Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2F6_LEIMU

TriTrypDb:

LmxM.31.0350

Length:

467

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9B2F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2F6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.514
CLV_NRD_NRD_1	126	128	PF00675	0.508
CLV_NRD_NRD_1	437	439	PF00675	0.374
CLV_NRD_NRD_1	83	85	PF00675	0.634
CLV_PCSK_KEX2_1	126	128	PF00082	0.508
CLV_PCSK_KEX2_1	437	439	PF00082	0.612
CLV_PCSK_KEX2_1	451	453	PF00082	0.458
CLV_PCSK_KEX2_1	82	84	PF00082	0.636
CLV_PCSK_KEX2_1	99	101	PF00082	0.527
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.592
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.626
CLV_PCSK_SKI1_1	126	130	PF00082	0.633
CLV_PCSK_SKI1_1	460	464	PF00082	0.609
CLV_PCSK_SKI1_1	59	63	PF00082	0.548
CLV_PCSK_SKI1_1	84	88	PF00082	0.490
DEG_APCC_DBOX_1	100	108	PF00400	0.498
DEG_Nend_Nbox_1	1	3	PF02207	0.470
DOC_MAPK_gen_1	123	131	PF00069	0.537
DOC_MAPK_gen_1	379	389	PF00069	0.729
DOC_MAPK_gen_1	82	91	PF00069	0.613
DOC_MAPK_gen_1	99	110	PF00069	0.513
DOC_PP2B_LxvP_1	129	132	PF13499	0.571
DOC_USP7_MATH_1	141	145	PF00917	0.752
DOC_USP7_MATH_1	194	198	PF00917	0.676
DOC_USP7_MATH_1	251	255	PF00917	0.668
DOC_USP7_MATH_1	26	30	PF00917	0.624
DOC_USP7_MATH_1	292	296	PF00917	0.724
DOC_USP7_MATH_1	317	321	PF00917	0.649
DOC_USP7_MATH_1	458	462	PF00917	0.695
DOC_USP7_UBL2_3	447	451	PF12436	0.593
DOC_USP7_UBL2_3	66	70	PF12436	0.558
DOC_WW_Pin1_4	165	170	PF00397	0.732
DOC_WW_Pin1_4	247	252	PF00397	0.643
LIG_14-3-3_CanoR_1	11	15	PF00244	0.555
LIG_14-3-3_CanoR_1	161	169	PF00244	0.731
LIG_14-3-3_CanoR_1	172	179	PF00244	0.639
LIG_14-3-3_CanoR_1	300	305	PF00244	0.634
LIG_14-3-3_CanoR_1	335	341	PF00244	0.725
LIG_Actin_WH2_2	309	324	PF00022	0.453
LIG_BRCT_BRCA1_1	253	257	PF00533	0.631
LIG_BRCT_BRCA1_1	280	284	PF00533	0.614
LIG_BRCT_BRCA1_1	332	336	PF00533	0.721
LIG_Clathr_ClatBox_1	107	111	PF01394	0.467
LIG_eIF4E_1	207	213	PF01652	0.512
LIG_FHA_1	258	264	PF00498	0.664
LIG_FHA_1	309	315	PF00498	0.672
LIG_FHA_1	358	364	PF00498	0.666
LIG_FHA_1	384	390	PF00498	0.731
LIG_FHA_2	426	432	PF00498	0.552
LIG_LIR_Gen_1	29	37	PF02991	0.515
LIG_LIR_Nem_3	359	364	PF02991	0.583
LIG_PAM2_1	22	34	PF00658	0.531
LIG_Pex14_2	336	340	PF04695	0.726
LIG_SH2_STAP1	454	458	PF00017	0.528
LIG_SH2_STAT3	14	17	PF00017	0.582
LIG_SH2_STAT5	14	17	PF00017	0.476
LIG_SH2_STAT5	9	12	PF00017	0.479
LIG_SH3_3	260	266	PF00018	0.639
LIG_SH3_3	274	280	PF00018	0.714
LIG_SH3_3	311	317	PF00018	0.590
LIG_SH3_3	37	43	PF00018	0.349
LIG_SH3_3	410	416	PF00018	0.719
LIG_SUMO_SIM_anti_2	106	111	PF11976	0.470
LIG_SUMO_SIM_par_1	106	111	PF11976	0.470
LIG_TRAF2_1	132	135	PF00917	0.601
LIG_TRAF2_1	349	352	PF00917	0.676
MOD_CDK_SPxxK_3	165	172	PF00069	0.710
MOD_CK1_1	146	152	PF00069	0.764
MOD_CK1_1	154	160	PF00069	0.728
MOD_CK1_1	171	177	PF00069	0.659
MOD_CK1_1	299	305	PF00069	0.749
MOD_CK1_1	346	352	PF00069	0.664
MOD_CK1_1	394	400	PF00069	0.682
MOD_CK2_1	150	156	PF00069	0.746
MOD_CK2_1	346	352	PF00069	0.640
MOD_CK2_1	390	396	PF00069	0.796
MOD_Cter_Amidation	295	298	PF01082	0.609
MOD_GlcNHglycan	139	142	PF01048	0.730
MOD_GlcNHglycan	145	148	PF01048	0.738
MOD_GlcNHglycan	163	166	PF01048	0.635
MOD_GlcNHglycan	173	176	PF01048	0.480
MOD_GlcNHglycan	247	250	PF01048	0.722
MOD_GlcNHglycan	279	283	PF01048	0.699
MOD_GlcNHglycan	294	297	PF01048	0.670
MOD_GlcNHglycan	326	329	PF01048	0.754
MOD_GlcNHglycan	345	348	PF01048	0.756
MOD_GlcNHglycan	420	423	PF01048	0.587
MOD_GlcNHglycan	460	463	PF01048	0.577
MOD_GSK3_1	137	144	PF00069	0.772
MOD_GSK3_1	146	153	PF00069	0.704
MOD_GSK3_1	161	168	PF00069	0.732
MOD_GSK3_1	195	202	PF00069	0.602
MOD_GSK3_1	247	254	PF00069	0.630
MOD_GSK3_1	26	33	PF00069	0.509
MOD_GSK3_1	292	299	PF00069	0.662
MOD_GSK3_1	390	397	PF00069	0.730
MOD_GSK3_1	414	421	PF00069	0.621
MOD_GSK3_1	454	461	PF00069	0.620
MOD_GSK3_1	48	55	PF00069	0.476
MOD_N-GLC_1	284	289	PF02516	0.729
MOD_N-GLC_1	394	399	PF02516	0.697
MOD_N-GLC_1	418	423	PF02516	0.729
MOD_NEK2_1	212	217	PF00069	0.646
MOD_NEK2_1	257	262	PF00069	0.516
MOD_NEK2_1	284	289	PF00069	0.674
MOD_NEK2_1	336	341	PF00069	0.656
MOD_NEK2_1	424	429	PF00069	0.543
MOD_NEK2_1	52	57	PF00069	0.481
MOD_NEK2_1	61	66	PF00069	0.476
MOD_NEK2_1	77	82	PF00069	0.535
MOD_NEK2_2	317	322	PF00069	0.456
MOD_NEK2_2	383	388	PF00069	0.663
MOD_NEK2_2	48	53	PF00069	0.549
MOD_PIKK_1	212	218	PF00454	0.592
MOD_PIKK_1	322	328	PF00454	0.591
MOD_PIKK_1	395	401	PF00454	0.725
MOD_PKA_1	217	223	PF00069	0.570
MOD_PKA_2	10	16	PF00069	0.561
MOD_PKA_2	150	156	PF00069	0.775
MOD_PKA_2	160	166	PF00069	0.727
MOD_PKA_2	171	177	PF00069	0.651
MOD_PKA_2	299	305	PF00069	0.702
MOD_PKA_2	336	342	PF00069	0.711
MOD_Plk_1	20	26	PF00069	0.679
MOD_Plk_1	284	290	PF00069	0.599
MOD_Plk_4	178	184	PF00069	0.419
MOD_Plk_4	26	32	PF00069	0.579
MOD_ProDKin_1	165	171	PF00069	0.728
MOD_ProDKin_1	247	253	PF00069	0.643
MOD_SUMO_rev_2	398	408	PF00179	0.717
MOD_SUMO_rev_2	79	89	PF00179	0.619
TRG_ER_diArg_1	436	438	PF00400	0.379
TRG_ER_diArg_1	98	101	PF00400	0.523
TRG_NLS_MonoExtC_3	216	221	PF00514	0.605
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE29	Leptomonas seymouri	66%	98%
A0A1X0P7K1	Trypanosomatidae	37%	100%
A0A3Q8ICW8	Leishmania donovani	95%	100%
A0A3R7NTG2	Trypanosoma rangeli	36%	100%
A4HK15	Leishmania braziliensis	83%	100%
A4I7J9	Leishmania infantum	95%	100%
D0A0A1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4Q5Q0	Leishmania major	93%	100%
V5BS76	Trypanosoma cruzi	35%	100%