LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B2N9_LEIMU
TriTrypDb:
LmxM.31.1140
Length:
688

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9B2N9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2N9

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006378 mRNA polyadenylation 7 1
GO:0006396 RNA processing 6 1
GO:0006397 mRNA processing 7 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009894 regulation of catabolic process 4 1
GO:0009987 cellular process 1 1
GO:0010468 regulation of gene expression 5 1
GO:0010608 post-transcriptional regulation of gene expression 6 1
GO:0016070 RNA metabolic process 5 1
GO:0016071 mRNA metabolic process 6 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031123 RNA 3'-end processing 7 1
GO:0031124 mRNA 3'-end processing 8 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031329 regulation of cellular catabolic process 5 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043487 regulation of RNA stability 3 1
GO:0043488 regulation of mRNA stability 4 1
GO:0043631 RNA polyadenylation 6 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0046483 heterocycle metabolic process 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0061013 regulation of mRNA catabolic process 6 1
GO:0065007 biological regulation 1 1
GO:0065008 regulation of biological quality 2 1
GO:0071704 organic substance metabolic process 2 1
GO:0080090 regulation of primary metabolic process 4 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1903311 regulation of mRNA metabolic process 6 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0043021 ribonucleoprotein complex binding 3 1
GO:0043022 ribosome binding 4 1
GO:0044877 protein-containing complex binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 360 364 PF00656 0.749
CLV_NRD_NRD_1 104 106 PF00675 0.603
CLV_NRD_NRD_1 187 189 PF00675 0.422
CLV_NRD_NRD_1 316 318 PF00675 0.516
CLV_NRD_NRD_1 326 328 PF00675 0.480
CLV_NRD_NRD_1 385 387 PF00675 0.407
CLV_NRD_NRD_1 657 659 PF00675 0.515
CLV_PCSK_KEX2_1 104 106 PF00082 0.741
CLV_PCSK_KEX2_1 308 310 PF00082 0.359
CLV_PCSK_KEX2_1 326 328 PF00082 0.529
CLV_PCSK_KEX2_1 385 387 PF00082 0.407
CLV_PCSK_KEX2_1 657 659 PF00082 0.426
CLV_PCSK_PC1ET2_1 308 310 PF00082 0.365
CLV_PCSK_PC7_1 304 310 PF00082 0.274
CLV_PCSK_SKI1_1 115 119 PF00082 0.537
CLV_PCSK_SKI1_1 143 147 PF00082 0.577
CLV_PCSK_SKI1_1 231 235 PF00082 0.389
CLV_PCSK_SKI1_1 300 304 PF00082 0.604
CLV_PCSK_SKI1_1 647 651 PF00082 0.310
CLV_PCSK_SKI1_1 664 668 PF00082 0.280
DEG_APCC_DBOX_1 110 118 PF00400 0.512
DEG_Nend_UBRbox_2 1 3 PF02207 0.557
DOC_ANK_TNKS_1 325 332 PF00023 0.598
