RRM_8 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2K8_LEIMU

TriTrypDb:

LmxM.31.0840

Length:

519

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2K8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2K8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	25	31	PF00089	0.428
CLV_NRD_NRD_1	344	346	PF00675	0.402
CLV_NRD_NRD_1	42	44	PF00675	0.428
CLV_PCSK_KEX2_1	344	346	PF00082	0.402
CLV_PCSK_KEX2_1	42	44	PF00082	0.428
CLV_PCSK_SKI1_1	350	354	PF00082	0.430
CLV_PCSK_SKI1_1	42	46	PF00082	0.428
CLV_PCSK_SKI1_1	428	432	PF00082	0.500
CLV_PCSK_SKI1_1	477	481	PF00082	0.498
CLV_PCSK_SKI1_1	88	92	PF00082	0.335
DEG_Nend_UBRbox_1	1	4	PF02207	0.758
DEG_SCF_FBW7_1	110	115	PF00400	0.644
DOC_CKS1_1	161	166	PF01111	0.641
DOC_CKS1_1	56	61	PF01111	0.428
DOC_MAPK_gen_1	349	355	PF00069	0.431
DOC_MAPK_gen_1	42	50	PF00069	0.428
DOC_PP4_FxxP_1	213	216	PF00568	0.680
DOC_PP4_FxxP_1	308	311	PF00568	0.615
DOC_PP4_MxPP_1	220	223	PF00568	0.612
DOC_USP7_MATH_1	112	116	PF00917	0.752
DOC_USP7_MATH_1	167	171	PF00917	0.730
DOC_USP7_MATH_1	208	212	PF00917	0.668
DOC_USP7_MATH_1	424	428	PF00917	0.534
DOC_WW_Pin1_4	106	111	PF00397	0.688
DOC_WW_Pin1_4	160	165	PF00397	0.644
DOC_WW_Pin1_4	356	361	PF00397	0.516
DOC_WW_Pin1_4	414	419	PF00397	0.483
DOC_WW_Pin1_4	55	60	PF00397	0.444
LIG_14-3-3_CanoR_1	28	36	PF00244	0.335
LIG_14-3-3_CanoR_1	391	401	PF00244	0.528
LIG_14-3-3_CanoR_1	43	49	PF00244	0.335
LIG_14-3-3_CanoR_1	456	465	PF00244	0.542
LIG_14-3-3_CanoR_1	80	86	PF00244	0.445
LIG_AP2alpha_1	72	76	PF02296	0.428
LIG_AP2alpha_2	227	229	PF02296	0.635
LIG_EVH1_2	311	315	PF00568	0.530
LIG_FHA_1	100	106	PF00498	0.609
LIG_FHA_1	161	167	PF00498	0.641
LIG_FHA_1	20	26	PF00498	0.335
LIG_FHA_1	271	277	PF00498	0.604
LIG_FHA_1	311	317	PF00498	0.423
LIG_FHA_1	322	328	PF00498	0.429
LIG_FHA_1	35	41	PF00498	0.335
LIG_FHA_1	64	70	PF00498	0.380
LIG_FHA_2	330	336	PF00498	0.363
LIG_FHA_2	435	441	PF00498	0.439
LIG_FHA_2	456	462	PF00498	0.572
LIG_LIR_Apic_2	211	216	PF02991	0.740
LIG_LIR_Gen_1	313	323	PF02991	0.403
LIG_LIR_Gen_1	329	337	PF02991	0.367
LIG_LIR_Nem_3	13	17	PF02991	0.725
LIG_LIR_Nem_3	313	318	PF02991	0.393
LIG_LIR_Nem_3	335	340	PF02991	0.384
LIG_MYND_1	204	208	PF01753	0.541
LIG_Pex14_2	72	76	PF04695	0.428
LIG_SH2_GRB2like	101	104	PF00017	0.527
LIG_SH2_GRB2like	446	449	PF00017	0.531
LIG_SH2_SRC	446	449	PF00017	0.531
LIG_SH2_STAP1	101	105	PF00017	0.594
LIG_SH2_STAP1	408	412	PF00017	0.568
LIG_SH2_STAT5	101	104	PF00017	0.569
LIG_SH2_STAT5	302	305	PF00017	0.684
