Leucine-rich repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2G8_LEIMU

TriTrypDb:

LmxM.31.0470

Length:

884

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11

Expansion

Sequence features

E9B2G8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2G8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	186	190	PF00656	0.768
CLV_C14_Caspase3-7	347	351	PF00656	0.525
CLV_C14_Caspase3-7	437	441	PF00656	0.736
CLV_C14_Caspase3-7	695	699	PF00656	0.501
CLV_NRD_NRD_1	228	230	PF00675	0.634
CLV_NRD_NRD_1	262	264	PF00675	0.442
CLV_NRD_NRD_1	302	304	PF00675	0.512
CLV_NRD_NRD_1	379	381	PF00675	0.646
CLV_NRD_NRD_1	491	493	PF00675	0.389
CLV_NRD_NRD_1	740	742	PF00675	0.524
CLV_NRD_NRD_1	863	865	PF00675	0.471
CLV_PCSK_KEX2_1	245	247	PF00082	0.502
CLV_PCSK_KEX2_1	262	264	PF00082	0.418
CLV_PCSK_KEX2_1	302	304	PF00082	0.546
CLV_PCSK_KEX2_1	64	66	PF00082	0.469
CLV_PCSK_KEX2_1	740	742	PF00082	0.501
CLV_PCSK_KEX2_1	794	796	PF00082	0.443
CLV_PCSK_KEX2_1	863	865	PF00082	0.471
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.613
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.469
CLV_PCSK_PC1ET2_1	794	796	PF00082	0.443
CLV_PCSK_PC7_1	241	247	PF00082	0.488
CLV_PCSK_SKI1_1	151	155	PF00082	0.655
CLV_PCSK_SKI1_1	252	256	PF00082	0.562
CLV_PCSK_SKI1_1	376	380	PF00082	0.624
CLV_PCSK_SKI1_1	707	711	PF00082	0.488
CLV_PCSK_SKI1_1	858	862	PF00082	0.521
CLV_PCSK_SKI1_1	97	101	PF00082	0.436
CLV_Separin_Metazoa	377	381	PF03568	0.559
DEG_APCC_DBOX_1	247	255	PF00400	0.569
DOC_CKS1_1	749	754	PF01111	0.577
DOC_CYCLIN_RxL_1	681	692	PF00134	0.395
DOC_CYCLIN_RxL_1	794	805	PF00134	0.408
DOC_MAPK_DCC_7	814	823	PF00069	0.530
DOC_MAPK_gen_1	245	255	PF00069	0.572
DOC_MAPK_gen_1	474	482	PF00069	0.306
DOC_MAPK_gen_1	503	513	PF00069	0.519
DOC_MAPK_gen_1	94	104	PF00069	0.408
DOC_MAPK_MEF2A_6	246	255	PF00069	0.477
DOC_MAPK_MEF2A_6	412	419	PF00069	0.721
DOC_MAPK_MEF2A_6	814	823	PF00069	0.490
DOC_PP1_RVXF_1	797	804	PF00149	0.497
DOC_PP1_RVXF_1	856	862	PF00149	0.485
DOC_USP7_MATH_1	153	157	PF00917	0.759
DOC_USP7_MATH_1	183	187	PF00917	0.755
DOC_USP7_MATH_1	278	282	PF00917	0.547
DOC_USP7_MATH_1	298	302	PF00917	0.607
DOC_USP7_MATH_1	390	394	PF00917	0.457
DOC_USP7_MATH_1	517	521	PF00917	0.558
DOC_WW_Pin1_4	177	182	PF00397	0.777
DOC_WW_Pin1_4	383	388	PF00397	0.663
DOC_WW_Pin1_4	431	436	PF00397	0.766
DOC_WW_Pin1_4	561	566	PF00397	0.441
DOC_WW_Pin1_4	677	682	PF00397	0.609
DOC_WW_Pin1_4	748	753	PF00397	0.537
LIG_14-3-3_CanoR_1	394	404	PF00244	0.673
LIG_14-3-3_CanoR_1	424	431	PF00244	0.614
LIG_14-3-3_CanoR_1	576	582	PF00244	0.508
LIG_14-3-3_CanoR_1	65	69	PF00244	0.266
LIG_14-3-3_CanoR_1	707	715	PF00244	0.511
LIG_14-3-3_CanoR_1	741	749	PF00244	0.458
LIG_Actin_WH2_2	272	290	PF00022	0.497
LIG_APCC_ABBA_1	253	258	PF00400	0.584
LIG_APCC_ABBA_1	534	539	PF00400	0.600
LIG_APCC_ABBAyCdc20_2	252	258	PF00400	0.385
LIG_BIR_II_1	1	5	PF00653	0.439
LIG_BIR_III_2	178	182	PF00653	0.751
LIG_BRCT_BRCA1_1	385	389	PF00533	0.742
LIG_BRCT_BRCA1_1	849	853	PF00533	0.575
LIG_Clathr_ClatBox_1	832	836	PF01394	0.440
LIG_deltaCOP1_diTrp_1	456	460	PF00928	0.611
LIG_deltaCOP1_diTrp_1	788	792	PF00928	0.495
LIG_FHA_1	109	115	PF00498	0.511
LIG_FHA_1	124	130	PF00498	0.535
LIG_FHA_1	309	315	PF00498	0.453
LIG_FHA_1	477	483	PF00498	0.334
LIG_FHA_1	502	508	PF00498	0.515
LIG_FHA_1	577	583	PF00498	0.500
LIG_FHA_1	680	686	PF00498	0.499
LIG_FHA_1	749	755	PF00498	0.526
LIG_FHA_1	769	775	PF00498	0.195
LIG_FHA_1	877	883	PF00498	0.610
LIG_FHA_2	105	111	PF00498	0.543
LIG_FHA_2	166	172	PF00498	0.777
LIG_FHA_2	20	26	PF00498	0.608
LIG_FHA_2	220	226	PF00498	0.472
LIG_FHA_2	418	424	PF00498	0.687
LIG_FHA_2	693	699	PF00498	0.486
LIG_FHA_2	708	714	PF00498	0.428
LIG_GBD_Chelix_1	114	122	PF00786	0.449
LIG_GBD_Chelix_1	766	774	PF00786	0.474
LIG_LIR_Gen_1	304	314	PF02991	0.433
LIG_LIR_Gen_1	539	547	PF02991	0.459
LIG_LIR_Gen_1	557	568	PF02991	0.248
LIG_LIR_Gen_1	788	797	PF02991	0.509
LIG_LIR_Gen_1	850	861	PF02991	0.540
LIG_LIR_Nem_3	268	273	PF02991	0.590
LIG_LIR_Nem_3	304	309	PF02991	0.449
LIG_LIR_Nem_3	535	540	PF02991	0.511
LIG_LIR_Nem_3	557	563	PF02991	0.440
LIG_LIR_Nem_3	788	792	PF02991	0.507
LIG_NRBOX	250	256	PF00104	0.575
LIG_NRBOX	326	332	PF00104	0.452
LIG_NRBOX	701	707	PF00104	0.406
LIG_NRBOX	769	775	PF00104	0.494
LIG_Pex14_2	803	807	PF04695	0.499
LIG_Pex14_2	839	843	PF04695	0.578
LIG_RPA_C_Fungi	389	401	PF08784	0.447
LIG_SH2_CRK	270	274	PF00017	0.592
LIG_SH2_CRK	560	564	PF00017	0.276
LIG_SH2_SRC	734	737	PF00017	0.505
LIG_SH2_STAP1	410	414	PF00017	0.710
LIG_SH2_STAP1	608	612	PF00017	0.493
LIG_SH2_STAT3	597	600	PF00017	0.594
LIG_SH2_STAT5	299	302	PF00017	0.556
LIG_SH2_STAT5	560	563	PF00017	0.501
LIG_SH2_STAT5	606	609	PF00017	0.502
LIG_SH2_STAT5	734	737	PF00017	0.549
LIG_SH3_3	463	469	PF00018	0.575
LIG_SH3_3	671	677	PF00018	0.530
LIG_SH3_3	757	763	PF00018	0.454
LIG_SH3_3	775	781	PF00018	0.322
LIG_SUMO_SIM_par_1	110	119	PF11976	0.488
LIG_SUMO_SIM_par_1	275	282	PF11976	0.493
LIG_SUMO_SIM_par_1	415	420	PF11976	0.682
