GMC_OxRdtase_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FAD dependent oxidoreductase, putative

Species:

Leishmania mexicana

UniProt:

E9B2L7_LEIMU

TriTrypDb:

LmxM.31.0930

Length:

703

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2L7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2L7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	2
GO:0016491	oxidoreductase activity	2	1
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	1
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0050660	flavin adenine dinucleotide binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	387	391	PF00656	0.463
CLV_C14_Caspase3-7	684	688	PF00656	0.550
CLV_NRD_NRD_1	282	284	PF00675	0.343
CLV_NRD_NRD_1	301	303	PF00675	0.317
CLV_NRD_NRD_1	543	545	PF00675	0.333
CLV_NRD_NRD_1	616	618	PF00675	0.322
CLV_NRD_NRD_1	64	66	PF00675	0.346
CLV_NRD_NRD_1	95	97	PF00675	0.424
CLV_PCSK_KEX2_1	266	268	PF00082	0.390
CLV_PCSK_KEX2_1	282	284	PF00082	0.240
CLV_PCSK_KEX2_1	301	303	PF00082	0.317
CLV_PCSK_KEX2_1	543	545	PF00082	0.340
CLV_PCSK_KEX2_1	616	618	PF00082	0.311
CLV_PCSK_KEX2_1	64	66	PF00082	0.346
CLV_PCSK_KEX2_1	673	675	PF00082	0.377
CLV_PCSK_KEX2_1	95	97	PF00082	0.424
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.433
CLV_PCSK_PC1ET2_1	673	675	PF00082	0.377
CLV_PCSK_SKI1_1	249	253	PF00082	0.401
CLV_PCSK_SKI1_1	283	287	PF00082	0.396
CLV_PCSK_SKI1_1	370	374	PF00082	0.328
CLV_PCSK_SKI1_1	389	393	PF00082	0.220
CLV_PCSK_SKI1_1	451	455	PF00082	0.365
CLV_PCSK_SKI1_1	691	695	PF00082	0.397
CLV_Separin_Metazoa	61	65	PF03568	0.539
DEG_Nend_Nbox_1	1	3	PF02207	0.356
DEG_ODPH_VHL_1	294	305	PF01847	0.465
DEG_ODPH_VHL_1	444	457	PF01847	0.609
DEG_SPOP_SBC_1	216	220	PF00917	0.562
DEG_SPOP_SBC_1	638	642	PF00917	0.619
DEG_SPOP_SBC_1	662	666	PF00917	0.422
DOC_CDC14_PxL_1	100	108	PF14671	0.651
DOC_CKS1_1	428	433	PF01111	0.557
DOC_CKS1_1	474	479	PF01111	0.597
DOC_CYCLIN_yCln2_LP_2	253	259	PF00134	0.601
DOC_CYCLIN_yCln2_LP_2	392	398	PF00134	0.528
DOC_CYCLIN_yCln2_LP_2	474	480	PF00134	0.569
DOC_MAPK_gen_1	266	272	PF00069	0.455
DOC_MAPK_gen_1	327	336	PF00069	0.619
DOC_MAPK_gen_1	370	379	PF00069	0.557
DOC_MAPK_gen_1	95	102	PF00069	0.623
DOC_MAPK_HePTP_8	367	379	PF00069	0.543
DOC_MAPK_HePTP_8	386	398	PF00069	0.389
DOC_MAPK_MEF2A_6	108	115	PF00069	0.512
DOC_MAPK_MEF2A_6	370	379	PF00069	0.557
DOC_MAPK_MEF2A_6	389	398	PF00069	0.413
DOC_MAPK_NFAT4_5	389	397	PF00069	0.508
DOC_MAPK_RevD_3	251	267	PF00069	0.526
DOC_MIT_MIM_1	297	306	PF04212	0.577
DOC_PP1_RVXF_1	265	272	PF00149	0.503
DOC_PP1_RVXF_1	449	456	PF00149	0.569
DOC_PP1_RVXF_1	96	103	PF00149	0.626
DOC_PP2B_LxvP_1	253	256	PF13499	0.575
DOC_PP2B_LxvP_1	284	287	PF13499	0.594
DOC_PP2B_LxvP_1	392	395	PF13499	0.507
DOC_PP2B_LxvP_1	437	440	PF13499	0.573
DOC_USP7_MATH_1	216	220	PF00917	0.642
DOC_USP7_MATH_1	259	263	PF00917	0.562
DOC_USP7_MATH_1	285	289	PF00917	0.598
DOC_USP7_MATH_1	345	349	PF00917	0.528
DOC_USP7_MATH_1	402	406	PF00917	0.545
DOC_USP7_MATH_1	513	517	PF00917	0.713
DOC_USP7_MATH_1	629	633	PF00917	0.546
DOC_USP7_MATH_1	643	647	PF00917	0.569
DOC_USP7_MATH_1	678	682	PF00917	0.592
DOC_USP7_MATH_1	83	87	PF00917	0.593
DOC_USP7_UBL2_3	595	599	PF12436	0.658
DOC_WW_Pin1_4	123	128	PF00397	0.721
DOC_WW_Pin1_4	361	366	PF00397	0.543
DOC_WW_Pin1_4	427	432	PF00397	0.561
DOC_WW_Pin1_4	473	478	PF00397	0.607
DOC_WW_Pin1_4	501	506	PF00397	0.671
DOC_WW_Pin1_4	545	550	PF00397	0.585
LIG_14-3-3_CanoR_1	167	171	PF00244	0.552
LIG_14-3-3_CanoR_1	21	30	PF00244	0.567
LIG_14-3-3_CanoR_1	214	224	PF00244	0.674
LIG_14-3-3_CanoR_1	237	243	PF00244	0.500
LIG_14-3-3_CanoR_1	301	306	PF00244	0.528
LIG_14-3-3_CanoR_1	512	522	PF00244	0.697
LIG_14-3-3_CanoR_1	682	687	PF00244	0.593
LIG_14-3-3_CanoR_1	98	103	PF00244	0.627
LIG_BRCT_BRCA1_1	240	244	PF00533	0.483
LIG_BRCT_BRCA1_1	561	565	PF00533	0.586
LIG_BRCT_BRCA1_1	632	636	PF00533	0.578
LIG_DLG_GKlike_1	682	690	PF00625	0.516
LIG_EH1_1	480	488	PF00400	0.544
LIG_FHA_1	183	189	PF00498	0.578
LIG_FHA_1	23	29	PF00498	0.636
LIG_FHA_1	258	264	PF00498	0.616
LIG_FHA_1	383	389	PF00498	0.570
LIG_FHA_1	480	486	PF00498	0.520
LIG_FHA_1	546	552	PF00498	0.653
LIG_FHA_1	564	570	PF00498	0.516
LIG_FHA_1	633	639	PF00498	0.575
LIG_FHA_1	67	73	PF00498	0.652
LIG_FHA_1	692	698	PF00498	0.606
LIG_FHA_2	124	130	PF00498	0.708
LIG_FHA_2	308	314	PF00498	0.553
LIG_FHA_2	607	613	PF00498	0.528
LIG_FHA_2	682	688	PF00498	0.508
LIG_LIR_Apic_2	603	607	PF02991	0.443
LIG_LIR_Gen_1	307	317	PF02991	0.561
LIG_LIR_Gen_1	45	54	PF02991	0.470
LIG_LIR_Gen_1	562	570	PF02991	0.609
LIG_LIR_Gen_1	665	675	PF02991	0.622
LIG_LIR_LC3C_4	4	8	PF02991	0.173
LIG_LIR_Nem_3	307	312	PF02991	0.555
LIG_LIR_Nem_3	45	49	PF02991	0.479
LIG_LIR_Nem_3	562	568	PF02991	0.599
LIG_LIR_Nem_3	665	671	PF02991	0.632
LIG_MYND_1	427	431	PF01753	0.564
LIG_Pex14_1	16	20	PF04695	0.410
LIG_SH2_CRK	168	172	PF00017	0.608
LIG_SH2_GRB2like	17	20	PF00017	0.306
LIG_SH2_NCK_1	309	313	PF00017	0.508
LIG_SH2_PTP2	46	49	PF00017	0.490
LIG_SH2_SRC	618	621	PF00017	0.586
LIG_SH2_STAT3	131	134	PF00017	0.697
LIG_SH2_STAT5	131	134	PF00017	0.606
LIG_SH2_STAT5	17	20	PF00017	0.430
LIG_SH2_STAT5	257	260	PF00017	0.632
LIG_SH2_STAT5	274	277	PF00017	0.412
LIG_SH2_STAT5	309	312	PF00017	0.506
LIG_SH2_STAT5	428	431	PF00017	0.630
LIG_SH2_STAT5	46	49	PF00017	0.490
LIG_SH2_STAT5	618	621	PF00017	0.486
LIG_SH3_3	104	110	PF00018	0.661
LIG_SH3_3	144	150	PF00018	0.689
LIG_SH3_3	228	234	PF00018	0.599
LIG_SH3_3	253	259	PF00018	0.552
LIG_SH3_3	344	350	PF00018	0.641
LIG_SH3_3	376	382	PF00018	0.610
LIG_SH3_3	450	456	PF00018	0.552
LIG_SH3_5	42	46	PF00018	0.576
LIG_SUMO_SIM_anti_2	4	10	PF11976	0.410
LIG_SUMO_SIM_anti_2	482	488	PF11976	0.543
LIG_SUMO_SIM_par_1	384	390	PF11976	0.432
LIG_SUMO_SIM_par_1	561	573	PF11976	0.614
LIG_SUMO_SIM_par_1	71	77	PF11976	0.523
LIG_TYR_ITIM	272	277	PF00017	0.233
LIG_TYR_ITSM	305	312	PF00017	0.361
LIG_WRC_WIRS_1	99	104	PF05994	0.523
MOD_CDK_SPK_2	361	366	PF00069	0.418
MOD_CK1_1	212	218	PF00069	0.581
MOD_CK1_1	219	225	PF00069	0.687
MOD_CK1_1	304	310	PF00069	0.410
MOD_CK1_1	31	37	PF00069	0.552
MOD_CK1_1	384	390	PF00069	0.347
MOD_CK1_1	405	411	PF00069	0.616
MOD_CK1_1	588	594	PF00069	0.488
MOD_CK1_1	630	636	PF00069	0.415
MOD_CK1_1	639	645	PF00069	0.537
MOD_CK1_1	661	667	PF00069	0.344
MOD_CK1_1	681	687	PF00069	0.229
MOD_CK2_1	123	129	PF00069	0.659
MOD_CK2_1	215	221	PF00069	0.587
MOD_CK2_1	606	612	PF00069	0.431
MOD_Cter_Amidation	280	283	PF01082	0.401
MOD_Cter_Amidation	671	674	PF01082	0.479
MOD_Cter_Amidation	93	96	PF01082	0.532
MOD_GlcNHglycan	287	290	PF01048	0.496
MOD_GlcNHglycan	398	401	PF01048	0.467
MOD_GlcNHglycan	404	407	PF01048	0.483
MOD_GlcNHglycan	590	593	PF01048	0.571
MOD_GlcNHglycan	629	632	PF01048	0.323
MOD_GlcNHglycan	641	644	PF01048	0.489
MOD_GlcNHglycan	659	663	PF01048	0.278
MOD_GlcNHglycan	76	79	PF01048	0.474
MOD_GlcNHglycan	85	88	PF01048	0.546
MOD_GSK3_1	212	219	PF00069	0.776
MOD_GSK3_1	469	476	PF00069	0.487
MOD_GSK3_1	559	566	PF00069	0.441
MOD_GSK3_1	602	609	PF00069	0.541
MOD_GSK3_1	632	639	PF00069	0.400
MOD_GSK3_1	657	664	PF00069	0.374
MOD_GSK3_1	678	685	PF00069	0.397
MOD_N-GLC_1	209	214	PF02516	0.525
MOD_N-GLC_1	552	557	PF02516	0.421
MOD_N-GLC_1	66	71	PF02516	0.258
MOD_NEK2_1	182	187	PF00069	0.566
