Putative phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9B2I7_LEIMU

TriTrypDb:

LmxM.31.0640

Length:

604

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B2I7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2I7

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016311	dephosphorylation	5	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004721	phosphoprotein phosphatase activity	3	10
GO:0004725	protein tyrosine phosphatase activity	4	10
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	10
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10
GO:0016791	phosphatase activity	5	10
GO:0042578	phosphoric ester hydrolase activity	4	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.559
CLV_C14_Caspase3-7	41	45	PF00656	0.638
CLV_NRD_NRD_1	228	230	PF00675	0.444
CLV_NRD_NRD_1	30	32	PF00675	0.769
CLV_NRD_NRD_1	342	344	PF00675	0.434
CLV_NRD_NRD_1	398	400	PF00675	0.540
CLV_NRD_NRD_1	508	510	PF00675	0.770
CLV_NRD_NRD_1	578	580	PF00675	0.706
CLV_PCSK_KEX2_1	30	32	PF00082	0.770
CLV_PCSK_KEX2_1	341	343	PF00082	0.446
CLV_PCSK_KEX2_1	36	38	PF00082	0.745
CLV_PCSK_KEX2_1	398	400	PF00082	0.580
CLV_PCSK_KEX2_1	488	490	PF00082	0.511
CLV_PCSK_KEX2_1	508	510	PF00082	0.696
CLV_PCSK_KEX2_1	578	580	PF00082	0.706
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.770
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.745
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.511
CLV_PCSK_SKI1_1	118	122	PF00082	0.430
CLV_PCSK_SKI1_1	278	282	PF00082	0.371
CLV_PCSK_SKI1_1	315	319	PF00082	0.531
CLV_PCSK_SKI1_1	398	402	PF00082	0.507
CLV_PCSK_SKI1_1	461	465	PF00082	0.540
CLV_PCSK_SKI1_1	485	489	PF00082	0.484
CLV_PCSK_SKI1_1	592	596	PF00082	0.532
DEG_APCC_DBOX_1	314	322	PF00400	0.518
DEG_APCC_DBOX_1	405	413	PF00400	0.418
DEG_MDM2_SWIB_1	462	470	PF02201	0.390
DEG_Nend_Nbox_1	1	3	PF02207	0.700
DEG_SCF_FBW7_1	520	527	PF00400	0.616
DEG_SPOP_SBC_1	519	523	PF00917	0.783
DOC_CKS1_1	593	598	PF01111	0.530
DOC_CYCLIN_RxL_1	297	309	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	107	113	PF00134	0.568
DOC_CYCLIN_yCln2_LP_2	401	407	PF00134	0.496
DOC_MAPK_gen_1	189	196	PF00069	0.401
DOC_MAPK_gen_1	403	413	PF00069	0.396
DOC_MAPK_MEF2A_6	389	397	PF00069	0.555
DOC_PP2B_LxvP_1	517	520	PF13499	0.726
DOC_PP4_FxxP_1	164	167	PF00568	0.434
DOC_PP4_FxxP_1	553	556	PF00568	0.578
DOC_SPAK_OSR1_1	343	347	PF12202	0.460
DOC_USP7_MATH_1	101	105	PF00917	0.410
DOC_USP7_MATH_1	18	22	PF00917	0.580
DOC_USP7_MATH_1	317	321	PF00917	0.485
DOC_USP7_MATH_1	491	495	PF00917	0.400
DOC_USP7_MATH_1	500	504	PF00917	0.502
DOC_USP7_MATH_1	507	511	PF00917	0.771
DOC_USP7_MATH_1	524	528	PF00917	0.763
DOC_USP7_UBL2_3	189	193	PF12436	0.369
DOC_USP7_UBL2_3	25	29	PF12436	0.721
DOC_USP7_UBL2_3	30	34	PF12436	0.652
DOC_WW_Pin1_4	365	370	PF00397	0.428
DOC_WW_Pin1_4	449	454	PF00397	0.523
DOC_WW_Pin1_4	508	513	PF00397	0.697
DOC_WW_Pin1_4	520	525	PF00397	0.582
DOC_WW_Pin1_4	533	538	PF00397	0.579
DOC_WW_Pin1_4	592	597	PF00397	0.628
LIG_14-3-3_CanoR_1	100	106	PF00244	0.405
LIG_14-3-3_CanoR_1	254	261	PF00244	0.403
LIG_14-3-3_CanoR_1	345	350	PF00244	0.516
LIG_14-3-3_CanoR_1	364	369	PF00244	0.232
LIG_14-3-3_CanoR_1	406	410	PF00244	0.400
LIG_14-3-3_CanoR_1	508	512	PF00244	0.689
LIG_14-3-3_CanoR_1	515	520	PF00244	0.714
LIG_APCC_ABBA_1	279	284	PF00400	0.427
LIG_APCC_ABBAyCdc20_2	278	284	PF00400	0.382
LIG_BRCT_BRCA1_1	255	259	PF00533	0.431
LIG_BRCT_BRCA1_1	413	417	PF00533	0.494
LIG_eIF4E_1	289	295	PF01652	0.473
LIG_FHA_1	119	125	PF00498	0.456
LIG_FHA_1	514	520	PF00498	0.744
LIG_FHA_2	559	565	PF00498	0.681
LIG_LIR_Apic_2	160	165	PF02991	0.421
LIG_LIR_Apic_2	6	12	PF02991	0.739
LIG_LIR_Gen_1	68	77	PF02991	0.497
LIG_LIR_Nem_3	103	109	PF02991	0.455
LIG_LIR_Nem_3	160	164	PF02991	0.436
LIG_LIR_Nem_3	287	292	PF02991	0.387
LIG_LIR_Nem_3	414	419	PF02991	0.366
LIG_LIR_Nem_3	472	477	PF02991	0.448
LIG_LYPXL_yS_3	109	112	PF13949	0.504
LIG_MLH1_MIPbox_1	413	417	PF16413	0.305
LIG_NRBOX	299	305	PF00104	0.417
LIG_NRP_CendR_1	601	604	PF00754	0.809
LIG_Pex14_2	244	248	PF04695	0.344
LIG_Pex14_2	440	444	PF04695	0.556
LIG_Pex14_2	462	466	PF04695	0.384
LIG_Pex14_2	553	557	PF04695	0.484
LIG_PTB_Apo_2	427	434	PF02174	0.490
LIG_SH2_CRK	289	293	PF00017	0.372
LIG_SH2_CRK	477	481	PF00017	0.578
LIG_SH2_CRK	9	13	PF00017	0.803
LIG_SH2_GRB2like	474	477	PF00017	0.455
LIG_SH2_NCK_1	477	481	PF00017	0.536
LIG_SH2_SRC	213	216	PF00017	0.444
LIG_SH2_STAP1	215	219	PF00017	0.344
LIG_SH2_STAT5	213	216	PF00017	0.372
LIG_SH2_STAT5	474	477	PF00017	0.410
LIG_SH3_3	590	596	PF00018	0.626
LIG_Sin3_3	224	231	PF02671	0.408
LIG_SUMO_SIM_anti_2	223	229	PF11976	0.400
LIG_SUMO_SIM_anti_2	351	356	PF11976	0.429
LIG_SUMO_SIM_par_1	515	523	PF11976	0.726
LIG_TRAF2_1	388	391	PF00917	0.650
LIG_TYR_ITIM	107	112	PF00017	0.483
LIG_UBA3_1	299	308	PF00899	0.428
LIG_WW_3	505	509	PF00397	0.715
MOD_CDK_SPxxK_3	449	456	PF00069	0.511
MOD_CDK_SPxxK_3	508	515	PF00069	0.586
MOD_CK1_1	144	150	PF00069	0.506
MOD_CK1_1	365	371	PF00069	0.419
MOD_CK1_1	510	516	PF00069	0.744
MOD_CK1_1	518	524	PF00069	0.757
MOD_CK1_1	536	542	PF00069	0.750
MOD_CK1_1	544	550	PF00069	0.712
MOD_CK2_1	157	163	PF00069	0.438
MOD_CK2_1	385	391	PF00069	0.657
MOD_CK2_1	449	455	PF00069	0.482
MOD_CK2_1	519	525	PF00069	0.752
MOD_CK2_1	558	564	PF00069	0.686
MOD_DYRK1A_RPxSP_1	592	596	PF00069	0.532
MOD_GlcNHglycan	142	146	PF01048	0.518
MOD_GlcNHglycan	20	23	PF01048	0.674
MOD_GlcNHglycan	323	326	PF01048	0.471
MOD_GlcNHglycan	332	335	PF01048	0.421
MOD_GlcNHglycan	413	416	PF01048	0.354
MOD_GSK3_1	140	147	PF00069	0.448
MOD_GSK3_1	317	324	PF00069	0.439
MOD_GSK3_1	365	372	PF00069	0.459
MOD_GSK3_1	379	386	PF00069	0.472
MOD_GSK3_1	515	522	PF00069	0.772
MOD_GSK3_1	533	540	PF00069	0.498
MOD_GSK3_1	558	565	PF00069	0.723
MOD_GSK3_1	95	102	PF00069	0.390
MOD_LATS_1	116	122	PF00433	0.556
MOD_N-GLC_1	118	123	PF02516	0.466
MOD_N-GLC_1	304	309	PF02516	0.425
MOD_NEK2_1	202	207	PF00069	0.344
MOD_NEK2_1	288	293	PF00069	0.481
MOD_NEK2_1	295	300	PF00069	0.402
MOD_NEK2_1	363	368	PF00069	0.489
MOD_NEK2_1	383	388	PF00069	0.306
MOD_NEK2_1	411	416	PF00069	0.385
MOD_NEK2_1	417	422	PF00069	0.401
MOD_NEK2_1	492	497	PF00069	0.477
MOD_NEK2_1	498	503	PF00069	0.481
MOD_NEK2_1	54	59	PF00069	0.556
MOD_NEK2_1	541	546	PF00069	0.695
MOD_NEK2_2	101	106	PF00069	0.408
MOD_NEK2_2	483	488	PF00069	0.521
MOD_PIKK_1	213	219	PF00454	0.444
MOD_PIKK_1	253	259	PF00454	0.446
MOD_PIKK_1	542	548	PF00454	0.728
MOD_PIKK_1	95	101	PF00454	0.390
MOD_PK_1	345	351	PF00069	0.526
MOD_PK_1	515	521	PF00069	0.609
MOD_PKA_1	30	36	PF00069	0.799
MOD_PKA_1	578	584	PF00069	0.730
MOD_PKA_2	18	24	PF00069	0.629
MOD_PKA_2	253	259	PF00069	0.414
MOD_PKA_2	30	36	PF00069	0.766
MOD_PKA_2	363	369	PF00069	0.491
MOD_PKA_2	383	389	PF00069	0.315
MOD_PKA_2	405	411	PF00069	0.397
MOD_PKA_2	507	513	PF00069	0.733
MOD_PKA_2	578	584	PF00069	0.730
MOD_PKA_2	99	105	PF00069	0.404
MOD_PKB_1	343	351	PF00069	0.552
MOD_Plk_1	328	334	PF00069	0.526
MOD_Plk_1	350	356	PF00069	0.402
MOD_Plk_4	101	107	PF00069	0.437
MOD_Plk_4	295	301	PF00069	0.457
MOD_Plk_4	350	356	PF00069	0.410
MOD_Plk_4	492	498	PF00069	0.490
MOD_Plk_4	54	60	PF00069	0.565
MOD_ProDKin_1	365	371	PF00069	0.426
MOD_ProDKin_1	449	455	PF00069	0.513
MOD_ProDKin_1	508	514	PF00069	0.699
MOD_ProDKin_1	520	526	PF00069	0.584
MOD_ProDKin_1	533	539	PF00069	0.576
MOD_ProDKin_1	592	598	PF00069	0.626
MOD_SUMO_rev_2	560	567	PF00179	0.754
MOD_SUMO_rev_2	597	602	PF00179	0.729
TRG_DiLeu_BaEn_1	223	228	PF01217	0.401
TRG_DiLeu_BaLyEn_6	299	304	PF01217	0.413
TRG_ENDOCYTIC_2	109	112	PF00928	0.429
TRG_ENDOCYTIC_2	161	164	PF00928	0.414
TRG_ENDOCYTIC_2	289	292	PF00928	0.378
TRG_ENDOCYTIC_2	477	480	PF00928	0.519
TRG_ER_diArg_1	276	279	PF00400	0.438
TRG_ER_diArg_1	341	343	PF00400	0.448
TRG_ER_diArg_1	397	399	PF00400	0.588
TRG_ER_diArg_1	507	509	PF00400	0.691
TRG_ER_diArg_1	577	579	PF00400	0.700
TRG_ER_diArg_1	584	587	PF00400	0.752
TRG_NES_CRM1_1	262	275	PF08389	0.478
TRG_NLS_MonoCore_2	27	32	PF00514	0.763
TRG_NLS_MonoExtC_3	228	233	PF00514	0.444
TRG_NLS_MonoExtC_3	27	32	PF00514	0.779
TRG_NLS_MonoExtN_4	25	32	PF00514	0.743

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILW9	Leptomonas seymouri	75%	99%
A0A0S4KLI7	Bodo saltans	46%	100%
A0A1X0NUR4	Trypanosomatidae	66%	100%
A0A3Q8IG01	Leishmania donovani	94%	100%
A4HK44	Leishmania braziliensis	83%	100%
A4I7L8	Leishmania infantum	94%	100%
D0A9T0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
Q4Q5L9	Leishmania major	95%	100%