Outer_row_dynein-

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Outer_row_dynein-

Gene product:

Outer row dynein-assembly protein 7

Species:

Leishmania mexicana

UniProt:

E9B2J7_LEIMU

TriTrypDb:

LmxM.31.0730

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1
GO:0044297	cell body	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B2J7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2J7

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0036158	outer dynein arm assembly	7	11
GO:0036159	inner dynein arm assembly	7	11
GO:0043933	protein-containing complex organization	4	11
GO:0065003	protein-containing complex assembly	5	11
GO:0070286	axonemal dynein complex assembly	6	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0006996	organelle organization	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044458	motile cilium assembly	7	1
GO:0044782	cilium organization	5	1
GO:0048870	cell motility	2	1
GO:0060271	cilium assembly	6	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0070925	organelle assembly	5	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0044877	protein-containing complex binding	2	11
GO:0070840	dynein complex binding	3	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	515	519	PF00656	0.653
CLV_C14_Caspase3-7	523	527	PF00656	0.605
CLV_NRD_NRD_1	245	247	PF00675	0.384
CLV_NRD_NRD_1	268	270	PF00675	0.389
CLV_NRD_NRD_1	325	327	PF00675	0.476
CLV_NRD_NRD_1	338	340	PF00675	0.440
CLV_NRD_NRD_1	387	389	PF00675	0.521
CLV_NRD_NRD_1	411	413	PF00675	0.740
CLV_NRD_NRD_1	568	570	PF00675	0.713
CLV_NRD_NRD_1	588	590	PF00675	0.365
CLV_PCSK_FUR_1	336	340	PF00082	0.592
CLV_PCSK_KEX2_1	245	247	PF00082	0.402
CLV_PCSK_KEX2_1	268	270	PF00082	0.389
CLV_PCSK_KEX2_1	293	295	PF00082	0.551
CLV_PCSK_KEX2_1	325	327	PF00082	0.451
CLV_PCSK_KEX2_1	336	338	PF00082	0.474
CLV_PCSK_KEX2_1	387	389	PF00082	0.551
CLV_PCSK_KEX2_1	568	570	PF00082	0.662
CLV_PCSK_KEX2_1	588	590	PF00082	0.639
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.551
CLV_PCSK_SKI1_1	261	265	PF00082	0.424
CLV_PCSK_SKI1_1	299	303	PF00082	0.513
CLV_PCSK_SKI1_1	378	382	PF00082	0.578
CLV_PCSK_SKI1_1	528	532	PF00082	0.793
CLV_PCSK_SKI1_1	67	71	PF00082	0.518
CLV_Separin_Metazoa	480	484	PF03568	0.677
DOC_CDC14_PxL_1	249	257	PF14671	0.432
DOC_CKS1_1	467	472	PF01111	0.592
DOC_CYCLIN_RxL_1	375	385	PF00134	0.331
DOC_CYCLIN_yCln2_LP_2	467	473	PF00134	0.670
DOC_MAPK_gen_1	242	252	PF00069	0.430
DOC_MAPK_gen_1	586	596	PF00069	0.509
DOC_MAPK_MEF2A_6	245	252	PF00069	0.392
DOC_MAPK_MEF2A_6	67	75	PF00069	0.388
DOC_MAPK_NFAT4_5	245	253	PF00069	0.425
DOC_PP1_RVXF_1	46	52	PF00149	0.353
DOC_PP2B_LxvP_1	250	253	PF13499	0.441
DOC_PP2B_LxvP_1	471	474	PF13499	0.631
DOC_PP4_FxxP_1	450	453	PF00568	0.488
DOC_USP7_MATH_1	158	162	PF00917	0.586
DOC_USP7_MATH_1	225	229	PF00917	0.383
DOC_USP7_MATH_1	346	350	PF00917	0.581
DOC_USP7_MATH_1	567	571	PF00917	0.565
DOC_USP7_MATH_1	69	73	PF00917	0.266
DOC_WW_Pin1_4	443	448	PF00397	0.656
DOC_WW_Pin1_4	449	454	PF00397	0.628
DOC_WW_Pin1_4	466	471	PF00397	0.691
LIG_14-3-3_CanoR_1	261	271	PF00244	0.479
LIG_14-3-3_CanoR_1	299	304	PF00244	0.543
LIG_14-3-3_CanoR_1	528	536	PF00244	0.657
LIG_14-3-3_CanoR_1	539	543	PF00244	0.527
LIG_14-3-3_CanoR_1	568	574	PF00244	0.659
LIG_14-3-3_CanoR_1	588	596	PF00244	0.658
LIG_14-3-3_CanoR_1	81	87	PF00244	0.430
LIG_APCC_ABBA_1	41	46	PF00400	0.498
LIG_BIR_II_1	1	5	PF00653	0.482
LIG_Clathr_ClatBox_1	481	485	PF01394	0.655
LIG_deltaCOP1_diTrp_1	364	373	PF00928	0.572
LIG_deltaCOP1_diTrp_1	576	585	PF00928	0.575
LIG_FHA_1	170	176	PF00498	0.734
LIG_FHA_1	192	198	PF00498	0.616
LIG_FHA_1	296	302	PF00498	0.505
LIG_FHA_1	3	9	PF00498	0.398
LIG_FHA_1	396	402	PF00498	0.370
LIG_FHA_1	431	437	PF00498	0.516
LIG_FHA_1	85	91	PF00498	0.356
LIG_FHA_2	125	131	PF00498	0.456
LIG_FHA_2	141	147	PF00498	0.252
LIG_FHA_2	152	158	PF00498	0.462
LIG_FHA_2	179	185	PF00498	0.687
LIG_FHA_2	254	260	PF00498	0.472
LIG_FHA_2	286	292	PF00498	0.627
LIG_FHA_2	381	387	PF00498	0.534
LIG_FHA_2	463	469	PF00498	0.579
LIG_FHA_2	513	519	PF00498	0.612
LIG_LIR_Apic_2	448	453	PF02991	0.489
LIG_LIR_Gen_1	146	155	PF02991	0.386
LIG_LIR_Gen_1	42	52	PF02991	0.343
LIG_LIR_Gen_1	576	587	PF02991	0.621
LIG_LIR_Nem_3	146	152	PF02991	0.389
LIG_LIR_Nem_3	42	47	PF02991	0.372
LIG_LIR_Nem_3	576	582	PF02991	0.582
LIG_LRP6_Inhibitor_1	75	81	PF00058	0.430
LIG_NRBOX	477	483	PF00104	0.663
LIG_PDZ_Class_2	591	596	PF00595	0.532
LIG_SH2_CRK	19	23	PF00017	0.388
LIG_SH2_STAP1	391	395	PF00017	0.593
LIG_SH2_STAT5	102	105	PF00017	0.306
LIG_SH2_STAT5	231	234	PF00017	0.381
LIG_SH2_STAT5	257	260	PF00017	0.383
LIG_SH2_STAT5	44	47	PF00017	0.345
LIG_SH3_3	204	210	PF00018	0.673
LIG_SH3_3	467	473	PF00018	0.739
LIG_TRAF2_1	404	407	PF00917	0.627
MOD_CDC14_SPxK_1	452	455	PF00782	0.487
MOD_CDK_SPxK_1	449	455	PF00069	0.491
MOD_CK1_1	115	121	PF00069	0.433
MOD_CK1_1	141	147	PF00069	0.462
MOD_CK1_1	178	184	PF00069	0.645
MOD_CK1_1	457	463	PF00069	0.704
MOD_CK1_1	472	478	PF00069	0.729
MOD_CK1_1	537	543	PF00069	0.541
MOD_CK1_1	58	64	PF00069	0.503
MOD_CK1_1	82	88	PF00069	0.293
MOD_CK2_1	124	130	PF00069	0.439
MOD_CK2_1	151	157	PF00069	0.491
MOD_CK2_1	285	291	PF00069	0.619
MOD_CK2_1	380	386	PF00069	0.561
MOD_CK2_1	443	449	PF00069	0.593
MOD_CK2_1	462	468	PF00069	0.792
MOD_CK2_1	58	64	PF00069	0.435
MOD_GlcNHglycan	160	163	PF01048	0.603
MOD_GlcNHglycan	177	180	PF01048	0.582
MOD_GlcNHglycan	428	431	PF01048	0.703
MOD_GlcNHglycan	505	508	PF01048	0.602
MOD_GlcNHglycan	59	63	PF01048	0.494
MOD_GSK3_1	115	122	PF00069	0.306
MOD_GSK3_1	141	148	PF00069	0.339
MOD_GSK3_1	295	302	PF00069	0.531
MOD_GSK3_1	426	433	PF00069	0.645
MOD_GSK3_1	459	466	PF00069	0.721
MOD_GSK3_1	469	476	PF00069	0.625
MOD_GSK3_1	503	510	PF00069	0.690
MOD_GSK3_1	530	537	PF00069	0.596
MOD_GSK3_1	58	65	PF00069	0.472
MOD_GSK3_1	82	89	PF00069	0.336
MOD_N-GLC_1	415	420	PF02516	0.494
MOD_N-GLC_1	524	529	PF02516	0.488
MOD_N-GLC_1	96	101	PF02516	0.350
MOD_NEK2_1	119	124	PF00069	0.330
MOD_NEK2_1	138	143	PF00069	0.227
MOD_NEK2_1	524	529	PF00069	0.671
MOD_NEK2_1	530	535	PF00069	0.594
MOD_NEK2_1	79	84	PF00069	0.409
MOD_NEK2_1	86	91	PF00069	0.333
MOD_NEK2_1	96	101	PF00069	0.194
MOD_NEK2_2	102	107	PF00069	0.430
MOD_NEK2_2	432	437	PF00069	0.468
MOD_NEK2_2	69	74	PF00069	0.266
MOD_PIKK_1	316	322	PF00454	0.560
MOD_PIKK_1	331	337	PF00454	0.526
MOD_PIKK_1	554	560	PF00454	0.509
MOD_PIKK_1	588	594	PF00454	0.714
MOD_PIKK_1	62	68	PF00454	0.512
MOD_PKA_1	568	574	PF00069	0.630
MOD_PKA_1	588	594	PF00069	0.623
MOD_PKA_2	175	181	PF00069	0.551
MOD_PKA_2	285	291	PF00069	0.497
MOD_PKA_2	316	322	PF00069	0.507
MOD_PKA_2	454	460	PF00069	0.679
MOD_PKA_2	538	544	PF00069	0.652
MOD_PKA_2	567	573	PF00069	0.623
MOD_PKA_2	588	594	PF00069	0.650
MOD_Plk_1	145	151	PF00069	0.364
MOD_Plk_1	537	543	PF00069	0.599
MOD_Plk_1	575	581	PF00069	0.392
MOD_Plk_2-3	285	291	PF00069	0.497
MOD_Plk_4	225	231	PF00069	0.369
MOD_Plk_4	253	259	PF00069	0.432
MOD_Plk_4	299	305	PF00069	0.531
MOD_Plk_4	473	479	PF00069	0.612
MOD_Plk_4	69	75	PF00069	0.302
MOD_ProDKin_1	443	449	PF00069	0.659
MOD_ProDKin_1	466	472	PF00069	0.715
MOD_SUMO_rev_2	285	295	PF00179	0.558
MOD_SUMO_rev_2	407	414	PF00179	0.694
MOD_SUMO_rev_2	42	50	PF00179	0.490
TRG_DiLeu_BaEn_1	133	138	PF01217	0.320
TRG_DiLeu_BaEn_4	133	139	PF01217	0.487
TRG_ENDOCYTIC_2	44	47	PF00928	0.363
TRG_ER_diArg_1	244	246	PF00400	0.403
TRG_ER_diArg_1	268	270	PF00400	0.465
TRG_ER_diArg_1	336	339	PF00400	0.504
TRG_ER_diArg_1	567	569	PF00400	0.735

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P804	Leptomonas seymouri	59%	99%
A0A0S4KIJ3	Bodo saltans	37%	100%
A0A3Q8IJ31	Leishmania donovani	88%	100%
A0A3R7KFT3	Trypanosoma rangeli	48%	100%
A4HK54	Leishmania braziliensis	77%	100%
A4I7P0	Leishmania infantum	88%	100%
D0A9U1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
Q4Q5K9	Leishmania major	87%	100%
V5D6Q2	Trypanosoma cruzi	48%	100%