RGS domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2H3_LEIMU

TriTrypDb:

LmxM.31.0500

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2H3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2H3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.396
CLV_NRD_NRD_1	16	18	PF00675	0.600
CLV_NRD_NRD_1	222	224	PF00675	0.569
CLV_PCSK_SKI1_1	235	239	PF00082	0.611
CLV_PCSK_SKI1_1	4	8	PF00082	0.575
DEG_MDM2_SWIB_1	118	125	PF02201	0.543
DOC_CYCLIN_RxL_1	31	42	PF00134	0.510
DOC_MAPK_gen_1	103	110	PF00069	0.585
DOC_MAPK_gen_1	79	88	PF00069	0.576
DOC_MAPK_JIP1_4	32	38	PF00069	0.510
DOC_MAPK_MEF2A_6	103	110	PF00069	0.528
DOC_MAPK_MEF2A_6	117	125	PF00069	0.395
DOC_MAPK_MEF2A_6	67	76	PF00069	0.476
DOC_MAPK_NFAT4_5	103	111	PF00069	0.498
DOC_PP1_RVXF_1	32	39	PF00149	0.602
DOC_SPAK_OSR1_1	117	121	PF12202	0.542
DOC_USP7_MATH_1	49	53	PF00917	0.543
DOC_USP7_UBL2_3	79	83	PF12436	0.516
LIG_14-3-3_CanoR_1	183	189	PF00244	0.248
LIG_14-3-3_CanoR_1	223	231	PF00244	0.557
LIG_14-3-3_CanoR_1	32	37	PF00244	0.473
LIG_14-3-3_CanoR_1	61	70	PF00244	0.422
LIG_APCC_ABBA_1	72	77	PF00400	0.384
LIG_BRCT_BRCA1_1	227	231	PF00533	0.443
LIG_Clathr_ClatBox_1	149	153	PF01394	0.431
LIG_Clathr_ClatBox_1	27	31	PF01394	0.308
LIG_FHA_1	67	73	PF00498	0.568
LIG_FHA_2	55	61	PF00498	0.304
LIG_LIR_Gen_1	119	128	PF02991	0.479
LIG_LIR_Gen_1	203	212	PF02991	0.410
LIG_LIR_Gen_1	84	92	PF02991	0.431
LIG_LIR_Nem_3	119	125	PF02991	0.407
LIG_LIR_Nem_3	135	141	PF02991	0.334
LIG_LIR_Nem_3	180	184	PF02991	0.474
LIG_LIR_Nem_3	203	207	PF02991	0.410
LIG_LIR_Nem_3	84	88	PF02991	0.281
LIG_NRBOX	105	111	PF00104	0.497
LIG_PDZ_Class_2	255	260	PF00595	0.602
LIG_Pex14_2	118	122	PF04695	0.538
LIG_REV1ctd_RIR_1	236	244	PF16727	0.681
LIG_SH2_CRK	255	259	PF00017	0.593
LIG_SH2_CRK	50	54	PF00017	0.493
LIG_SH2_STAP1	50	54	PF00017	0.493
LIG_SH2_STAT3	171	174	PF00017	0.368
LIG_SH2_STAT5	146	149	PF00017	0.402
LIG_SH2_STAT5	204	207	PF00017	0.437
LIG_SH2_STAT5	70	73	PF00017	0.553
LIG_SH3_3	240	246	PF00018	0.675
LIG_SUMO_SIM_par_1	187	193	PF11976	0.370
LIG_TYR_ITIM	253	258	PF00017	0.482
LIG_UBA3_1	100	105	PF00899	0.557
MOD_CK1_1	222	228	PF00069	0.527
MOD_CK1_1	39	45	PF00069	0.504
MOD_CK2_1	174	180	PF00069	0.456
MOD_CK2_1	184	190	PF00069	0.372
MOD_GlcNHglycan	176	179	PF01048	0.515
MOD_GlcNHglycan	56	60	PF01048	0.555
MOD_GSK3_1	170	177	PF00069	0.549
MOD_GSK3_1	215	222	PF00069	0.671
MOD_GSK3_1	225	232	PF00069	0.520
MOD_GSK3_1	32	39	PF00069	0.589
MOD_NEK2_1	108	113	PF00069	0.518
MOD_NEK2_1	145	150	PF00069	0.467
MOD_NEK2_1	184	189	PF00069	0.392
MOD_NEK2_1	36	41	PF00069	0.458
MOD_PIKK_1	170	176	PF00454	0.388
MOD_PIKK_1	61	67	PF00454	0.514
MOD_PKA_2	222	228	PF00069	0.536
MOD_PKA_2	60	66	PF00069	0.424
MOD_PKB_1	32	40	PF00069	0.513
MOD_Plk_1	229	235	PF00069	0.626
MOD_Plk_4	153	159	PF00069	0.471
MOD_Plk_4	184	190	PF00069	0.429
MOD_Plk_4	49	55	PF00069	0.547
MOD_Plk_4	81	87	PF00069	0.407
MOD_Plk_4	91	97	PF00069	0.441
MOD_SUMO_for_1	104	107	PF00179	0.378
MOD_SUMO_for_1	78	81	PF00179	0.580
MOD_SUMO_rev_2	77	84	PF00179	0.456
TRG_DiLeu_BaEn_1	153	158	PF01217	0.608
TRG_ENDOCYTIC_2	138	141	PF00928	0.379
TRG_ENDOCYTIC_2	146	149	PF00928	0.368
TRG_ENDOCYTIC_2	204	207	PF00928	0.437
TRG_ENDOCYTIC_2	255	258	PF00928	0.598
TRG_ENDOCYTIC_2	50	53	PF00928	0.411
TRG_NES_CRM1_1	66	77	PF08389	0.375
TRG_Pf-PMV_PEXEL_1	17	22	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NW65	Trypanosomatidae	35%	100%
A0A3S7X585	Leishmania donovani	87%	100%
A0A422NJP5	Trypanosoma rangeli	37%	100%
A4HK32	Leishmania braziliensis	73%	100%
A4I7N2	Leishmania infantum	87%	100%
D0A9R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
Q4Q5N3	Leishmania major	86%	100%