Myosin heavy chain

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Myosin heavy chain

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2M9_LEIMU

TriTrypDb:

LmxM.31.1040

Length:

708

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9B2M9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2M9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.637
CLV_C14_Caspase3-7	315	319	PF00656	0.756
CLV_C14_Caspase3-7	497	501	PF00656	0.644
CLV_C14_Caspase3-7	626	630	PF00656	0.553
CLV_NRD_NRD_1	19	21	PF00675	0.604
CLV_NRD_NRD_1	669	671	PF00675	0.511
CLV_NRD_NRD_1	702	704	PF00675	0.669
CLV_PCSK_KEX2_1	19	21	PF00082	0.597
CLV_PCSK_KEX2_1	397	399	PF00082	0.449
CLV_PCSK_KEX2_1	50	52	PF00082	0.595
CLV_PCSK_KEX2_1	555	557	PF00082	0.538
CLV_PCSK_KEX2_1	669	671	PF00082	0.511
CLV_PCSK_KEX2_1	702	704	PF00082	0.736
CLV_PCSK_PC1ET2_1	397	399	PF00082	0.449
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.595
CLV_PCSK_PC1ET2_1	555	557	PF00082	0.467
CLV_PCSK_SKI1_1	2	6	PF00082	0.583
CLV_PCSK_SKI1_1	356	360	PF00082	0.536
CLV_PCSK_SKI1_1	447	451	PF00082	0.568
CLV_PCSK_SKI1_1	623	627	PF00082	0.511
CLV_PCSK_SKI1_1	71	75	PF00082	0.600
CLV_Separin_Metazoa	166	170	PF03568	0.688
CLV_Separin_Metazoa	199	203	PF03568	0.527
DEG_APCC_DBOX_1	446	454	PF00400	0.681
DOC_CYCLIN_RxL_1	216	224	PF00134	0.521
DOC_MAPK_gen_1	134	142	PF00069	0.647
DOC_MAPK_gen_1	445	453	PF00069	0.748
DOC_MAPK_gen_1	564	572	PF00069	0.721
DOC_MAPK_gen_1	669	678	PF00069	0.682
DOC_MAPK_MEF2A_6	198	207	PF00069	0.729
DOC_MAPK_MEF2A_6	600	608	PF00069	0.647
DOC_PP1_RVXF_1	202	208	PF00149	0.725
DOC_PP2B_LxvP_1	586	589	PF13499	0.732
DOC_PP2B_LxvP_1	610	613	PF13499	0.632
DOC_PP4_FxxP_1	103	106	PF00568	0.412
DOC_PP4_FxxP_1	120	123	PF00568	0.274
DOC_PP4_FxxP_1	151	154	PF00568	0.620
DOC_PP4_FxxP_1	4	7	PF00568	0.396
DOC_USP7_MATH_1	242	246	PF00917	0.761
DOC_USP7_MATH_1	376	380	PF00917	0.732
DOC_USP7_MATH_1	62	66	PF00917	0.442
DOC_USP7_MATH_1	662	666	PF00917	0.738
DOC_WW_Pin1_4	123	128	PF00397	0.482
DOC_WW_Pin1_4	416	421	PF00397	0.761
DOC_WW_Pin1_4	435	440	PF00397	0.769
DOC_WW_Pin1_4	51	56	PF00397	0.391
DOC_WW_Pin1_4	57	62	PF00397	0.392
DOC_WW_Pin1_4	66	71	PF00397	0.389
DOC_WW_Pin1_4	87	92	PF00397	0.426
LIG_14-3-3_CanoR_1	128	133	PF00244	0.578
LIG_14-3-3_CanoR_1	169	179	PF00244	0.710
LIG_14-3-3_CanoR_1	181	187	PF00244	0.606
LIG_14-3-3_CanoR_1	26	30	PF00244	0.394
LIG_14-3-3_CanoR_1	413	421	PF00244	0.780
LIG_14-3-3_CanoR_1	642	647	PF00244	0.701
LIG_Actin_WH2_2	193	208	PF00022	0.730
LIG_APCC_ABBA_1	691	696	PF00400	0.323
LIG_BRCT_BRCA1_1	116	120	PF00533	0.256
LIG_BRCT_BRCA1_1	147	151	PF00533	0.601
LIG_BRCT_BRCA1_1	244	248	PF00533	0.761
LIG_BRCT_BRCA1_1	27	31	PF00533	0.390
LIG_BRCT_BRCA1_1	38	42	PF00533	0.375
LIG_Clathr_ClatBox_1	450	454	PF01394	0.813
LIG_FHA_1	13	19	PF00498	0.414
LIG_FHA_1	174	180	PF00498	0.610
LIG_FHA_1	260	266	PF00498	0.718
LIG_FHA_1	435	441	PF00498	0.730
LIG_FHA_1	546	552	PF00498	0.633
LIG_FHA_2	192	198	PF00498	0.600
LIG_FHA_2	400	406	PF00498	0.755
LIG_FHA_2	624	630	PF00498	0.695
LIG_LIR_Apic_2	117	123	PF02991	0.229
LIG_LIR_Apic_2	148	154	PF02991	0.612
LIG_LIR_Apic_2	54	59	PF02991	0.413
LIG_LIR_Gen_1	185	192	PF02991	0.611
LIG_LIR_Gen_1	297	307	PF02991	0.676
LIG_LIR_Gen_1	618	625	PF02991	0.598
LIG_LIR_Nem_3	107	113	PF02991	0.216
LIG_LIR_Nem_3	117	121	PF02991	0.398
LIG_LIR_Nem_3	135	139	PF02991	0.631
LIG_LIR_Nem_3	185	189	PF02991	0.636
LIG_LIR_Nem_3	297	303	PF02991	0.610
LIG_LIR_Nem_3	618	624	PF02991	0.602
LIG_MYND_1	123	127	PF01753	0.427
LIG_MYND_1	55	59	PF01753	0.397
LIG_NRBOX	71	77	PF00104	0.399
LIG_PDZ_Class_3	703	708	PF00595	0.497
LIG_Pex14_2	5	9	PF04695	0.382
LIG_REV1ctd_RIR_1	100	105	PF16727	0.394
LIG_SH2_CRK	110	114	PF00017	0.229
LIG_SH2_GRB2like	216	219	PF00017	0.519
LIG_SH2_GRB2like	56	59	PF00017	0.405
LIG_SH2_NCK_1	300	304	PF00017	0.677
LIG_SH2_NCK_1	621	625	PF00017	0.740
LIG_SH2_SRC	300	303	PF00017	0.678
LIG_SH2_SRC	56	59	PF00017	0.405
LIG_SH2_STAP1	339	343	PF00017	0.609
LIG_SH2_STAP1	621	625	PF00017	0.730
LIG_SH2_STAT5	110	113	PF00017	0.229
LIG_SH2_STAT5	216	219	PF00017	0.519
LIG_SH2_STAT5	269	272	PF00017	0.660
LIG_SH2_STAT5	56	59	PF00017	0.405
LIG_SH3_1	56	62	PF00018	0.400
LIG_SH3_1	669	675	PF00018	0.702
LIG_SH3_3	118	124	PF00018	0.514
LIG_SH3_3	238	244	PF00018	0.815
LIG_SH3_3	56	62	PF00018	0.417
LIG_SH3_3	603	609	PF00018	0.737
LIG_SH3_3	645	651	PF00018	0.608
LIG_SH3_3	669	675	PF00018	0.702
LIG_SUMO_SIM_par_1	138	148	PF11976	0.757
LIG_SUMO_SIM_par_1	449	454	PF11976	0.749
LIG_TRAF2_1	185	188	PF00917	0.611
LIG_TRAF2_1	508	511	PF00917	0.685
LIG_TYR_ITIM	619	624	PF00017	0.604
LIG_WRC_WIRS_1	133	138	PF05994	0.659
LIG_WW_3	646	650	PF00397	0.675
MOD_CDK_SPK_2	123	128	PF00069	0.426
MOD_CDK_SPK_2	66	71	PF00069	0.397
MOD_CDK_SPxK_1	87	93	PF00069	0.410
MOD_CK1_1	114	120	PF00069	0.278
MOD_CK1_1	12	18	PF00069	0.408
MOD_CK1_1	173	179	PF00069	0.724
MOD_CK1_1	419	425	PF00069	0.737
MOD_CK1_1	435	441	PF00069	0.767
MOD_CK1_1	558	564	PF00069	0.650
MOD_CK1_1	84	90	PF00069	0.413
MOD_CK2_1	160	166	PF00069	0.700
MOD_CK2_1	182	188	PF00069	0.642
MOD_CK2_1	191	197	PF00069	0.644
MOD_CK2_1	269	275	PF00069	0.658
MOD_CK2_1	338	344	PF00069	0.652
MOD_CK2_1	376	382	PF00069	0.753
MOD_CK2_1	399	405	PF00069	0.723
MOD_CK2_1	505	511	PF00069	0.614
MOD_CK2_1	627	633	PF00069	0.570
MOD_Cter_Amidation	48	51	PF01082	0.591
MOD_GlcNHglycan	113	116	PF01048	0.270
MOD_GlcNHglycan	144	150	PF01048	0.387
MOD_GlcNHglycan	251	254	PF01048	0.552
MOD_GlcNHglycan	378	381	PF01048	0.483
MOD_GlcNHglycan	382	385	PF01048	0.504
MOD_GlcNHglycan	407	410	PF01048	0.547
MOD_GlcNHglycan	491	495	PF01048	0.516
MOD_GlcNHglycan	557	560	PF01048	0.436
MOD_GlcNHglycan	629	632	PF01048	0.407
MOD_GlcNHglycan	657	660	PF01048	0.600
MOD_GlcNHglycan	664	667	PF01048	0.559
MOD_GlcNHglycan	696	699	PF01048	0.638
MOD_GSK3_1	104	111	PF00069	0.422
MOD_GSK3_1	128	135	PF00069	0.623
MOD_GSK3_1	217	224	PF00069	0.635
MOD_GSK3_1	243	250	PF00069	0.771
MOD_GSK3_1	25	32	PF00069	0.394
MOD_GSK3_1	265	272	PF00069	0.680
MOD_GSK3_1	289	296	PF00069	0.721
MOD_GSK3_1	338	345	PF00069	0.721
MOD_GSK3_1	372	379	PF00069	0.752
MOD_GSK3_1	399	406	PF00069	0.682
MOD_GSK3_1	412	419	PF00069	0.748
MOD_GSK3_1	434	441	PF00069	0.667
MOD_GSK3_1	486	493	PF00069	0.715
MOD_GSK3_1	590	597	PF00069	0.738
MOD_GSK3_1	611	618	PF00069	0.597
MOD_GSK3_1	62	69	PF00069	0.475
MOD_GSK3_1	623	630	PF00069	0.546
MOD_GSK3_1	83	90	PF00069	0.431
MOD_N-GLC_1	217	222	PF02516	0.528
MOD_N-GLC_1	423	428	PF02516	0.530
MOD_N-GLC_1	505	510	PF02516	0.437
MOD_NEK2_1	132	137	PF00069	0.691
MOD_NEK2_1	221	226	PF00069	0.643
MOD_NEK2_1	248	253	PF00069	0.763
MOD_NEK2_1	265	270	PF00069	0.545
MOD_NEK2_1	29	34	PF00069	0.355
MOD_NEK2_1	312	317	PF00069	0.658
MOD_NEK2_1	414	419	PF00069	0.737
MOD_NEK2_1	42	47	PF00069	0.391
MOD_NEK2_1	596	601	PF00069	0.646
MOD_NEK2_1	615	620	PF00069	0.669
MOD_NEK2_1	694	699	PF00069	0.538
MOD_NEK2_1	9	14	PF00069	0.399
MOD_NEK2_2	269	274	PF00069	0.661
MOD_OFUCOSY	78	85	PF10250	0.594
MOD_PIKK_1	104	110	PF00454	0.395
MOD_PIKK_1	12	18	PF00454	0.402
MOD_PIKK_1	173	179	PF00454	0.665
MOD_PIKK_1	289	295	PF00454	0.666
MOD_PIKK_1	412	418	PF00454	0.798
MOD_PIKK_1	423	429	PF00454	0.751
MOD_PKA_1	555	561	PF00069	0.659
MOD_PKA_2	242	248	PF00069	0.760
MOD_PKA_2	25	31	PF00069	0.406
MOD_PKA_2	412	418	PF00069	0.781
MOD_PKA_2	486	492	PF00069	0.649
MOD_PKA_2	555	561	PF00069	0.659
MOD_PKA_2	662	668	PF00069	0.694
MOD_Plk_1	191	197	PF00069	0.658
MOD_Plk_1	217	223	PF00069	0.531
MOD_Plk_1	265	271	PF00069	0.668
MOD_Plk_1	35	41	PF00069	0.403
MOD_Plk_1	399	405	PF00069	0.656
MOD_Plk_1	505	511	PF00069	0.637
MOD_Plk_1	615	621	PF00069	0.743
MOD_Plk_2-3	192	198	PF00069	0.733
MOD_Plk_2-3	505	511	PF00069	0.637
MOD_Plk_4	128	134	PF00069	0.693
MOD_Plk_4	260	266	PF00069	0.723
MOD_Plk_4	338	344	PF00069	0.643
MOD_Plk_4	582	588	PF00069	0.658
MOD_ProDKin_1	123	129	PF00069	0.473
MOD_ProDKin_1	416	422	PF00069	0.763
MOD_ProDKin_1	435	441	PF00069	0.767
MOD_ProDKin_1	51	57	PF00069	0.393
MOD_ProDKin_1	66	72	PF00069	0.390
MOD_ProDKin_1	87	93	PF00069	0.425
MOD_SUMO_for_1	364	367	PF00179	0.655
MOD_SUMO_rev_2	552	557	PF00179	0.679
TRG_DiLeu_BaEn_1	355	360	PF01217	0.666
TRG_ENDOCYTIC_2	110	113	PF00928	0.229
TRG_ENDOCYTIC_2	186	189	PF00928	0.664
TRG_ENDOCYTIC_2	300	303	PF00928	0.678
TRG_ENDOCYTIC_2	339	342	PF00928	0.648
TRG_ENDOCYTIC_2	621	624	PF00928	0.604
TRG_ER_diArg_1	18	20	PF00400	0.399
TRG_ER_diArg_1	201	204	PF00400	0.660
TRG_ER_diArg_1	668	670	PF00400	0.753
TRG_ER_diArg_1	702	705	PF00400	0.473
TRG_NES_CRM1_1	275	289	PF08389	0.674
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	479	483	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	507	511	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	549	553	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4B6	Leptomonas seymouri	39%	100%
A0A3S7X5F4	Leishmania donovani	83%	100%
A4HK86	Leishmania braziliensis	62%	100%
A4I7S1	Leishmania infantum	83%	100%
Q4Q5H8	Leishmania major	80%	100%