Kinesin motor domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin motor domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B2G3_LEIMU

TriTrypDb:

LmxM.31.0420

Length:

718

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B2G3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2G3

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	14
GO:0007018	microtubule-based movement	3	14
GO:0009987	cellular process	1	14

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	14
GO:0003774	cytoskeletal motor activity	1	14
GO:0003777	microtubule motor activity	2	14
GO:0005488	binding	1	14
GO:0005515	protein binding	2	14
GO:0005524	ATP binding	5	14
GO:0008017	microtubule binding	5	14
GO:0008092	cytoskeletal protein binding	3	14
GO:0015631	tubulin binding	4	14
GO:0017076	purine nucleotide binding	4	14
GO:0030554	adenyl nucleotide binding	5	14
GO:0032553	ribonucleotide binding	3	14
GO:0032555	purine ribonucleotide binding	4	14
GO:0032559	adenyl ribonucleotide binding	5	14
GO:0035639	purine ribonucleoside triphosphate binding	4	14
GO:0036094	small molecule binding	2	14
GO:0043167	ion binding	2	14
GO:0043168	anion binding	3	14
GO:0097159	organic cyclic compound binding	2	14
GO:0097367	carbohydrate derivative binding	2	14
GO:0140657	ATP-dependent activity	1	14
GO:1901265	nucleoside phosphate binding	3	14
GO:1901363	heterocyclic compound binding	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.378
CLV_NRD_NRD_1	213	215	PF00675	0.403
CLV_NRD_NRD_1	216	218	PF00675	0.388
CLV_NRD_NRD_1	247	249	PF00675	0.415
CLV_NRD_NRD_1	456	458	PF00675	0.553
CLV_NRD_NRD_1	500	502	PF00675	0.406
CLV_NRD_NRD_1	666	668	PF00675	0.439
CLV_PCSK_FUR_1	214	218	PF00082	0.423
CLV_PCSK_FUR_1	294	298	PF00082	0.301
CLV_PCSK_KEX2_1	127	129	PF00082	0.378
CLV_PCSK_KEX2_1	213	215	PF00082	0.325
CLV_PCSK_KEX2_1	216	218	PF00082	0.318
CLV_PCSK_KEX2_1	247	249	PF00082	0.423
CLV_PCSK_KEX2_1	296	298	PF00082	0.276
CLV_PCSK_KEX2_1	500	502	PF00082	0.388
CLV_PCSK_KEX2_1	665	667	PF00082	0.461
CLV_PCSK_KEX2_1	685	687	PF00082	0.516
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.301
CLV_PCSK_PC1ET2_1	665	667	PF00082	0.564
CLV_PCSK_PC1ET2_1	685	687	PF00082	0.516
CLV_PCSK_PC7_1	123	129	PF00082	0.330
CLV_PCSK_PC7_1	661	667	PF00082	0.477
CLV_PCSK_SKI1_1	123	127	PF00082	0.318
CLV_PCSK_SKI1_1	243	247	PF00082	0.281
CLV_PCSK_SKI1_1	267	271	PF00082	0.455
CLV_PCSK_SKI1_1	362	366	PF00082	0.400
CLV_PCSK_SKI1_1	458	462	PF00082	0.485
CLV_PCSK_SKI1_1	466	470	PF00082	0.395
CLV_PCSK_SKI1_1	622	626	PF00082	0.512
DEG_APCC_DBOX_1	185	193	PF00400	0.346
DEG_APCC_DBOX_1	552	560	PF00400	0.330
DEG_Nend_UBRbox_3	1	3	PF02207	0.471
DEG_SPOP_SBC_1	169	173	PF00917	0.285
DOC_CYCLIN_RxL_1	120	130	PF00134	0.347
DOC_MAPK_gen_1	221	231	PF00069	0.273
DOC_MAPK_gen_1	454	462	PF00069	0.557
DOC_MAPK_gen_1	500	509	PF00069	0.315
DOC_MAPK_MEF2A_6	224	233	PF00069	0.273
DOC_PP1_RVXF_1	245	252	PF00149	0.402
DOC_PP1_RVXF_1	43	50	PF00149	0.391
DOC_PP1_RVXF_1	455	462	PF00149	0.476
DOC_PP1_RVXF_1	664	671	PF00149	0.479
DOC_PP4_FxxP_1	109	112	PF00568	0.449
DOC_USP7_MATH_1	112	116	PF00917	0.440
DOC_USP7_MATH_1	164	168	PF00917	0.423
DOC_USP7_MATH_1	169	173	PF00917	0.429
DOC_USP7_MATH_1	434	438	PF00917	0.735
DOC_WW_Pin1_4	108	113	PF00397	0.330
DOC_WW_Pin1_4	442	447	PF00397	0.718
DOC_WW_Pin1_4	512	517	PF00397	0.390
DOC_WW_Pin1_4	693	698	PF00397	0.783
DOC_WW_Pin1_4	702	707	PF00397	0.442
LIG_14-3-3_CanoR_1	133	140	PF00244	0.285
LIG_14-3-3_CanoR_1	186	196	PF00244	0.457
LIG_14-3-3_CanoR_1	247	252	PF00244	0.315
LIG_14-3-3_CanoR_1	25	34	PF00244	0.495
LIG_14-3-3_CanoR_1	322	330	PF00244	0.381
LIG_14-3-3_CanoR_1	407	416	PF00244	0.538
LIG_14-3-3_CanoR_1	686	692	PF00244	0.732
LIG_BIR_III_4	450	454	PF00653	0.452
LIG_BRCT_BRCA1_1	138	142	PF00533	0.330
LIG_BRCT_BRCA1_1	313	317	PF00533	0.307
LIG_Clathr_ClatBox_1	233	237	PF01394	0.330
LIG_Clathr_ClatBox_1	399	403	PF01394	0.343
LIG_deltaCOP1_diTrp_1	471	479	PF00928	0.301
LIG_deltaCOP1_diTrp_1	588	594	PF00928	0.286
LIG_FHA_1	103	109	PF00498	0.273
LIG_FHA_1	2	8	PF00498	0.461
LIG_FHA_1	33	39	PF00498	0.515
LIG_FHA_1	350	356	PF00498	0.364
LIG_FHA_1	454	460	PF00498	0.514
LIG_FHA_1	504	510	PF00498	0.277
LIG_FHA_1	75	81	PF00498	0.423
LIG_FHA_2	119	125	PF00498	0.321
LIG_FHA_2	25	31	PF00498	0.295
LIG_FHA_2	371	377	PF00498	0.445
LIG_FHA_2	408	414	PF00498	0.514
LIG_FHA_2	583	589	PF00498	0.421
LIG_FHA_2	625	631	PF00498	0.435
LIG_FHA_2	674	680	PF00498	0.596
LIG_FHA_2	703	709	PF00498	0.560
LIG_Integrin_isoDGR_2	498	500	PF01839	0.285
LIG_LIR_Apic_2	107	112	PF02991	0.463
LIG_LIR_Apic_2	60	66	PF02991	0.346
LIG_LIR_Gen_1	151	161	PF02991	0.381
LIG_LIR_Gen_1	199	207	PF02991	0.297
LIG_LIR_Gen_1	320	331	PF02991	0.273
LIG_LIR_Gen_1	514	521	PF02991	0.270
LIG_LIR_Gen_1	60	69	PF02991	0.345
LIG_LIR_Gen_1	679	684	PF02991	0.640
LIG_LIR_Gen_1	73	83	PF02991	0.208
LIG_LIR_Nem_3	124	129	PF02991	0.321
LIG_LIR_Nem_3	151	156	PF02991	0.381
LIG_LIR_Nem_3	182	187	PF02991	0.344
LIG_LIR_Nem_3	199	203	PF02991	0.248
LIG_LIR_Nem_3	320	326	PF02991	0.289
LIG_LIR_Nem_3	514	520	PF02991	0.385
LIG_LIR_Nem_3	577	582	PF02991	0.445
LIG_LIR_Nem_3	588	593	PF02991	0.196
LIG_LIR_Nem_3	60	64	PF02991	0.336
LIG_LIR_Nem_3	676	680	PF02991	0.520
LIG_LIR_Nem_3	73	78	PF02991	0.208
LIG_PCNA_PIPBox_1	119	128	PF02747	0.423
LIG_PCNA_yPIPBox_3	119	133	PF02747	0.423
LIG_PCNA_yPIPBox_3	297	311	PF02747	0.423
LIG_Pex14_1	589	593	PF04695	0.293
LIG_Pex14_2	590	594	PF04695	0.378
LIG_SH2_CRK	323	327	PF00017	0.423
LIG_SH2_CRK	361	365	PF00017	0.393
LIG_SH2_CRK	517	521	PF00017	0.511
LIG_SH2_STAP1	138	142	PF00017	0.182
LIG_SH2_STAP1	219	223	PF00017	0.423
LIG_SH2_STAP1	323	327	PF00017	0.443
LIG_SH2_STAP1	59	63	PF00017	0.279
LIG_SH2_STAT3	219	222	PF00017	0.408
LIG_SH2_STAT3	470	473	PF00017	0.273
LIG_SH2_STAT5	188	191	PF00017	0.356
LIG_SH2_STAT5	323	326	PF00017	0.424
LIG_SH2_STAT5	401	404	PF00017	0.553
LIG_SH2_STAT5	517	520	PF00017	0.373
LIG_SH2_STAT5	560	563	PF00017	0.347
LIG_SH2_STAT5	607	610	PF00017	0.301
LIG_SH2_STAT5	63	66	PF00017	0.304
LIG_SH3_3	638	644	PF00018	0.465
LIG_SH3_3	7	13	PF00018	0.676
LIG_SUMO_SIM_anti_2	81	87	PF11976	0.321
LIG_SUMO_SIM_par_1	370	376	PF11976	0.413
LIG_TRAF2_1	28	31	PF00917	0.560
LIG_TRAF2_1	410	413	PF00917	0.569
LIG_UBA3_1	233	238	PF00899	0.228
LIG_UBA3_1	416	422	PF00899	0.488
MOD_CDK_SPxxK_3	512	519	PF00069	0.387
MOD_CK1_1	190	196	PF00069	0.332
MOD_CK1_1	232	238	PF00069	0.452
MOD_CK1_1	3	9	PF00069	0.557
MOD_CK1_1	349	355	PF00069	0.319
MOD_CK2_1	108	114	PF00069	0.346
MOD_CK2_1	118	124	PF00069	0.270
MOD_CK2_1	140	146	PF00069	0.321
MOD_CK2_1	24	30	PF00069	0.462
MOD_CK2_1	344	350	PF00069	0.427
MOD_CK2_1	370	376	PF00069	0.537
MOD_CK2_1	407	413	PF00069	0.513
MOD_CK2_1	536	542	PF00069	0.314
MOD_Cter_Amidation	498	501	PF01082	0.423
MOD_GlcNHglycan	114	117	PF01048	0.407
MOD_GlcNHglycan	165	169	PF01048	0.418
MOD_GlcNHglycan	172	175	PF01048	0.430
MOD_GlcNHglycan	403	407	PF01048	0.641
MOD_GlcNHglycan	436	439	PF01048	0.582
MOD_GlcNHglycan	526	529	PF01048	0.342
MOD_GlcNHglycan	90	93	PF01048	0.364
MOD_GSK3_1	104	111	PF00069	0.396
MOD_GSK3_1	132	139	PF00069	0.409
MOD_GSK3_1	164	171	PF00069	0.420
MOD_GSK3_1	247	254	PF00069	0.351
MOD_GSK3_1	321	328	PF00069	0.287
MOD_GSK3_1	344	351	PF00069	0.430
MOD_GSK3_1	425	432	PF00069	0.666
MOD_GSK3_1	532	539	PF00069	0.285
MOD_GSK3_1	685	692	PF00069	0.662
MOD_GSK3_1	693	700	PF00069	0.731
MOD_N-GLC_1	1	6	PF02516	0.466
MOD_N-GLC_1	112	117	PF02516	0.426
MOD_N-GLC_1	276	281	PF02516	0.286
MOD_N-GLC_2	574	576	PF02516	0.516
MOD_NEK2_1	187	192	PF00069	0.384
MOD_NEK2_1	251	256	PF00069	0.390
MOD_NEK2_1	387	392	PF00069	0.443
MOD_NEK2_1	402	407	PF00069	0.689
MOD_NEK2_1	582	587	PF00069	0.435
MOD_NEK2_2	503	508	PF00069	0.407
MOD_PIKK_1	205	211	PF00454	0.235
MOD_PIKK_1	271	277	PF00454	0.330
MOD_PIKK_1	300	306	PF00454	0.328
MOD_PIKK_1	32	38	PF00454	0.553
MOD_PIKK_1	321	327	PF00454	0.321
MOD_PIKK_1	532	538	PF00454	0.423
MOD_PKA_1	247	253	PF00069	0.423
MOD_PKA_1	685	691	PF00069	0.713
MOD_PKA_2	132	138	PF00069	0.431
MOD_PKA_2	24	30	PF00069	0.429
MOD_PKA_2	247	253	PF00069	0.407
MOD_PKA_2	321	327	PF00069	0.381
MOD_PKA_2	453	459	PF00069	0.526
MOD_PKA_2	503	509	PF00069	0.395
MOD_PKA_2	532	538	PF00069	0.371
MOD_PKA_2	582	588	PF00069	0.488
MOD_PKA_2	685	691	PF00069	0.595
MOD_PKB_1	23	31	PF00069	0.437
MOD_Plk_1	136	142	PF00069	0.423
MOD_Plk_1	387	393	PF00069	0.327
MOD_Plk_2-3	344	350	PF00069	0.423
MOD_Plk_4	104	110	PF00069	0.262
MOD_Plk_4	148	154	PF00069	0.365
MOD_Plk_4	202	208	PF00069	0.285
MOD_Plk_4	229	235	PF00069	0.330
MOD_Plk_4	247	253	PF00069	0.295
MOD_Plk_4	278	284	PF00069	0.291
MOD_Plk_4	313	319	PF00069	0.300
MOD_Plk_4	503	509	PF00069	0.251
MOD_Plk_4	673	679	PF00069	0.592
MOD_ProDKin_1	108	114	PF00069	0.330
MOD_ProDKin_1	442	448	PF00069	0.711
MOD_ProDKin_1	512	518	PF00069	0.389
MOD_ProDKin_1	693	699	PF00069	0.784
MOD_ProDKin_1	702	708	PF00069	0.443
TRG_AP2beta_CARGO_1	124	133	PF09066	0.285
TRG_DiLeu_BaEn_1	376	381	PF01217	0.460
TRG_DiLeu_BaEn_1	395	400	PF01217	0.301
TRG_DiLeu_BaEn_1	81	86	PF01217	0.321
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.330
TRG_DiLeu_BaLyEn_6	658	663	PF01217	0.435
TRG_DiLeu_LyEn_5	376	381	PF01217	0.562
TRG_ENDOCYTIC_2	144	147	PF00928	0.262
TRG_ENDOCYTIC_2	323	326	PF00928	0.423
TRG_ENDOCYTIC_2	361	364	PF00928	0.384
TRG_ENDOCYTIC_2	517	520	PF00928	0.508
TRG_ENDOCYTIC_2	680	683	PF00928	0.610
TRG_ER_diArg_1	126	128	PF00400	0.378
TRG_ER_diArg_1	17	20	PF00400	0.372
TRG_ER_diArg_1	213	216	PF00400	0.349
TRG_ER_diArg_1	246	248	PF00400	0.423
TRG_ER_diArg_1	377	380	PF00400	0.526
TRG_ER_diArg_1	659	662	PF00400	0.562
TRG_ER_diArg_1	666	668	PF00400	0.498
TRG_NES_CRM1_1	414	429	PF08389	0.427
TRG_Pf-PMV_PEXEL_1	127	132	PF00026	0.378
TRG_Pf-PMV_PEXEL_1	379	383	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	612	617	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2F2	Leptomonas seymouri	69%	97%
A0A0S4IK37	Bodo saltans	41%	100%
A0A0S4INH0	Bodo saltans	41%	100%
A0A1X0P6P1	Trypanosomatidae	47%	100%
A0A3S7X544	Leishmania donovani	93%	100%
A0A422N1G2	Trypanosoma rangeli	46%	100%
A4HK22	Leishmania braziliensis	85%	100%
A4I7K6	Leishmania infantum	93%	100%
D0A0B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
Q4Q5P3	Leishmania major	93%	100%
V5B8M1	Trypanosoma cruzi	24%	100%
V5C1Q9	Trypanosoma cruzi	46%	100%