WW domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1279), putative

Species:

Leishmania mexicana

UniProt:

E9B2G5_LEIMU

TriTrypDb:

LmxM.31.0440

Length:

291

Annotations

LeishMANIAdb annotations

Homologous to animal FAM210 mitochondrial proteins. This protein might have a mitochondrial transit signal.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005739	mitochondrion	5	1
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9B2G5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2G5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	55	57	PF00675	0.477
CLV_PCSK_KEX2_1	212	214	PF00082	0.529
CLV_PCSK_KEX2_1	223	225	PF00082	0.519
CLV_PCSK_KEX2_1	55	57	PF00082	0.478
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.529
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.503
DEG_APCC_DBOX_1	196	204	PF00400	0.340
DEG_Nend_UBRbox_1	1	4	PF02207	0.640
DOC_MAPK_gen_1	212	219	PF00069	0.329
DOC_MAPK_gen_1	8	16	PF00069	0.696
DOC_MAPK_HePTP_8	236	248	PF00069	0.325
DOC_MAPK_MEF2A_6	229	237	PF00069	0.264
DOC_MAPK_MEF2A_6	239	248	PF00069	0.223
DOC_PP1_RVXF_1	78	84	PF00149	0.625
DOC_USP7_MATH_1	40	44	PF00917	0.734
DOC_WW_Pin1_4	29	34	PF00397	0.681
DOC_WW_Pin1_4	56	61	PF00397	0.695
DOC_WW_Pin1_4	72	77	PF00397	0.717
LIG_14-3-3_CanoR_1	135	140	PF00244	0.706
LIG_14-3-3_CanoR_1	24	33	PF00244	0.600
LIG_14-3-3_CanoR_1	8	16	PF00244	0.633
LIG_BIR_III_4	128	132	PF00653	0.540
LIG_BRCT_BRCA1_1	205	209	PF00533	0.270
LIG_CtBP_PxDLS_1	50	56	PF00389	0.685
LIG_deltaCOP1_diTrp_1	103	112	PF00928	0.606
LIG_eIF4E_1	170	176	PF01652	0.431
LIG_FHA_1	128	134	PF00498	0.659
LIG_FHA_1	228	234	PF00498	0.281
LIG_FHA_1	99	105	PF00498	0.525
LIG_FHA_2	136	142	PF00498	0.722
LIG_LIR_Apic_2	103	109	PF02991	0.526
LIG_LIR_Nem_3	114	119	PF02991	0.532
LIG_LIR_Nem_3	265	271	PF02991	0.546
LIG_NRBOX	15	21	PF00104	0.609
LIG_PCNA_yPIPBox_3	183	197	PF02747	0.331
LIG_PDZ_Class_2	286	291	PF00595	0.505
LIG_Pex14_1	83	87	PF04695	0.522
LIG_Pex14_2	112	116	PF04695	0.498
LIG_Pex14_2	227	231	PF04695	0.282
LIG_Pex14_2	64	68	PF04695	0.689
LIG_SH2_CRK	36	40	PF00017	0.671
LIG_SH2_CRK	96	100	PF00017	0.516
LIG_SH2_GRB2like	96	99	PF00017	0.518
LIG_SH2_SRC	178	181	PF00017	0.266
LIG_SH2_SRC	96	99	PF00017	0.597
LIG_SH2_STAP1	87	91	PF00017	0.644
LIG_SH2_STAT5	178	181	PF00017	0.266
LIG_SH2_STAT5	194	197	PF00017	0.266
LIG_SH3_3	137	143	PF00018	0.698
LIG_SH3_3	43	49	PF00018	0.589
LIG_SH3_3	70	76	PF00018	0.641
LIG_SH3_4	93	100	PF00018	0.605
LIG_SUMO_SIM_par_1	246	252	PF11976	0.361
LIG_TRAF2_1	60	63	PF00917	0.669
LIG_TYR_ITIM	176	181	PF00017	0.266
LIG_UBA3_1	267	272	PF00899	0.565
MOD_CDK_SPxK_1	29	35	PF00069	0.708
MOD_CK1_1	26	32	PF00069	0.749
MOD_CK2_1	135	141	PF00069	0.672
MOD_CK2_1	66	72	PF00069	0.647
MOD_DYRK1A_RPxSP_1	56	60	PF00069	0.635
MOD_GlcNHglycan	251	254	PF01048	0.344
MOD_GlcNHglycan	42	45	PF01048	0.459
MOD_GlcNHglycan	68	71	PF01048	0.447
MOD_GSK3_1	144	151	PF00069	0.732
MOD_GSK3_1	227	234	PF00069	0.253
MOD_GSK3_1	24	31	PF00069	0.672
MOD_GSK3_1	98	105	PF00069	0.542
MOD_N-GLC_1	182	187	PF02516	0.331
MOD_N-GLC_1	219	224	PF02516	0.500
MOD_N-GLC_1	29	34	PF02516	0.544
MOD_NEK2_1	119	124	PF00069	0.584
MOD_NEK2_1	134	139	PF00069	0.556
MOD_NEK2_1	203	208	PF00069	0.337
MOD_NEK2_1	227	232	PF00069	0.233
MOD_NEK2_1	246	251	PF00069	0.324
MOD_NEK2_1	274	279	PF00069	0.579
MOD_NEK2_2	285	290	PF00069	0.500
MOD_PKA_2	134	140	PF00069	0.646
MOD_PKA_2	23	29	PF00069	0.712
MOD_Plk_1	102	108	PF00069	0.547
MOD_Plk_1	182	188	PF00069	0.331
MOD_Plk_2-3	85	91	PF00069	0.547
MOD_Plk_4	15	21	PF00069	0.668
MOD_Plk_4	227	233	PF00069	0.242
MOD_Plk_4	263	269	PF00069	0.627
MOD_ProDKin_1	29	35	PF00069	0.684
MOD_ProDKin_1	56	62	PF00069	0.703
MOD_ProDKin_1	72	78	PF00069	0.711
MOD_SUMO_rev_2	206	214	PF00179	0.335
MOD_SUMO_rev_2	215	225	PF00179	0.296
TRG_DiLeu_BaLyEn_6	251	256	PF01217	0.425
TRG_ENDOCYTIC_2	178	181	PF00928	0.266
TRG_ENDOCYTIC_2	36	39	PF00928	0.672
TRG_ENDOCYTIC_2	96	99	PF00928	0.518
TRG_ER_diArg_1	5	8	PF00400	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I946	Leptomonas seymouri	65%	98%
A0A0S4J0N1	Bodo saltans	42%	100%
A0A1X0P6G8	Trypanosomatidae	43%	96%
A0A3Q8IKN2	Leishmania donovani	93%	100%
A0A3R7LL16	Trypanosoma rangeli	44%	100%
A4HK24	Leishmania braziliensis	80%	100%
A4I7K8	Leishmania infantum	93%	100%
D0A0B3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	84%
Q4Q5P1	Leishmania major	93%	100%
V5BS86	Trypanosoma cruzi	43%	95%