MOD_NEK2_1	396	401	PF00069	0.526
MOD_NEK2_1	432	437	PF00069	0.366
MOD_NEK2_1	636	641	PF00069	0.546
MOD_NEK2_1	696	701	PF00069	0.402
MOD_NEK2_1	74	79	PF00069	0.564
MOD_PIKK_1	315	321	PF00454	0.486
MOD_PIKK_1	420	426	PF00454	0.532
MOD_PIKK_1	663	669	PF00454	0.328
MOD_PK_1	301	307	PF00069	0.460
MOD_PKA_1	301	307	PF00069	0.428
MOD_PKA_1	543	549	PF00069	0.433
MOD_PKA_1	673	679	PF00069	0.444
MOD_PKA_2	166	172	PF00069	0.552
MOD_PKA_2	22	28	PF00069	0.458
MOD_PKA_2	301	307	PF00069	0.371
MOD_PKA_2	329	335	PF00069	0.434
MOD_PKA_2	336	342	PF00069	0.426
MOD_PKA_2	543	549	PF00069	0.522
MOD_PKA_2	63	69	PF00069	0.442
MOD_PKA_2	673	679	PF00069	0.500
MOD_PKA_2	681	687	PF00069	0.490
MOD_PKB_1	96	104	PF00069	0.540
MOD_Plk_1	154	160	PF00069	0.489
MOD_Plk_1	552	558	PF00069	0.478
MOD_Plk_1	563	569	PF00069	0.348
MOD_Plk_1	658	664	PF00069	0.395
MOD_Plk_4	166	172	PF00069	0.605
MOD_Plk_4	193	199	PF00069	0.431
MOD_Plk_4	301	307	PF00069	0.372
MOD_Plk_4	432	438	PF00069	0.407
MOD_Plk_4	469	475	PF00069	0.493
MOD_Plk_4	610	616	PF00069	0.479
MOD_Plk_4	632	638	PF00069	0.467
MOD_ProDKin_1	123	129	PF00069	0.659
MOD_ProDKin_1	361	367	PF00069	0.418
MOD_ProDKin_1	427	433	PF00069	0.442
MOD_ProDKin_1	473	479	PF00069	0.506
MOD_ProDKin_1	501	507	PF00069	0.596
MOD_ProDKin_1	545	551	PF00069	0.477
MOD_SUMO_rev_2	494	504	PF00179	0.456
MOD_SUMO_rev_2	571	577	PF00179	0.479
MOD_SUMO_rev_2	591	601	PF00179	0.600
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.464
TRG_DiLeu_BaLyEn_6	392	397	PF01217	0.324
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.528
TRG_ENDOCYTIC_2	168	171	PF00928	0.593
TRG_ENDOCYTIC_2	17	20	PF00928	0.415
TRG_ENDOCYTIC_2	274	277	PF00928	0.461
TRG_ENDOCYTIC_2	309	312	PF00928	0.369
TRG_ENDOCYTIC_2	46	49	PF00928	0.353
TRG_ER_diArg_1	20	23	PF00400	0.458
TRG_ER_diArg_1	282	284	PF00400	0.392
TRG_ER_diArg_1	301	303	PF00400	0.384
TRG_ER_diArg_1	543	545	PF00400	0.416
TRG_ER_diArg_1	615	617	PF00400	0.374
TRG_ER_diArg_1	63	65	PF00400	0.424
TRG_Pf-PMV_PEXEL_1	599	603	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAY3	Leptomonas seymouri	60%	99%
A0A1X0NUW5	Trypanosomatidae	33%	100%
A0A3S5H7R6	Leishmania donovani	92%	100%
A0A422N8N4	Trypanosoma rangeli	32%	100%
A4HK74	Leishmania braziliensis	79%	100%
A4I7Q9	Leishmania infantum	91%	100%
D0A9W4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4Q5I9	Leishmania major	91%	100%
V5BGK4	Trypanosoma cruzi	33%	100%