LIG_SUMO_SIM_par_1	468	473	PF11976	0.581
LIG_SUMO_SIM_par_1	481	487	PF11976	0.259
LIG_SUMO_SIM_par_1	579	585	PF11976	0.521
LIG_SUMO_SIM_par_1	762	768	PF11976	0.476
LIG_SUMO_SIM_par_1	878	884	PF11976	0.453
LIG_TRAF2_1	215	218	PF00917	0.767
LIG_TRAF2_1	338	341	PF00917	0.549
LIG_TRAF2_1	711	714	PF00917	0.472
LIG_TRAF2_1	716	719	PF00917	0.426
MOD_CDK_SPxxK_3	677	684	PF00069	0.556
MOD_CK1_1	163	169	PF00069	0.700
MOD_CK1_1	19	25	PF00069	0.442
MOD_CK1_1	301	307	PF00069	0.521
MOD_CK1_1	393	399	PF00069	0.705
MOD_CK1_1	425	431	PF00069	0.788
MOD_CK1_1	434	440	PF00069	0.625
MOD_CK1_1	580	586	PF00069	0.424
MOD_CK1_1	77	83	PF00069	0.625
MOD_CK1_1	805	811	PF00069	0.367
MOD_CK2_1	165	171	PF00069	0.726
MOD_CK2_1	197	203	PF00069	0.777
MOD_CK2_1	212	218	PF00069	0.611
MOD_CK2_1	219	225	PF00069	0.495
MOD_CK2_1	304	310	PF00069	0.567
MOD_CK2_1	335	341	PF00069	0.604
MOD_CK2_1	352	358	PF00069	0.479
MOD_CK2_1	417	423	PF00069	0.712
MOD_CK2_1	427	433	PF00069	0.762
MOD_CK2_1	707	713	PF00069	0.493
MOD_CK2_1	77	83	PF00069	0.568
MOD_CK2_1	85	91	PF00069	0.500
MOD_CMANNOS	457	460	PF00535	0.619
MOD_GlcNHglycan	10	13	PF01048	0.516
MOD_GlcNHglycan	155	158	PF01048	0.757
MOD_GlcNHglycan	18	21	PF01048	0.556
MOD_GlcNHglycan	303	306	PF01048	0.490
MOD_GlcNHglycan	32	35	PF01048	0.515
MOD_GlcNHglycan	397	400	PF01048	0.622
MOD_GlcNHglycan	446	449	PF01048	0.697
MOD_GlcNHglycan	520	523	PF01048	0.664
MOD_GlcNHglycan	618	621	PF01048	0.461
MOD_GlcNHglycan	725	728	PF01048	0.379
MOD_GlcNHglycan	76	79	PF01048	0.642
MOD_GlcNHglycan	836	839	PF01048	0.572
MOD_GSK3_1	165	172	PF00069	0.775
MOD_GSK3_1	179	186	PF00069	0.734
MOD_GSK3_1	304	311	PF00069	0.555
MOD_GSK3_1	388	395	PF00069	0.600
MOD_GSK3_1	422	429	PF00069	0.725
MOD_GSK3_1	440	447	PF00069	0.497
MOD_GSK3_1	484	491	PF00069	0.495
MOD_GSK3_1	576	583	PF00069	0.499
MOD_GSK3_1	598	605	PF00069	0.524
MOD_GSK3_1	64	71	PF00069	0.523
MOD_GSK3_1	649	656	PF00069	0.448
MOD_GSK3_1	675	682	PF00069	0.634
MOD_GSK3_1	744	751	PF00069	0.482
MOD_GSK3_1	79	86	PF00069	0.560
MOD_GSK3_1	843	850	PF00069	0.651
MOD_GSK3_1	98	105	PF00069	0.499
MOD_N-GLC_1	102	107	PF02516	0.417
MOD_N-GLC_1	163	168	PF02516	0.698
MOD_N-GLC_1	577	582	PF02516	0.426
MOD_N-GLC_1	742	747	PF02516	0.480
MOD_NEK2_1	104	109	PF00069	0.251
MOD_NEK2_1	30	35	PF00069	0.517
MOD_NEK2_1	352	357	PF00069	0.603
MOD_NEK2_1	47	52	PF00069	0.355
MOD_NEK2_1	610	615	PF00069	0.421
MOD_NEK2_1	653	658	PF00069	0.434
MOD_NEK2_1	722	727	PF00069	0.427
MOD_NEK2_1	742	747	PF00069	0.480
MOD_NEK2_1	825	830	PF00069	0.568
MOD_NEK2_1	843	848	PF00069	0.456
MOD_NEK2_1	85	90	PF00069	0.549
MOD_NEK2_1	98	103	PF00069	0.371
MOD_NEK2_2	476	481	PF00069	0.364
MOD_PKA_1	64	70	PF00069	0.280
MOD_PKA_2	197	203	PF00069	0.509
MOD_PKA_2	301	307	PF00069	0.487
MOD_PKA_2	352	358	PF00069	0.541
MOD_PKA_2	393	399	PF00069	0.658
MOD_PKA_2	425	431	PF00069	0.574
MOD_PKA_2	64	70	PF00069	0.280
MOD_PKB_1	424	432	PF00069	0.504
MOD_Plk_1	109	115	PF00069	0.463
MOD_Plk_1	163	169	PF00069	0.825
MOD_Plk_1	47	53	PF00069	0.538
MOD_Plk_1	577	583	PF00069	0.419
MOD_Plk_1	713	719	PF00069	0.433
MOD_Plk_2-3	169	175	PF00069	0.751
MOD_Plk_2-3	197	203	PF00069	0.614
MOD_Plk_2-3	212	218	PF00069	0.666
MOD_Plk_2-3	692	698	PF00069	0.558
MOD_Plk_2-3	713	719	PF00069	0.453
MOD_Plk_4	109	115	PF00069	0.521
MOD_Plk_4	308	314	PF00069	0.489
MOD_Plk_4	532	538	PF00069	0.581
MOD_Plk_4	577	583	PF00069	0.535
MOD_Plk_4	602	608	PF00069	0.508
MOD_Plk_4	631	637	PF00069	0.318
MOD_Plk_4	788	794	PF00069	0.439
MOD_Plk_4	802	808	PF00069	0.350
MOD_Plk_4	828	834	PF00069	0.474
MOD_ProDKin_1	177	183	PF00069	0.770
MOD_ProDKin_1	383	389	PF00069	0.668
MOD_ProDKin_1	431	437	PF00069	0.767
MOD_ProDKin_1	561	567	PF00069	0.438
MOD_ProDKin_1	677	683	PF00069	0.594
MOD_ProDKin_1	748	754	PF00069	0.537
MOD_SUMO_for_1	35	38	PF00179	0.346
MOD_SUMO_rev_2	119	129	PF00179	0.595
MOD_SUMO_rev_2	219	228	PF00179	0.648
MOD_SUMO_rev_2	56	66	PF00179	0.541
TRG_DiLeu_BaEn_1	250	255	PF01217	0.665
TRG_DiLeu_BaEn_1	38	43	PF01217	0.500
TRG_DiLeu_BaEn_2	787	793	PF01217	0.514
TRG_DiLeu_BaEn_4	638	644	PF01217	0.441
TRG_DiLeu_BaEn_4	718	724	PF01217	0.517
TRG_DiLeu_BaLyEn_6	855	860	PF01217	0.440
TRG_DiLeu_LyEn_5	718	723	PF01217	0.532
TRG_ENDOCYTIC_2	270	273	PF00928	0.588
TRG_ENDOCYTIC_2	560	563	PF00928	0.382
TRG_ER_diArg_1	660	663	PF00400	0.534
TRG_ER_diArg_1	739	741	PF00400	0.500
TRG_ER_diArg_1	862	864	PF00400	0.465
TRG_NLS_Bipartite_1	229	249	PF00514	0.487
TRG_NLS_MonoExtC_3	244	250	PF00514	0.468
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.738
TRG_Pf-PMV_PEXEL_1	263	268	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	622	627	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM54	Leptomonas seymouri	46%	84%
A0A1X0P6G6	Trypanosomatidae	29%	79%
A0A3Q8IFP5	Leishmania donovani	90%	84%
A0A422N1D3	Trypanosoma rangeli	29%	80%
A4HK27	Leishmania braziliensis	78%	100%
A4I7L1	Leishmania infantum	90%	94%
D0A0B5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	80%
Q4Q5N8	Leishmania major	88%	100%
V5DTH3	Trypanosoma cruzi	30%	80%