CanoR_1	54	60	PF00244	0.372
LIG_BRCT_BRCA1_1	186	190	PF00533	0.258
LIG_BRCT_BRCA1_1	85	89	PF00533	0.328
LIG_CtBP_PxDLS_1	12	16	PF00389	0.353
LIG_deltaCOP1_diTrp_1	174	184	PF00928	0.431
LIG_DLG_GKlike_1	151	158	PF00625	0.284
LIG_EH1_1	396	404	PF00400	0.173
LIG_FHA_1	128	134	PF00498	0.566
LIG_FHA_1	140	146	PF00498	0.246
LIG_FHA_1	180	186	PF00498	0.356
LIG_FHA_1	288	294	PF00498	0.559
LIG_FHA_1	302	308	PF00498	0.729
LIG_FHA_1	361	367	PF00498	0.636
LIG_FHA_1	404	410	PF00498	0.431
LIG_FHA_1	56	62	PF00498	0.345
LIG_FHA_2	236	242	PF00498	0.381
LIG_LIR_Apic_2	211	215	PF02991	0.341
LIG_LIR_Gen_1	152	163	PF02991	0.293
LIG_LIR_Gen_1	227	236	PF02991	0.456
LIG_LIR_Gen_1	256	263	PF02991	0.421
LIG_LIR_Gen_1	376	386	PF02991	0.397
LIG_LIR_Gen_1	84	95	PF02991	0.297
LIG_LIR_Nem_3	152	158	PF02991	0.311
LIG_LIR_Nem_3	174	180	PF02991	0.441
LIG_LIR_Nem_3	187	193	PF02991	0.360
LIG_LIR_Nem_3	219	225	PF02991	0.488
LIG_LIR_Nem_3	227	231	PF02991	0.360
LIG_LIR_Nem_3	256	260	PF02991	0.376
LIG_LIR_Nem_3	376	382	PF02991	0.328
LIG_LIR_Nem_3	84	90	PF02991	0.297
LIG_SH2_CRK	146	150	PF00017	0.395
LIG_SH2_CRK	155	159	PF00017	0.320
LIG_SH2_CRK	228	232	PF00017	0.450
LIG_SH2_CRK	245	249	PF00017	0.150
LIG_SH2_CRK	267	271	PF00017	0.564
LIG_SH2_CRK	379	383	PF00017	0.284
LIG_SH2_SRC	383	386	PF00017	0.193
LIG_SH2_STAP1	379	383	PF00017	0.357
LIG_SH2_STAT5	155	158	PF00017	0.290
LIG_SH2_STAT5	191	194	PF00017	0.379
LIG_SH2_STAT5	28	31	PF00017	0.339
LIG_SH2_STAT5	385	388	PF00017	0.286
LIG_SH3_3	230	236	PF00018	0.483
LIG_SH3_3	320	326	PF00018	0.650
LIG_SH3_3	356	362	PF00018	0.627
LIG_SUMO_SIM_anti_2	256	262	PF11976	0.410
LIG_SUMO_SIM_par_1	136	142	PF11976	0.355
LIG_SUMO_SIM_par_1	400	406	PF11976	0.333
LIG_TYR_ITSM	379	386	PF00017	0.355
LIG_WRC_WIRS_1	24	29	PF05994	0.369
LIG_WRC_WIRS_1	89	94	PF05994	0.366
MOD_CK1_1	11	17	PF00069	0.380
MOD_CK1_1	127	133	PF00069	0.624
MOD_CK1_1	197	203	PF00069	0.432
MOD_CK1_1	205	211	PF00069	0.323
MOD_CK1_1	235	241	PF00069	0.468
MOD_CK1_1	276	282	PF00069	0.700
MOD_CK1_1	361	367	PF00069	0.604
MOD_CK1_1	373	379	PF00069	0.328
MOD_CK1_1	57	63	PF00069	0.426
MOD_CK2_1	235	241	PF00069	0.389
MOD_CMANNOS	181	184	PF00535	0.595
MOD_CMANNOS	368	371	PF00535	0.417
MOD_GlcNHglycan	111	114	PF01048	0.467
MOD_GlcNHglycan	158	161	PF01048	0.514
MOD_GlcNHglycan	196	199	PF01048	0.599
MOD_GlcNHglycan	200	203	PF01048	0.613
MOD_GlcNHglycan	275	278	PF01048	0.472
MOD_GlcNHglycan	279	282	PF01048	0.511
MOD_GlcNHglycan	29	32	PF01048	0.564
MOD_GlcNHglycan	347	350	PF01048	0.431
MOD_GlcNHglycan	354	357	PF01048	0.380
MOD_GSK3_1	194	201	PF00069	0.389
MOD_GSK3_1	23	30	PF00069	0.326
MOD_GSK3_1	231	238	PF00069	0.500
MOD_GSK3_1	249	256	PF00069	0.266
MOD_GSK3_1	273	280	PF00069	0.677
MOD_GSK3_1	283	290	PF00069	0.689
MOD_GSK3_1	301	308	PF00069	0.742
MOD_GSK3_1	318	325	PF00069	0.676
MOD_GSK3_1	4	11	PF00069	0.387
MOD_GSK3_1	403	410	PF00069	0.259
MOD_GSK3_1	53	60	PF00069	0.501
MOD_GSK3_1	77	84	PF00069	0.323
MOD_N-GLC_1	231	236	PF02516	0.653
MOD_N-GLC_2	116	118	PF02516	0.414
MOD_NEK2_1	216	221	PF00069	0.378
MOD_NEK2_1	231	236	PF00069	0.434
MOD_NEK2_1	253	258	PF00069	0.321
MOD_NEK2_1	273	278	PF00069	0.638
MOD_NEK2_1	53	58	PF00069	0.512
MOD_NEK2_1	81	86	PF00069	0.303
MOD_NEK2_2	184	189	PF00069	0.351
MOD_PIKK_1	4	10	PF00454	0.387
MOD_PKA_2	109	115	PF00069	0.648
MOD_PKA_2	150	156	PF00069	0.224
MOD_PKA_2	283	289	PF00069	0.710
MOD_PKA_2	345	351	PF00069	0.710
MOD_PKA_2	53	59	PF00069	0.352
MOD_Plk_1	124	130	PF00069	0.547
MOD_Plk_1	318	324	PF00069	0.688
MOD_Plk_4	23	29	PF00069	0.342
MOD_Plk_4	318	324	PF00069	0.658
MOD_Plk_4	378	384	PF00069	0.417
MOD_Plk_4	403	409	PF00069	0.272
MOD_Plk_4	83	89	PF00069	0.292
MOD_ProDKin_1	232	238	PF00069	0.402
MOD_ProDKin_1	322	328	PF00069	0.597
MOD_ProDKin_1	358	364	PF00069	0.725
MOD_ProDKin_1	8	14	PF00069	0.384
MOD_SUMO_rev_2	205	215	PF00179	0.466
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.554
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.391
TRG_ENDOCYTIC_2	146	149	PF00928	0.328
TRG_ENDOCYTIC_2	155	158	PF00928	0.270
TRG_ENDOCYTIC_2	228	231	PF00928	0.445
TRG_ENDOCYTIC_2	245	248	PF00928	0.188
TRG_ENDOCYTIC_2	267	270	PF00928	0.569
TRG_ENDOCYTIC_2	379	382	PF00928	0.302
TRG_ENDOCYTIC_2	383	386	PF00928	0.304
TRG_ER_diArg_1	106	108	PF00400	0.605
TRG_ER_diArg_1	131	133	PF00400	0.550
TRG_ER_diArg_1	165	167	PF00400	0.304
TRG_ER_diArg_1	270	272	PF00400	0.667
TRG_ER_diArg_1	47	50	PF00400	0.341

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEL3	Leptomonas seymouri	41%	100%
A0A1X0NUK5	Trypanosomatidae	29%	100%
A0A3Q8ID27	Leishmania donovani	85%	100%
A0A422P1F3	Trypanosoma rangeli	26%	100%
A4HKA4	Leishmania braziliensis	69%	100%
A4I7T4	Leishmania infantum	85%	100%
D0A9Z4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
Q4Q5G5	Leishmania major	81%	100%
V5DHL3	Trypanosoma cruzi	28%	100%