LeishMANIAdb
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WW domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
WW domain-containing protein
Gene product:
Protein of unknown function (DUF1279), putative
Species:
Leishmania mexicana
UniProt:
E9B2G5_LEIMU
TriTrypDb:
LmxM.31.0440
Length:
291

Annotations

LeishMANIAdb annotations

Homologous to animal FAM210 mitochondrial proteins. This protein might have a mitochondrial transit signal.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005739 mitochondrion 5 1
GO:0005783 endoplasmic reticulum 5 1
GO:0016020 membrane 2 11
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 11
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Expansion

Sequence features

E9B2G5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2G5

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 55 57 PF00675 0.477
CLV_PCSK_KEX2_1 212 214 PF00082 0.529
CLV_PCSK_KEX2_1 223 225 PF00082 0.519
CLV_PCSK_KEX2_1 55 57 PF00082 0.478
CLV_PCSK_PC1ET2_1 212 214 PF00082 0.529
CLV_PCSK_PC1ET2_1 223 225 PF00082 0.503
DEG_APCC_DBOX_1 196 204 PF00400 0.340
DEG_Nend_UBRbox_1 1 4 PF02207 0.640
DOC_MAPK_gen_1 212 219 PF00069 0.329
DOC_MAPK_gen_1 8 16 PF00069 0.696
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I946 Leptomonas seymouri 65% 98%
A0A0S4J0N1 Bodo saltans 42% 100%
A0A1X0P6G8 Trypanosomatidae 43% 96%
A0A3Q8IKN2 Leishmania donovani 93% 100%
A0A3R7LL16 Trypanosoma rangeli 44% 100%
A4HK24 Leishmania braziliensis 80% 100%
A4I7K8 Leishmania infantum 93% 100%
D0A0B3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 84%
Q4Q5P1 Leishmania major 93% 100%
V5BS86 Trypanosoma cruzi 43% 95%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS