RING-type domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2H9_LEIMU

TriTrypDb:

LmxM.31.0560

Length:

178

Annotations

LeishMANIAdb annotations

Might be a component of some unusual ubiquitin ligase (due to its C-terminal RING domain). Probably membrane-associated, although a purely cytoplasmic protein cannot be excluded.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9B2H9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2H9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	79	81	PF00675	0.519
CLV_PCSK_FUR_1	77	81	PF00082	0.514
CLV_PCSK_KEX2_1	77	79	PF00082	0.510
CLV_PCSK_SKI1_1	109	113	PF00082	0.588
CLV_PCSK_SKI1_1	120	124	PF00082	0.496
CLV_PCSK_SKI1_1	16	20	PF00082	0.593
DEG_Nend_UBRbox_2	1	3	PF02207	0.472
DOC_CYCLIN_RxL_1	106	115	PF00134	0.759
DOC_CYCLIN_yCln2_LP_2	118	124	PF00134	0.745
DOC_MAPK_gen_1	89	97	PF00069	0.782
DOC_PP1_RVXF_1	45	51	PF00149	0.545
DOC_PP4_FxxP_1	19	22	PF00568	0.442
DOC_USP7_MATH_1	91	95	PF00917	0.726
DOC_WW_Pin1_4	112	117	PF00397	0.789
DOC_WW_Pin1_4	25	30	PF00397	0.519
LIG_14-3-3_CanoR_1	92	96	PF00244	0.727
LIG_FHA_1	139	145	PF00498	0.666
LIG_FHA_1	38	44	PF00498	0.580
LIG_GBD_Chelix_1	61	69	PF00786	0.530
LIG_Integrin_isoDGR_2	129	131	PF01839	0.524
LIG_LIR_Apic_2	17	22	PF02991	0.451
LIG_LIR_Nem_3	160	164	PF02991	0.638
LIG_LIR_Nem_3	28	33	PF02991	0.475
LIG_LIR_Nem_3	71	76	PF02991	0.452
LIG_PDZ_Class_2	173	178	PF00595	0.740
LIG_REV1ctd_RIR_1	72	83	PF16727	0.631
LIG_SH2_STAT5	161	164	PF00017	0.636
LIG_SH2_STAT5	73	76	PF00017	0.530
LIG_SH3_3	100	106	PF00018	0.749
LIG_SH3_3	118	124	PF00018	0.582
LIG_SH3_3	139	145	PF00018	0.666
LIG_TRAF2_1	36	39	PF00917	0.379
LIG_TYR_ITSM	69	76	PF00017	0.452
MOD_CK2_1	33	39	PF00069	0.408
MOD_GlcNHglycan	12	15	PF01048	0.736
MOD_GlcNHglycan	35	38	PF01048	0.726
MOD_GlcNHglycan	5	8	PF01048	0.824
MOD_GlcNHglycan	52	55	PF01048	0.700
MOD_GSK3_1	10	17	PF00069	0.514
MOD_GSK3_1	110	117	PF00069	0.800
MOD_GSK3_1	153	160	PF00069	0.689
MOD_GSK3_1	33	40	PF00069	0.528
MOD_NEK2_1	3	8	PF00069	0.626
MOD_NEK2_1	42	47	PF00069	0.567
MOD_NEK2_1	68	73	PF00069	0.464
MOD_NEK2_1	85	90	PF00069	0.600
MOD_NEK2_2	14	19	PF00069	0.487
MOD_NEK2_2	37	42	PF00069	0.530
MOD_NEK2_2	91	96	PF00069	0.730
MOD_PIKK_1	110	116	PF00454	0.658
MOD_PIKK_1	8	14	PF00454	0.526
MOD_PKA_2	91	97	PF00069	0.725
MOD_Plk_1	14	20	PF00069	0.538
MOD_Plk_1	37	43	PF00069	0.476
MOD_Plk_4	138	144	PF00069	0.669
MOD_Plk_4	14	20	PF00069	0.482
MOD_Plk_4	37	43	PF00069	0.584
MOD_Plk_4	68	74	PF00069	0.452
MOD_ProDKin_1	112	118	PF00069	0.789
MOD_ProDKin_1	25	31	PF00069	0.517
TRG_DiLeu_BaEn_2	37	43	PF01217	0.584
TRG_ENDOCYTIC_2	161	164	PF00928	0.636
TRG_ENDOCYTIC_2	73	76	PF00928	0.530
TRG_ER_diArg_1	172	175	PF00400	0.703
TRG_ER_diArg_1	76	79	PF00400	0.706

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5B4	Leishmania donovani	94%	100%
A4HK37	Leishmania braziliensis	76%	99%
A4I7M6	Leishmania infantum	94%	100%
Q4Q5M7	Leishmania major	92%	100%