Replication termination factor 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rtf2 RING-finger, putative

Species:

Leishmania mexicana

UniProt:

E9B2G9_LEIMU

TriTrypDb:

LmxM.31.0473

Length:

206

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

E9B2G9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2G9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006274	DNA replication termination	5	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0022402	cell cycle process	2	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1902294	cell cycle DNA replication termination	3	11
GO:1902317	nuclear DNA replication termination	4	11
GO:1902979	mitotic DNA replication termination	4	11
GO:1903047	mitotic cell cycle process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	196	198	PF00675	0.462
CLV_NRD_NRD_1	80	82	PF00675	0.263
CLV_PCSK_KEX2_1	11	13	PF00082	0.237
CLV_PCSK_KEX2_1	194	196	PF00082	0.425
CLV_PCSK_KEX2_1	198	200	PF00082	0.460
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.245
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.418
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.439
CLV_PCSK_PC7_1	190	196	PF00082	0.455
CLV_PCSK_SKI1_1	12	16	PF00082	0.238
CLV_PCSK_SKI1_1	99	103	PF00082	0.319
DOC_CYCLIN_yCln2_LP_2	56	62	PF00134	0.445
DOC_PP2B_LxvP_1	56	59	PF13499	0.520
DOC_USP7_UBL2_3	194	198	PF12436	0.497
DOC_USP7_UBL2_3	35	39	PF12436	0.520
DOC_USP7_UBL2_3	95	99	PF12436	0.483
LIG_14-3-3_CanoR_1	19	27	PF00244	0.464
LIG_14-3-3_CanoR_1	45	53	PF00244	0.463
LIG_FHA_1	153	159	PF00498	0.413
LIG_FHA_2	21	27	PF00498	0.450
LIG_LIR_Gen_1	122	130	PF02991	0.544
LIG_LIR_Gen_1	168	179	PF02991	0.477
LIG_LIR_Nem_3	122	127	PF02991	0.509
LIG_LIR_Nem_3	132	136	PF02991	0.454
LIG_LIR_Nem_3	161	167	PF02991	0.520
LIG_LIR_Nem_3	168	174	PF02991	0.439
LIG_Pex14_2	133	137	PF04695	0.431
LIG_SH2_CRK	124	128	PF00017	0.520
LIG_SH2_NCK_1	124	128	PF00017	0.511
LIG_SH2_PTP2	171	174	PF00017	0.430
LIG_SH2_STAT5	171	174	PF00017	0.430
LIG_SH2_STAT5	192	195	PF00017	0.423
LIG_SH2_STAT5	21	24	PF00017	0.520
LIG_SH2_STAT5	77	80	PF00017	0.496
LIG_SH3_3	114	120	PF00018	0.526
LIG_SH3_3	157	163	PF00018	0.493
LIG_SH3_5	120	124	PF00018	0.483
LIG_TYR_ITSM	120	127	PF00017	0.483
LIG_WRC_WIRS_1	130	135	PF05994	0.487
LIG_WRC_WIRS_1	167	172	PF05994	0.445
MOD_CK1_1	113	119	PF00069	0.550
MOD_CK1_1	125	131	PF00069	0.384
MOD_CK1_1	144	150	PF00069	0.392
MOD_CK1_1	152	158	PF00069	0.502
MOD_CK1_1	37	43	PF00069	0.542
MOD_CK1_1	70	76	PF00069	0.520
MOD_GlcNHglycan	127	130	PF01048	0.265
MOD_GlcNHglycan	143	146	PF01048	0.263
MOD_GlcNHglycan	28	31	PF01048	0.332
MOD_GSK3_1	119	126	PF00069	0.463
MOD_GSK3_1	144	151	PF00069	0.497
MOD_GSK3_1	33	40	PF00069	0.520
MOD_NEK2_1	15	20	PF00069	0.452
MOD_NEK2_2	166	171	PF00069	0.544
MOD_PIKK_1	153	159	PF00454	0.520
MOD_PIKK_1	34	40	PF00454	0.563
MOD_PKA_1	99	105	PF00069	0.557
MOD_PKA_2	44	50	PF00069	0.463
MOD_Plk_1	122	128	PF00069	0.516
MOD_Plk_4	129	135	PF00069	0.520
MOD_Plk_4	166	172	PF00069	0.557
MOD_Plk_4	184	190	PF00069	0.385
MOD_Plk_4	70	76	PF00069	0.520
MOD_SUMO_rev_2	91	96	PF00179	0.510
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.418
TRG_ENDOCYTIC_2	124	127	PF00928	0.520
TRG_ENDOCYTIC_2	171	174	PF00928	0.416
TRG_ER_diArg_1	197	200	PF00400	0.499
TRG_NLS_MonoExtC_3	193	198	PF00514	0.430
TRG_NLS_MonoExtN_4	194	201	PF00514	0.480
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.245
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEQ3	Leptomonas seymouri	59%	100%
A0A0S4J1X6	Bodo saltans	30%	100%
A0A1X0P6S0	Trypanosomatidae	41%	95%
A0A3R7N309	Trypanosoma rangeli	41%	94%
A0A3S7X5A4	Leishmania donovani	94%	100%
A4HK35	Leishmania braziliensis	80%	100%
A4I7N6	Leishmania infantum	94%	100%
D0A0B9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	94%
Q10154	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	86%
Q4Q5N7	Leishmania major	92%	100%