DOC_CKS1_1 47 52 PF01111 0.571
DOC_CYCLIN_RxL_1 225 236 PF00134 0.329
DOC_MAPK_gen_1 326 334 PF00069 0.533
DOC_MAPK_gen_1 395 405 PF00069 0.438
DOC_MAPK_gen_1 664 672 PF00069 0.354
DOC_MAPK_MEF2A_6 27 35 PF00069 0.451
DOC_USP7_MATH_1 165 169 PF00917 0.726
DOC_USP7_MATH_1 174 178 PF00917 0.658
DOC_USP7_MATH_1 387 391 PF00917 0.594
DOC_USP7_MATH_1 39 43 PF00917 0.662
DOC_USP7_MATH_1 45 49 PF00917 0.599
DOC_USP7_MATH_1 554 558 PF00917 0.707
DOC_USP7_MATH_1 636 640 PF00917 0.652
DOC_USP7_MATH_1 68 72 PF00917 0.696
DOC_USP7_MATH_1 77 81 PF00917 0.778
DOC_WW_Pin1_4 175 180 PF00397 0.579
DOC_WW_Pin1_4 21 26 PF00397 0.763
DOC_WW_Pin1_4 284 289 PF00397 0.567
DOC_WW_Pin1_4 46 51 PF00397 0.596
DOC_WW_Pin1_4 560 565 PF00397 0.724
DOC_WW_Pin1_4 73 78 PF00397 0.723
DOC_WW_Pin1_4 82 87 PF00397 0.633
DOC_WW_Pin1_4 96 101 PF00397 0.631
LIG_14-3-3_CanoR_1 111 115 PF00244 0.580
LIG_14-3-3_CanoR_1 244 249 PF00244 0.486
LIG_14-3-3_CanoR_1 273 282 PF00244 0.561
LIG_14-3-3_CanoR_1 326 334 PF00244 0.509
LIG_14-3-3_CanoR_1 386 396 PF00244 0.537
LIG_14-3-3_CanoR_1 515 523 PF00244 0.491
LIG_14-3-3_CanoR_1 573 578 PF00244 0.509
LIG_14-3-3_CanoR_1 62 68 PF00244 0.775
LIG_14-3-3_CanoR_1 638 648 PF00244 0.503
LIG_APCC_ABBA_1 650 655 PF00400 0.380
LIG_BRCT_BRCA1_1 180 184 PF00533 0.492
LIG_BRCT_BRCA1_1 644 648 PF00533 0.377
LIG_deltaCOP1_diTrp_1 124 134 PF00928 0.446
LIG_FHA_1 133 139 PF00498 0.537
LIG_FHA_1 150 156 PF00498 0.460
LIG_FHA_1 234 240 PF00498 0.331
LIG_FHA_1 250 256 PF00498 0.267
LIG_FHA_1 391 397 PF00498 0.397
LIG_FHA_1 501 507 PF00498 0.381
LIG_FHA_1 523 529 PF00498 0.457
LIG_FHA_1 53 59 PF00498 0.690
LIG_FHA_1 580 586 PF00498 0.343
LIG_FHA_1 612 618 PF00498 0.373
LIG_FHA_1 667 673 PF00498 0.437
LIG_FHA_2 348 354 PF00498 0.747
LIG_FHA_2 428 434 PF00498 0.490
LIG_FHA_2 446 452 PF00498 0.734
LIG_FHA_2 454 460 PF00498 0.623
LIG_FHA_2 475 481 PF00498 0.438
LIG_FHA_2 535 541 PF00498 0.528
LIG_FHA_2 542 548 PF00498 0.550
LIG_LIR_Gen_1 181 192 PF02991 0.467
LIG_LIR_Gen_1 2 9 PF02991 0.576
LIG_LIR_Gen_1 243 254 PF02991 0.367
LIG_LIR_Gen_1 411 419 PF02991 0.464
LIG_LIR_Gen_1 444 452 PF02991 0.489
LIG_LIR_Gen_1 505 514 PF02991 0.336
LIG_LIR_Gen_1 518 528 PF02991 0.419
LIG_LIR_Gen_1 582 590 PF02991 0.333
LIG_LIR_Gen_1 615 623 PF02991 0.327
LIG_LIR_Nem_3 181 187 PF02991 0.463
LIG_LIR_Nem_3 2 6 PF02991 0.651
LIG_LIR_Nem_3 252 257 PF02991 0.405
LIG_LIR_Nem_3 379 383 PF02991 0.395
LIG_LIR_Nem_3 411 415 PF02991 0.412
LIG_LIR_Nem_3 477 482 PF02991 0.544
LIG_LIR_Nem_3 505 510 PF02991 0.450
LIG_LIR_Nem_3 518 523 PF02991 0.401
LIG_LIR_Nem_3 582 586 PF02991 0.344
LIG_LIR_Nem_3 597 603 PF02991 0.361
LIG_LIR_Nem_3 615 621 PF02991 0.497
LIG_NRBOX 509 515 PF00104 0.456
LIG_Pex14_2 366 370 PF04695 0.457
LIG_RPA_C_Fungi 321 333 PF08784 0.535
LIG_SH2_CRK 412 416 PF00017 0.403
LIG_SH2_PTP2 424 427 PF00017 0.454
LIG_SH2_STAP1 412 416 PF00017 0.403
LIG_SH2_STAP1 583 587 PF00017 0.334
LIG_SH2_STAP1 603 607 PF00017 0.384
LIG_SH2_STAP1 618 622 PF00017 0.384
LIG_SH2_STAT3 592 595 PF00017 0.492
LIG_SH2_STAT5 227 230 PF00017 0.358
LIG_SH2_STAT5 424 427 PF00017 0.456
LIG_SH2_STAT5 447 450 PF00017 0.493
LIG_SH2_STAT5 512 515 PF00017 0.468
LIG_SH2_STAT5 592 595 PF00017 0.447
LIG_SH3_3 142 148 PF00018 0.524
LIG_SH3_3 193 199 PF00018 0.566
LIG_SH3_3 282 288 PF00018 0.652
LIG_SH3_3 48 54 PF00018 0.691
LIG_SUMO_SIM_anti_2 619 624 PF11976 0.423
LIG_SUMO_SIM_par_1 266 272 PF11976 0.269
LIG_SUMO_SIM_par_1 371 379 PF11976 0.460
LIG_SUMO_SIM_par_1 619 624 PF11976 0.423
LIG_TRAF2_1 430 433 PF00917 0.557
LIG_TRAF2_1 449 452 PF00917 0.713
LIG_TYR_ITIM 410 415 PF00017 0.412
LIG_UBA3_1 302 308 PF00899 0.516
LIG_UBA3_1 396 402 PF00899 0.453
LIG_UBA3_1 510 517 PF00899 0.415
LIG_WRC_WIRS_1 663 668 PF05994 0.514
LIG_WW_3 194 198 PF00397 0.530
MOD_CDC14_SPxK_1 24 27 PF00782 0.466
MOD_CDC14_SPxK_1 287 290 PF00782 0.459
MOD_CDK_SPxK_1 21 27 PF00069 0.473
MOD_CDK_SPxK_1 284 290 PF00069 0.479
MOD_CK1_1 156 162 PF00069 0.603
MOD_CK1_1 207 213 PF00069 0.575
MOD_CK1_1 272 278 PF00069 0.532
MOD_CK1_1 293 299 PF00069 0.624
MOD_CK1_1 389 395 PF00069 0.421
MOD_CK1_1 463 469 PF00069 0.729
MOD_CK1_1 52 58 PF00069 0.524
MOD_CK1_1 563 569 PF00069 0.652
MOD_CK1_1 639 645 PF00069 0.567
MOD_CK1_1 73 79 PF00069 0.763
MOD_CK1_1 99 105 PF00069 0.672
MOD_CK2_1 174 180 PF00069 0.634
MOD_CK2_1 427 433 PF00069 0.575
MOD_CK2_1 445 451 PF00069 0.727
MOD_CK2_1 453 459 PF00069 0.561
MOD_CK2_1 474 480 PF00069 0.473
MOD_CK2_1 534 540 PF00069 0.473
MOD_CK2_1 541 547 PF00069 0.492
MOD_CMANNOS 574 577 PF00535 0.456
MOD_GlcNHglycan 135 138 PF01048 0.421
MOD_GlcNHglycan 155 158 PF01048 0.612
MOD_GlcNHglycan 349 353 PF01048 0.812
MOD_GlcNHglycan 41 44 PF01048 0.647
MOD_GlcNHglycan 462 465 PF01048 0.672
MOD_GlcNHglycan 471 475 PF01048 0.482
MOD_GlcNHglycan 51 54 PF01048 0.648
MOD_GlcNHglycan 556 559 PF01048 0.665
MOD_GlcNHglycan 565 568 PF01048 0.613
MOD_GlcNHglycan 637 641 PF01048 0.565
MOD_GlcNHglycan 72 75 PF01048 0.739
MOD_GSK3_1 149 156 PF00069 0.616
MOD_GSK3_1 165 172 PF00069 0.754
MOD_GSK3_1 174 181 PF00069 0.677
MOD_GSK3_1 271 278 PF00069 0.526
MOD_GSK3_1 290 297 PF00069 0.593
MOD_GSK3_1 386 393 PF00069 0.437
MOD_GSK3_1 441 448 PF00069 0.621
MOD_GSK3_1 45 52 PF00069 0.656
MOD_GSK3_1 460 467 PF00069 0.769
MOD_GSK3_1 470 477 PF00069 0.605
MOD_GSK3_1 541 548 PF00069 0.448
MOD_GSK3_1 639 646 PF00069 0.530
MOD_GSK3_1 662 669 PF00069 0.441
MOD_GSK3_1 674 681 PF00069 0.484
MOD_GSK3_1 73 80 PF00069 0.795
MOD_GSK3_1 95 102 PF00069 0.558
MOD_N-GLC_1 105 110 PF02516 0.646
MOD_N-GLC_1 175 180 PF02516 0.639
MOD_NEK2_1 133 138 PF00069 0.383
MOD_NEK2_1 219 224 PF00069 0.428
MOD_NEK2_1 233 238 PF00069 0.322
MOD_NEK2_1 249 254 PF00069 0.301
MOD_NEK2_1 271 276 PF00069 0.546
MOD_NEK2_1 292 297 PF00069 0.528
MOD_NEK2_1 472 477 PF00069 0.555
MOD_NEK2_1 545 550 PF00069 0.521
MOD_NEK2_1 606 611 PF00069 0.449
MOD_NEK2_1 666 671 PF00069 0.516
MOD_NEK2_2 110 115 PF00069 0.358
MOD_PIKK_1 149 155 PF00454 0.448
MOD_PIKK_1 441 447 PF00454 0.683
MOD_PIKK_1 93 99 PF00454 0.835
MOD_PK_1 244 250 PF00069 0.444
MOD_PKA_2 110 116 PF00069 0.586
MOD_PKA_2 201 207 PF00069 0.642
MOD_PKA_2 219 225 PF00069 0.336
MOD_PKA_2 272 278 PF00069 0.472
MOD_PKA_2 325 331 PF00069 0.565
MOD_PKA_2 347 353 PF00069 0.716
MOD_PKA_2 387 393 PF00069 0.515
MOD_PKA_2 572 578 PF00069 0.500
MOD_PKA_2 611 617 PF00069 0.428
MOD_PKB_1 678 686 PF00069 0.492
MOD_Plk_1 260 266 PF00069 0.467
MOD_Plk_2-3 401 407 PF00069 0.317
MOD_Plk_4 411 417 PF00069 0.457
MOD_Plk_4 522 528 PF00069 0.544
MOD_Plk_4 565 571 PF00069 0.479
MOD_ProDKin_1 175 181 PF00069 0.572
MOD_ProDKin_1 21 27 PF00069 0.762
MOD_ProDKin_1 284 290 PF00069 0.565
MOD_ProDKin_1 46 52 PF00069 0.596
MOD_ProDKin_1 560 566 PF00069 0.720
MOD_ProDKin_1 73 79 PF00069 0.725
MOD_ProDKin_1 82 88 PF00069 0.628
MOD_ProDKin_1 96 102 PF00069 0.705
MOD_SUMO_for_1 33 36 PF00179 0.449
MOD_SUMO_rev_2 30 35 PF00179 0.606
TRG_DiLeu_BaEn_1 509 514 PF01217 0.448
TRG_ENDOCYTIC_2 226 229 PF00928 0.339
TRG_ENDOCYTIC_2 412 415 PF00928 0.405
TRG_ENDOCYTIC_2 447 450 PF00928 0.493
TRG_ENDOCYTIC_2 583 586 PF00928 0.335
TRG_ENDOCYTIC_2 603 606 PF00928 0.406
TRG_ENDOCYTIC_2 618 621 PF00928 0.323
TRG_ENDOCYTIC_2 653 656 PF00928 0.370
TRG_ER_diArg_1 103 105 PF00400 0.627
TRG_ER_diArg_1 384 386 PF00400 0.404
TRG_ER_diArg_1 589 592 PF00400 0.477
TRG_ER_diArg_1 656 658 PF00400 0.497
TRG_NES_CRM1_1 394 408 PF08389 0.437
TRG_Pf-PMV_PEXEL_1 231 235 PF00026 0.469
TRG_Pf-PMV_PEXEL_1 290 294 PF00026 0.684

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PGR3 Leptomonas seymouri 50% 92%
A0A1X0NVZ4 Trypanosomatidae 31% 100%
A0A3Q8IG45 Leishmania donovani 83% 100%
A0A3R7NTQ6 Trypanosoma rangeli 30% 100%
A4HKA1 Leishmania braziliensis 69% 100%
A4I7T1 Leishmania infantum 83% 100%
D0A9Z2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
Q4Q5G8 Leishmania major 83% 99%
V5BQR4 Trypanosoma cruzi 28% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS