U6 snRNA-associated Sm-like protein LSm4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U6 snRNA-associated Sm-like protein LSm4p

Species:

Leishmania mexicana

UniProt:

E9B2J5_LEIMU

TriTrypDb:

LmxM.31.0715

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	4
GO:0032991	protein-containing complex	1	4
GO:0140513	nuclear protein-containing complex	2	4
GO:1990904	ribonucleoprotein complex	2	4
GO:0000932	P-body	5	1
GO:0005688	U6 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0097526	spliceosomal tri-snRNP complex	5	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0120114	Sm-like protein family complex	2	1

Expansion

Sequence features

E9B2J5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2J5

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	3
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	3
GO:0000398	mRNA splicing, via spliceosome	8	3
GO:0000956	nuclear-transcribed mRNA catabolic process	7	4
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006396	RNA processing	6	3
GO:0006397	mRNA processing	7	3
GO:0006401	RNA catabolic process	5	4
GO:0006402	mRNA catabolic process	6	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0008380	RNA splicing	7	3
GO:0009056	catabolic process	2	4
GO:0009057	macromolecule catabolic process	4	4
GO:0009892	negative regulation of metabolic process	4	4
GO:0009987	cellular process	1	4
GO:0010468	regulation of gene expression	5	4
GO:0010605	negative regulation of macromolecule metabolic process	5	4
GO:0010629	negative regulation of gene expression	6	4
GO:0016070	RNA metabolic process	5	4
GO:0016071	mRNA metabolic process	6	4
GO:0019222	regulation of metabolic process	3	4
GO:0019439	aromatic compound catabolic process	4	4
GO:0034641	cellular nitrogen compound metabolic process	3	4
GO:0034655	nucleobase-containing compound catabolic process	4	4
GO:0043170	macromolecule metabolic process	3	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044248	cellular catabolic process	3	4
GO:0044260	obsolete cellular macromolecule metabolic process	3	4
GO:0044265	obsolete cellular macromolecule catabolic process	4	4
GO:0044270	cellular nitrogen compound catabolic process	4	4
GO:0046483	heterocycle metabolic process	3	4
GO:0046700	heterocycle catabolic process	4	4
GO:0048519	negative regulation of biological process	3	4
GO:0050789	regulation of biological process	2	4
GO:0060255	regulation of macromolecule metabolic process	4	4
GO:0065007	biological regulation	1	4
GO:0071704	organic substance metabolic process	2	4
GO:0090304	nucleic acid metabolic process	4	4
GO:1901360	organic cyclic compound metabolic process	3	4
GO:1901361	organic cyclic compound catabolic process	4	4
GO:1901575	organic substance catabolic process	3	4
GO:0000387	spliceosomal snRNP assembly	7	1
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0033962	P-body assembly	7	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0070925	organelle assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0140694	non-membrane-bounded organelle assembly	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003723	RNA binding	4	4