LIG_SH2_STAT5	375	378	PF00017	0.582
LIG_SH2_STAT5	388	391	PF00017	0.474
LIG_SH2_STAT5	446	449	PF00017	0.438
LIG_SH3_3	135	141	PF00018	0.736
LIG_SH3_3	148	154	PF00018	0.796
LIG_SH3_3	161	167	PF00018	0.739
LIG_SH3_3	172	178	PF00018	0.603
LIG_SH3_3	181	187	PF00018	0.578
LIG_SH3_3	188	194	PF00018	0.638
LIG_SH3_3	240	246	PF00018	0.712
LIG_SH3_3	397	403	PF00018	0.607
LIG_SH3_3	494	500	PF00018	0.549
LIG_SUMO_SIM_anti_2	317	322	PF11976	0.406
LIG_SUMO_SIM_anti_2	361	368	PF11976	0.504
LIG_TRAF2_1	511	514	PF00917	0.570
LIG_TRAF2_2	222	227	PF00917	0.627
LIG_WRC_WIRS_1	366	371	PF05994	0.450
MOD_CDK_SPxxK_3	414	421	PF00069	0.474
MOD_CK1_1	51	57	PF00069	0.390
MOD_CK2_1	329	335	PF00069	0.375
MOD_CK2_1	455	461	PF00069	0.625
MOD_GlcNHglycan	106	109	PF01048	0.699
MOD_GlcNHglycan	123	126	PF01048	0.515
MOD_GlcNHglycan	380	383	PF01048	0.399
MOD_GSK3_1	104	111	PF00069	0.581
MOD_GSK3_1	15	22	PF00069	0.579
MOD_GSK3_1	23	30	PF00069	0.253
MOD_GSK3_1	310	317	PF00069	0.445
MOD_GSK3_1	410	417	PF00069	0.568
MOD_GSK3_1	430	437	PF00069	0.398
MOD_GSK3_1	438	445	PF00069	0.434
MOD_GSK3_1	44	51	PF00069	0.433
MOD_GSK3_1	457	464	PF00069	0.362
MOD_GSK3_1	95	102	PF00069	0.458
MOD_NEK2_1	121	126	PF00069	0.747
MOD_NEK2_1	239	244	PF00069	0.709
MOD_NEK2_1	255	260	PF00069	0.545
MOD_NEK2_1	410	415	PF00069	0.567
MOD_NEK2_1	99	104	PF00069	0.370
MOD_NEK2_2	208	213	PF00069	0.652
MOD_NEK2_2	326	331	PF00069	0.383
MOD_PIKK_1	15	21	PF00454	0.655
MOD_PIKK_1	167	173	PF00454	0.642
MOD_PKA_2	255	261	PF00069	0.616
MOD_PKA_2	27	33	PF00069	0.335
MOD_PKA_2	455	461	PF00069	0.563
MOD_Plk_1	64	70	PF00069	0.342
MOD_Plk_2-3	461	467	PF00069	0.532
MOD_Plk_4	208	214	PF00069	0.740
MOD_Plk_4	310	316	PF00069	0.433
MOD_Plk_4	326	332	PF00069	0.469
MOD_Plk_4	365	371	PF00069	0.491
MOD_Plk_4	442	448	PF00069	0.431
MOD_Plk_4	64	70	PF00069	0.338
MOD_ProDKin_1	106	112	PF00069	0.694
MOD_ProDKin_1	160	166	PF00069	0.643
MOD_ProDKin_1	356	362	PF00069	0.510
MOD_ProDKin_1	414	420	PF00069	0.481
MOD_ProDKin_1	55	61	PF00069	0.444
MOD_SUMO_rev_2	485	492	PF00179	0.544
MOD_SUMO_rev_2	502	512	PF00179	0.675
TRG_ENDOCYTIC_2	280	283	PF00928	0.622
TRG_ENDOCYTIC_2	305	308	PF00928	0.647
TRG_ER_diArg_1	1	4	PF00400	0.842
TRG_ER_diArg_1	343	345	PF00400	0.384
TRG_ER_diArg_1	41	43	PF00400	0.428
TRG_Pf-PMV_PEXEL_1	477	481	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7M5	Leptomonas seymouri	58%	100%
A0A422N8U4	Trypanosoma rangeli	38%	100%
A4HK65	Leishmania braziliensis	80%	100%
V5B118	Trypanosoma cruzi	42%	100%