Elongation of fatty acids protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

long chain polyunsaturated fatty acid elongation enzyme-like protein

Species:

Leishmania mexicana

UniProt:

E9B2P1_LEIMU

TriTrypDb:

LmxM.31.1160

Length:

381

Annotations

LeishMANIAdb annotations

Related to ELOVL5 proteins found in multicellular animals. Probably also involved in very long chain fatty acid biosynthesis in ER.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9B2P1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2P1

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	10
GO:0006629	lipid metabolic process	3	10
GO:0006631	fatty acid metabolic process	4	10
GO:0006633	fatty acid biosynthetic process	5	10
GO:0008152	metabolic process	1	10
GO:0008610	lipid biosynthetic process	4	10
GO:0009058	biosynthetic process	2	10
GO:0009987	cellular process	1	10
GO:0016053	organic acid biosynthetic process	4	10
GO:0019752	carboxylic acid metabolic process	5	10
GO:0032787	monocarboxylic acid metabolic process	6	10
GO:0043436	oxoacid metabolic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044255	cellular lipid metabolic process	3	10
GO:0044281	small molecule metabolic process	2	10
GO:0044283	small molecule biosynthetic process	3	10
GO:0046394	carboxylic acid biosynthetic process	5	10
GO:0071704	organic substance metabolic process	2	10
GO:0072330	monocarboxylic acid biosynthetic process	6	10
GO:1901576	organic substance biosynthetic process	3	10
GO:0000038	very long-chain fatty acid metabolic process	5	1
GO:0006643	membrane lipid metabolic process	4	1
GO:0006665	sphingolipid metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0019367	fatty acid elongation, saturated fatty acid	7	1
GO:0019368	fatty acid elongation, unsaturated fatty acid	7	1
GO:0030148	sphingolipid biosynthetic process	5	1
GO:0030497	fatty acid elongation	6	1
GO:0034625	fatty acid elongation, monounsaturated fatty acid	8	1
GO:0034626	fatty acid elongation, polyunsaturated fatty acid	8	1
GO:0042761	very long-chain fatty acid biosynthetic process	6	1
GO:0046467	membrane lipid biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004312	fatty acid synthase activity	5	10
GO:0009922	fatty acid elongase activity	6	10
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity	5	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	327	331	PF00656	0.540
CLV_NRD_NRD_1	309	311	PF00675	0.388
CLV_NRD_NRD_1	361	363	PF00675	0.392
CLV_PCSK_KEX2_1	308	310	PF00082	0.390
CLV_PCSK_KEX2_1	358	360	PF00082	0.393
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.309
CLV_PCSK_SKI1_1	149	153	PF00082	0.431
CLV_PCSK_SKI1_1	237	241	PF00082	0.216
DEG_APCC_KENBOX_2	319	323	PF00400	0.466
DEG_MDM2_SWIB_1	192	200	PF02201	0.365
DOC_MAPK_MEF2A_6	275	283	PF00069	0.190
DOC_MAPK_RevD_3	289	304	PF00069	0.248
DOC_PP1_RVXF_1	150	156	PF00149	0.214
DOC_PP1_RVXF_1	159	166	PF00149	0.249
DOC_PP1_RVXF_1	42	48	PF00149	0.282
DOC_PP2B_LxvP_1	200	203	PF13499	0.365
DOC_USP7_MATH_1	314	318	PF00917	0.616
DOC_USP7_MATH_1	324	328	PF00917	0.619
DOC_WW_Pin1_4	141	146	PF00397	0.260
LIG_14-3-3_CanoR_1	59	64	PF00244	0.282
LIG_Actin_WH2_2	262	277	PF00022	0.377
LIG_BRCT_BRCA1_1	61	65	PF00533	0.267
LIG_CaMK_CASK_1	265	271	PF00069	0.313
LIG_CSL_BTD_1	267	270	PF09270	0.365
LIG_deltaCOP1_diTrp_1	147	155	PF00928	0.222
LIG_EH1_1	75	83	PF00400	0.299
LIG_eIF4E_1	120	126	PF01652	0.365
LIG_eIF4E_1	224	230	PF01652	0.275
LIG_FHA_1	103	109	PF00498	0.551
LIG_FHA_1	188	194	PF00498	0.341
LIG_FHA_1	276	282	PF00498	0.177
LIG_GBD_Chelix_1	108	116	PF00786	0.313
LIG_IRF3_LxIS_1	123	128	PF10401	0.365
LIG_LIR_Gen_1	118	127	PF02991	0.308
LIG_LIR_Gen_1	181	186	PF02991	0.440
LIG_LIR_Gen_1	206	217	PF02991	0.264
LIG_LIR_Gen_1	26	36	PF02991	0.263
LIG_LIR_Gen_1	262	270	PF02991	0.404
LIG_LIR_Gen_1	273	284	PF02991	0.349
LIG_LIR_Nem_3	118	123	PF02991	0.308
LIG_LIR_Nem_3	181	185	PF02991	0.414
LIG_LIR_Nem_3	241	246	PF02991	0.462
LIG_LIR_Nem_3	26	32	PF02991	0.312
LIG_LIR_Nem_3	262	267	PF02991	0.322
LIG_LIR_Nem_3	273	279	PF02991	0.281
LIG_LIR_Nem_3	293	298	PF02991	0.227
LIG_LRP6_Inhibitor_1	38	44	PF00058	0.388
LIG_MYND_1	70	74	PF01753	0.297
LIG_PCNA_PIPBox_1	288	297	PF02747	0.308
LIG_Pex14_1	253	257	PF04695	0.313
LIG_Pex14_2	192	196	PF04695	0.272
LIG_Pex14_2	53	57	PF04695	0.305
LIG_SH2_CRK	120	124	PF00017	0.365
LIG_SH2_CRK	177	181	PF00017	0.415
LIG_SH2_CRK	276	280	PF00017	0.252
LIG_SH2_CRK	95	99	PF00017	0.441
LIG_SH2_GRB2like	71	74	PF00017	0.297
LIG_SH2_SRC	71	74	PF00017	0.297
LIG_SH2_STAP1	209	213	PF00017	0.297
LIG_SH2_STAP1	264	268	PF00017	0.262
LIG_SH2_STAP1	276	280	PF00017	0.282
LIG_SH2_STAT5	158	161	PF00017	0.249
LIG_SH2_STAT5	225	228	PF00017	0.249
LIG_SH2_STAT5	71	74	PF00017	0.244
LIG_SH2_STAT5	84	87	PF00017	0.241
LIG_SH2_STAT5	95	98	PF00017	0.486
LIG_SH3_3	264	270	PF00018	0.373
LIG_SUMO_SIM_anti_2	167	174	PF11976	0.365
LIG_SUMO_SIM_anti_2	86	92	PF11976	0.203
LIG_SUMO_SIM_par_1	287	293	PF11976	0.270
LIG_TRAF2_1	270	273	PF00917	0.229
LIG_TYR_ITIM	274	279	PF00017	0.190
LIG_TYR_ITIM	82	87	PF00017	0.313
LIG_TYR_ITIM	93	98	PF00017	0.387
LIG_UBA3_1	153	161	PF00899	0.272
LIG_UBA3_1	170	174	PF00899	0.272
MOD_CK1_1	102	108	PF00069	0.455
MOD_CK1_1	207	213	PF00069	0.260
MOD_CK1_1	290	296	PF00069	0.428
MOD_CK2_1	141	147	PF00069	0.307
MOD_GlcNHglycan	127	130	PF01048	0.465
MOD_GlcNHglycan	209	212	PF01048	0.414
MOD_GlcNHglycan	214	217	PF01048	0.414
MOD_GlcNHglycan	23	26	PF01048	0.564
MOD_GlcNHglycan	232	235	PF01048	0.339
MOD_GlcNHglycan	261	264	PF01048	0.330
MOD_GlcNHglycan	316	319	PF01048	0.441
MOD_GlcNHglycan	367	370	PF01048	0.313
MOD_GSK3_1	115	122	PF00069	0.248
MOD_GSK3_1	19	26	PF00069	0.281
MOD_GSK3_1	320	327	PF00069	0.689
MOD_N-GLC_1	365	370	PF02516	0.307
MOD_NEK2_1	119	124	PF00069	0.315
MOD_NEK2_1	125	130	PF00069	0.344
MOD_NEK2_1	157	162	PF00069	0.257
MOD_NEK2_1	21	26	PF00069	0.377
MOD_NEK2_1	212	217	PF00069	0.255
MOD_NEK2_1	245	250	PF00069	0.453
MOD_NEK2_1	27	32	PF00069	0.405
MOD_NEK2_1	274	279	PF00069	0.275
MOD_NEK2_1	39	44	PF00069	0.300
MOD_NEK2_2	99	104	PF00069	0.482
MOD_OFUCOSY	96	103	PF10250	0.143
MOD_PKA_1	303	309	PF00069	0.555
MOD_Plk_1	39	45	PF00069	0.306
MOD_Plk_4	115	121	PF00069	0.249
MOD_Plk_4	132	138	PF00069	0.231
MOD_Plk_4	165	171	PF00069	0.249
MOD_Plk_4	178	184	PF00069	0.414
MOD_Plk_4	187	193	PF00069	0.223
MOD_Plk_4	196	202	PF00069	0.267
MOD_Plk_4	204	210	PF00069	0.310
MOD_Plk_4	225	231	PF00069	0.267
MOD_Plk_4	23	29	PF00069	0.298
MOD_Plk_4	275	281	PF00069	0.332
MOD_Plk_4	290	296	PF00069	0.265
MOD_Plk_4	77	83	PF00069	0.339
MOD_ProDKin_1	141	147	PF00069	0.260
MOD_SUMO_rev_2	272	277	PF00179	0.229
MOD_SUMO_rev_2	352	360	PF00179	0.542
TRG_DiLeu_BaEn_1	356	361	PF01217	0.546
TRG_DiLeu_BaLyEn_6	89	94	PF01217	0.398
TRG_ENDOCYTIC_2	120	123	PF00928	0.308
TRG_ENDOCYTIC_2	177	180	PF00928	0.415
TRG_ENDOCYTIC_2	209	212	PF00928	0.297
TRG_ENDOCYTIC_2	224	227	PF00928	0.308
TRG_ENDOCYTIC_2	264	267	PF00928	0.404
TRG_ENDOCYTIC_2	276	279	PF00928	0.190
TRG_ENDOCYTIC_2	29	32	PF00928	0.294
TRG_ENDOCYTIC_2	84	87	PF00928	0.278
TRG_ENDOCYTIC_2	95	98	PF00928	0.481
TRG_ER_diArg_1	308	310	PF00400	0.646
TRG_NLS_MonoExtN_4	359	366	PF00514	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0C5PHQ7	Tachysurus fulvidraco	32%	100%
A0A0N0P994	Leptomonas seymouri	67%	100%
A0A0S4JCZ3	Bodo saltans	52%	100%
A0A0S4JH58	Bodo saltans	30%	100%
A0A0S4KMP5	Bodo saltans	49%	100%
A0A1X0NUJ4	Trypanosomatidae	54%	100%
A0A3Q8IC05	Leishmania donovani	29%	100%
A0A3Q8IT78	Leishmania donovani	90%	100%
A4H7M6	Leishmania braziliensis	25%	100%
A4HKA3	Leishmania braziliensis	79%	100%
A4HW18	Leishmania infantum	28%	100%
A4I7T3	Leishmania infantum	90%	100%
D4A612	Rattus norvegicus	29%	100%
E9APR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4Q5G6	Leishmania major	88%	100%
Q4QFQ9	Leishmania major	27%	100%
Q4R516	Macaca fascicularis	36%	100%
Q5RFL5	Pongo abelii	35%	100%
Q9EQC4	Mus musculus	30%	100%
Q9NYP7	Homo sapiens	36%	100%
Q9VHX7	Drosophila melanogaster	28%	100%