GO:0005488	binding	1	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4
GO:0017069	snRNA binding	5	1
GO:0017070	U6 snRNA binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.650
CLV_C14_Caspase3-7	99	103	PF00656	0.650
CLV_NRD_NRD_1	165	167	PF00675	0.826
CLV_NRD_NRD_1	79	81	PF00675	0.736
CLV_PCSK_KEX2_1	165	167	PF00082	0.826
CLV_PCSK_KEX2_1	186	188	PF00082	0.849
CLV_PCSK_KEX2_1	5	7	PF00082	0.612
CLV_PCSK_KEX2_1	79	81	PF00082	0.736
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.826
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.849
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.612
CLV_PCSK_SKI1_1	52	56	PF00082	0.684
CLV_PCSK_SKI1_1	80	84	PF00082	0.699
CLV_Separin_Metazoa	86	90	PF03568	0.549
DEG_APCC_DBOX_1	51	59	PF00400	0.684
DOC_ANK_TNKS_1	125	132	PF00023	0.650
DOC_CKS1_1	14	19	PF01111	0.534
DOC_CKS1_1	81	86	PF01111	0.669
DOC_MAPK_DCC_7	79	87	PF00069	0.681
DOC_MAPK_gen_1	112	121	PF00069	0.650
DOC_MAPK_gen_1	79	87	PF00069	0.681
DOC_MAPK_gen_1	89	98	PF00069	0.487
DOC_MAPK_MEF2A_6	112	121	PF00069	0.400
DOC_MAPK_MEF2A_6	52	59	PF00069	0.511
DOC_MAPK_MEF2A_6	92	100	PF00069	0.650
DOC_PP4_FxxP_1	14	17	PF00568	0.578
DOC_USP7_MATH_1	161	165	PF00917	0.776
DOC_USP7_UBL2_3	186	190	PF12436	0.784
DOC_WW_Pin1_4	13	18	PF00397	0.531
DOC_WW_Pin1_4	80	85	PF00397	0.687
LIG_14-3-3_CanoR_1	143	148	PF00244	0.650
LIG_14-3-3_CanoR_1	151	158	PF00244	0.556
LIG_14-3-3_CanoR_1	6	15	PF00244	0.604
LIG_14-3-3_CanoR_1	74	78	PF00244	0.770
LIG_BIR_III_2	30	34	PF00653	0.541
LIG_deltaCOP1_diTrp_1	132	141	PF00928	0.650
LIG_FHA_1	14	20	PF00498	0.537
LIG_FHA_2	125	131	PF00498	0.650
LIG_FHA_2	81	87	PF00498	0.663
LIG_LIR_Apic_2	13	17	PF02991	0.581
LIG_LIR_Gen_1	10	20	PF02991	0.543
LIG_LIR_Nem_3	10	15	PF02991	0.547
LIG_SH3_3	155	161	PF00018	0.731
LIG_SH3_3	78	84	PF00018	0.714
LIG_SUMO_SIM_anti_2	83	89	PF11976	0.646
MOD_CK1_1	10	16	PF00069	0.672
MOD_CK1_1	39	45	PF00069	0.628
MOD_CK2_1	80	86	PF00069	0.680
MOD_Cter_Amidation	184	187	PF01082	0.862
MOD_DYRK1A_RPxSP_1	80	84	PF00069	0.699
MOD_GlcNHglycan	154	157	PF01048	0.703
MOD_GlcNHglycan	20	23	PF01048	0.634
MOD_GSK3_1	102	109	PF00069	0.650
MOD_GSK3_1	65	72	PF00069	0.690
MOD_N-GLC_1	106	111	PF02516	0.449
MOD_NEK2_1	152	157	PF00069	0.692
MOD_NEK2_1	24	29	PF00069	0.569
MOD_NEK2_1	69	74	PF00069	0.773
MOD_NEK2_1	7	12	PF00069	0.744
MOD_PK_1	143	149	PF00069	0.650
MOD_PK_1	178	184	PF00069	0.859
MOD_PK_1	94	100	PF00069	0.650
MOD_PKA_1	5	11	PF00069	0.603
MOD_PKA_2	150	156	PF00069	0.675
MOD_PKA_2	5	11	PF00069	0.603
MOD_PKA_2	73	79	PF00069	0.767
MOD_Plk_1	178	184	PF00069	0.859
MOD_Plk_1	94	100	PF00069	0.650
MOD_Plk_4	106	112	PF00069	0.585
MOD_Plk_4	130	136	PF00069	0.650
MOD_ProDKin_1	13	19	PF00069	0.530
MOD_ProDKin_1	80	86	PF00069	0.680
TRG_ER_diArg_1	79	81	PF00400	0.736
TRG_NLS_MonoExtN_4	163	169	PF00514	0.762

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I7N8	Leishmania infantum	79%	96%
Q4Q5L1	Leishmania major	66%	98%