Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2I1_LEIMU

TriTrypDb:

LmxM.31.0580

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2I1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2I1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	60	64	PF00656	0.442
CLV_NRD_NRD_1	228	230	PF00675	0.714
CLV_NRD_NRD_1	258	260	PF00675	0.714
CLV_NRD_NRD_1	382	384	PF00675	0.791
CLV_NRD_NRD_1	427	429	PF00675	0.767
CLV_NRD_NRD_1	471	473	PF00675	0.668
CLV_NRD_NRD_1	475	477	PF00675	0.653
CLV_NRD_NRD_1	548	550	PF00675	0.674
CLV_PCSK_FUR_1	378	382	PF00082	0.684
CLV_PCSK_FUR_1	87	91	PF00082	0.546
CLV_PCSK_KEX2_1	114	116	PF00082	0.617
CLV_PCSK_KEX2_1	228	230	PF00082	0.726
CLV_PCSK_KEX2_1	241	243	PF00082	0.574
CLV_PCSK_KEX2_1	258	260	PF00082	0.590
CLV_PCSK_KEX2_1	378	380	PF00082	0.664
CLV_PCSK_KEX2_1	381	383	PF00082	0.683
CLV_PCSK_KEX2_1	426	428	PF00082	0.783
CLV_PCSK_KEX2_1	471	473	PF00082	0.664
CLV_PCSK_KEX2_1	475	477	PF00082	0.658
CLV_PCSK_KEX2_1	548	550	PF00082	0.665
CLV_PCSK_KEX2_1	89	91	PF00082	0.422
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.617
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.632
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.712
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.665
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.422
CLV_PCSK_PC7_1	224	230	PF00082	0.698
CLV_PCSK_PC7_1	378	384	PF00082	0.668
CLV_PCSK_PC7_1	471	477	PF00082	0.716
CLV_PCSK_SKI1_1	115	119	PF00082	0.514
CLV_PCSK_SKI1_1	147	151	PF00082	0.579
CLV_PCSK_SKI1_1	229	233	PF00082	0.765
CLV_PCSK_SKI1_1	550	554	PF00082	0.779
CLV_PCSK_SKI1_1	78	82	PF00082	0.485
DOC_ANK_TNKS_1	426	433	PF00023	0.547
DOC_CKS1_1	156	161	PF01111	0.537
DOC_MAPK_MEF2A_6	484	493	PF00069	0.667
DOC_PP4_MxPP_1	123	126	PF00568	0.611
DOC_USP7_MATH_1	133	137	PF00917	0.546
DOC_USP7_MATH_1	154	158	PF00917	0.724
DOC_USP7_MATH_1	2	6	PF00917	0.572
DOC_USP7_MATH_1	216	220	PF00917	0.712
DOC_USP7_MATH_1	223	227	PF00917	0.612
DOC_USP7_MATH_1	422	426	PF00917	0.631
DOC_USP7_MATH_1	460	464	PF00917	0.717
DOC_USP7_MATH_1	512	516	PF00917	0.684
DOC_USP7_MATH_1	54	58	PF00917	0.636
DOC_USP7_MATH_1	557	561	PF00917	0.716
DOC_USP7_UBL2_3	114	118	PF12436	0.622
DOC_USP7_UBL2_3	453	457	PF12436	0.725
DOC_USP7_UBL2_3	473	477	PF12436	0.588
DOC_WW_Pin1_4	131	136	PF00397	0.721
DOC_WW_Pin1_4	137	142	PF00397	0.664
DOC_WW_Pin1_4	152	157	PF00397	0.619
DOC_WW_Pin1_4	241	246	PF00397	0.640
DOC_WW_Pin1_4	435	440	PF00397	0.752
DOC_WW_Pin1_4	517	522	PF00397	0.747
LIG_14-3-3_CanoR_1	224	231	PF00244	0.648
LIG_14-3-3_CanoR_1	348	352	PF00244	0.516
LIG_14-3-3_CanoR_1	356	364	PF00244	0.617
LIG_14-3-3_CanoR_1	78	83	PF00244	0.477
LIG_Actin_WH2_2	64	80	PF00022	0.585
LIG_BIR_III_2	153	157	PF00653	0.617
LIG_BRCT_BRCA1_1	266	270	PF00533	0.560
LIG_BRCT_BRCA1_1	489	493	PF00533	0.594
LIG_deltaCOP1_diTrp_1	33	42	PF00928	0.438
LIG_FHA_1	17	23	PF00498	0.429
LIG_FHA_1	173	179	PF00498	0.611
LIG_FHA_1	60	66	PF00498	0.448
LIG_FHA_1	71	77	PF00498	0.484
LIG_FHA_1	94	100	PF00498	0.510
LIG_FHA_2	195	201	PF00498	0.586
LIG_FHA_2	387	393	PF00498	0.661
LIG_FHA_2	410	416	PF00498	0.644
LIG_Integrin_RGD_1	383	385	PF01839	0.622
LIG_LIR_Apic_2	249	255	PF02991	0.759
LIG_LIR_Apic_2	282	288	PF02991	0.608
LIG_LIR_Apic_2	496	502	PF02991	0.651
LIG_LIR_Gen_1	271	278	PF02991	0.402
LIG_LIR_Gen_1	51	59	PF02991	0.479
LIG_LIR_Gen_1	95	106	PF02991	0.439
LIG_LIR_LC3C_4	350	354	PF02991	0.602
LIG_LIR_Nem_3	110	116	PF02991	0.511
LIG_LIR_Nem_3	305	310	PF02991	0.557
LIG_LIR_Nem_3	33	38	PF02991	0.610
LIG_LIR_Nem_3	51	56	PF02991	0.352
LIG_LIR_Nem_3	95	101	PF02991	0.440
LIG_LYPXL_S_1	43	47	PF13949	0.430
LIG_LYPXL_yS_3	44	47	PF13949	0.443
LIG_PDZ_Class_3	580	585	PF00595	0.566
LIG_Pex14_1	272	276	PF04695	0.447
LIG_SH2_CRK	252	256	PF00017	0.738
LIG_SH2_CRK	499	503	PF00017	0.638
LIG_SH2_NCK_1	499	503	PF00017	0.638
LIG_SH2_PTP2	98	101	PF00017	0.409
LIG_SH2_STAP1	66	70	PF00017	0.438
LIG_SH2_STAT5	276	279	PF00017	0.473
LIG_SH2_STAT5	285	288	PF00017	0.359
LIG_SH2_STAT5	499	502	PF00017	0.467
LIG_SH2_STAT5	534	537	PF00017	0.530
LIG_SH2_STAT5	98	101	PF00017	0.409
LIG_SH3_3	122	128	PF00018	0.616
LIG_SH3_3	153	159	PF00018	0.776
LIG_SH3_3	73	79	PF00018	0.601
LIG_SH3_3	96	102	PF00018	0.419
LIG_SUMO_SIM_anti_2	350	355	PF11976	0.501
LIG_SUMO_SIM_par_1	148	153	PF11976	0.682
LIG_SUMO_SIM_par_1	350	355	PF11976	0.501
LIG_TRAF2_1	102	105	PF00917	0.451
LIG_TRAF2_1	160	163	PF00917	0.547
LIG_TRAF2_1	390	393	PF00917	0.659
LIG_TYR_ITSM	94	101	PF00017	0.415
LIG_WW_3	126	130	PF00397	0.642
MOD_CDK_SPxK_1	241	247	PF00069	0.628
MOD_CK1_1	155	161	PF00069	0.621
MOD_CK1_1	177	183	PF00069	0.700
MOD_CK1_1	214	220	PF00069	0.726
MOD_CK1_1	233	239	PF00069	0.649
MOD_CK1_1	388	394	PF00069	0.664
MOD_CK1_1	409	415	PF00069	0.684
MOD_CK1_1	515	521	PF00069	0.707
MOD_CK2_1	133	139	PF00069	0.668
MOD_CK2_1	194	200	PF00069	0.629
MOD_CK2_1	386	392	PF00069	0.660
MOD_CK2_1	409	415	PF00069	0.755
MOD_CK2_1	54	60	PF00069	0.463
MOD_Cter_Amidation	87	90	PF01082	0.553
MOD_GlcNHglycan	135	138	PF01048	0.703
MOD_GlcNHglycan	183	186	PF01048	0.695
MOD_GlcNHglycan	200	206	PF01048	0.772
MOD_GlcNHglycan	218	221	PF01048	0.834
MOD_GlcNHglycan	324	328	PF01048	0.489
MOD_GlcNHglycan	338	341	PF01048	0.654
MOD_GlcNHglycan	462	465	PF01048	0.772
MOD_GlcNHglycan	467	470	PF01048	0.692
MOD_GlcNHglycan	55	59	PF01048	0.482
MOD_GSK3_1	12	19	PF00069	0.574
MOD_GSK3_1	127	134	PF00069	0.748
MOD_GSK3_1	148	155	PF00069	0.550
MOD_GSK3_1	174	181	PF00069	0.645
MOD_GSK3_1	211	218	PF00069	0.672
MOD_GSK3_1	229	236	PF00069	0.765
MOD_GSK3_1	313	320	PF00069	0.454
MOD_GSK3_1	352	359	PF00069	0.591
MOD_GSK3_1	370	377	PF00069	0.647
MOD_GSK3_1	433	440	PF00069	0.649
MOD_GSK3_1	520	527	PF00069	0.558
MOD_GSK3_1	530	537	PF00069	0.545
MOD_GSK3_1	54	61	PF00069	0.506
MOD_LATS_1	227	233	PF00433	0.706
MOD_N-GLC_1	317	322	PF02516	0.461
MOD_N-GLC_1	385	390	PF02516	0.538
MOD_N-GLC_1	48	53	PF02516	0.471
MOD_NEK2_1	119	124	PF00069	0.616
MOD_NEK2_1	172	177	PF00069	0.653
MOD_NEK2_1	178	183	PF00069	0.637
MOD_NEK2_1	311	316	PF00069	0.458
MOD_NEK2_1	352	357	PF00069	0.528
MOD_NEK2_1	564	569	PF00069	0.629
MOD_PIKK_1	178	184	PF00454	0.699
MOD_PKA_1	258	264	PF00069	0.597
MOD_PKA_1	548	554	PF00069	0.665
MOD_PKA_2	223	229	PF00069	0.569
MOD_PKA_2	246	252	PF00069	0.620
MOD_PKA_2	258	264	PF00069	0.543
MOD_PKA_2	279	285	PF00069	0.469
MOD_PKA_2	347	353	PF00069	0.530
MOD_PKA_2	355	361	PF00069	0.570
MOD_PKA_2	548	554	PF00069	0.661
MOD_Plk_1	119	125	PF00069	0.640
MOD_Plk_1	16	22	PF00069	0.445
MOD_Plk_1	409	415	PF00069	0.556
MOD_Plk_1	564	570	PF00069	0.573
MOD_Plk_1	94	100	PF00069	0.592
MOD_Plk_2-3	406	412	PF00069	0.644
MOD_Plk_4	16	22	PF00069	0.445
MOD_Plk_4	174	180	PF00069	0.739
MOD_Plk_4	247	253	PF00069	0.781
MOD_Plk_4	347	353	PF00069	0.509
MOD_Plk_4	520	526	PF00069	0.545
MOD_Plk_4	564	570	PF00069	0.573
MOD_Plk_4	94	100	PF00069	0.443
MOD_ProDKin_1	131	137	PF00069	0.719
MOD_ProDKin_1	152	158	PF00069	0.776
MOD_ProDKin_1	241	247	PF00069	0.642
MOD_ProDKin_1	435	441	PF00069	0.754
MOD_ProDKin_1	517	523	PF00069	0.742
MOD_SUMO_for_1	117	120	PF00179	0.523
MOD_SUMO_for_1	452	455	PF00179	0.647
MOD_SUMO_for_1	513	516	PF00179	0.679
MOD_SUMO_rev_2	104	109	PF00179	0.431
MOD_SUMO_rev_2	139	149	PF00179	0.770
MOD_SUMO_rev_2	163	172	PF00179	0.709
MOD_SUMO_rev_2	33	38	PF00179	0.571
TRG_DiLeu_BaEn_4	104	110	PF01217	0.432
TRG_ENDOCYTIC_2	44	47	PF00928	0.443
TRG_ENDOCYTIC_2	98	101	PF00928	0.409
TRG_ER_diArg_1	258	260	PF00400	0.469
TRG_ER_diArg_1	378	381	PF00400	0.687
TRG_ER_diArg_1	426	428	PF00400	0.783
TRG_ER_diLys_1	581	585	PF00400	0.515
TRG_NES_CRM1_1	108	120	PF08389	0.597
TRG_NLS_MonoCore_2	449	454	PF00514	0.727
TRG_NLS_MonoExtC_3	449	455	PF00514	0.666
TRG_NLS_MonoExtN_4	545	552	PF00514	0.763
TRG_NLS_MonoExtN_4	87	93	PF00514	0.438
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1J1	Leptomonas seymouri	53%	99%
A0A3S5H7R3	Leishmania donovani	92%	100%
A4HK39	Leishmania braziliensis	75%	99%
A4I7M4	Leishmania infantum	91%	100%
Q4Q5M5	Leishmania major	93%	100%