RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2M2_LEIMU

TriTrypDb:

LmxM.31.0980

Length:

558

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2M2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2M2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	537	539	PF00675	0.700
CLV_PCSK_KEX2_1	241	243	PF00082	0.513
CLV_PCSK_KEX2_1	537	539	PF00082	0.700
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.513
CLV_PCSK_SKI1_1	160	164	PF00082	0.516
CLV_PCSK_SKI1_1	212	216	PF00082	0.526
CLV_PCSK_SKI1_1	241	245	PF00082	0.513
CLV_PCSK_SKI1_1	278	282	PF00082	0.493
CLV_PCSK_SKI1_1	481	485	PF00082	0.443
DEG_APCC_DBOX_1	269	277	PF00400	0.510
DEG_Nend_UBRbox_3	1	3	PF02207	0.532
DEG_SCF_FBW7_1	389	395	PF00400	0.484
DEG_SPOP_SBC_1	122	126	PF00917	0.698
DOC_CDC14_PxL_1	65	73	PF14671	0.473
DOC_CKS1_1	389	394	PF01111	0.535
DOC_CKS1_1	39	44	PF01111	0.674
DOC_CYCLIN_RxL_1	152	161	PF00134	0.546
DOC_CYCLIN_RxL_1	476	486	PF00134	0.427
DOC_CYCLIN_yCln2_LP_2	330	336	PF00134	0.593
DOC_MAPK_gen_1	219	228	PF00069	0.487
DOC_PP4_FxxP_1	396	399	PF00568	0.619
DOC_PP4_FxxP_1	91	94	PF00568	0.574
DOC_USP7_MATH_1	121	125	PF00917	0.779
DOC_USP7_MATH_1	325	329	PF00917	0.589
DOC_USP7_MATH_1	363	367	PF00917	0.476
DOC_USP7_MATH_1	40	44	PF00917	0.640
DOC_USP7_MATH_1	432	436	PF00917	0.587
DOC_USP7_MATH_1	471	475	PF00917	0.629
DOC_USP7_MATH_1	522	526	PF00917	0.635
DOC_USP7_MATH_1	75	79	PF00917	0.672
DOC_USP7_MATH_1	80	84	PF00917	0.500
DOC_USP7_MATH_1	94	98	PF00917	0.785
DOC_WW_Pin1_4	123	128	PF00397	0.668
DOC_WW_Pin1_4	284	289	PF00397	0.573
DOC_WW_Pin1_4	301	306	PF00397	0.654
DOC_WW_Pin1_4	315	320	PF00397	0.625
DOC_WW_Pin1_4	341	346	PF00397	0.628
DOC_WW_Pin1_4	359	364	PF00397	0.641
DOC_WW_Pin1_4	38	43	PF00397	0.671
DOC_WW_Pin1_4	388	393	PF00397	0.667
DOC_WW_Pin1_4	400	405	PF00397	0.651
DOC_WW_Pin1_4	447	452	PF00397	0.717
DOC_WW_Pin1_4	499	504	PF00397	0.489
DOC_WW_Pin1_4	96	101	PF00397	0.616
LIG_Actin_WH2_2	258	276	PF00022	0.495
LIG_APCC_ABBA_1	168	173	PF00400	0.563
LIG_BRCT_BRCA1_1	134	138	PF00533	0.654
LIG_BRCT_BRCA1_1	155	159	PF00533	0.572
LIG_BRCT_BRCA1_1	383	387	PF00533	0.629
LIG_BRCT_BRCA1_1	42	46	PF00533	0.509
LIG_FHA_1	12	18	PF00498	0.772
LIG_FHA_1	238	244	PF00498	0.560
LIG_FHA_1	312	318	PF00498	0.776
LIG_FHA_1	39	45	PF00498	0.676
LIG_FHA_1	409	415	PF00498	0.610
LIG_FHA_1	463	469	PF00498	0.670
LIG_FHA_2	551	557	PF00498	0.499
LIG_LIR_Apic_2	395	399	PF02991	0.749
LIG_LIR_Gen_1	135	145	PF02991	0.654
LIG_LIR_Gen_1	222	233	PF02991	0.434
LIG_LIR_Gen_1	307	317	PF02991	0.543
LIG_LIR_Nem_3	135	141	PF02991	0.663
LIG_LIR_Nem_3	156	162	PF02991	0.567
LIG_LIR_Nem_3	222	228	PF02991	0.445
LIG_LIR_Nem_3	307	312	PF02991	0.651
LIG_LIR_Nem_3	438	442	PF02991	0.624
LIG_LIR_Nem_3	505	511	PF02991	0.522
LIG_SH2_CRK	144	148	PF00017	0.475
LIG_SH2_CRK	309	313	PF00017	0.588
LIG_SH2_NCK_1	144	148	PF00017	0.448
LIG_SH2_NCK_1	309	313	PF00017	0.588
LIG_SH2_STAP1	144	148	PF00017	0.448
LIG_SH2_STAP1	410	414	PF00017	0.595
LIG_SH2_STAT3	410	413	PF00017	0.603
LIG_SH2_STAT3	488	491	PF00017	0.557
LIG_SH2_STAT5	309	312	PF00017	0.591
LIG_SH2_STAT5	369	372	PF00017	0.620
LIG_SH2_STAT5	410	413	PF00017	0.612
LIG_SH3_1	386	392	PF00018	0.666
LIG_SH3_3	386	392	PF00018	0.725
LIG_SH3_3	445	451	PF00018	0.670
LIG_SH3_3	457	463	PF00018	0.577
LIG_SH3_3	497	503	PF00018	0.564
LIG_SUMO_SIM_par_1	231	238	PF11976	0.290
LIG_SUMO_SIM_par_1	481	486	PF11976	0.601
LIG_TYR_ITIM	506	511	PF00017	0.522
LIG_TYR_ITSM	305	312	PF00017	0.544
MOD_CDK_SPxxK_3	284	291	PF00069	0.635
MOD_CDK_SPxxK_3	447	454	PF00069	0.682
MOD_CK1_1	126	132	PF00069	0.659
MOD_CK1_1	137	143	PF00069	0.730
MOD_CK1_1	292	298	PF00069	0.784
MOD_CK1_1	304	310	PF00069	0.675
MOD_CK1_1	328	334	PF00069	0.625
MOD_CK1_1	408	414	PF00069	0.601
MOD_CK1_1	450	456	PF00069	0.660
MOD_CK1_1	540	546	PF00069	0.774
MOD_CK1_1	99	105	PF00069	0.734
MOD_CK2_1	185	191	PF00069	0.481
MOD_CK2_1	432	438	PF00069	0.615
MOD_CK2_1	449	455	PF00069	0.793
MOD_CK2_1	5	11	PF00069	0.641
MOD_Cter_Amidation	535	538	PF01082	0.658
MOD_GlcNHglycan	230	233	PF01048	0.363
MOD_GlcNHglycan	35	38	PF01048	0.700
MOD_GlcNHglycan	354	358	PF01048	0.632
MOD_GlcNHglycan	416	419	PF01048	0.590
MOD_GlcNHglycan	455	459	PF01048	0.721
MOD_GlcNHglycan	511	514	PF01048	0.631
MOD_GlcNHglycan	529	532	PF01048	0.524
MOD_GlcNHglycan	533	537	PF01048	0.607
MOD_GlcNHglycan	539	542	PF01048	0.642
MOD_GlcNHglycan	57	60	PF01048	0.686
MOD_GSK3_1	122	129	PF00069	0.679
MOD_GSK3_1	132	139	PF00069	0.599
MOD_GSK3_1	292	299	PF00069	0.758
MOD_GSK3_1	300	307	PF00069	0.599
MOD_GSK3_1	311	318	PF00069	0.657
MOD_GSK3_1	359	366	PF00069	0.492
MOD_GSK3_1	388	395	PF00069	0.604
MOD_GSK3_1	446	453	PF00069	0.668
MOD_GSK3_1	471	478	PF00069	0.709
MOD_GSK3_1	71	78	PF00069	0.630
MOD_LATS_1	217	223	PF00433	0.527
MOD_N-GLC_1	132	137	PF02516	0.670
MOD_N-GLC_1	228	233	PF02516	0.383
MOD_N-GLC_1	54	59	PF02516	0.647
MOD_NEK2_1	237	242	PF00069	0.480
MOD_NEK2_1	320	325	PF00069	0.652
MOD_NEK2_1	353	358	PF00069	0.614
MOD_NEK2_1	364	369	PF00069	0.482
MOD_NEK2_1	381	386	PF00069	0.740
MOD_NEK2_1	414	419	PF00069	0.573
MOD_NEK2_1	430	435	PF00069	0.580
MOD_NEK2_1	483	488	PF00069	0.565
MOD_NEK2_1	71	76	PF00069	0.592
MOD_NEK2_2	392	397	PF00069	0.671
MOD_NEK2_2	405	410	PF00069	0.462
MOD_OFUCOSY	216	223	PF10250	0.538
MOD_PIKK_1	132	138	PF00454	0.696
MOD_PIKK_1	483	489	PF00454	0.614
MOD_PIKK_1	542	548	PF00454	0.619
MOD_PKA_1	537	543	PF00069	0.649
MOD_PKA_2	292	298	PF00069	0.713
MOD_PKA_2	537	543	PF00069	0.828
MOD_Plk_1	228	234	PF00069	0.362
MOD_Plk_1	353	359	PF00069	0.641
MOD_Plk_1	71	77	PF00069	0.580
MOD_Plk_2-3	5	11	PF00069	0.627
MOD_Plk_4	325	331	PF00069	0.675
MOD_Plk_4	392	398	PF00069	0.683
MOD_Plk_4	40	46	PF00069	0.580
MOD_Plk_4	405	411	PF00069	0.467
MOD_ProDKin_1	123	129	PF00069	0.670
MOD_ProDKin_1	284	290	PF00069	0.576
MOD_ProDKin_1	301	307	PF00069	0.655
MOD_ProDKin_1	315	321	PF00069	0.625
MOD_ProDKin_1	341	347	PF00069	0.628
MOD_ProDKin_1	359	365	PF00069	0.640
MOD_ProDKin_1	38	44	PF00069	0.675
MOD_ProDKin_1	388	394	PF00069	0.668
MOD_ProDKin_1	400	406	PF00069	0.649
MOD_ProDKin_1	447	453	PF00069	0.719
MOD_ProDKin_1	499	505	PF00069	0.483
MOD_ProDKin_1	96	102	PF00069	0.619
MOD_SUMO_rev_2	540	545	PF00179	0.631
TRG_ENDOCYTIC_2	144	147	PF00928	0.472
TRG_ENDOCYTIC_2	309	312	PF00928	0.591
TRG_ENDOCYTIC_2	508	511	PF00928	0.533
TRG_ER_diArg_1	537	539	PF00400	0.657
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMP7	Leptomonas seymouri	55%	100%
A0A1X0NUL4	Trypanosomatidae	36%	87%
A0A3S7X5C4	Leishmania donovani	92%	100%
A4HK79	Leishmania braziliensis	74%	99%
A4I7R4	Leishmania infantum	93%	100%
Q4Q5I4	Leishmania major	90%	100%