Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9B2M7_LEIMU

TriTrypDb:

LmxM.31.1020

Length:

811

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B2M7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2M7

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016310	phosphorylation	5	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0004672	protein kinase activity	3	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	354	356	PF00675	0.732
CLV_NRD_NRD_1	611	613	PF00675	0.313
CLV_NRD_NRD_1	772	774	PF00675	0.622
CLV_NRD_NRD_1	782	784	PF00675	0.614
CLV_PCSK_FUR_1	2	6	PF00082	0.628
CLV_PCSK_KEX2_1	354	356	PF00082	0.745
CLV_PCSK_KEX2_1	4	6	PF00082	0.614
CLV_PCSK_KEX2_1	543	545	PF00082	0.425
CLV_PCSK_KEX2_1	611	613	PF00082	0.314
CLV_PCSK_KEX2_1	755	757	PF00082	0.490
CLV_PCSK_KEX2_1	772	774	PF00082	0.554
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.700
CLV_PCSK_PC1ET2_1	543	545	PF00082	0.425
CLV_PCSK_PC1ET2_1	755	757	PF00082	0.576
CLV_PCSK_SKI1_1	250	254	PF00082	0.686
CLV_PCSK_SKI1_1	428	432	PF00082	0.512
CLV_PCSK_SKI1_1	524	528	PF00082	0.626
CLV_PCSK_SKI1_1	540	544	PF00082	0.209
CLV_PCSK_SKI1_1	558	562	PF00082	0.252
CLV_Separin_Metazoa	487	491	PF03568	0.512
DEG_APCC_DBOX_1	557	565	PF00400	0.425
DEG_Nend_UBRbox_1	1	4	PF02207	0.626
DEG_SPOP_SBC_1	281	285	PF00917	0.513
DEG_SPOP_SBC_1	301	305	PF00917	0.705
DOC_CKS1_1	295	300	PF01111	0.673
DOC_CYCLIN_yCln2_LP_2	723	729	PF00134	0.333
DOC_MAPK_gen_1	354	361	PF00069	0.489
DOC_MAPK_gen_1	459	466	PF00069	0.254
DOC_MAPK_MEF2A_6	459	468	PF00069	0.395
DOC_MAPK_MEF2A_6	544	553	PF00069	0.307
DOC_MAPK_MEF2A_6	707	715	PF00069	0.362
DOC_PP1_RVXF_1	691	698	PF00149	0.307
DOC_PP2B_LxvP_1	217	220	PF13499	0.662
DOC_USP7_MATH_1	175	179	PF00917	0.675
DOC_USP7_MATH_1	189	193	PF00917	0.524
DOC_USP7_MATH_1	232	236	PF00917	0.679
DOC_USP7_MATH_1	267	271	PF00917	0.726
DOC_USP7_MATH_1	281	285	PF00917	0.593
DOC_USP7_MATH_1	301	305	PF00917	0.607
DOC_USP7_MATH_1	451	455	PF00917	0.509
DOC_USP7_MATH_2	188	194	PF00917	0.487
DOC_USP7_UBL2_3	424	428	PF12436	0.529
DOC_USP7_UBL2_3	507	511	PF12436	0.484
DOC_USP7_UBL2_3	751	755	PF12436	0.556
DOC_WW_Pin1_4	171	176	PF00397	0.623
DOC_WW_Pin1_4	181	186	PF00397	0.718
DOC_WW_Pin1_4	243	248	PF00397	0.645
DOC_WW_Pin1_4	282	287	PF00397	0.732
DOC_WW_Pin1_4	294	299	PF00397	0.569
DOC_WW_Pin1_4	47	52	PF00397	0.580
DOC_WW_Pin1_4	543	548	PF00397	0.322
DOC_WW_Pin1_4	94	99	PF00397	0.726
LIG_14-3-3_CanoR_1	191	195	PF00244	0.631
LIG_14-3-3_CanoR_1	313	319	PF00244	0.755
LIG_14-3-3_CanoR_1	490	500	PF00244	0.525
LIG_14-3-3_CanoR_1	5	14	PF00244	0.529
LIG_14-3-3_CanoR_1	529	533	PF00244	0.556
LIG_14-3-3_CanoR_1	716	720	PF00244	0.308
LIG_14-3-3_CanoR_1	783	793	PF00244	0.521
LIG_14-3-3_CterR_2	809	811	PF00244	0.717
LIG_Actin_WH2_2	702	718	PF00022	0.397
LIG_APCC_ABBA_1	119	124	PF00400	0.575
LIG_BRCT_BRCA1_1	245	249	PF00533	0.693
LIG_BRCT_BRCA1_1	261	265	PF00533	0.744
LIG_BRCT_BRCA1_1	316	320	PF00533	0.724
LIG_BRCT_BRCA1_1	697	701	PF00533	0.333
LIG_BRCT_BRCA1_1	749	753	PF00533	0.403
LIG_BRCT_BRCA1_2	749	755	PF00533	0.534
LIG_EVH1_1	217	221	PF00568	0.486
LIG_FHA_1	171	177	PF00498	0.700
LIG_FHA_1	222	228	PF00498	0.483
LIG_FHA_1	285	291	PF00498	0.739
LIG_FHA_1	303	309	PF00498	0.746
LIG_FHA_1	313	319	PF00498	0.607
LIG_FHA_1	354	360	PF00498	0.594
LIG_FHA_1	412	418	PF00498	0.506
LIG_FHA_1	513	519	PF00498	0.381
LIG_FHA_1	71	77	PF00498	0.529
LIG_FHA_1	775	781	PF00498	0.585
LIG_FHA_1	788	794	PF00498	0.452
LIG_FHA_2	128	134	PF00498	0.586
LIG_FHA_2	151	157	PF00498	0.535
LIG_FHA_2	529	535	PF00498	0.606
LIG_FHA_2	75	81	PF00498	0.723
LIG_FHA_2	86	92	PF00498	0.764
LIG_LIR_Apic_2	260	266	PF02991	0.550
LIG_LIR_Apic_2	531	535	PF02991	0.551
LIG_LIR_Apic_2	618	624	PF02991	0.307
LIG_LIR_Gen_1	101	112	PF02991	0.606
LIG_LIR_Gen_1	569	578	PF02991	0.309
LIG_LIR_Gen_1	699	709	PF02991	0.335
LIG_LIR_Nem_3	101	107	PF02991	0.661
LIG_LIR_Nem_3	110	116	PF02991	0.603
LIG_LIR_Nem_3	246	252	PF02991	0.708
LIG_LIR_Nem_3	317	323	PF02991	0.720
LIG_LIR_Nem_3	494	499	PF02991	0.529
LIG_LIR_Nem_3	569	574	PF02991	0.307
LIG_LIR_Nem_3	677	682	PF02991	0.307
LIG_LIR_Nem_3	698	704	PF02991	0.333
LIG_LIR_Nem_3	787	792	PF02991	0.521
LIG_LIR_Nem_3	803	808	PF02991	0.720
LIG_Pex14_1	233	237	PF04695	0.693
LIG_Pex14_1	697	701	PF04695	0.333
LIG_Pex14_2	675	679	PF04695	0.419
LIG_Pex14_2	727	731	PF04695	0.462
LIG_SH2_CRK	263	267	PF00017	0.559
LIG_SH2_CRK	571	575	PF00017	0.309
LIG_SH2_CRK	702	706	PF00017	0.419
LIG_SH2_STAP1	702	706	PF00017	0.388
LIG_SH2_STAP1	789	793	PF00017	0.633
LIG_SH2_STAT3	444	447	PF00017	0.452
LIG_SH2_STAT3	587	590	PF00017	0.395
LIG_SH2_STAT3	792	795	PF00017	0.646
LIG_SH2_STAT5	444	447	PF00017	0.552
LIG_SH2_STAT5	789	792	PF00017	0.633
LIG_SH3_2	220	225	PF14604	0.687
LIG_SH3_3	182	188	PF00018	0.650
LIG_SH3_3	215	221	PF00018	0.655
LIG_SH3_3	292	298	PF00018	0.597
LIG_SH3_3	315	321	PF00018	0.694
LIG_SUMO_SIM_par_1	463	470	PF11976	0.229
LIG_SUMO_SIM_par_1	72	77	PF11976	0.572
LIG_TRAF2_1	153	156	PF00917	0.572
LIG_TRAF2_1	360	363	PF00917	0.593
LIG_TRAF2_1	484	487	PF00917	0.550
LIG_TYR_ITSM	567	574	PF00017	0.419
LIG_WRC_WIRS_1	249	254	PF05994	0.646
LIG_WRC_WIRS_1	468	473	PF05994	0.351
LIG_WW_1	441	444	PF00397	0.450
MOD_CDK_SPxxK_3	243	250	PF00069	0.696
MOD_CK1_1	127	133	PF00069	0.615
MOD_CK1_1	150	156	PF00069	0.597
MOD_CK1_1	193	199	PF00069	0.570
MOD_CK1_1	256	262	PF00069	0.702
MOD_CK1_1	276	282	PF00069	0.487
MOD_CK1_1	284	290	PF00069	0.584
MOD_CK1_1	300	306	PF00069	0.544
MOD_CK1_1	312	318	PF00069	0.629
MOD_CK1_1	319	325	PF00069	0.466
MOD_CK1_1	328	334	PF00069	0.583
MOD_CK1_1	367	373	PF00069	0.498
MOD_CK1_1	501	507	PF00069	0.393
MOD_CK1_1	58	64	PF00069	0.713
MOD_CK1_1	69	75	PF00069	0.697
MOD_CK1_1	787	793	PF00069	0.627
MOD_CK2_1	127	133	PF00069	0.596
MOD_CK2_1	150	156	PF00069	0.595
MOD_CK2_1	232	238	PF00069	0.694
MOD_CK2_1	357	363	PF00069	0.536
MOD_CK2_1	528	534	PF00069	0.667
MOD_CK2_1	598	604	PF00069	0.362
MOD_CK2_1	69	75	PF00069	0.696
MOD_CK2_1	85	91	PF00069	0.546
MOD_GlcNHglycan	163	166	PF01048	0.623
MOD_GlcNHglycan	177	180	PF01048	0.586
MOD_GlcNHglycan	181	184	PF01048	0.505
MOD_GlcNHglycan	243	246	PF01048	0.690
MOD_GlcNHglycan	275	278	PF01048	0.751
MOD_GlcNHglycan	299	302	PF01048	0.698
MOD_GlcNHglycan	336	339	PF01048	0.788
MOD_GlcNHglycan	343	346	PF01048	0.720
MOD_GlcNHglycan	500	503	PF01048	0.468
MOD_GlcNHglycan	504	507	PF01048	0.458
MOD_GlcNHglycan	63	66	PF01048	0.533
MOD_GlcNHglycan	9	12	PF01048	0.699
MOD_GSK3_1	125	132	PF00069	0.626
MOD_GSK3_1	171	178	PF00069	0.646
MOD_GSK3_1	189	196	PF00069	0.593
MOD_GSK3_1	197	204	PF00069	0.680
MOD_GSK3_1	208	215	PF00069	0.448
MOD_GSK3_1	253	260	PF00069	0.716
MOD_GSK3_1	276	283	PF00069	0.628
MOD_GSK3_1	296	303	PF00069	0.582
MOD_GSK3_1	308	315	PF00069	0.596
MOD_GSK3_1	327	334	PF00069	0.576
MOD_GSK3_1	341	348	PF00069	0.643
MOD_GSK3_1	353	360	PF00069	0.628
MOD_GSK3_1	431	438	PF00069	0.539
MOD_GSK3_1	47	54	PF00069	0.586
MOD_GSK3_1	478	485	PF00069	0.527
MOD_GSK3_1	498	505	PF00069	0.309
MOD_GSK3_1	55	62	PF00069	0.606
MOD_GSK3_1	65	72	PF00069	0.601
MOD_GSK3_1	711	718	PF00069	0.368
MOD_GSK3_1	796	803	PF00069	0.665
MOD_GSK3_1	81	88	PF00069	0.783
MOD_LATS_1	754	760	PF00433	0.572
MOD_N-GLC_1	107	112	PF02516	0.546
MOD_N-GLC_1	308	313	PF02516	0.684
MOD_N-GLC_1	367	372	PF02516	0.461
MOD_N-GLC_1	411	416	PF02516	0.585
MOD_N-GLC_1	69	74	PF02516	0.694
MOD_N-GLC_1	695	700	PF02516	0.354
MOD_NEK2_1	194	199	PF00069	0.651
MOD_NEK2_1	208	213	PF00069	0.562
MOD_NEK2_1	248	253	PF00069	0.735
MOD_NEK2_1	257	262	PF00069	0.704
MOD_NEK2_1	302	307	PF00069	0.665
MOD_NEK2_1	308	313	PF00069	0.638
MOD_NEK2_1	314	319	PF00069	0.613
MOD_NEK2_1	332	337	PF00069	0.658
MOD_NEK2_1	435	440	PF00069	0.538
MOD_NEK2_1	489	494	PF00069	0.409
MOD_NEK2_1	519	524	PF00069	0.665
MOD_NEK2_1	52	57	PF00069	0.669
MOD_NEK2_1	59	64	PF00069	0.634
