LeishMANIAdb
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CHCH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
CHCH domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B2H8_LEIMU
TriTrypDb:
LmxM.31.0550
Length:
113

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9B2H8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2H8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 3 5 PF00675 0.477
CLV_NRD_NRD_1 82 84 PF00675 0.513
CLV_PCSK_KEX2_1 3 5 PF00082 0.403
DOC_MAPK_gen_1 50 59 PF00069 0.547
DOC_MAPK_gen_1 91 98 PF00069 0.234
DOC_USP7_MATH_1 72 76 PF00917 0.391
DOC_USP7_UBL2_3 100 104 PF12436 0.407
DOC_USP7_UBL2_3 29 33 PF12436 0.532
LIG_14-3-3_CanoR_1 3 8 PF00244 0.361
LIG_FHA_2 3 9 PF00498 0.568
LIG_LIR_Gen_1 5 15 PF02991 0.524
LIG_LIR_Nem_3 5 10 PF02991 0.559
LIG_PDZ_Class_2 108 113 PF00595 0.454
LIG_REV1ctd_RIR_1 96 104 PF16727 0.461
LIG_SH2_STAT5 101 104 PF00017 0.462
LIG_SH3_4 93 100 PF00018 0.435
LIG_WRC_WIRS_1 103 108 PF05994 0.382
MOD_Cter_Amidation 1 4 PF01082 0.502
MOD_GlcNHglycan 46 49 PF01048 0.514
MOD_NEK2_2 102 107 PF00069 0.372
MOD_NEK2_2 72 77 PF00069 0.364
MOD_OFUCOSY 71 76 PF10250 0.365
MOD_PKA_1 3 9 PF00069 0.355
MOD_PKA_2 2 8 PF00069 0.368
MOD_Plk_4 102 108 PF00069 0.397
MOD_SUMO_for_1 59 62 PF00179 0.529

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7N4 Leptomonas seymouri 66% 100%
A0A0S4JBG6 Bodo saltans 50% 100%
A0A1X0NUS0 Trypanosomatidae 55% 100%
A0A3S7X589 Leishmania donovani 87% 100%
A0A422NJZ3 Trypanosoma rangeli 54% 100%
A4HK36 Leishmania braziliensis 76% 100%
A4I7M7 Leishmania infantum 87% 100%
D0A9S2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
Q4Q5M8 Leishmania major 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS