Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2L0_LEIMU

TriTrypDb:

LmxM.31.0860

Length:

569

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B2L0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2L0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	369	373	PF00656	0.568
CLV_NRD_NRD_1	114	116	PF00675	0.647
CLV_NRD_NRD_1	221	223	PF00675	0.418
CLV_NRD_NRD_1	523	525	PF00675	0.656
CLV_NRD_NRD_1	560	562	PF00675	0.641
CLV_NRD_NRD_1	564	566	PF00675	0.647
CLV_PCSK_FUR_1	112	116	PF00082	0.675
CLV_PCSK_KEX2_1	114	116	PF00082	0.638
CLV_PCSK_KEX2_1	133	135	PF00082	0.269
CLV_PCSK_KEX2_1	220	222	PF00082	0.403
CLV_PCSK_KEX2_1	290	292	PF00082	0.628
CLV_PCSK_KEX2_1	436	438	PF00082	0.467
CLV_PCSK_KEX2_1	521	523	PF00082	0.629
CLV_PCSK_KEX2_1	560	562	PF00082	0.639
CLV_PCSK_KEX2_1	566	568	PF00082	0.661
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.460
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.628
CLV_PCSK_PC1ET2_1	436	438	PF00082	0.458
CLV_PCSK_PC1ET2_1	521	523	PF00082	0.629
CLV_PCSK_PC1ET2_1	566	568	PF00082	0.577
CLV_PCSK_PC7_1	286	292	PF00082	0.526
CLV_PCSK_SKI1_1	133	137	PF00082	0.528
CLV_PCSK_SKI1_1	145	149	PF00082	0.539
CLV_PCSK_SKI1_1	226	230	PF00082	0.344
CLV_PCSK_SKI1_1	254	258	PF00082	0.504
CLV_PCSK_SKI1_1	433	437	PF00082	0.466
CLV_PCSK_SKI1_1	523	527	PF00082	0.734
DEG_APCC_DBOX_1	72	80	PF00400	0.428
DEG_Nend_UBRbox_2	1	3	PF02207	0.508
DEG_SPOP_SBC_1	305	309	PF00917	0.706
DOC_CYCLIN_RxL_1	142	149	PF00134	0.388
DOC_CYCLIN_yCln2_LP_2	281	284	PF00134	0.528
DOC_MAPK_gen_1	251	261	PF00069	0.478
DOC_MAPK_gen_1	273	281	PF00069	0.598
DOC_MAPK_MEF2A_6	254	261	PF00069	0.462
DOC_MAPK_MEF2A_6	407	416	PF00069	0.553
DOC_MAPK_NFAT4_5	254	262	PF00069	0.467
DOC_PP1_RVXF_1	69	75	PF00149	0.498
DOC_PP2B_LxvP_1	281	284	PF13499	0.528
DOC_PP4_MxPP_1	439	442	PF00568	0.573
DOC_USP7_MATH_1	175	179	PF00917	0.693
DOC_USP7_MATH_1	197	201	PF00917	0.478
DOC_USP7_MATH_1	305	309	PF00917	0.746
DOC_USP7_MATH_1	329	333	PF00917	0.609
DOC_USP7_MATH_1	366	370	PF00917	0.444
DOC_USP7_MATH_1	505	509	PF00917	0.643
DOC_USP7_MATH_1	510	514	PF00917	0.594
LIG_14-3-3_CanoR_1	145	155	PF00244	0.468
LIG_14-3-3_CanoR_1	22	30	PF00244	0.419
LIG_14-3-3_CanoR_1	32	41	PF00244	0.461
LIG_14-3-3_CanoR_1	393	399	PF00244	0.548
LIG_14-3-3_CanoR_1	407	413	PF00244	0.567
LIG_14-3-3_CanoR_1	415	422	PF00244	0.527
LIG_14-3-3_CanoR_1	445	451	PF00244	0.541
LIG_14-3-3_CanoR_1	511	519	PF00244	0.605
LIG_14-3-3_CanoR_1	537	542	PF00244	0.553
LIG_Actin_WH2_2	432	447	PF00022	0.587
LIG_AP_GAE_1	548	554	PF02883	0.540
LIG_AP2alpha_2	349	351	PF02296	0.374
LIG_BIR_III_4	102	106	PF00653	0.544
LIG_BRCT_BRCA1_1	233	237	PF00533	0.423
LIG_BRCT_BRCA1_1	363	367	PF00533	0.407
LIG_deltaCOP1_diTrp_1	479	488	PF00928	0.649
LIG_FHA_1	142	148	PF00498	0.468
LIG_FHA_1	38	44	PF00498	0.397
LIG_FHA_1	445	451	PF00498	0.617
LIG_FHA_1	557	563	PF00498	0.599
LIG_FHA_2	382	388	PF00498	0.424
LIG_FHA_2	55	61	PF00498	0.331
LIG_LIR_Apic_2	361	366	PF02991	0.384
LIG_LIR_Gen_1	364	374	PF02991	0.415
LIG_LIR_Gen_1	548	557	PF02991	0.522
LIG_LIR_LC3C_4	40	44	PF02991	0.450
LIG_LIR_Nem_3	234	239	PF02991	0.480
LIG_LIR_Nem_3	364	370	PF02991	0.391
LIG_LIR_Nem_3	399	405	PF02991	0.524
LIG_LIR_Nem_3	548	554	PF02991	0.512
LIG_LIR_Nem_3	63	67	PF02991	0.297
LIG_MAD2	433	441	PF02301	0.367
LIG_MLH1_MIPbox_1	233	237	PF16413	0.423
LIG_PCNA_yPIPBox_3	265	275	PF02747	0.416
LIG_PTAP_UEV_1	12	17	PF05743	0.462
LIG_SH2_CRK	363	367	PF00017	0.391
LIG_SH2_GRB2like	129	132	PF00017	0.354
LIG_SH2_NCK_1	140	144	PF00017	0.384
LIG_SH2_NCK_1	363	367	PF00017	0.476
LIG_SH2_NCK_1	459	463	PF00017	0.565
LIG_SH2_SRC	140	143	PF00017	0.421
LIG_SH2_SRC	160	163	PF00017	0.445
LIG_SH2_STAP1	547	551	PF00017	0.573
LIG_SH2_STAT5	129	132	PF00017	0.354
LIG_SH2_STAT5	160	163	PF00017	0.547
LIG_SH2_STAT5	236	239	PF00017	0.491
LIG_SH2_STAT5	30	33	PF00017	0.481
LIG_SH2_STAT5	64	67	PF00017	0.367
LIG_SH3_3	10	16	PF00018	0.507
LIG_SH3_3	551	557	PF00018	0.612
LIG_SUMO_SIM_anti_2	277	283	PF11976	0.553
LIG_SUMO_SIM_anti_2	40	46	PF11976	0.330
LIG_SUMO_SIM_par_1	39	46	PF11976	0.402
LIG_TRAF2_1	468	471	PF00917	0.613
LIG_TRAF2_1	57	60	PF00917	0.472
LIG_TYR_ITIM	138	143	PF00017	0.340
LIG_TYR_ITIM	62	67	PF00017	0.498
MOD_CK1_1	308	314	PF00069	0.656
MOD_CK1_1	361	367	PF00069	0.384
MOD_CK1_1	512	518	PF00069	0.703
MOD_CK1_1	92	98	PF00069	0.666
MOD_CK2_1	307	313	PF00069	0.631
MOD_CK2_1	381	387	PF00069	0.398
MOD_CK2_1	415	421	PF00069	0.565
MOD_CK2_1	54	60	PF00069	0.346
MOD_Cter_Amidation	563	566	PF01082	0.563
MOD_GlcNHglycan	12	16	PF01048	0.536
MOD_GlcNHglycan	148	151	PF01048	0.526
MOD_GlcNHglycan	185	188	PF01048	0.676
MOD_GlcNHglycan	199	202	PF01048	0.617
MOD_GlcNHglycan	331	334	PF01048	0.660
MOD_GlcNHglycan	460	463	PF01048	0.682
MOD_GSK3_1	146	153	PF00069	0.542
MOD_GSK3_1	295	302	PF00069	0.631
MOD_GSK3_1	304	311	PF00069	0.547
MOD_GSK3_1	319	326	PF00069	0.626
MOD_GSK3_1	368	375	PF00069	0.542
MOD_GSK3_1	501	508	PF00069	0.627
MOD_GSK3_1	533	540	PF00069	0.554
MOD_LATS_1	413	419	PF00433	0.603
MOD_N-GLC_1	320	325	PF02516	0.671
MOD_N-GLC_1	445	450	PF02516	0.520
MOD_NEK2_1	146	151	PF00069	0.413
MOD_NEK2_1	183	188	PF00069	0.597
MOD_NEK2_1	21	26	PF00069	0.483
MOD_NEK2_1	231	236	PF00069	0.399
MOD_NEK2_1	242	247	PF00069	0.310
MOD_NEK2_1	31	36	PF00069	0.322
MOD_NEK2_1	342	347	PF00069	0.383
MOD_NEK2_1	444	449	PF00069	0.582
MOD_NEK2_1	453	458	PF00069	0.598
MOD_NEK2_1	488	493	PF00069	0.609
MOD_NEK2_1	535	540	PF00069	0.527
MOD_NEK2_1	541	546	PF00069	0.623
MOD_NEK2_2	358	363	PF00069	0.367
MOD_OFUCOSY	230	235	PF10250	0.482
MOD_PIKK_1	295	301	PF00454	0.745
MOD_PIKK_1	415	421	PF00454	0.606
MOD_PIKK_1	466	472	PF00454	0.752
MOD_PKA_1	523	529	PF00069	0.568
MOD_PKA_2	21	27	PF00069	0.426
MOD_PKA_2	31	37	PF00069	0.445
MOD_PKA_2	394	400	PF00069	0.587
MOD_PKA_2	444	450	PF00069	0.612
MOD_PKA_2	488	494	PF00069	0.607
MOD_PKA_2	510	516	PF00069	0.720
MOD_PKA_2	523	529	PF00069	0.488
MOD_PKB_1	522	530	PF00069	0.686
MOD_Plk_1	175	181	PF00069	0.598
MOD_Plk_1	342	348	PF00069	0.300
MOD_Plk_1	445	451	PF00069	0.697
MOD_Plk_1	505	511	PF00069	0.724
MOD_Plk_2-3	381	387	PF00069	0.535
MOD_Plk_2-3	54	60	PF00069	0.389
MOD_Plk_4	274	280	PF00069	0.563
MOD_Plk_4	358	364	PF00069	0.492
MOD_Plk_4	37	43	PF00069	0.339
MOD_Plk_4	372	378	PF00069	0.442
MOD_Plk_4	537	543	PF00069	0.590
MOD_Plk_4	92	98	PF00069	0.585
TRG_DiLeu_BaEn_1	274	279	PF01217	0.543
TRG_DiLeu_BaEn_1	482	487	PF01217	0.470
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.515
TRG_ENDOCYTIC_2	132	135	PF00928	0.350
TRG_ENDOCYTIC_2	140	143	PF00928	0.342
TRG_ENDOCYTIC_2	236	239	PF00928	0.444
TRG_ENDOCYTIC_2	30	33	PF00928	0.349
TRG_ENDOCYTIC_2	64	67	PF00928	0.367
TRG_ER_diArg_1	114	116	PF00400	0.610
TRG_ER_diArg_1	219	222	PF00400	0.403
TRG_ER_diArg_1	392	395	PF00400	0.596
TRG_ER_diArg_1	522	524	PF00400	0.617
TRG_ER_diArg_1	560	563	PF00400	0.665
TRG_ER_diArg_1	71	74	PF00400	0.494
TRG_NLS_MonoCore_2	520	525	PF00514	0.596
TRG_NLS_MonoExtN_4	518	525	PF00514	0.672
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I873	Leptomonas seymouri	55%	98%
A0A1X0NWB4	Trypanosomatidae	33%	100%
A0A3S7X5C7	Leishmania donovani	88%	100%
A0A422N8X2	Trypanosoma rangeli	31%	100%
A4HK67	Leishmania braziliensis	77%	100%
A4I7Q2	Leishmania infantum	88%	100%
D0A9V7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4Q5J6	Leishmania major	89%	100%
V5BQN4	Trypanosoma cruzi	34%	100%