MOD_NEK2_1	686	691	PF00069	0.307
MOD_NEK2_1	7	12	PF00069	0.699
MOD_NEK2_1	715	720	PF00069	0.425
MOD_NEK2_1	767	772	PF00069	0.490
MOD_NEK2_1	81	86	PF00069	0.606
MOD_NEK2_2	232	237	PF00069	0.639
MOD_NEK2_2	286	291	PF00069	0.643
MOD_NEK2_2	697	702	PF00069	0.362
MOD_PIKK_1	383	389	PF00454	0.452
MOD_PIKK_1	489	495	PF00454	0.404
MOD_PK_1	357	363	PF00069	0.440
MOD_PK_1	460	466	PF00069	0.477
MOD_PKA_2	190	196	PF00069	0.609
MOD_PKA_2	312	318	PF00069	0.739
MOD_PKA_2	341	347	PF00069	0.719
MOD_PKA_2	353	359	PF00069	0.685
MOD_PKA_2	489	495	PF00069	0.516
MOD_PKA_2	528	534	PF00069	0.547
MOD_PKA_2	59	65	PF00069	0.574
MOD_PKA_2	7	13	PF00069	0.601
MOD_PKA_2	715	721	PF00069	0.307
MOD_Plk_1	189	195	PF00069	0.627
MOD_Plk_1	268	274	PF00069	0.695
MOD_Plk_1	367	373	PF00069	0.456
MOD_Plk_1	428	434	PF00069	0.526
MOD_Plk_1	569	575	PF00069	0.285
MOD_Plk_1	69	75	PF00069	0.708
MOD_Plk_1	711	717	PF00069	0.494
MOD_Plk_1	800	806	PF00069	0.768
MOD_Plk_4	232	238	PF00069	0.651
MOD_Plk_4	268	274	PF00069	0.664
MOD_Plk_4	286	292	PF00069	0.581
MOD_Plk_4	328	334	PF00069	0.751
MOD_Plk_4	386	392	PF00069	0.505
MOD_Plk_4	428	434	PF00069	0.515
MOD_Plk_4	460	466	PF00069	0.477
MOD_Plk_4	551	557	PF00069	0.307
MOD_Plk_4	569	575	PF00069	0.307
MOD_Plk_4	598	604	PF00069	0.362
MOD_Plk_4	615	621	PF00069	0.424
MOD_Plk_4	697	703	PF00069	0.222
MOD_Plk_4	800	806	PF00069	0.694
MOD_ProDKin_1	171	177	PF00069	0.624
MOD_ProDKin_1	181	187	PF00069	0.721
MOD_ProDKin_1	243	249	PF00069	0.647
MOD_ProDKin_1	282	288	PF00069	0.733
MOD_ProDKin_1	294	300	PF00069	0.568
MOD_ProDKin_1	47	53	PF00069	0.583
MOD_ProDKin_1	543	549	PF00069	0.322
MOD_ProDKin_1	94	100	PF00069	0.722
MOD_SUMO_for_1	542	545	PF00179	0.425
MOD_SUMO_rev_2	120	128	PF00179	0.579
MOD_SUMO_rev_2	235	243	PF00179	0.696
MOD_SUMO_rev_2	454	462	PF00179	0.553
MOD_SUMO_rev_2	572	581	PF00179	0.285
MOD_SUMO_rev_2	747	753	PF00179	0.516
MOD_SUMO_rev_2	97	105	PF00179	0.704
TRG_DiLeu_BaEn_1	133	138	PF01217	0.554
TRG_DiLeu_LyEn_5	133	138	PF01217	0.641
TRG_ENDOCYTIC_2	571	574	PF00928	0.333
TRG_ENDOCYTIC_2	702	705	PF00928	0.337
TRG_ER_diArg_1	391	394	PF00400	0.487
TRG_ER_diArg_1	437	440	PF00400	0.559
TRG_NES_CRM1_1	550	566	PF08389	0.362
TRG_NES_CRM1_1	737	749	PF08389	0.320
TRG_Pf-PMV_PEXEL_1	136	140	PF00026	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9E7	Leptomonas seymouri	64%	99%
A0A1X0NW98	Trypanosomatidae	39%	100%
A0A3Q8ID17	Leishmania donovani	92%	100%
A0A3R7KXA1	Trypanosoma rangeli	42%	100%
A4HK84	Leishmania braziliensis	78%	100%
A4I7R9	Leishmania infantum	92%	100%
Q4Q5I0	Leishmania major	92%	100%
V5BQQ4	Trypanosoma cruzi	41%	100%