LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Tyrosine-protein phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Tyrosine-protein phosphatase domain-containing protein
Gene product:
Tyrosine phosphatase family, putative
Species:
Leishmania mexicana
UniProt:
E9B2M6_LEIMU
TriTrypDb:
LmxM.31.1010
Length:
416

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9B2M6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2M6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 4
GO:0016787 hydrolase activity 2 4
GO:0016788 hydrolase activity, acting on ester bonds 3 4
GO:0016791 phosphatase activity 5 4
GO:0042578 phosphoric ester hydrolase activity 4 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 118 120 PF00675 0.346
CLV_NRD_NRD_1 142 144 PF00675 0.304
CLV_NRD_NRD_1 193 195 PF00675 0.611
CLV_NRD_NRD_1 201 203 PF00675 0.481
CLV_NRD_NRD_1 235 237 PF00675 0.689
CLV_NRD_NRD_1 299 301 PF00675 0.562
CLV_PCSK_KEX2_1 118 120 PF00082 0.352
CLV_PCSK_KEX2_1 142 144 PF00082 0.304
CLV_PCSK_KEX2_1 201 203 PF00082 0.575
CLV_PCSK_KEX2_1 235 237 PF00082 0.689
CLV_PCSK_KEX2_1 299 301 PF00082 0.580
CLV_PCSK_KEX2_1 60 62 PF00082 0.346
CLV_PCSK_PC1ET2_1 60 62 PF00082 0.346
CLV_PCSK_SKI1_1 60 64 PF00082 0.419
DEG_SPOP_SBC_1 268 272 PF00917 0.729
DOC_CYCLIN_RxL_1 106 117 PF00134 0.549
DOC_CYCLIN_RxL_1 57 66 PF00134 0.619
DOC_CYCLIN_yCln2_LP_2 12 15 PF00134 0.546
DOC_MAPK_gen_1 118 125 PF00069 0.619
DOC_MAPK_gen_1 164 174 PF00069 0.619
DOC_MAPK_MEF2A_6 167 174 PF00069 0.619
DOC_MAPK_NFAT4_5 167 175 PF00069 0.619
DOC_PP1_RVXF_1 108 115 PF00149 0.546
DOC_PP2B_LxvP_1 11 14 PF13499 0.415
DOC_PP2B_LxvP_1 383 386 PF13499 0.613
DOC_PP4_FxxP_1 125 128 PF00568 0.504
DOC_USP7_MATH_1 234 238 PF00917 0.576
DOC_WW_Pin1_4 101 106 PF00397 0.563
DOC_WW_Pin1_4 269 274 PF00397 0.618
LIG_14-3-3_CanoR_1 235 239 PF00244 0.519
LIG_14-3-3_CanoR_1 269 273 PF00244 0.728
LIG_14-3-3_CanoR_1 363 368 PF00244 0.525
LIG_14-3-3_CanoR_1 402 406 PF00244 0.720
LIG_APCC_ABBA_1 170 175 PF00400 0.619
LIG_APCC_ABBAyCdc20_2 194 200 PF00400 0.394
LIG_BRCT_BRCA1_1 149 153 PF00533 0.619
LIG_BRCT_BRCA1_1 219 223 PF00533 0.754
LIG_Clathr_ClatBox_1 171 175 PF01394 0.619
LIG_Clathr_ClatBox_1 49 53 PF01394 0.546
LIG_deltaCOP1_diTrp_1 117 125 PF00928 0.546
LIG_EVH1_2 14 18 PF00568 0.546
LIG_FHA_1 107 113 PF00498 0.601
LIG_FHA_1 132 138 PF00498 0.546
LIG_FHA_1 43 49 PF00498 0.572
LIG_FHA_1 89 95 PF00498 0.528
LIG_FHA_2 260 266 PF00498 0.705
LIG_FHA_2 377 383 PF00498 0.551
LIG_LIR_Gen_1 157 166 PF02991 0.546
LIG_LIR_Gen_1 16 26 PF02991 0.619
LIG_LIR_Gen_1 262 268 PF02991 0.726
LIG_LIR_Nem_3 117 123 PF02991 0.546
LIG_LIR_Nem_3 157 162 PF02991 0.543
LIG_LIR_Nem_3 16 21 PF02991 0.619
LIG_LIR_Nem_3 262 266 PF02991 0.609
