SB domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vps23 core domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B2M3_LEIMU

TriTrypDb:

LmxM.31.0985

Length:

409

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	12
GO:0031410	cytoplasmic vesicle	6	12
GO:0031982	vesicle	4	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0097708	intracellular vesicle	5	12
GO:0110165	cellular anatomical entity	1	12
GO:0000813	ESCRT I complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0036452	ESCRT complex	2	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

E9B2M3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2M3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	14
GO:0008104	protein localization	4	14
GO:0009987	cellular process	1	14
GO:0015031	protein transport	4	14
GO:0033036	macromolecule localization	2	14
GO:0045184	establishment of protein localization	3	14
GO:0051179	localization	1	14
GO:0051234	establishment of localization	2	14
GO:0051641	cellular localization	2	14
GO:0070727	cellular macromolecule localization	3	14
GO:0071702	organic substance transport	4	14
GO:0071705	nitrogen compound transport	4	14
GO:0007034	vacuolar transport	4	1
GO:0007041	lysosomal transport	5	1
GO:0008333	endosome to lysosome transport	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0046907	intracellular transport	3	1
GO:0051649	establishment of localization in cell	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	328	334	PF00089	0.367
CLV_NRD_NRD_1	207	209	PF00675	0.499
CLV_NRD_NRD_1	65	67	PF00675	0.516
CLV_PCSK_KEX2_1	302	304	PF00082	0.308
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.341
CLV_PCSK_SKI1_1	209	213	PF00082	0.461
CLV_PCSK_SKI1_1	229	233	PF00082	0.448
CLV_PCSK_SKI1_1	387	391	PF00082	0.400
CLV_PCSK_SKI1_1	405	409	PF00082	0.481
CLV_Separin_Metazoa	230	234	PF03568	0.291
CLV_TASPASE1	255	261	PF01112	0.530
DEG_APCC_DBOX_1	386	394	PF00400	0.535
DEG_APCC_DBOX_1	400	408	PF00400	0.407
DEG_Nend_UBRbox_2	1	3	PF02207	0.501
DOC_CKS1_1	349	354	PF01111	0.692
DOC_CKS1_1	355	360	PF01111	0.651
DOC_CKS1_1	73	78	PF01111	0.500
DOC_CYCLIN_RxL_1	276	286	PF00134	0.442
DOC_CYCLIN_RxL_1	320	334	PF00134	0.541
DOC_CYCLIN_yCln2_LP_2	96	99	PF00134	0.443
DOC_MAPK_gen_1	208	215	PF00069	0.505
DOC_PP1_RVXF_1	54	60	PF00149	0.222
DOC_PP2B_LxvP_1	96	99	PF13499	0.493
DOC_USP7_MATH_1	162	166	PF00917	0.666
DOC_USP7_MATH_1	181	185	PF00917	0.606
DOC_WW_Pin1_4	16	21	PF00397	0.440
DOC_WW_Pin1_4	344	349	PF00397	0.682
DOC_WW_Pin1_4	354	359	PF00397	0.749
DOC_WW_Pin1_4	45	50	PF00397	0.509
DOC_WW_Pin1_4	65	70	PF00397	0.508
DOC_WW_Pin1_4	72	77	PF00397	0.481
LIG_14-3-3_CanoR_1	131	136	PF00244	0.493
LIG_14-3-3_CanoR_1	182	186	PF00244	0.579
LIG_Actin_WH2_2	111	129	PF00022	0.350
LIG_BRCT_BRCA1_1	142	146	PF00533	0.444
LIG_FHA_1	25	31	PF00498	0.388
LIG_FHA_1	291	297	PF00498	0.562
LIG_FHA_1	344	350	PF00498	0.734
LIG_FHA_1	73	79	PF00498	0.459
LIG_FHA_2	260	266	PF00498	0.565
LIG_FHA_2	305	311	PF00498	0.508
LIG_HCF-1_HBM_1	234	237	PF13415	0.290
LIG_IRF3_LxIS_1	136	143	PF10401	0.438
LIG_LIR_Apic_2	15	20	PF02991	0.494
LIG_LIR_Gen_1	202	212	PF02991	0.393
LIG_LIR_Gen_1	60	69	PF02991	0.508
LIG_LIR_LC3C_4	75	80	PF02991	0.492
LIG_LIR_Nem_3	147	153	PF02991	0.410
LIG_LIR_Nem_3	15	21	PF02991	0.461
LIG_LIR_Nem_3	31	36	PF02991	0.244
LIG_LIR_Nem_3	60	65	PF02991	0.478
LIG_LYPXL_yS_3	150	153	PF13949	0.465
LIG_NRBOX	135	141	PF00104	0.354
LIG_OCRL_FandH_1	322	334	PF00620	0.472
LIG_PCNA_PIPBox_1	236	245	PF02747	0.426
LIG_PCNA_yPIPBox_3	229	243	PF02747	0.563
LIG_SH2_CRK	18	22	PF00017	0.459
LIG_SH2_GRB2like	36	39	PF00017	0.375
LIG_SH2_NCK_1	18	22	PF00017	0.353
LIG_SH2_SRC	242	245	PF00017	0.599
LIG_SH2_SRC	28	31	PF00017	0.460
LIG_SH2_STAP1	36	40	PF00017	0.495
LIG_SH2_STAT3	237	240	PF00017	0.300
LIG_SH2_STAT5	125	128	PF00017	0.399
LIG_SH2_STAT5	204	207	PF00017	0.371
LIG_SH2_STAT5	214	217	PF00017	0.388
LIG_SH2_STAT5	242	245	PF00017	0.599
LIG_SH2_STAT5	311	314	PF00017	0.458
LIG_SH2_STAT5	329	332	PF00017	0.409
LIG_SH3_1	359	365	PF00018	0.580
LIG_SH3_2	362	367	PF14604	0.717
LIG_SH3_3	126	132	PF00018	0.544
LIG_SH3_3	145	151	PF00018	0.207
LIG_SH3_3	269	275	PF00018	0.537
LIG_SH3_3	352	358	PF00018	0.644
LIG_SH3_3	359	365	PF00018	0.658
LIG_SH3_3	92	98	PF00018	0.464
LIG_SUMO_SIM_anti_2	10	15	PF11976	0.438
LIG_SUMO_SIM_anti_2	291	299	PF11976	0.433
LIG_SUMO_SIM_anti_2	382	388	PF11976	0.484
LIG_SUMO_SIM_anti_2	75	82	PF11976	0.441
LIG_SUMO_SIM_par_1	137	144	PF11976	0.325
LIG_SUMO_SIM_par_1	291	299	PF11976	0.467
LIG_SUMO_SIM_par_1	75	82	PF11976	0.441
LIG_TRAF2_1	262	265	PF00917	0.591
LIG_TYR_ITIM	148	153	PF00017	0.492
LIG_UBA3_1	212	217	PF00899	0.524
LIG_WRC_WIRS_1	80	85	PF05994	0.468
MOD_CDK_SPK_2	354	359	PF00069	0.592
MOD_CDK_SPxK_1	45	51	PF00069	0.389
MOD_CK1_1	110	116	PF00069	0.477
MOD_CK1_1	12	18	PF00069	0.369
MOD_CK1_1	169	175	PF00069	0.690
MOD_CK1_1	24	30	PF00069	0.450
MOD_CK2_1	218	224	PF00069	0.484
MOD_CK2_1	259	265	PF00069	0.540
MOD_CK2_1	304	310	PF00069	0.409
MOD_CK2_1	357	363	PF00069	0.781
MOD_GlcNHglycan	171	174	PF01048	0.725
MOD_GlcNHglycan	23	26	PF01048	0.353
MOD_GlcNHglycan	341	344	PF01048	0.578
MOD_GlcNHglycan	379	382	PF01048	0.458
MOD_GlcNHglycan	92	95	PF01048	0.467
MOD_GSK3_1	12	19	PF00069	0.517
MOD_GSK3_1	158	165	PF00069	0.603
MOD_GSK3_1	24	31	PF00069	0.370
MOD_GSK3_1	339	346	PF00069	0.601
MOD_GSK3_1	61	68	PF00069	0.451
MOD_N-GLC_1	218	223	PF02516	0.536
MOD_N-GLC_1	247	252	PF02516	0.566
MOD_N-GLC_1	313	318	PF02516	0.326
MOD_N-GLC_1	339	344	PF02516	0.453
MOD_NEK2_1	1	6	PF00069	0.447
MOD_NEK2_1	218	223	PF00069	0.536
MOD_NEK2_1	336	341	PF00069	0.557
MOD_NEK2_2	61	66	PF00069	0.334
MOD_PIKK_1	12	18	PF00454	0.438
MOD_PIKK_1	69	75	PF00454	0.403
MOD_PKA_2	166	172	PF00069	0.454
MOD_PKA_2	181	187	PF00069	0.541
MOD_PKA_2	330	336	PF00069	0.460
MOD_Plk_1	1	7	PF00069	0.449
MOD_Plk_1	247	253	PF00069	0.558
MOD_Plk_1	259	265	PF00069	0.616
MOD_Plk_1	290	296	PF00069	0.508
MOD_Plk_1	395	401	PF00069	0.447
MOD_Plk_1	9	15	PF00069	0.433
MOD_Plk_4	1	7	PF00069	0.242
MOD_Plk_4	107	113	PF00069	0.424
MOD_Plk_4	121	127	PF00069	0.288
MOD_Plk_4	131	137	PF00069	0.352
MOD_Plk_4	181	187	PF00069	0.487
MOD_Plk_4	248	254	PF00069	0.506
MOD_ProDKin_1	16	22	PF00069	0.431
MOD_ProDKin_1	344	350	PF00069	0.684
MOD_ProDKin_1	354	360	PF00069	0.783
MOD_ProDKin_1	45	51	PF00069	0.522
MOD_ProDKin_1	65	71	PF00069	0.503
MOD_ProDKin_1	72	78	PF00069	0.476
MOD_SUMO_for_1	301	304	PF00179	0.541
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.515
TRG_ENDOCYTIC_2	109	112	PF00928	0.483
TRG_ENDOCYTIC_2	133	136	PF00928	0.306
TRG_ENDOCYTIC_2	150	153	PF00928	0.287
TRG_ENDOCYTIC_2	18	21	PF00928	0.440
TRG_ENDOCYTIC_2	204	207	PF00928	0.421
TRG_ENDOCYTIC_2	329	332	PF00928	0.583
TRG_NES_CRM1_1	137	149	PF08389	0.374
TRG_NES_CRM1_1	388	403	PF08389	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9L8	Leptomonas seymouri	69%	100%
A0A0S4KPG1	Bodo saltans	29%	84%
A0A1X0NUL1	Trypanosomatidae	28%	90%
A0A1X0NUM5	Trypanosomatidae	34%	96%
A0A3Q8IJ55	Leishmania donovani	91%	100%
A0A422P1F9	Trypanosoma rangeli	28%	100%
A0A422P1H3	Trypanosoma rangeli	34%	96%
A4HK80	Leishmania braziliensis	78%	100%
A4I7R5	Leishmania infantum	91%	100%
D0A9X4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	90%
E9AEF7	Leishmania major	89%	100%
V5BQQ0	Trypanosoma cruzi	33%	96%