LeishMANIAdb
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Sulfite exporter TauE/SafE family protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Sulfite exporter TauE/SafE family protein
Gene product:
sulfite exporter TauE/SafE, putative
Species:
Leishmania mexicana
UniProt:
E9B2H7_LEIMU
TriTrypDb:
LmxM.31.0540
Length:
511

Annotations

LeishMANIAdb annotations

Related to plant TauE sulfite exporters. Due to a re-entrant loop, the number of full TM segments is only 10

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 12, no: 0
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 13
GO:0110165 cellular anatomical entity 1 13
GO:0000151 ubiquitin ligase complex 3 1
GO:0031461 cullin-RING ubiquitin ligase complex 4 1
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex 6 1
GO:0032991 protein-containing complex 1 1
GO:0080008 Cul4-RING E3 ubiquitin ligase complex 5 1
GO:0140535 intracellular protein-containing complex 2 1
GO:1902494 catalytic complex 2 1
GO:1990234 transferase complex 3 1

Expansion

Sequence features

E9B2H7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2H7

Function

Biological processes
Term Name Level Count
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0016567 protein ubiquitination 7 1
GO:0019538 protein metabolic process 3 1
GO:0032446 protein modification by small protein conjugation 6 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0044238 primary metabolic process 2 1
GO:0070647 protein modification by small protein conjugation or removal 5 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 28 32 PF00656 0.356
CLV_NRD_NRD_1 347 349 PF00675 0.416
CLV_NRD_NRD_1 5 7 PF00675 0.662
CLV_PCSK_KEX2_1 265 267 PF00082 0.356
CLV_PCSK_KEX2_1 5 7 PF00082 0.660
CLV_PCSK_PC1ET2_1 265 267 PF00082 0.356
CLV_PCSK_SKI1_1 198 202 PF00082 0.292
CLV_PCSK_SKI1_1 83 87 PF00082 0.618
CLV_PCSK_SKI1_1 92 96 PF00082 0.520
DEG_APCC_DBOX_1 197 205 PF00400 0.298
DEG_APCC_DBOX_1 343 351 PF00400 0.503
DEG_APCC_DBOX_1 91 99 PF00400 0.293
DEG_SCF_FBW7_1 274 281 PF00400 0.727
DOC_CDC14_PxL_1 125 133 PF14671 0.346
DOC_CKS1_1 275 280 PF01111 0.726
DOC_CYCLIN_yCln2_LP_2 175 178 PF00134 0.329
DOC_MAPK_MEF2A_6 11 20 PF00069 0.577
DOC_MAPK_MEF2A_6 198 206 PF00069 0.298
DOC_MAPK_NFAT4_5 198 206 PF00069 0.364
DOC_PP2B_LxvP_1 174 177 PF13499 0.327
DOC_USP7_MATH_1 158 162 PF00917 0.503
DOC_USP7_MATH_1 32 36 PF00917 0.545
DOC_USP7_MATH_1 377 381 PF00917 0.390
DOC_USP7_MATH_1 418 422 PF00917 0.287
DOC_USP7_MATH_1 496 500 PF00917 0.467
DOC_WW_Pin1_4 274 279 PF00397 0.681
LIG_14-3-3_CanoR_1 365 369 PF00244 0.532
LIG_14-3-3_CanoR_1 83 89 PF00244 0.410
LIG_Actin_WH2_2 182 200 PF00022 0.306
LIG_BRCT_BRCA1_1 298 302 PF00533 0.261
LIG_BRCT_BRCA1_1 336 340 PF00533 0.426
LIG_BRCT_BRCA1_1 34 38 PF00533 0.381
LIG_BRCT_BRCA1_1 469 473 PF00533 0.399
LIG_eIF4E_1 169 175 PF01652 0.467
LIG_eIF4E_1 325 331 PF01652 0.372
LIG_FHA_1 270 276 PF00498 0.682
LIG_FHA_1 314 320 PF00498 0.499
LIG_FHA_1 38 44 PF00498 0.363
LIG_FHA_1 412 418 PF00498 0.275
LIG_FHA_1 426 432 PF00498 0.339
LIG_GBD_Chelix_1 184 192 PF00786 0.286
LIG_LIR_Apic_2 159 165 PF02991 0.514
LIG_LIR_Gen_1 299 310 PF02991 0.354
LIG_LIR_Gen_1 414 423 PF02991 0.270
LIG_LIR_Gen_1 464 473 PF02991 0.324
LIG_LIR_Gen_1 84 91 PF02991 0.361
LIG_LIR_LC3C_4 428 433 PF02991 0.426
LIG_LIR_Nem_3 299 305 PF02991 0.354
LIG_LIR_Nem_3 367 373 PF02991 0.504
LIG_LIR_Nem_3 414 419 PF02991 0.268
LIG_LIR_Nem_3 434 438 PF02991 0.220
LIG_LIR_Nem_3 464 468 PF02991 0.290
LIG_LIR_Nem_3 84 88 PF02991 0.361
LIG_LYPXL_yS_3 370 373 PF13949 0.521
LIG_MYND_2 177 181 PF01753 0.261
LIG_NRBOX 198 204 PF00104 0.320
LIG_NRBOX 305 311 PF00104 0.446
LIG_Pex14_2 415 419 PF04695 0.322
LIG_Pex14_2 435 439 PF04695 0.199
LIG_Pex14_2 85 89 PF04695 0.384
LIG_PTB_Apo_2 165 172 PF02174 0.446
LIG_PTB_Phospho_1 165 171 PF10480 0.446
LIG_REV1ctd_RIR_1 338 348 PF16727 0.295
LIG_SH2_CRK 169 173 PF00017 0.456
LIG_SH2_CRK 488 492 PF00017 0.348
LIG_SH2_SRC 465 468 PF00017 0.393
LIG_SH2_STAT3 293 296 PF00017 0.628
LIG_SH2_STAT5 150 153 PF00017 0.537
LIG_SH2_STAT5 171 174 PF00017 0.298
LIG_SH2_STAT5 457 460 PF00017 0.547
LIG_SH2_STAT5 465 468 PF00017 0.333
LIG_SH3_3 326 332 PF00018 0.426
LIG_SH3_3 365 371 PF00018 0.567
LIG_SUMO_SIM_anti_2 105 110 PF11976 0.376
LIG_SUMO_SIM_par_1 201 207 PF11976 0.419
LIG_TRAF2_1 152 155 PF00917 0.346
LIG_TRAF2_1 294 297 PF00917 0.586
LIG_TYR_ITIM 167 172 PF00017 0.446
LIG_TYR_ITIM 368 373 PF00017 0.528
LIG_TYR_ITIM 463 468 PF00017 0.514
LIG_WRC_WIRS_1 412 417 PF05994 0.316
LIG_WRC_WIRS_1 82 87 PF05994 0.369
MOD_CK1_1 137 143 PF00069 0.453
MOD_CK1_1 213 219 PF00069 0.630
MOD_CK1_1 228 234 PF00069 0.644
MOD_CK1_1 27 33 PF00069 0.581
MOD_CK1_1 281 287 PF00069 0.669
MOD_CK1_1 478 484 PF00069 0.414
MOD_CK1_1 84 90 PF00069 0.303
MOD_CK2_1 238 244 PF00069 0.666
MOD_CK2_1 273 279 PF00069 0.625
MOD_GlcNHglycan 131 134 PF01048 0.292
MOD_GlcNHglycan 27 30 PF01048 0.604
MOD_GlcNHglycan 379 382 PF01048 0.427
MOD_GlcNHglycan 420 423 PF01048 0.444
MOD_GlcNHglycan 446 449 PF01048 0.370
MOD_GlcNHglycan 7 10 PF01048 0.570
MOD_GlcNHglycan 76 79 PF01048 0.526
MOD_GSK3_1 269 276 PF00069 0.701
MOD_GSK3_1 27 34 PF00069 0.624
MOD_GSK3_1 356 363 PF00069 0.597
MOD_GSK3_1 453 460 PF00069 0.510
MOD_GSK3_1 69 76 PF00069 0.268
MOD_N-GLC_1 237 242 PF02516 0.567
MOD_NEK2_1 136 141 PF00069 0.475
MOD_NEK2_1 180 185 PF00069 0.362
MOD_NEK2_1 210 215 PF00069 0.331
MOD_NEK2_1 24 29 PF00069 0.547
MOD_NEK2_1 350 355 PF00069 0.515
MOD_NEK2_1 360 365 PF00069 0.587
MOD_NEK2_1 425 430 PF00069 0.358
MOD_NEK2_1 444 449 PF00069 0.150
MOD_NEK2_2 411 416 PF00069 0.281
MOD_OFUCOSY 66 73 PF10250 0.459
MOD_PIKK_1 134 140 PF00454 0.446
MOD_PIKK_1 249 255 PF00454 0.731
MOD_PIKK_1 288 294 PF00454 0.630
MOD_PIKK_1 360 366 PF00454 0.560
MOD_PIKK_1 37 43 PF00454 0.354
MOD_PKA_1 5 11 PF00069 0.480
MOD_PKA_2 364 370 PF00069 0.546
MOD_PKA_2 5 11 PF00069 0.351
MOD_Plk_1 158 164 PF00069 0.552
MOD_Plk_1 269 275 PF00069 0.738
MOD_Plk_1 296 302 PF00069 0.497
MOD_Plk_1 404 410 PF00069 0.241
MOD_Plk_4 180 186 PF00069 0.295
MOD_Plk_4 204 210 PF00069 0.349
MOD_Plk_4 334 340 PF00069 0.396
MOD_Plk_4 411 417 PF00069 0.270
MOD_Plk_4 427 433 PF00069 0.274
MOD_Plk_4 453 459 PF00069 0.529
MOD_Plk_4 461 467 PF00069 0.465
MOD_Plk_4 475 481 PF00069 0.285
MOD_Plk_4 496 502 PF00069 0.336
MOD_Plk_4 84 90 PF00069 0.360
MOD_ProDKin_1 274 280 PF00069 0.680
MOD_SUMO_for_1 264 267 PF00179 0.615
MOD_SUMO_rev_2 47 56 PF00179 0.407
TRG_DiLeu_BaLyEn_6 162 167 PF01217 0.467
TRG_DiLeu_BaLyEn_6 195 200 PF01217 0.393
TRG_ENDOCYTIC_2 150 153 PF00928 0.537
TRG_ENDOCYTIC_2 169 172 PF00928 0.446
TRG_ENDOCYTIC_2 370 373 PF00928 0.514
TRG_ENDOCYTIC_2 465 468 PF00928 0.393
TRG_ENDOCYTIC_2 488 491 PF00928 0.317
TRG_ER_diArg_1 4 6 PF00400 0.580
TRG_NES_CRM1_1 127 138 PF08389 0.397
TRG_Pf-PMV_PEXEL_1 266 270 PF00026 0.504

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P810 Leptomonas seymouri 63% 100%
A0A0S4IUN5 Bodo saltans 37% 96%
A0A0S4IWE0 Bodo saltans 38% 97%
A0A1X0NUS8 Trypanosomatidae 48% 100%
A0A3Q8IGK2 Leishmania donovani 85% 100%
A0A3R7KFU6 Trypanosoma rangeli 45% 100%
A0A3R7KMV5 Trypanosoma rangeli 47% 100%
A4HK28 Leishmania braziliensis 70% 100%
A4I7M8 Leishmania infantum 85% 100%
F4I8X6 Arabidopsis thaliana 24% 100%
Q4Q5M9 Leishmania major 82% 100%
Q8L7A0 Arabidopsis thaliana 26% 100%
Q8S9J0 Arabidopsis thaliana 25% 100%
V5BFC3 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS