LeishMANIAdb
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Death domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Death domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B2I3_LEIMU
TriTrypDb:
LmxM.31.0600
Length:
810

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2I3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2I3

Function

Biological processes
Term Name Level Count
GO:0007165 signal transduction 2 2
GO:0009987 cellular process 1 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0065007 biological regulation 1 2
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 30 34 PF00656 0.609
CLV_C14_Caspase3-7 35 39 PF00656 0.581
CLV_C14_Caspase3-7 675 679 PF00656 0.513
CLV_NRD_NRD_1 161 163 PF00675 0.580
CLV_NRD_NRD_1 202 204 PF00675 0.551
CLV_NRD_NRD_1 209 211 PF00675 0.573
CLV_NRD_NRD_1 352 354 PF00675 0.650
CLV_NRD_NRD_1 518 520 PF00675 0.499
CLV_NRD_NRD_1 610 612 PF00675 0.522
CLV_NRD_NRD_1 693 695 PF00675 0.590
CLV_PCSK_FUR_1 206 210 PF00082 0.642
CLV_PCSK_KEX2_1 161 163 PF00082 0.580
CLV_PCSK_KEX2_1 208 210 PF00082 0.543
CLV_PCSK_KEX2_1 352 354 PF00082 0.612
CLV_PCSK_KEX2_1 518 520 PF00082 0.499
CLV_PCSK_KEX2_1 610 612 PF00082 0.506
CLV_PCSK_KEX2_1 693 695 PF00082 0.590
CLV_PCSK_SKI1_1 147 151 PF00082 0.578
CLV_PCSK_SKI1_1 209 213 PF00082 0.611
CLV_PCSK_SKI1_1 258 262 PF00082 0.338
CLV_PCSK_SKI1_1 318 322 PF00082 0.597
DEG_APCC_DBOX_1 359 367 PF00400 0.648
DEG_SCF_FBW7_1 445 450 PF00400 0.525
DEG_SPOP_SBC_1 120 124 PF00917 0.609
DOC_CKS1_1 474 479 PF01111 0.756
DOC_CKS1_1 631 636 PF01111 0.539
DOC_CYCLIN_RxL_1 144 153 PF00134 0.453
DOC_CYCLIN_RxL_1 204 218 PF00134 0.635
DOC_MAPK_gen_1 206 214 PF00069 0.558
DOC_MAPK_gen_1 311 321 PF00069 0.359
DOC_MAPK_gen_1 355 363 PF00069 0.728
DOC_MAPK_gen_1 431 440 PF00069 0.729
DOC_MAPK_gen_1 9 16 PF00069 0.478
DOC_PP1_RVXF_1 208 215 PF00149 0.371
DOC_PP1_RVXF_1 316 322 PF00149 0.657
DOC_PP2B_LxvP_1 509 512 PF13499 0.681
DOC_PP2B_LxvP_1 525 528 PF13499 0.723
DOC_PP4_FxxP_1 771 774 PF00568 0.378
DOC_USP7_MATH_1 128 132 PF00917 0.736
DOC_USP7_MATH_1 15 19 PF00917 0.662
DOC_USP7_MATH_1 238 242 PF00917 0.602
DOC_USP7_MATH_1 278 282 PF00917 0.523
DOC_USP7_MATH_1 526 530 PF00917 0.791
DOC_USP7_MATH_1 682 686 PF00917 0.437
DOC_USP7_MATH_1 720 724 PF00917 0.599
DOC_USP7_MATH_1 780 784 PF00917 0.613
DOC_USP7_UBL2_3 289 293 PF12436 0.522
DOC_WW_Pin1_4 116 121 PF00397 0.607
DOC_WW_Pin1_4 443 448 PF00397 0.521
DOC_WW_Pin1_4 473 478 PF00397 0.686
DOC_WW_Pin1_4 50 55 PF00397 0.501
DOC_WW_Pin1_4 534 539 PF00397 0.740
DOC_WW_Pin1_4 630 635 PF00397 0.540
DOC_WW_Pin1_4 738 743 PF00397 0.581
DOC_WW_Pin1_4 776 781 PF00397 0.491
DOC_WW_Pin1_4 793 798 PF00397 0.492
LIG_14-3-3_CanoR_1 127 134 PF00244 0.536
LIG_14-3-3_CanoR_1 242 246 PF00244 0.601
LIG_14-3-3_CanoR_1 4 9 PF00244 0.619
LIG_14-3-3_CanoR_1 421 429 PF00244 0.666
LIG_14-3-3_CanoR_1 518 526 PF00244 0.563
LIG_14-3-3_CanoR_1 66 75 PF00244 0.658
LIG_14-3-3_CanoR_1 693 701 PF00244 0.555
LIG_14-3-3_CanoR_1 77 87 PF00244 0.546
LIG_APCC_ABBA_1 21 26 PF00400 0.726
LIG_BIR_III_4 410 414 PF00653 0.624
LIG_BRCT_BRCA1_1 529 533 PF00533 0.797
LIG_BRCT_BRCA1_2 529 535 PF00533 0.709
LIG_CaM_IQ_9 562 578 PF13499 0.712
LIG_deltaCOP1_diTrp_1 182 190 PF00928 0.533
LIG_deltaCOP1_diTrp_1 308 313 PF00928 0.511
LIG_deltaCOP1_diTrp_1 763 771 PF00928 0.533
LIG_FHA_1 231 237 PF00498 0.604
LIG_FHA_1 335 341 PF00498 0.640
LIG_FHA_1 380 386 PF00498 0.700
LIG_FHA_1 423 429 PF00498 0.803
LIG_FHA_1 433 439 PF00498 0.652
LIG_FHA_1 455 461 PF00498 0.526
LIG_FHA_1 651 657 PF00498 0.594
LIG_FHA_1 709 715 PF00498 0.521
LIG_FHA_1 780 786 PF00498 0.537
LIG_FHA_1 96 102 PF00498 0.613
LIG_FHA_2 310 316 PF00498 0.633
LIG_FHA_2 739 745 PF00498 0.549
LIG_LIR_Apic_2 772 778 PF02991 0.467
LIG_LIR_Gen_1 182 191 PF02991 0.586
LIG_LIR_Gen_1 262 271 PF02991 0.621
LIG_LIR_Gen_1 650 660 PF02991 0.510
LIG_LIR_Gen_1 680 691 PF02991 0.467
LIG_LIR_Gen_1 764 775 PF02991 0.473
LIG_LIR_Gen_1 779 789 PF02991 0.527
LIG_LIR_Gen_1 796 806 PF02991 0.437
LIG_LIR_Nem_3 12 16 PF02991 0.497
LIG_LIR_Nem_3 192 196 PF02991 0.541
LIG_LIR_Nem_3 226 230 PF02991 0.495
LIG_LIR_Nem_3 262 267 PF02991 0.623
LIG_LIR_Nem_3 38 44 PF02991 0.526
LIG_LIR_Nem_3 462 467 PF02991 0.581
LIG_LIR_Nem_3 530 536 PF02991 0.712
LIG_LIR_Nem_3 557 563 PF02991 0.604
LIG_LIR_Nem_3 625 631 PF02991 0.608
LIG_LIR_Nem_3 650 655 PF02991 0.515
LIG_LIR_Nem_3 680 686 PF02991 0.458
LIG_LIR_Nem_3 764 770 PF02991 0.415
LIG_LIR_Nem_3 779 784 PF02991 0.502
LIG_LIR_Nem_3 796 802 PF02991 0.416
LIG_MYND_1 473 477 PF01753 0.687
LIG_NRBOX 708 714 PF00104 0.521
LIG_NRBOX 729 735 PF00104 0.505
LIG_PCNA_PIPBox_1 247 256 PF02747 0.577
LIG_PCNA_PIPBox_1 303 312 PF02747 0.557
LIG_PCNA_yPIPBox_3 242 254 PF02747 0.536
LIG_PCNA_yPIPBox_3 34 42 PF02747 0.625
LIG_PCNA_yPIPBox_3 96 110 PF02747 0.601
LIG_Pex14_1 767 771 PF04695 0.535
LIG_Pex14_2 223 227 PF04695 0.610
LIG_SH2_CRK 51 55 PF00017 0.552
LIG_SH2_PTP2 13 16 PF00017 0.690
LIG_SH2_PTP2 775 778 PF00017 0.521
LIG_SH2_SRC 13 16 PF00017 0.690
LIG_SH2_SRC 24 27 PF00017 0.663
LIG_SH2_SRC 264 267 PF00017 0.341
LIG_SH2_SRC 43 46 PF00017 0.368
LIG_SH2_SRC 775 778 PF00017 0.521
LIG_SH2_STAP1 230 234 PF00017 0.547
LIG_SH2_STAT5 115 118 PF00017 0.596
LIG_SH2_STAT5 13 16 PF00017 0.690
LIG_SH2_STAT5 339 342 PF00017 0.672
LIG_SH2_STAT5 43 46 PF00017 0.597
LIG_SH2_STAT5 585 588 PF00017 0.576
LIG_SH2_STAT5 604 607 PF00017 0.438
LIG_SH2_STAT5 658 661 PF00017 0.444
LIG_SH2_STAT5 715 718 PF00017 0.483
LIG_SH2_STAT5 775 778 PF00017 0.456
LIG_SH2_STAT5 79 82 PF00017 0.525
LIG_SH3_3 439 445 PF00018 0.662
LIG_SH3_3 471 477 PF00018 0.588
LIG_SH3_3 624 630 PF00018 0.522
LIG_SUMO_SIM_anti_2 596 602 PF11976 0.590
LIG_SUMO_SIM_anti_2 728 735 PF11976 0.488
LIG_SUMO_SIM_par_1 232 237 PF11976 0.496
LIG_TRAF2_1 23 26 PF00917 0.644
LIG_UBA3_1 712 719 PF00899 0.461
MOD_CDK_SPxK_1 630 636 PF00069 0.541
MOD_CK1_1 126 132 PF00069 0.759
MOD_CK1_1 192 198 PF00069 0.625
MOD_CK1_1 241 247 PF00069 0.600
MOD_CK1_1 304 310 PF00069 0.429
MOD_CK1_1 348 354 PF00069 0.710
MOD_CK1_1 401 407 PF00069 0.674
MOD_CK1_1 417 423 PF00069 0.646
MOD_CK1_1 443 449 PF00069 0.727
MOD_CK1_1 496 502 PF00069 0.489
MOD_CK1_1 666 672 PF00069 0.513
MOD_CK1_1 779 785 PF00069 0.525
MOD_CK1_1 95 101 PF00069 0.549
MOD_CK2_1 309 315 PF00069 0.628
MOD_CK2_1 593 599 PF00069 0.564
MOD_CK2_1 682 688 PF00069 0.580
MOD_CK2_1 738 744 PF00069 0.540
MOD_CK2_1 780 786 PF00069 0.493
MOD_CMANNOS 310 313 PF00535 0.508
MOD_GlcNHglycan 17 20 PF01048 0.677
MOD_GlcNHglycan 347 350 PF01048 0.702
MOD_GlcNHglycan 395 398 PF01048 0.701
MOD_GlcNHglycan 451 454 PF01048 0.610
MOD_GlcNHglycan 664 668 PF01048 0.551
MOD_GlcNHglycan 771 774 PF01048 0.457
MOD_GlcNHglycan 806 809 PF01048 0.589
MOD_GSK3_1 116 123 PF00069 0.569
MOD_GSK3_1 237 244 PF00069 0.683
MOD_GSK3_1 341 348 PF00069 0.609
MOD_GSK3_1 393 400 PF00069 0.756
MOD_GSK3_1 443 450 PF00069 0.743
MOD_GSK3_1 493 500 PF00069 0.617
MOD_GSK3_1 692 699 PF00069 0.523
MOD_GSK3_1 776 783 PF00069 0.535
MOD_GSK3_1 802 809 PF00069 0.463
MOD_N-GLC_1 331 336 PF02516 0.653
MOD_N-GLC_1 341 346 PF02516 0.569
MOD_N-GLC_1 491 496 PF02516 0.575
MOD_N-GLC_1 720 725 PF02516 0.618
MOD_NEK2_1 113 118 PF00069 0.538
MOD_NEK2_1 121 126 PF00069 0.607
MOD_NEK2_1 150 155 PF00069 0.507
MOD_NEK2_1 223 228 PF00069 0.639
MOD_NEK2_1 285 290 PF00069 0.596
MOD_NEK2_1 388 393 PF00069 0.790
MOD_NEK2_1 416 421 PF00069 0.615
MOD_NEK2_1 432 437 PF00069 0.512
MOD_NEK2_1 491 496 PF00069 0.614
MOD_NEK2_1 497 502 PF00069 0.614
MOD_NEK2_1 677 682 PF00069 0.519
MOD_NEK2_1 769 774 PF00069 0.531
MOD_NEK2_1 78 83 PF00069 0.545
MOD_NEK2_1 802 807 PF00069 0.447
MOD_NEK2_2 505 510 PF00069 0.622
MOD_NEK2_2 585 590 PF00069 0.610
MOD_PIKK_1 135 141 PF00454 0.608
MOD_PIKK_1 150 156 PF00454 0.545
MOD_PIKK_1 299 305 PF00454 0.595
MOD_PIKK_1 379 385 PF00454 0.698
MOD_PIKK_1 527 533 PF00454 0.738
MOD_PIKK_1 617 623 PF00454 0.542
MOD_PIKK_1 720 726 PF00454 0.615
MOD_PK_1 623 629 PF00069 0.514
MOD_PKA_2 126 132 PF00069 0.602
MOD_PKA_2 241 247 PF00069 0.600
MOD_PKA_2 517 523 PF00069 0.565
MOD_PKA_2 692 698 PF00069 0.552
MOD_Plk_1 314 320 PF00069 0.642
MOD_Plk_1 331 337 PF00069 0.610
MOD_Plk_1 491 497 PF00069 0.586
MOD_Plk_1 520 526 PF00069 0.605
MOD_Plk_1 677 683 PF00069 0.523
MOD_Plk_1 720 726 PF00069 0.615
MOD_Plk_1 746 752 PF00069 0.620
MOD_Plk_4 241 247 PF00069 0.670
MOD_Plk_4 27 33 PF00069 0.708
MOD_Plk_4 36 42 PF00069 0.458
MOD_Plk_4 493 499 PF00069 0.591
MOD_Plk_4 505 511 PF00069 0.555
MOD_Plk_4 520 526 PF00069 0.669
MOD_Plk_4 623 629 PF00069 0.507
MOD_Plk_4 708 714 PF00069 0.477
MOD_Plk_4 728 734 PF00069 0.354
MOD_Plk_4 780 786 PF00069 0.536
MOD_Plk_4 9 15 PF00069 0.570
MOD_ProDKin_1 116 122 PF00069 0.613
MOD_ProDKin_1 443 449 PF00069 0.522
MOD_ProDKin_1 473 479 PF00069 0.684
MOD_ProDKin_1 50 56 PF00069 0.501
MOD_ProDKin_1 534 540 PF00069 0.742
MOD_ProDKin_1 630 636 PF00069 0.541
MOD_ProDKin_1 738 744 PF00069 0.581
MOD_ProDKin_1 776 782 PF00069 0.486
MOD_ProDKin_1 793 799 PF00069 0.487
MOD_SUMO_rev_2 257 262 PF00179 0.556
TRG_DiLeu_BaEn_1 315 320 PF01217 0.644
TRG_DiLeu_BaEn_1 764 769 PF01217 0.462
TRG_DiLeu_BaLyEn_6 144 149 PF01217 0.655
TRG_DiLeu_BaLyEn_6 207 212 PF01217 0.642
TRG_DiLeu_BaLyEn_6 787 792 PF01217 0.551
TRG_ENDOCYTIC_2 13 16 PF00928 0.690
TRG_ENDOCYTIC_2 264 267 PF00928 0.626
TRG_ENDOCYTIC_2 464 467 PF00928 0.700
TRG_ENDOCYTIC_2 683 686 PF00928 0.545
TRG_ER_diArg_1 160 162 PF00400 0.631
TRG_ER_diArg_1 206 209 PF00400 0.567
TRG_ER_diArg_1 352 355 PF00400 0.713
TRG_ER_diArg_1 609 611 PF00400 0.509
TRG_ER_diArg_1 65 68 PF00400 0.557
TRG_ER_diArg_1 692 694 PF00400 0.585
TRG_NES_CRM1_1 728 744 PF08389 0.500
TRG_Pf-PMV_PEXEL_1 147 151 PF00026 0.458
TRG_Pf-PMV_PEXEL_1 790 794 PF00026 0.575

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I9Y4 Leptomonas seymouri 55% 97%
A0A3Q8IFA7 Leishmania donovani 91% 100%
A4I7M2 Leishmania infantum 92% 100%
D0A9S6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
E9AIU9 Leishmania braziliensis 78% 100%
Q4Q5M3 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS