Protein SEY1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

root hair defective 3 GTP-binding protein (RHD3), putative

Species:

Leishmania mexicana

UniProt:

E9B2F8_LEIMU

TriTrypDb:

LmxM.31.0370

Length:

893

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	11
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	11
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0005783	endoplasmic reticulum	5	1

Expansion

Sequence features

E9B2F8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2F8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	11
GO:0003924	GTPase activity	7	11
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.361
CLV_C14_Caspase3-7	163	167	PF00656	0.411
CLV_C14_Caspase3-7	241	245	PF00656	0.138
CLV_C14_Caspase3-7	431	435	PF00656	0.351
CLV_C14_Caspase3-7	581	585	PF00656	0.378
CLV_C14_Caspase3-7	678	682	PF00656	0.312
CLV_NRD_NRD_1	254	256	PF00675	0.454
CLV_NRD_NRD_1	305	307	PF00675	0.481
CLV_NRD_NRD_1	666	668	PF00675	0.563
CLV_NRD_NRD_1	88	90	PF00675	0.259
CLV_NRD_NRD_1	889	891	PF00675	0.459
CLV_PCSK_KEX2_1	16	18	PF00082	0.313
CLV_PCSK_KEX2_1	305	307	PF00082	0.471
CLV_PCSK_KEX2_1	666	668	PF00082	0.562
CLV_PCSK_KEX2_1	88	90	PF00082	0.261
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.313
CLV_PCSK_SKI1_1	16	20	PF00082	0.365
CLV_PCSK_SKI1_1	212	216	PF00082	0.434
CLV_PCSK_SKI1_1	240	244	PF00082	0.418
CLV_PCSK_SKI1_1	355	359	PF00082	0.505
CLV_PCSK_SKI1_1	364	368	PF00082	0.486
CLV_PCSK_SKI1_1	468	472	PF00082	0.510
CLV_PCSK_SKI1_1	596	600	PF00082	0.594
CLV_PCSK_SKI1_1	674	678	PF00082	0.586
CLV_PCSK_SKI1_1	796	800	PF00082	0.254
CLV_PCSK_SKI1_1	830	834	PF00082	0.476
CLV_PCSK_SKI1_1	94	98	PF00082	0.207
DEG_MDM2_SWIB_1	258	265	PF02201	0.236
DEG_MDM2_SWIB_1	767	775	PF02201	0.263
DOC_CYCLIN_RxL_1	175	186	PF00134	0.422
DOC_CYCLIN_RxL_1	827	837	PF00134	0.599
DOC_CYCLIN_yCln2_LP_2	778	784	PF00134	0.282
DOC_MAPK_gen_1	384	394	PF00069	0.374
DOC_MAPK_gen_1	669	677	PF00069	0.370
DOC_MAPK_MEF2A_6	212	221	PF00069	0.241
DOC_MAPK_MEF2A_6	228	237	PF00069	0.241
DOC_MAPK_MEF2A_6	387	394	PF00069	0.333
DOC_MAPK_NFAT4_5	387	395	PF00069	0.244
DOC_PP1_RVXF_1	672	678	PF00149	0.313
DOC_PP2B_LxvP_1	349	352	PF13499	0.241
DOC_USP7_MATH_1	125	129	PF00917	0.491
DOC_USP7_MATH_1	247	251	PF00917	0.278
DOC_USP7_MATH_1	28	32	PF00917	0.656
DOC_USP7_MATH_1	99	103	PF00917	0.491
DOC_USP7_UBL2_3	256	260	PF12436	0.164
DOC_USP7_UBL2_3	613	617	PF12436	0.313
DOC_WW_Pin1_4	152	157	PF00397	0.450
DOC_WW_Pin1_4	508	513	PF00397	0.380
DOC_WW_Pin1_4	777	782	PF00397	0.247
DOC_WW_Pin1_4	868	873	PF00397	0.707
LIG_14-3-3_CanoR_1	100	106	PF00244	0.404
LIG_14-3-3_CanoR_1	178	183	PF00244	0.411
LIG_14-3-3_CanoR_1	255	259	PF00244	0.222
LIG_14-3-3_CanoR_1	405	410	PF00244	0.319
LIG_14-3-3_CanoR_1	458	464	PF00244	0.327
LIG_14-3-3_CanoR_1	523	533	PF00244	0.333
LIG_14-3-3_CanoR_1	578	583	PF00244	0.295
LIG_14-3-3_CanoR_1	607	615	PF00244	0.297
LIG_14-3-3_CanoR_1	856	865	PF00244	0.556
LIG_14-3-3_CanoR_1	88	98	PF00244	0.427
LIG_14-3-3_CanoR_1	885	892	PF00244	0.676
LIG_Actin_WH2_2	456	474	PF00022	0.329
LIG_Actin_WH2_2	623	641	PF00022	0.318
LIG_BIR_III_4	653	657	PF00653	0.380
LIG_BIR_III_4	849	853	PF00653	0.562
LIG_Clathr_ClatBox_1	157	161	PF01394	0.391
LIG_DLG_GKlike_1	178	185	PF00625	0.411
LIG_eIF4E_1	635	641	PF01652	0.354
LIG_FHA_1	163	169	PF00498	0.438
LIG_FHA_1	21	27	PF00498	0.529
LIG_FHA_1	232	238	PF00498	0.215
LIG_FHA_1	428	434	PF00498	0.324
LIG_FHA_1	447	453	PF00498	0.196
LIG_FHA_1	556	562	PF00498	0.356
LIG_FHA_1	566	572	PF00498	0.352
LIG_FHA_1	610	616	PF00498	0.299
LIG_FHA_1	717	723	PF00498	0.138
LIG_FHA_1	741	747	PF00498	0.244
LIG_FHA_1	816	822	PF00498	0.562
LIG_FHA_2	211	217	PF00498	0.211
LIG_FHA_2	241	247	PF00498	0.219
LIG_FHA_2	297	303	PF00498	0.262
LIG_FHA_2	343	349	PF00498	0.230
LIG_FHA_2	351	357	PF00498	0.289
LIG_FHA_2	36	42	PF00498	0.630
LIG_FHA_2	590	596	PF00498	0.294
LIG_FHA_2	704	710	PF00498	0.267
LIG_FHA_2	80	86	PF00498	0.421
LIG_FHA_2	864	870	PF00498	0.731
LIG_GBD_Chelix_1	187	195	PF00786	0.247
LIG_LIR_Gen_1	257	265	PF02991	0.232
LIG_LIR_Gen_1	569	580	PF02991	0.297
LIG_LIR_Gen_1	689	697	PF02991	0.332
LIG_LIR_Gen_1	78	87	PF02991	0.407
LIG_LIR_Nem_3	257	261	PF02991	0.245
LIG_LIR_Nem_3	337	343	PF02991	0.231
LIG_LIR_Nem_3	373	377	PF02991	0.317
LIG_LIR_Nem_3	569	575	PF02991	0.301
LIG_LIR_Nem_3	632	638	PF02991	0.338
LIG_LIR_Nem_3	689	693	PF02991	0.403
LIG_LIR_Nem_3	78	83	PF02991	0.511
LIG_LIR_Nem_3	801	806	PF02991	0.453
LIG_NRBOX	466	472	PF00104	0.376
LIG_PCNA_PIPBox_1	515	524	PF02747	0.377
LIG_PCNA_yPIPBox_3	508	522	PF02747	0.349
LIG_Pex14_2	258	262	PF04695	0.236
LIG_Pex14_2	76	80	PF04695	0.407
LIG_Pex14_2	767	771	PF04695	0.263
LIG_Pex14_2	794	798	PF04695	0.263
LIG_Pex14_2	799	803	PF04695	0.422
LIG_PTAP_UEV_1	877	882	PF05743	0.692
LIG_PTB_Apo_2	70	77	PF02174	0.407
LIG_REV1ctd_RIR_1	792	800	PF16727	0.341
LIG_SH2_CRK	55	59	PF00017	0.479
LIG_SH2_CRK	701	705	PF00017	0.389
LIG_SH2_GRB2like	424	427	PF00017	0.326
LIG_SH2_PTP2	285	288	PF00017	0.314
LIG_SH2_PTP2	549	552	PF00017	0.297
LIG_SH2_STAP1	381	385	PF00017	0.288
LIG_SH2_STAP1	424	428	PF00017	0.377
LIG_SH2_STAT3	290	293	PF00017	0.254
LIG_SH2_STAT5	21	24	PF00017	0.515
LIG_SH2_STAT5	285	288	PF00017	0.314
LIG_SH2_STAT5	316	319	PF00017	0.226
LIG_SH2_STAT5	335	338	PF00017	0.150
LIG_SH2_STAT5	4	7	PF00017	0.503
LIG_SH2_STAT5	549	552	PF00017	0.393
LIG_SH2_STAT5	635	638	PF00017	0.350
LIG_SH2_STAT5	687	690	PF00017	0.299
LIG_SH2_STAT5	776	779	PF00017	0.247
LIG_SH3_3	694	700	PF00018	0.291
LIG_SH3_3	811	817	PF00018	0.621
LIG_SH3_3	875	881	PF00018	0.702
LIG_SH3_5	831	835	PF00018	0.528
LIG_SUMO_SIM_anti_2	155	161	PF11976	0.401
LIG_SUMO_SIM_anti_2	189	194	PF11976	0.164
LIG_SUMO_SIM_anti_2	234	241	PF11976	0.222
LIG_SUMO_SIM_par_1	155	161	PF11976	0.479
LIG_SUMO_SIM_par_1	234	241	PF11976	0.211
LIG_SUMO_SIM_par_1	626	632	PF11976	0.328
LIG_TRAF2_1	462	465	PF00917	0.323
LIG_TRAF2_1	805	808	PF00917	0.589
LIG_TYR_ITIM	53	58	PF00017	0.476
LIG_TYR_ITIM	633	638	PF00017	0.260
LIG_TYR_ITIM	688	693	PF00017	0.292
LIG_UBA3_1	279	283	PF00899	0.314
LIG_WRC_WIRS_1	371	376	PF05994	0.252
LIG_WRC_WIRS_1	406	411	PF05994	0.305
LIG_WW_3	539	543	PF00397	0.347
MOD_CK1_1	250	256	PF00069	0.278
MOD_CK1_1	272	278	PF00069	0.138
MOD_CK1_1	300	306	PF00069	0.300
MOD_CK1_1	35	41	PF00069	0.747
MOD_CK1_1	473	479	PF00069	0.404
MOD_CK1_1	524	530	PF00069	0.339
MOD_CK1_1	602	608	PF00069	0.425
MOD_CK1_1	66	72	PF00069	0.437
MOD_CK1_1	689	695	PF00069	0.416
MOD_CK2_1	210	216	PF00069	0.211
MOD_CK2_1	296	302	PF00069	0.262
MOD_CK2_1	350	356	PF00069	0.345
MOD_CK2_1	43	49	PF00069	0.551
MOD_CK2_1	450	456	PF00069	0.332
MOD_CK2_1	459	465	PF00069	0.294
MOD_CK2_1	477	483	PF00069	0.464
MOD_CK2_1	589	595	PF00069	0.296
MOD_CK2_1	79	85	PF00069	0.421
MOD_GlcNHglycan	111	114	PF01048	0.280
MOD_GlcNHglycan	121	124	PF01048	0.272
MOD_GlcNHglycan	271	274	PF01048	0.338
MOD_GlcNHglycan	32	35	PF01048	0.472
MOD_GlcNHglycan	43	48	PF01048	0.439
MOD_GlcNHglycan	472	475	PF01048	0.574
MOD_GlcNHglycan	479	482	PF01048	0.600
MOD_GlcNHglycan	485	488	PF01048	0.655
MOD_GlcNHglycan	584	587	PF01048	0.551
MOD_GlcNHglycan	643	646	PF01048	0.572
MOD_GlcNHglycan	65	68	PF01048	0.218
MOD_GlcNHglycan	663	666	PF01048	0.607
MOD_GSK3_1	206	213	PF00069	0.200
MOD_GSK3_1	250	257	PF00069	0.261
MOD_GSK3_1	26	33	PF00069	0.642
MOD_GSK3_1	292	299	PF00069	0.327
MOD_GSK3_1	401	408	PF00069	0.403
MOD_GSK3_1	446	453	PF00069	0.290
MOD_GSK3_1	459	466	PF00069	0.350
MOD_GSK3_1	473	480	PF00069	0.369
MOD_GSK3_1	574	581	PF00069	0.341
MOD_GSK3_1	582	589	PF00069	0.348
MOD_GSK3_1	62	69	PF00069	0.407
MOD_GSK3_1	688	695	PF00069	0.379
MOD_GSK3_1	722	729	PF00069	0.291
MOD_GSK3_1	75	82	PF00069	0.407
MOD_GSK3_1	806	813	PF00069	0.593
MOD_GSK3_1	876	883	PF00069	0.648
MOD_N-GLC_1	206	211	PF02516	0.400
MOD_NEK2_1	108	113	PF00069	0.504
MOD_NEK2_1	183	188	PF00069	0.247
MOD_NEK2_1	210	215	PF00069	0.211
MOD_NEK2_1	308	313	PF00069	0.235
MOD_NEK2_1	470	475	PF00069	0.359
MOD_NEK2_1	521	526	PF00069	0.318
MOD_NEK2_1	582	587	PF00069	0.378
MOD_NEK2_1	594	599	PF00069	0.303
MOD_NEK2_1	608	613	PF00069	0.263
MOD_NEK2_1	686	691	PF00069	0.303
MOD_NEK2_1	798	803	PF00069	0.430
MOD_NEK2_1	806	811	PF00069	0.491
MOD_NEK2_1	83	88	PF00069	0.377
MOD_NEK2_2	586	591	PF00069	0.309
MOD_PIKK_1	28	34	PF00454	0.679
MOD_PIKK_1	308	314	PF00454	0.254
MOD_PIKK_1	350	356	PF00454	0.307
MOD_PIKK_1	722	728	PF00454	0.236
MOD_PIKK_1	741	747	PF00454	0.242
MOD_PIKK_1	798	804	PF00454	0.429
MOD_PKA_2	126	132	PF00069	0.474
MOD_PKA_2	254	260	PF00069	0.222
MOD_PKA_2	343	349	PF00069	0.265
MOD_PKA_2	392	398	PF00069	0.413
MOD_PKA_2	404	410	PF00069	0.336
MOD_PKA_2	441	447	PF00069	0.324
MOD_PKA_2	840	846	PF00069	0.587
MOD_PKA_2	886	892	PF00069	0.732
MOD_PKA_2	99	105	PF00069	0.338
MOD_Plk_1	206	212	PF00069	0.200
MOD_Plk_1	43	49	PF00069	0.496
MOD_Plk_1	433	439	PF00069	0.369
MOD_Plk_1	463	469	PF00069	0.336
MOD_Plk_1	594	600	PF00069	0.394
MOD_Plk_1	83	89	PF00069	0.366
MOD_Plk_2-3	79	85	PF00069	0.500
MOD_Plk_4	178	184	PF00069	0.441
MOD_Plk_4	206	212	PF00069	0.199
MOD_Plk_4	21	27	PF00069	0.561
MOD_Plk_4	231	237	PF00069	0.246
MOD_Plk_4	405	411	PF00069	0.312
MOD_Plk_4	629	635	PF00069	0.331
MOD_Plk_4	67	73	PF00069	0.407
MOD_Plk_4	810	816	PF00069	0.560
MOD_Plk_4	824	830	PF00069	0.509
MOD_ProDKin_1	152	158	PF00069	0.450
MOD_ProDKin_1	508	514	PF00069	0.374
MOD_ProDKin_1	777	783	PF00069	0.247
MOD_ProDKin_1	868	874	PF00069	0.710
MOD_SUMO_rev_2	365	374	PF00179	0.378
TRG_DiLeu_BaEn_1	231	236	PF01217	0.211
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.496
TRG_DiLeu_BaLyEn_6	381	386	PF01217	0.323
TRG_DiLeu_BaLyEn_6	828	833	PF01217	0.505
TRG_ENDOCYTIC_2	284	287	PF00928	0.258
TRG_ENDOCYTIC_2	549	552	PF00928	0.300
TRG_ENDOCYTIC_2	55	58	PF00928	0.480
TRG_ENDOCYTIC_2	635	638	PF00928	0.246
TRG_ENDOCYTIC_2	690	693	PF00928	0.284
TRG_ER_diArg_1	304	306	PF00400	0.255
TRG_ER_diArg_1	666	669	PF00400	0.384
TRG_ER_diArg_1	672	675	PF00400	0.333
TRG_ER_diArg_1	87	89	PF00400	0.476
TRG_ER_diArg_1	884	887	PF00400	0.657
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	384	389	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	830	834	PF00026	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P867	Leptomonas seymouri	64%	100%
A0A0S4IQA8	Bodo saltans	37%	100%
A0A1X0P6I5	Trypanosomatidae	45%	97%
A0A3R7KQ50	Trypanosoma rangeli	43%	100%
A0A3S7X571	Leishmania donovani	89%	93%
A2EK80	Trichomonas vaginalis	26%	100%
A4HK17	Leishmania braziliensis	79%	100%
A4I7K1	Leishmania infantum	89%	100%
A6ZP10	Saccharomyces cerevisiae (strain YJM789)	25%	100%
A8N5E5	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	27%	100%
B0D0N9	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	27%	100%
B5VS52	Saccharomyces cerevisiae (strain AWRI1631)	25%	100%
D0A0A4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
Q0JLS6	Oryza sativa subsp. japonica	25%	100%
Q2QMH2	Oryza sativa subsp. japonica	25%	100%
Q388F1	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	45%	100%
Q4DHA1	Trypanosoma cruzi (strain CL Brener)	44%	100%
Q4Q5P8	Leishmania major	88%	100%
Q99287	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q9FKE9	Arabidopsis thaliana	25%	100%
Q9SSN0	Arabidopsis thaliana	26%	100%
V5DTG5	Trypanosoma cruzi	46%	100%