DUF3444 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2H1_LEIMU

TriTrypDb:

LmxM.31.0480

Length:

383

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B2H1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2H1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.669
CLV_C14_Caspase3-7	312	316	PF00656	0.713
CLV_C14_Caspase3-7	325	329	PF00656	0.754
CLV_NRD_NRD_1	375	377	PF00675	0.609
CLV_NRD_NRD_1	71	73	PF00675	0.593
CLV_PCSK_KEX2_1	145	147	PF00082	0.550
CLV_PCSK_KEX2_1	263	265	PF00082	0.549
CLV_PCSK_KEX2_1	375	377	PF00082	0.609
CLV_PCSK_KEX2_1	71	73	PF00082	0.560
CLV_PCSK_KEX2_1	76	78	PF00082	0.509
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.550
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.607
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.505
CLV_PCSK_PC7_1	72	78	PF00082	0.562
CLV_PCSK_SKI1_1	151	155	PF00082	0.531
CLV_PCSK_SKI1_1	177	181	PF00082	0.430
CLV_PCSK_SKI1_1	241	245	PF00082	0.357
DEG_APCC_DBOX_1	176	184	PF00400	0.425
DEG_APCC_DBOX_1	275	283	PF00400	0.506
DEG_COP1_1	287	297	PF00400	0.549
DEG_SCF_FBW7_2	186	192	PF00400	0.480
DEG_SCF_TRCP1_1	328	334	PF00400	0.682
DOC_CKS1_1	186	191	PF01111	0.483
DOC_PP1_RVXF_1	17	24	PF00149	0.702
DOC_PP1_RVXF_1	239	245	PF00149	0.285
DOC_USP7_MATH_1	135	139	PF00917	0.634
DOC_USP7_MATH_1	168	172	PF00917	0.644
DOC_USP7_MATH_1	6	10	PF00917	0.750
DOC_USP7_MATH_2	119	125	PF00917	0.641
DOC_WW_Pin1_4	10	15	PF00397	0.514
DOC_WW_Pin1_4	161	166	PF00397	0.489
DOC_WW_Pin1_4	185	190	PF00397	0.581
LIG_14-3-3_CanoR_1	16	22	PF00244	0.800
LIG_14-3-3_CanoR_1	252	256	PF00244	0.475
LIG_14-3-3_CanoR_1	269	275	PF00244	0.458
LIG_14-3-3_CanoR_1	302	310	PF00244	0.629
LIG_14-3-3_CanoR_1	320	325	PF00244	0.556
LIG_14-3-3_CanoR_1	39	48	PF00244	0.658
LIG_14-3-3_CanoR_1	71	75	PF00244	0.573
LIG_APCC_ABBA_1	198	203	PF00400	0.580
LIG_BIR_II_1	1	5	PF00653	0.676
LIG_BRCT_BRCA1_1	36	40	PF00533	0.716
LIG_FHA_1	186	192	PF00498	0.527
LIG_FHA_1	224	230	PF00498	0.476
LIG_FHA_1	347	353	PF00498	0.619
LIG_FHA_1	354	360	PF00498	0.579
LIG_FHA_2	158	164	PF00498	0.450
LIG_FHA_2	214	220	PF00498	0.452
LIG_FHA_2	26	32	PF00498	0.697
LIG_FHA_2	285	291	PF00498	0.484
LIG_FHA_2	5	11	PF00498	0.720
LIG_FHA_2	63	69	PF00498	0.644
LIG_Integrin_RGD_1	264	266	PF01839	0.493
LIG_LIR_Gen_1	105	115	PF02991	0.550
LIG_LIR_Gen_1	278	288	PF02991	0.507
LIG_LIR_Nem_3	105	111	PF02991	0.514
LIG_LIR_Nem_3	278	284	PF02991	0.492
LIG_LIR_Nem_3	287	292	PF02991	0.448
LIG_LIR_Nem_3	73	78	PF02991	0.483
LIG_NRBOX	178	184	PF00104	0.468
LIG_SH2_CRK	197	201	PF00017	0.536
LIG_SH2_CRK	75	79	PF00017	0.374
LIG_SH2_STAT3	57	60	PF00017	0.729
LIG_SH2_STAT3	85	88	PF00017	0.503
LIG_SH2_STAT5	214	217	PF00017	0.432
LIG_SH2_STAT5	256	259	PF00017	0.448
LIG_SH2_STAT5	281	284	PF00017	0.449
LIG_SH3_3	285	291	PF00018	0.398
LIG_SH3_3	334	340	PF00018	0.667
LIG_SUMO_SIM_anti_2	178	184	PF11976	0.448
LIG_SUMO_SIM_anti_2	349	354	PF11976	0.476
LIG_SUMO_SIM_par_1	281	287	PF11976	0.464
LIG_SUMO_SIM_par_1	290	296	PF11976	0.527
LIG_TYR_ITIM	279	284	PF00017	0.521
LIG_UBA3_1	107	114	PF00899	0.492
LIG_WW_3	13	17	PF00397	0.625
MOD_CDC14_SPxK_1	13	16	PF00782	0.764
MOD_CDK_SPxK_1	10	16	PF00069	0.675
MOD_CK1_1	124	130	PF00069	0.670
MOD_CK1_1	133	139	PF00069	0.508
MOD_CK1_1	303	309	PF00069	0.603
MOD_CK1_1	322	328	PF00069	0.489
MOD_CK1_1	329	335	PF00069	0.649
MOD_CK1_1	4	10	PF00069	0.809
MOD_CK1_1	41	47	PF00069	0.629
MOD_CK1_1	50	56	PF00069	0.679
MOD_CK2_1	157	163	PF00069	0.481
MOD_CK2_1	213	219	PF00069	0.437
MOD_CK2_1	25	31	PF00069	0.777
MOD_CK2_1	303	309	PF00069	0.641
MOD_CK2_1	375	381	PF00069	0.514
MOD_CK2_1	4	10	PF00069	0.689
MOD_CK2_1	62	68	PF00069	0.690
MOD_Cter_Amidation	143	146	PF01082	0.545
MOD_GlcNHglycan	1	4	PF01048	0.706
MOD_GlcNHglycan	126	129	PF01048	0.671
MOD_GlcNHglycan	133	136	PF01048	0.601
MOD_GlcNHglycan	142	145	PF01048	0.544
MOD_GlcNHglycan	238	241	PF01048	0.550
MOD_GlcNHglycan	325	328	PF01048	0.669
MOD_GlcNHglycan	54	57	PF01048	0.679
MOD_GSK3_1	120	127	PF00069	0.666
MOD_GSK3_1	131	138	PF00069	0.491
MOD_GSK3_1	157	164	PF00069	0.446
MOD_GSK3_1	229	236	PF00069	0.498
MOD_GSK3_1	251	258	PF00069	0.470
MOD_GSK3_1	316	323	PF00069	0.676
MOD_GSK3_1	326	333	PF00069	0.637
MOD_GSK3_1	34	41	PF00069	0.616
MOD_GSK3_1	6	13	PF00069	0.605
MOD_N-GLC_1	224	229	PF02516	0.452
MOD_N-GLC_1	300	305	PF02516	0.717
MOD_NEK2_1	1	6	PF00069	0.763
MOD_NEK2_1	140	145	PF00069	0.582
MOD_NEK2_1	229	234	PF00069	0.491
MOD_NEK2_1	250	255	PF00069	0.498
MOD_NEK2_1	284	289	PF00069	0.430
MOD_NEK2_1	300	305	PF00069	0.525
MOD_NEK2_2	270	275	PF00069	0.400
MOD_PIKK_1	34	40	PF00454	0.748
MOD_PKA_1	375	381	PF00069	0.602
MOD_PKA_2	251	257	PF00069	0.453
MOD_PKA_2	270	276	PF00069	0.456
MOD_PKA_2	319	325	PF00069	0.684
MOD_PKA_2	375	381	PF00069	0.528
MOD_PKA_2	38	44	PF00069	0.679
MOD_PKA_2	50	56	PF00069	0.671
MOD_PKA_2	70	76	PF00069	0.560
MOD_Plk_1	224	230	PF00069	0.391
MOD_Plk_1	25	31	PF00069	0.710
MOD_Plk_2-3	157	163	PF00069	0.525
MOD_Plk_4	121	127	PF00069	0.745
MOD_Plk_4	135	141	PF00069	0.389
MOD_Plk_4	169	175	PF00069	0.533
MOD_Plk_4	224	230	PF00069	0.533
MOD_Plk_4	251	257	PF00069	0.412
MOD_Plk_4	270	276	PF00069	0.404
MOD_ProDKin_1	10	16	PF00069	0.517
MOD_ProDKin_1	161	167	PF00069	0.485
MOD_ProDKin_1	185	191	PF00069	0.486
MOD_SUMO_for_1	153	156	PF00179	0.516
TRG_DiLeu_BaEn_1	278	283	PF01217	0.524
TRG_DiLeu_BaEn_3	120	126	PF01217	0.658
TRG_ENDOCYTIC_2	197	200	PF00928	0.478
TRG_ENDOCYTIC_2	281	284	PF00928	0.446
TRG_ENDOCYTIC_2	75	78	PF00928	0.409
TRG_ER_diArg_1	375	377	PF00400	0.612
TRG_ER_diArg_1	70	72	PF00400	0.610
TRG_NLS_MonoExtC_3	150	155	PF00514	0.576
TRG_NLS_MonoExtN_4	150	155	PF00514	0.576
TRG_Pf-PMV_PEXEL_1	357	361	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILX2	Leptomonas seymouri	76%	99%
A0A0S4J1T4	Bodo saltans	40%	79%
A0A1X0P7I4	Trypanosomatidae	51%	98%
A0A3Q8IT20	Leishmania donovani	93%	100%
A0A422N1D9	Trypanosoma rangeli	49%	98%
A4HK34	Leishmania braziliensis	82%	100%
A4I7N4	Leishmania infantum	93%	100%
D0A0C1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	98%
Q4Q5N5	Leishmania major	93%	100%
V5BWX0	Trypanosoma cruzi	50%	98%