LeishMANIAdb
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Profilin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Profilin
Gene product:
profilin, putative
Species:
Leishmania mexicana
UniProt:
E9B2H5_LEIMU
TriTrypDb:
LmxM.31.0520
Length:
150

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005938 cell cortex 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9B2H5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2H5

Function

Biological processes
Term Name Level Count
GO:0008064 regulation of actin polymerization or depolymerization 6 1
GO:0009987 cellular process 1 1
GO:0010639 negative regulation of organelle organization 6 1
GO:0016043 cellular component organization 3 1
GO:0030832 regulation of actin filament length 5 1
GO:0030833 regulation of actin filament polymerization 7 1
GO:0030837 negative regulation of actin filament polymerization 7 1
GO:0031333 negative regulation of protein-containing complex assembly 6 1
GO:0032271 regulation of protein polymerization 6 1
GO:0032272 negative regulation of protein polymerization 7 1
GO:0032507 maintenance of protein location in cell 3 1
GO:0032535 regulation of cellular component size 4 1
GO:0032956 regulation of actin cytoskeleton organization 5 1
GO:0032970 regulation of actin filament-based process 4 1
GO:0033043 regulation of organelle organization 5 1
GO:0042989 sequestering of actin monomers 4 1
GO:0043254 regulation of protein-containing complex assembly 5 1
GO:0044087 regulation of cellular component biogenesis 4 1
GO:0045185 maintenance of protein location 3 1
GO:0048519 negative regulation of biological process 3 1
GO:0048523 negative regulation of cellular process 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051128 regulation of cellular component organization 4 1
GO:0051129 negative regulation of cellular component organization 5 1
GO:0051179 localization 1 1
GO:0051235 maintenance of location 2 1
GO:0051493 regulation of cytoskeleton organization 6 1
GO:0051494 negative regulation of cytoskeleton organization 7 1
GO:0051651 maintenance of location in cell 2 1
GO:0065007 biological regulation 1 1
GO:0065008 regulation of biological quality 2 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0090066 regulation of anatomical structure size 3 1
GO:0110053 regulation of actin filament organization 6 1
GO:1902903 regulation of supramolecular fiber organization 5 1
GO:1902904 negative regulation of supramolecular fiber organization 6 1
Molecular functions
Term Name Level Count
GO:0003779 actin binding 4 11
GO:0005488 binding 1 11
GO:0005515 protein binding 2 11
GO:0008092 cytoskeletal protein binding 3 11
GO:0003785 actin monomer binding 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 139 141 PF00082 0.319
CLV_PCSK_PC1ET2_1 139 141 PF00082 0.319
CLV_PCSK_SKI1_1 81 85 PF00082 0.317
CLV_PCSK_SKI1_1 98 102 PF00082 0.385
DOC_PP1_RVXF_1 79 86 PF00149 0.519
DOC_USP7_MATH_1 26 30 PF00917 0.528
LIG_BIR_II_1 1 5 PF00653 0.511
LIG_eIF4E_1 6 12 PF01652 0.506
LIG_FHA_1 110 116 PF00498 0.606
LIG_FHA_1 124 130 PF00498 0.557
LIG_FHA_2 74 80 PF00498 0.585
LIG_LIR_Gen_1 52 62 PF02991 0.542
LIG_LIR_Gen_1 79 90 PF02991 0.545
LIG_LIR_Nem_3 2 6 PF02991 0.506
LIG_LIR_Nem_3 27 33 PF02991 0.506
LIG_LIR_Nem_3 52 57 PF02991 0.542
LIG_LIR_Nem_3 79 85 PF02991 0.528
LIG_REV1ctd_RIR_1 82 91 PF16727 0.519
LIG_SH2_CRK 106 110 PF00017 0.490
LIG_SH2_STAT3 37 40 PF00017 0.506
LIG_SH2_STAT5 144 147 PF00017 0.501
LIG_SH2_STAT5 37 40 PF00017 0.504
LIG_SH2_STAT5 6 9 PF00017 0.513
LIG_SH2_STAT5 82 85 PF00017 0.490
LIG_SH2_STAT5 95 98 PF00017 0.506
LIG_SH3_3 35 41 PF00018 0.576
MOD_CK1_1 52 58 PF00069 0.543
MOD_GlcNHglycan 13 16 PF01048 0.306
MOD_GlcNHglycan 18 21 PF01048 0.306
MOD_GlcNHglycan 59 62 PF01048 0.319
MOD_GSK3_1 52 59 PF00069 0.522
MOD_GSK3_1 7 14 PF00069 0.497
MOD_N-GLC_1 134 139 PF02516 0.295
MOD_NEK2_1 11 16 PF00069 0.506
MOD_NEK2_1 56 61 PF00069 0.519
MOD_NEK2_2 134 139 PF00069 0.519
MOD_Plk_1 110 116 PF00069 0.514
MOD_Plk_1 134 140 PF00069 0.513
MOD_Plk_1 52 58 PF00069 0.546
MOD_Plk_1 7 13 PF00069 0.506
MOD_Plk_4 26 32 PF00069 0.373
MOD_Plk_4 33 39 PF00069 0.515
MOD_Plk_4 7 13 PF00069 0.509
MOD_SUMO_rev_2 77 83 PF00179 0.585
TRG_ENDOCYTIC_2 82 85 PF00928 0.493

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7M9 Leptomonas seymouri 89% 100%
A0A0S4J547 Bodo saltans 56% 99%
A0A1X0NUR1 Trypanosomatidae 77% 100%
A0A3R7NPC2 Trypanosoma rangeli 78% 100%
A0A3S7X570 Leishmania donovani 99% 100%
A4GCR5 Olea europaea 32% 100%
A4GCR6 Olea europaea 32% 100%
A4GCR7 Olea europaea 33% 100%
A4GCR8 Olea europaea 33% 100%
A4GD50 Olea europaea 31% 100%
A4GD54 Olea europaea 31% 100%
A4GD55 Olea europaea 33% 100%
A4GD56 Olea europaea 33% 100%
A4GD58 Olea europaea 33% 100%
A4GDQ6 Olea europaea 32% 100%
A4GDQ8 Olea europaea 33% 100%
A4GDR1 Olea europaea 32% 100%
A4GDR3 Olea europaea 32% 100%
A4GDR4 Olea europaea 31% 100%
A4GDR6 Olea europaea 32% 100%
A4GDR7 Olea europaea 33% 100%
A4GDR8 Olea europaea 33% 100%
A4GDR9 Olea europaea 32% 100%
A4GDS0 Olea europaea 33% 100%
A4GDS6 Olea europaea 33% 100%
A4GDS7 Olea europaea 33% 100%
A4GDS9 Olea europaea 31% 100%
A4GDT0 Olea europaea 33% 100%
A4GDT1 Olea europaea 32% 100%
A4GDT3 Olea europaea 32% 100%
A4GDT4 Olea europaea 32% 100%
A4GDT5 Olea europaea 33% 100%
A4GDT9 Olea europaea 33% 100%
A4GDU0 Olea europaea 31% 100%
A4GDU2 Olea europaea 32% 100%
A4GDU3 Olea europaea 32% 100%
A4GDU5 Olea europaea 32% 100%
A4GDU6 Olea europaea 32% 100%
A4GE38 Olea europaea 31% 100%
A4GE39 Olea europaea 34% 100%
A4GE42 Olea europaea 33% 100%
A4GE44 Olea europaea 33% 100%
A4GE45 Olea europaea 32% 100%
A4GE47 Olea europaea 31% 100%
A4GE48 Olea europaea 33% 100%
A4GE49 Olea europaea 32% 100%
A4GE50 Olea europaea 32% 100%
A4GE53 Olea europaea 33% 100%
A4GE54 Olea europaea 32% 100%
A4GE55 Olea europaea 32% 100%
A4GFB7 Olea europaea 32% 100%
A4GFB9 Olea europaea 34% 100%
A4GFC0 Olea europaea 34% 100%
A4GFC2 Olea europaea 34% 100%
A4GFC3 Olea europaea 35% 100%
A4GFC4 Olea europaea 36% 100%
A4HK30 Leishmania braziliensis 89% 100%
A4I7N0 Leishmania infantum 99% 100%
A4K9Z8 Betula pendula 33% 100%
A4KA31 Phleum pratense 34% 100%
A4KA32 Phleum pratense 34% 100%
A4KA33 Phleum pratense 34% 100%
A4KA34 Phleum pratense 34% 100%
A4KA36 Phleum pratense 34% 100%
A4KA37 Phleum pratense 34% 100%
A4KA38 Phleum pratense 34% 100%
A4KA39 Corylus avellana 34% 100%
A4KA40 Corylus avellana 34% 100%
A4KA41 Corylus avellana 35% 100%
A4KA43 Corylus avellana 33% 100%
A4KA44 Corylus avellana 34% 100%
A4KA45 Corylus avellana 34% 100%
A4KA49 Olea europaea 34% 100%
A4KA50 Olea europaea 34% 100%
A4KA51 Olea europaea 33% 100%
A4KA52 Olea europaea 34% 100%
A4KA53 Olea europaea 34% 100%
A4KA54 Olea europaea 32% 100%
A4KA55 Zea mays 32% 100%
A4KA56 Zea mays 32% 100%
A4KA57 Zea mays 31% 100%
A4KA58 Zea mays 31% 100%
A4KA59 Zea mays 31% 100%
A4KA60 Zea mays 32% 100%
A4KA61 Zea mays 32% 100%
C0HL99 Actinidia deliciosa 40% 100%
C6JWH0 Kali turgidum 32% 100%
D0A9S0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 78% 100%
E2D0Y9 Kali turgidum 34% 100%
O04725 Cynodon dactylon 31% 100%
O22655 Zea mays 34% 100%
O24169 Olea europaea 33% 100%
O24170 Olea europaea 33% 100%
O24171 Olea europaea 32% 100%
O24282 Phleum pratense 34% 100%
O24650 Phleum pratense 34% 100%
O49894 Mercurialis annua 35% 100%
O65809 Glycine max 34% 100%
O65810 Glycine max 34% 100%
O65812 Hevea brasiliensis 32% 100%
O81982 Helianthus annuus 37% 100%
O82572 Ricinus communis 34% 100%
P07274 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 32% 100%
P0C0Y3 Fragaria ananassa 32% 100%
P0DKD0 Olea europaea 33% 100%
P0DKD1 Olea europaea 33% 100%
P0DKD2 Olea europaea 33% 100%
P0DKD3 Olea europaea 33% 100%
P0DKD4 Olea europaea 33% 100%
P0DKD5 Olea europaea 33% 100%
P0DKD6 Olea europaea 33% 100%
P0DKD7 Olea europaea 33% 100%
P0DKD8 Olea europaea 33% 100%
P0DKD9 Olea europaea 33% 100%
P0DKE0 Olea europaea 33% 100%
P0DKE1 Olea europaea 33% 100%
P0DKE2 Olea europaea 31% 100%
P0DKE3 Olea europaea 31% 100%
P0DKE4 Olea europaea 33% 100%
P0DKE5 Olea europaea 33% 100%
P0DKE6 Olea europaea 33% 100%
P0DKE7 Olea europaea 33% 100%
P0DKE8 Olea europaea 33% 100%
P0DKE9 Olea europaea 33% 100%
P0DKF0 Olea europaea 33% 100%
P0DKF1 Olea europaea 33% 100%
P0DKF2 Olea europaea 33% 100%
P0DKF3 Olea europaea 33% 100%
P0DKF4 Olea europaea 32% 100%
P0DKF5 Olea europaea 32% 100%
P0DKF6 Olea europaea 32% 100%
P0DKF7 Olea europaea 32% 100%
P0DKF8 Olea europaea 32% 100%
P0DKF9 Olea europaea 32% 100%
P0DKG0 Olea europaea 32% 100%
P0DKG1 Olea europaea 32% 100%
P18322 Physarum polycephalum 33% 100%
P19984 Acanthamoeba castellanii 29% 100%
P22271 Physarum polycephalum 33% 100%
P25816 Betula pendula 32% 100%
P25843 Drosophila melanogaster 29% 100%
P26199 Dictyostelium discoideum 33% 100%
P26200 Dictyostelium discoideum 32% 100%
P35079 Phleum pratense 34% 100%
P35081 Zea mays 31% 100%
P35082 Zea mays 29% 100%
P35083 Zea mays 31% 100%
P39825 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 27% 100%
P41372 Nicotiana tabacum 33% 100%
P49230 Entamoeba histolytica 35% 100%
P49231 Phaseolus vulgaris 33% 100%
P49232 Triticum aestivum 33% 100%
P49233 Triticum aestivum 34% 100%
P49234 Triticum aestivum 35% 100%
P52184 Hordeum vulgare 32% 100%
P53696 Candida albicans 33% 100%
P68696 Acanthamoeba castellanii 30% 100%
P83647 Oryza sativa subsp. indica 34% 100%
P84177 Citrus sinensis 32% 100%
Q21193 Caenorhabditis elegans 30% 100%
Q26734 Trypanosoma brucei brucei 78% 100%
Q38904 Arabidopsis thaliana 31% 100%
Q38905 Arabidopsis thaliana 32% 100%
Q41344 Solanum lycopersicum 34% 100%
Q42418 Arabidopsis thaliana 32% 100%
Q42449 Arabidopsis thaliana 32% 100%
Q4Q5N1 Leishmania major 97% 100%
Q5EF31 Crocus sativus 30% 100%
Q5FX67 Cucumis melo 34% 100%
Q5VMJ3 Oryza sativa subsp. japonica 34% 100%
Q5XWE1 Citrullus lanatus 34% 100%
Q64LH0 Ambrosia artemisiifolia 35% 100%
Q64LH1 Ambrosia artemisiifolia 32% 100%
Q64LH2 Ambrosia artemisiifolia 33% 100%
Q68HB4 Bombyx mori 31% 100%
Q6QEJ7 Apis mellifera 29% 100%
Q84V37 Chenopodium album 37% 100%
Q8GSL5 Prunus dulcis 32% 100%
Q8GT39 Prunus persica 32% 100%
Q8H2C8 Artemisia vulgaris 33% 100%
Q8H2C9 Artemisia vulgaris 34% 100%
Q8L5D8 Phoenix dactylifera 32% 100%
Q8SAE6 Daucus carota 32% 100%
Q8T8M2 Dictyostelium discoideum 41% 100%
Q8T938 Branchiostoma belcheri 30% 100%
Q93YG7 Solanum lycopersicum 32% 100%
Q93YI9 Capsicum annuum 34% 100%
Q941H7 Litchi chinensis 32% 100%
Q94JN2 Ananas comosus 32% 100%
Q94JN3 Musa acuminata 33% 100%
Q95VF7 Acanthamoeba castellanii 30% 100%
Q9FE63 Arabidopsis thaliana 31% 89%
Q9FR39 Zea mays 32% 100%
Q9FUB8 Brassica napus 32% 100%
Q9FUD1 Oryza sativa subsp. japonica 32% 100%
Q9LEI8 Hevea brasiliensis 32% 100%
Q9M7M8 Hevea brasiliensis 31% 100%
Q9M7M9 Hevea brasiliensis 32% 100%
Q9M7N0 Hevea brasiliensis 34% 100%
Q9SNW5 Lilium longiflorum 31% 100%
Q9SNW6 Lilium longiflorum 33% 100%
Q9SNW7 Lilium longiflorum 32% 100%
Q9SQI9 Arachis hypogaea 34% 100%
Q9ST98 Nicotiana tabacum 34% 100%
Q9ST99 Nicotiana tabacum 32% 100%
Q9STB6 Hevea brasiliensis 35% 100%
Q9T0M8 Parietaria judaica 34% 100%
Q9XF37 Apium graveolens 33% 100%
Q9XF38 Pyrus communis 33% 100%
Q9XF39 Prunus avium 33% 100%
Q9XF40 Malus domestica 33% 100%
Q9XF41 Malus domestica 32% 100%
Q9XF42 Malus domestica 34% 100%
Q9XG85 Parietaria judaica 32% 100%
Q9XW16 Caenorhabditis elegans 29% 100%
W8P570 Kali turgidum 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS