RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

polypyrimidine tract-binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9B2K9_LEIMU

TriTrypDb:

LmxM.31.0850

Length:

763

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B2K9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2K9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.485
CLV_C14_Caspase3-7	390	394	PF00656	0.603
CLV_C14_Caspase3-7	638	642	PF00656	0.534
CLV_C14_Caspase3-7	681	685	PF00656	0.695
CLV_NRD_NRD_1	200	202	PF00675	0.542
CLV_NRD_NRD_1	56	58	PF00675	0.564
CLV_NRD_NRD_1	623	625	PF00675	0.328
CLV_PCSK_FUR_1	538	542	PF00082	0.429
CLV_PCSK_KEX2_1	200	202	PF00082	0.542
CLV_PCSK_KEX2_1	501	503	PF00082	0.453
CLV_PCSK_KEX2_1	540	542	PF00082	0.447
CLV_PCSK_KEX2_1	56	58	PF00082	0.564
CLV_PCSK_KEX2_1	623	625	PF00082	0.328
CLV_PCSK_PC1ET2_1	501	503	PF00082	0.413
CLV_PCSK_PC1ET2_1	540	542	PF00082	0.447
CLV_PCSK_SKI1_1	20	24	PF00082	0.444
CLV_PCSK_SKI1_1	215	219	PF00082	0.453
CLV_PCSK_SKI1_1	272	276	PF00082	0.492
CLV_PCSK_SKI1_1	555	559	PF00082	0.582
CLV_PCSK_SKI1_1	752	756	PF00082	0.670
CLV_PCSK_SKI1_1	759	763	PF00082	0.598
DEG_APCC_DBOX_1	214	222	PF00400	0.421
DEG_COP1_1	741	749	PF00400	0.665
DEG_MDM2_SWIB_1	275	282	PF02201	0.419
DOC_ANK_TNKS_1	407	414	PF00023	0.736
DOC_CYCLIN_RxL_1	17	27	PF00134	0.432
DOC_MAPK_gen_1	200	206	PF00069	0.528
DOC_MAPK_gen_1	649	658	PF00069	0.534
DOC_MAPK_MEF2A_6	652	660	PF00069	0.534
DOC_PP1_RVXF_1	270	276	PF00149	0.396
DOC_PP1_RVXF_1	655	661	PF00149	0.611
DOC_PP4_FxxP_1	514	517	PF00568	0.499
DOC_USP7_MATH_1	143	147	PF00917	0.620
DOC_USP7_MATH_1	153	157	PF00917	0.746
DOC_USP7_MATH_1	178	182	PF00917	0.801
DOC_USP7_MATH_1	196	200	PF00917	0.449
DOC_USP7_MATH_1	288	292	PF00917	0.785
DOC_USP7_MATH_1	327	331	PF00917	0.600
DOC_USP7_MATH_1	373	377	PF00917	0.635
DOC_USP7_MATH_1	667	671	PF00917	0.638
DOC_USP7_MATH_1	706	710	PF00917	0.721
DOC_USP7_MATH_1	716	720	PF00917	0.639
DOC_USP7_MATH_1	97	101	PF00917	0.521
DOC_USP7_UBL2_3	608	612	PF12436	0.534
DOC_USP7_UBL2_3	755	759	PF12436	0.645
DOC_WW_Pin1_4	165	170	PF00397	0.694
DOC_WW_Pin1_4	350	355	PF00397	0.595
DOC_WW_Pin1_4	440	445	PF00397	0.667
LIG_14-3-3_CanoR_1	56	60	PF00244	0.545
LIG_14-3-3_CanoR_1	657	661	PF00244	0.502
LIG_Actin_WH2_2	595	610	PF00022	0.534
LIG_APCC_ABBA_1	271	276	PF00400	0.472
LIG_APCC_ABBAyCdc20_2	584	590	PF00400	0.485
LIG_BIR_II_1	1	5	PF00653	0.451
LIG_BIR_III_4	334	338	PF00653	0.636
LIG_deltaCOP1_diTrp_1	486	494	PF00928	0.433
LIG_eIF4E_1	485	491	PF01652	0.344
LIG_FHA_1	1	7	PF00498	0.424
LIG_FHA_1	212	218	PF00498	0.436
LIG_FHA_1	239	245	PF00498	0.480
LIG_FHA_1	470	476	PF00498	0.537
LIG_FHA_1	506	512	PF00498	0.417
LIG_FHA_1	518	524	PF00498	0.394
LIG_FHA_1	597	603	PF00498	0.479
LIG_FHA_2	44	50	PF00498	0.469
LIG_FHA_2	548	554	PF00498	0.571
LIG_FHA_2	636	642	PF00498	0.551
LIG_IBAR_NPY_1	321	323	PF08397	0.692
LIG_Integrin_RGD_1	381	383	PF01839	0.522
LIG_LIR_Apic_2	302	307	PF02991	0.709
LIG_LIR_Gen_1	276	287	PF02991	0.620
LIG_LIR_Gen_1	486	494	PF02991	0.367
LIG_LIR_Gen_1	653	663	PF02991	0.579
LIG_LIR_Nem_3	110	114	PF02991	0.523
LIG_LIR_Nem_3	276	282	PF02991	0.594
LIG_LIR_Nem_3	440	445	PF02991	0.667
LIG_LIR_Nem_3	486	491	PF02991	0.364
LIG_LIR_Nem_3	492	497	PF02991	0.417
LIG_LIR_Nem_3	653	658	PF02991	0.481
LIG_LIR_Nem_3	659	663	PF02991	0.457
LIG_NRBOX	486	492	PF00104	0.356
LIG_NRP_CendR_1	762	763	PF00754	0.698
LIG_Pex14_2	275	279	PF04695	0.494
LIG_PTB_Apo_2	264	271	PF02174	0.495
LIG_PTB_Phospho_1	264	270	PF10480	0.504
LIG_REV1ctd_RIR_1	619	628	PF16727	0.499
LIG_SH2_CRK	111	115	PF00017	0.523
LIG_SH2_CRK	304	308	PF00017	0.707
LIG_SH2_PTP2	150	153	PF00017	0.540
LIG_SH2_PTP2	270	273	PF00017	0.379
LIG_SH2_STAP1	485	489	PF00017	0.346
LIG_SH2_STAT3	157	160	PF00017	0.716
LIG_SH2_STAT3	306	309	PF00017	0.627
LIG_SH2_STAT5	113	116	PF00017	0.517
LIG_SH2_STAT5	150	153	PF00017	0.540
LIG_SH2_STAT5	270	273	PF00017	0.410
LIG_SH2_STAT5	526	529	PF00017	0.439
LIG_SH2_STAT5	594	597	PF00017	0.551
LIG_SH3_1	281	287	PF00018	0.565
LIG_SH3_1	574	580	PF00018	0.523
LIG_SH3_2	195	200	PF14604	0.611
LIG_SH3_2	727	732	PF14604	0.584
LIG_SH3_3	155	161	PF00018	0.694
LIG_SH3_3	190	196	PF00018	0.612
LIG_SH3_3	232	238	PF00018	0.503
LIG_SH3_3	281	287	PF00018	0.611
LIG_SH3_3	366	372	PF00018	0.699
LIG_SH3_3	441	447	PF00018	0.659
LIG_SH3_3	574	580	PF00018	0.523
LIG_SH3_3	661	667	PF00018	0.539
LIG_SH3_3	719	725	PF00018	0.595
LIG_SH3_3	72	78	PF00018	0.618
LIG_SH3_3	741	747	PF00018	0.532
LIG_SH3_3	83	89	PF00018	0.613
LIG_SH3_CIN85_PxpxPR_1	747	752	PF14604	0.586
LIG_SUMO_SIM_anti_2	519	525	PF11976	0.414
LIG_SUMO_SIM_par_1	2	7	PF11976	0.482
LIG_SUMO_SIM_par_1	227	232	PF11976	0.426
LIG_SUMO_SIM_par_1	471	476	PF11976	0.467
LIG_TRAF2_1	46	49	PF00917	0.485
LIG_TRAF2_1	715	718	PF00917	0.714
LIG_TRAF2_1	726	729	PF00917	0.578
LIG_TRAF2_1	733	736	PF00917	0.520
LIG_UBA3_1	643	649	PF00899	0.464
MOD_CK1_1	172	178	PF00069	0.731
MOD_CK1_1	35	41	PF00069	0.564
MOD_CK1_1	352	358	PF00069	0.685
MOD_CK1_1	404	410	PF00069	0.664
MOD_CK1_1	466	472	PF00069	0.432
MOD_CK1_1	55	61	PF00069	0.336
MOD_CK2_1	429	435	PF00069	0.581
MOD_CK2_1	43	49	PF00069	0.472
MOD_CK2_1	440	446	PF00069	0.653
MOD_CK2_1	547	553	PF00069	0.564
MOD_CK2_1	600	606	PF00069	0.483
MOD_GlcNHglycan	114	117	PF01048	0.695
MOD_GlcNHglycan	186	189	PF01048	0.629
MOD_GlcNHglycan	250	253	PF01048	0.352
MOD_GlcNHglycan	301	304	PF01048	0.823
MOD_GlcNHglycan	329	332	PF01048	0.597
MOD_GlcNHglycan	355	358	PF01048	0.729
MOD_GlcNHglycan	389	392	PF01048	0.666
MOD_GlcNHglycan	431	434	PF01048	0.689
MOD_GlcNHglycan	446	450	PF01048	0.774
MOD_GlcNHglycan	467	471	PF01048	0.482
MOD_GlcNHglycan	555	558	PF01048	0.478
MOD_GlcNHglycan	718	721	PF01048	0.690
MOD_GlcNHglycan	759	762	PF01048	0.559
MOD_GSK3_1	121	128	PF00069	0.518
MOD_GSK3_1	165	172	PF00069	0.719
MOD_GSK3_1	293	300	PF00069	0.701
MOD_GSK3_1	349	356	PF00069	0.668
MOD_GSK3_1	465	472	PF00069	0.636
MOD_GSK3_1	547	554	PF00069	0.576
MOD_GSK3_1	555	562	PF00069	0.479
MOD_GSK3_1	596	603	PF00069	0.491
MOD_N-GLC_1	178	183	PF02516	0.658
MOD_N-GLC_1	478	483	PF02516	0.470
MOD_N-GLC_1	596	601	PF02516	0.279
MOD_N-GLC_2	267	269	PF02516	0.504
MOD_NEK2_1	24	29	PF00069	0.520
MOD_NEK2_1	532	537	PF00069	0.378
MOD_NEK2_1	566	571	PF00069	0.635
MOD_NEK2_1	593	598	PF00069	0.479
MOD_NEK2_1	656	661	PF00069	0.423
MOD_NEK2_2	40	45	PF00069	0.445
MOD_OFUCOSY	471	477	PF10250	0.422
MOD_PIKK_1	143	149	PF00454	0.586
MOD_PIKK_1	35	41	PF00454	0.490
MOD_PIKK_1	358	364	PF00454	0.765
MOD_PIKK_1	559	565	PF00454	0.344
MOD_PIKK_1	706	712	PF00454	0.575
MOD_PIKK_1	97	103	PF00454	0.748
MOD_PKA_2	404	410	PF00069	0.695
MOD_PKA_2	429	435	PF00069	0.681
MOD_PKA_2	532	538	PF00069	0.396
MOD_PKA_2	547	553	PF00069	0.563
MOD_PKA_2	55	61	PF00069	0.539
MOD_PKA_2	656	662	PF00069	0.512
MOD_PKA_2	667	673	PF00069	0.581
MOD_Plk_1	478	484	PF00069	0.416
MOD_Plk_2-3	547	553	PF00069	0.564
MOD_Plk_2-3	600	606	PF00069	0.464
MOD_Plk_4	121	127	PF00069	0.516
MOD_Plk_4	172	178	PF00069	0.670
MOD_Plk_4	469	475	PF00069	0.555
MOD_Plk_4	519	525	PF00069	0.399
MOD_Plk_4	532	538	PF00069	0.518
MOD_ProDKin_1	165	171	PF00069	0.696
MOD_ProDKin_1	350	356	PF00069	0.596
MOD_ProDKin_1	440	446	PF00069	0.668
MOD_SUMO_rev_2	547	557	PF00179	0.606
MOD_SUMO_rev_2	600	610	PF00179	0.534
TRG_DiLeu_BaEn_1	49	54	PF01217	0.451
TRG_ENDOCYTIC_2	111	114	PF00928	0.572
TRG_ENDOCYTIC_2	126	129	PF00928	0.693
TRG_ENDOCYTIC_2	270	273	PF00928	0.379
TRG_ER_diArg_1	200	203	PF00400	0.553
TRG_ER_diArg_1	583	586	PF00400	0.571
TRG_ER_diArg_1	622	624	PF00400	0.528
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1I1	Leptomonas seymouri	45%	100%
A0A3Q8IFS5	Leishmania donovani	23%	100%
A0A3Q8IJ43	Leishmania donovani	90%	100%
A4HK66	Leishmania braziliensis	72%	98%
A4I7Q0	Leishmania infantum	23%	100%
A4I7Q1	Leishmania infantum	90%	100%
Q4Q5J7	Leishmania major	90%	100%