Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2P0_LEIMU

TriTrypDb:

LmxM.31.1150

Length:

304

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2P0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2P0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	89	93	PF00656	0.353
CLV_NRD_NRD_1	151	153	PF00675	0.314
DEG_SPOP_SBC_1	87	91	PF00917	0.491
DOC_MAPK_gen_1	74	81	PF00069	0.423
DOC_MAPK_RevD_3	234	249	PF00069	0.492
DOC_PP1_RVXF_1	159	165	PF00149	0.414
DOC_PP1_RVXF_1	240	247	PF00149	0.406
DOC_USP7_MATH_1	238	242	PF00917	0.448
DOC_USP7_MATH_1	87	91	PF00917	0.512
DOC_USP7_MATH_2	124	130	PF00917	0.419
LIG_14-3-3_CanoR_1	14	21	PF00244	0.506
LIG_14-3-3_CanoR_1	147	154	PF00244	0.289
LIG_14-3-3_CanoR_1	52	61	PF00244	0.431
LIG_Actin_WH2_2	244	260	PF00022	0.441
LIG_APCC_ABBA_1	65	70	PF00400	0.377
LIG_BRCT_BRCA1_1	129	133	PF00533	0.396
LIG_Clathr_ClatBox_1	285	289	PF01394	0.494
LIG_deltaCOP1_diTrp_1	225	234	PF00928	0.492
LIG_FHA_1	154	160	PF00498	0.321
LIG_FHA_1	231	237	PF00498	0.370
LIG_FHA_2	204	210	PF00498	0.679
LIG_FHA_2	220	226	PF00498	0.675
LIG_FHA_2	258	264	PF00498	0.563
LIG_FHA_2	285	291	PF00498	0.566
LIG_FHA_2	31	37	PF00498	0.466
LIG_FHA_2	52	58	PF00498	0.519
LIG_FHA_2	89	95	PF00498	0.554
LIG_GBD_Chelix_1	104	112	PF00786	0.458
LIG_LIR_Gen_1	102	109	PF02991	0.463
LIG_LIR_Nem_3	102	106	PF02991	0.472
LIG_LIR_Nem_3	225	231	PF02991	0.445
LIG_LIR_Nem_3	253	257	PF02991	0.504
LIG_LIR_Nem_3	73	79	PF02991	0.336
LIG_MYND_1	142	146	PF01753	0.518
LIG_PDZ_Class_1	299	304	PF00595	0.534
LIG_Pex14_2	133	137	PF04695	0.373
LIG_SH2_CRK	21	25	PF00017	0.397
LIG_SH2_CRK	26	30	PF00017	0.433
LIG_SH2_STAP1	26	30	PF00017	0.396
LIG_SH2_STAT5	78	81	PF00017	0.419
LIG_SH3_1	249	255	PF00018	0.509
LIG_SH3_3	249	255	PF00018	0.509
LIG_TRAF2_1	287	290	PF00917	0.341
LIG_TRAF2_1	33	36	PF00917	0.257
LIG_TYR_ITIM	24	29	PF00017	0.284
LIG_WRC_WIRS_1	154	159	PF05994	0.327
LIG_WRC_WIRS_1	231	236	PF05994	0.430
LIG_WRC_WIRS_1	78	83	PF05994	0.387
MOD_CK1_1	189	195	PF00069	0.630
MOD_CK1_1	205	211	PF00069	0.690
MOD_CK1_1	44	50	PF00069	0.437
MOD_CK2_1	203	209	PF00069	0.750
MOD_CK2_1	219	225	PF00069	0.540
MOD_CK2_1	237	243	PF00069	0.277
MOD_CK2_1	284	290	PF00069	0.515
MOD_CK2_1	30	36	PF00069	0.306
MOD_GlcNHglycan	169	172	PF01048	0.462
MOD_GlcNHglycan	188	191	PF01048	0.683
MOD_GlcNHglycan	301	304	PF01048	0.666
MOD_GlcNHglycan	54	57	PF01048	0.494
MOD_GSK3_1	107	114	PF00069	0.423
MOD_GSK3_1	194	201	PF00069	0.739
MOD_GSK3_1	2	9	PF00069	0.629
MOD_GSK3_1	215	222	PF00069	0.615
MOD_NEK2_1	12	17	PF00069	0.591
MOD_NEK2_1	257	262	PF00069	0.576
MOD_NEK2_1	277	282	PF00069	0.351
MOD_NEK2_1	30	35	PF00069	0.415
MOD_NEK2_2	77	82	PF00069	0.382
MOD_PIKK_1	107	113	PF00454	0.473
MOD_PKA_2	13	19	PF00069	0.492
MOD_PKA_2	146	152	PF00069	0.418
MOD_PKA_2	257	263	PF00069	0.415
MOD_PKA_2	51	57	PF00069	0.490
MOD_Plk_1	278	284	PF00069	0.423
MOD_Plk_1	296	302	PF00069	0.417
MOD_Plk_1	30	36	PF00069	0.453
MOD_Plk_2-3	198	204	PF00069	0.737
MOD_Plk_4	153	159	PF00069	0.397
MOD_Plk_4	6	12	PF00069	0.580
MOD_Plk_4	77	83	PF00069	0.360
MOD_SUMO_rev_2	145	154	PF00179	0.400
MOD_SUMO_rev_2	265	275	PF00179	0.489
MOD_SUMO_rev_2	70	76	PF00179	0.412
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.505
TRG_ENDOCYTIC_2	21	24	PF00928	0.397
TRG_ENDOCYTIC_2	26	29	PF00928	0.428
TRG_ENDOCYTIC_2	78	81	PF00928	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9E0	Leptomonas seymouri	52%	100%
A0A0S4J915	Bodo saltans	31%	100%
A0A1X0NV05	Trypanosomatidae	36%	100%
A0A3R7N1Z4	Trypanosoma rangeli	36%	100%
A0A3S7X5F5	Leishmania donovani	83%	100%
A4HKA2	Leishmania braziliensis	68%	100%
A4I7T2	Leishmania infantum	83%	100%
D0A9Z3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4Q5G7	Leishmania major	84%	100%
V5BGN1	Trypanosoma cruzi	40%	100%