Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear RNA binding domain

Species:

Leishmania mexicana

UniProt:

E9B2J9_LEIMU

TriTrypDb:

LmxM.31.0750

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

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Expansion

Sequence features

E9B2J9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2J9

PDB structure(s): 5osg_h

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	66	70	PF00656	0.457
CLV_NRD_NRD_1	86	88	PF00675	0.291
CLV_PCSK_KEX2_1	86	88	PF00082	0.287
CLV_PCSK_SKI1_1	111	115	PF00082	0.330
CLV_PCSK_SKI1_1	201	205	PF00082	0.462
CLV_PCSK_SKI1_1	8	12	PF00082	0.764
DOC_CYCLIN_yCln2_LP_2	177	183	PF00134	0.482
DOC_MAPK_gen_1	86	95	PF00069	0.488
DOC_MAPK_MEF2A_6	196	204	PF00069	0.461
DOC_PP2B_LxvP_1	119	122	PF13499	0.600

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM50	Leptomonas seymouri	88%	100%
A0A0S4JT34	Bodo saltans	61%	100%
A0A1X0NUY5	Trypanosomatidae	70%	100%
A0A3Q8IT45	Leishmania donovani	94%	100%
A0A3R7KPL2	Trypanosoma rangeli	72%	100%
A4HK56	Leishmania braziliensis	89%	100%
A4I7P2	Leishmania infantum	94%	100%
D0A9U3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	90%
D0A9U5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	84%
Q4Q5K7	Leishmania major	94%	100%

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