LIG_MYND_1 10 14 PF01753 0.393
LIG_Pex14_1 346 350 PF04695 0.459
LIG_Pex14_2 173 177 PF04695 0.619
LIG_SH2_CRK 159 163 PF00017 0.619
LIG_SH2_CRK 365 369 PF00017 0.627
LIG_SH2_NCK_1 365 369 PF00017 0.413
LIG_SH2_SRC 350 353 PF00017 0.568
LIG_SH2_STAT5 159 162 PF00017 0.619
LIG_SH2_STAT5 350 353 PF00017 0.566
LIG_SH2_STAT5 38 41 PF00017 0.546
LIG_SH3_3 276 282 PF00018 0.747
LIG_SUMO_SIM_anti_2 45 51 PF11976 0.619
LIG_SUMO_SIM_par_1 45 51 PF11976 0.549
LIG_TRAF2_1 226 229 PF00917 0.527
MOD_CDK_SPxxK_3 269 276 PF00069 0.695
MOD_CK1_1 237 243 PF00069 0.702
MOD_CK1_1 254 260 PF00069 0.538
MOD_CK1_1 264 270 PF00069 0.566
MOD_CK1_1 366 372 PF00069 0.507
MOD_CK1_1 403 409 PF00069 0.619
MOD_CK1_1 65 71 PF00069 0.531
MOD_CK2_1 151 157 PF00069 0.546
MOD_CK2_1 223 229 PF00069 0.742
MOD_CK2_1 259 265 PF00069 0.703
MOD_CK2_1 320 326 PF00069 0.750
MOD_CK2_1 376 382 PF00069 0.560
MOD_CMANNOS 346 349 PF00535 0.465
MOD_DYRK1A_RPxSP_1 269 273 PF00069 0.630
MOD_GlcNHglycan 149 152 PF01048 0.363
MOD_GlcNHglycan 184 187 PF01048 0.485
MOD_GlcNHglycan 217 220 PF01048 0.670
MOD_GlcNHglycan 246 249 PF01048 0.688
MOD_GlcNHglycan 289 292 PF01048 0.668
MOD_GlcNHglycan 322 325 PF01048 0.671
MOD_GlcNHglycan 98 101 PF01048 0.346
MOD_GSK3_1 147 154 PF00069 0.620
MOD_GSK3_1 158 165 PF00069 0.524
MOD_GSK3_1 215 222 PF00069 0.683
MOD_GSK3_1 250 257 PF00069 0.683
MOD_GSK3_1 264 271 PF00069 0.558
MOD_GSK3_1 70 77 PF00069 0.562
MOD_NEK2_1 1 6 PF00069 0.626
MOD_NEK2_1 158 163 PF00069 0.572
MOD_NEK2_1 166 171 PF00069 0.516
MOD_NEK2_1 286 291 PF00069 0.652
MOD_PIKK_1 256 262 PF00454 0.610
MOD_PKA_2 166 172 PF00069 0.546
MOD_PKA_2 215 221 PF00069 0.665
MOD_PKA_2 234 240 PF00069 0.513
MOD_PKA_2 268 274 PF00069 0.725
MOD_PKA_2 401 407 PF00069 0.723
MOD_Plk_1 223 229 PF00069 0.528
MOD_Plk_1 264 270 PF00069 0.704
MOD_Plk_4 166 172 PF00069 0.617
MOD_ProDKin_1 101 107 PF00069 0.563
MOD_ProDKin_1 269 275 PF00069 0.620
MOD_SUMO_rev_2 337 342 PF00179 0.623
MOD_SUMO_rev_2 358 362 PF00179 0.511
TRG_DiLeu_BaEn_3 328 334 PF01217 0.475
TRG_DiLeu_BaLyEn_6 58 63 PF01217 0.604
TRG_DiLeu_BaLyEn_6 7 12 PF01217 0.627
TRG_ENDOCYTIC_2 159 162 PF00928 0.619
TRG_ER_diArg_1 118 120 PF00400 0.580
TRG_ER_diArg_1 141 143 PF00400 0.506
TRG_ER_diArg_1 191 194 PF00400 0.533
TRG_ER_diArg_1 298 300 PF00400 0.584
TRG_NLS_MonoExtN_4 201 206 PF00514 0.688
TRG_Pf-PMV_PEXEL_1 164 168 PF00026 0.419
TRG_Pf-PMV_PEXEL_1 61 66 PF00026 0.346

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PE45 Leptomonas seymouri 58% 97%
A0A3Q8IT66 Leishmania donovani 89% 98%
A4HK83 Leishmania braziliensis 76% 100%
A4I7R8 Leishmania infantum 89% 98%
Q4Q5I1 Leishmania major 88% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS