Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2F5_LEIMU

TriTrypDb:

LmxM.31.0340

Length:

653

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2F5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2F5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.574
CLV_NRD_NRD_1	162	164	PF00675	0.575
CLV_NRD_NRD_1	191	193	PF00675	0.623
CLV_NRD_NRD_1	210	212	PF00675	0.463
CLV_NRD_NRD_1	491	493	PF00675	0.676
CLV_NRD_NRD_1	517	519	PF00675	0.603
CLV_NRD_NRD_1	567	569	PF00675	0.702
CLV_NRD_NRD_1	641	643	PF00675	0.741
CLV_PCSK_FUR_1	208	212	PF00082	0.479
CLV_PCSK_KEX2_1	162	164	PF00082	0.582
CLV_PCSK_KEX2_1	191	193	PF00082	0.476
CLV_PCSK_KEX2_1	210	212	PF00082	0.500
CLV_PCSK_KEX2_1	519	521	PF00082	0.625
CLV_PCSK_KEX2_1	567	569	PF00082	0.803
CLV_PCSK_PC1ET2_1	519	521	PF00082	0.652
CLV_PCSK_SKI1_1	225	229	PF00082	0.424
CLV_PCSK_SKI1_1	340	344	PF00082	0.392
CLV_PCSK_SKI1_1	492	496	PF00082	0.670
CLV_Separin_Metazoa	154	158	PF03568	0.529
CLV_Separin_Metazoa	489	493	PF03568	0.548
DEG_SPOP_SBC_1	234	238	PF00917	0.548
DEG_SPOP_SBC_1	602	606	PF00917	0.744
DOC_CKS1_1	305	310	PF01111	0.545
DOC_CKS1_1	495	500	PF01111	0.720
DOC_CKS1_1	608	613	PF01111	0.505
DOC_CYCLIN_RxL_1	337	346	PF00134	0.400
DOC_MAPK_gen_1	208	218	PF00069	0.424
DOC_MAPK_MEF2A_6	211	220	PF00069	0.368
DOC_PP2B_LxvP_1	425	428	PF13499	0.509
DOC_PP4_FxxP_1	495	498	PF00568	0.668
DOC_USP7_MATH_1	118	122	PF00917	0.567
DOC_USP7_MATH_1	234	238	PF00917	0.561
DOC_USP7_MATH_1	37	41	PF00917	0.607
DOC_USP7_MATH_1	396	400	PF00917	0.692
DOC_USP7_MATH_1	436	440	PF00917	0.814
DOC_USP7_MATH_1	476	480	PF00917	0.627
DOC_USP7_MATH_1	542	546	PF00917	0.796
DOC_USP7_MATH_1	584	588	PF00917	0.792
DOC_USP7_MATH_1	596	600	PF00917	0.681
DOC_USP7_MATH_1	602	606	PF00917	0.688
DOC_USP7_MATH_1	623	627	PF00917	0.641
DOC_USP7_MATH_1	82	86	PF00917	0.711
DOC_WW_Pin1_4	304	309	PF00397	0.519
DOC_WW_Pin1_4	453	458	PF00397	0.645
DOC_WW_Pin1_4	462	467	PF00397	0.641
DOC_WW_Pin1_4	494	499	PF00397	0.630
DOC_WW_Pin1_4	560	565	PF00397	0.746
DOC_WW_Pin1_4	607	612	PF00397	0.698
DOC_WW_Pin1_4	613	618	PF00397	0.695
DOC_WW_Pin1_4	642	647	PF00397	0.526
LIG_14-3-3_CanoR_1	141	146	PF00244	0.583
LIG_14-3-3_CanoR_1	195	201	PF00244	0.448
LIG_14-3-3_CanoR_1	211	217	PF00244	0.431
LIG_14-3-3_CanoR_1	232	241	PF00244	0.418
LIG_14-3-3_CanoR_1	279	287	PF00244	0.434
LIG_14-3-3_CanoR_1	330	334	PF00244	0.378
LIG_14-3-3_CanoR_1	389	393	PF00244	0.620
LIG_14-3-3_CanoR_1	409	415	PF00244	0.570
LIG_14-3-3_CanoR_1	443	448	PF00244	0.622
LIG_14-3-3_CanoR_1	461	469	PF00244	0.635
LIG_14-3-3_CanoR_1	477	481	PF00244	0.785
LIG_14-3-3_CanoR_1	520	525	PF00244	0.637
LIG_14-3-3_CanoR_1	567	573	PF00244	0.792
LIG_14-3-3_CanoR_1	635	644	PF00244	0.641
LIG_BIR_III_2	614	618	PF00653	0.502
LIG_BRCT_BRCA1_1	53	57	PF00533	0.569
LIG_EVH1_1	495	499	PF00568	0.667
LIG_FHA_1	188	194	PF00498	0.571
LIG_FHA_1	287	293	PF00498	0.437
LIG_FHA_1	403	409	PF00498	0.659
LIG_FHA_1	607	613	PF00498	0.579
LIG_FHA_1	636	642	PF00498	0.655
LIG_FHA_1	91	97	PF00498	0.546
LIG_FHA_2	149	155	PF00498	0.621
LIG_FHA_2	243	249	PF00498	0.524
LIG_FHA_2	264	270	PF00498	0.541
LIG_FHA_2	401	407	PF00498	0.576
LIG_FHA_2	547	553	PF00498	0.597
LIG_HCF-1_HBM_1	66	69	PF13415	0.309
LIG_KLC1_Yacidic_2	361	366	PF13176	0.442
LIG_LIR_Apic_2	302	308	PF02991	0.466
LIG_LIR_Apic_2	390	395	PF02991	0.587
LIG_LIR_Apic_2	47	53	PF02991	0.630
LIG_LIR_Gen_1	151	160	PF02991	0.564
LIG_LIR_Gen_1	346	356	PF02991	0.359
LIG_LIR_Gen_1	54	65	PF02991	0.464
LIG_LIR_Gen_1	547	557	PF02991	0.725
LIG_LIR_Nem_3	151	155	PF02991	0.668
LIG_LIR_Nem_3	346	351	PF02991	0.365
LIG_LIR_Nem_3	357	363	PF02991	0.385
LIG_LIR_Nem_3	54	60	PF02991	0.507
LIG_LIR_Nem_3	547	553	PF02991	0.745
LIG_LIR_Nem_3	94	100	PF02991	0.408
LIG_Pex14_1	354	358	PF04695	0.397
LIG_Pex14_2	348	352	PF04695	0.362
LIG_Pex14_2	97	101	PF04695	0.373
LIG_PTB_Apo_2	206	213	PF02174	0.439
LIG_Rb_pABgroove_1	299	307	PF01858	0.324
LIG_RPA_C_Fungi	102	114	PF08784	0.454
LIG_SH2_CRK	305	309	PF00017	0.368
LIG_SH2_CRK	392	396	PF00017	0.618
LIG_SH2_CRK	50	54	PF00017	0.635
LIG_SH2_NCK_1	305	309	PF00017	0.537
LIG_SH2_NCK_1	392	396	PF00017	0.546
LIG_SH2_NCK_1	50	54	PF00017	0.635
LIG_SH2_SRC	221	224	PF00017	0.424
LIG_SH2_SRC	364	367	PF00017	0.363
LIG_SH2_SRC	50	53	PF00017	0.627
LIG_SH2_STAP1	360	364	PF00017	0.416
LIG_SH2_STAT5	358	361	PF00017	0.415
LIG_SH2_STAT5	364	367	PF00017	0.431
LIG_SH3_1	493	499	PF00018	0.716
LIG_SH3_1	643	649	PF00018	0.717
LIG_SH3_3	223	229	PF00018	0.380
LIG_SH3_3	425	431	PF00018	0.737
LIG_SH3_3	445	451	PF00018	0.635
LIG_SH3_3	463	469	PF00018	0.627
LIG_SH3_3	493	499	PF00018	0.626
LIG_SH3_3	528	534	PF00018	0.736
LIG_SH3_3	570	576	PF00018	0.506
LIG_SH3_3	590	596	PF00018	0.641
LIG_SH3_3	605	611	PF00018	0.703
LIG_SH3_3	638	644	PF00018	0.597
LIG_SH3_4	643	650	PF00018	0.558
LIG_SUMO_SIM_par_1	283	289	PF11976	0.463
LIG_TRAF2_1	151	154	PF00917	0.566
LIG_TRAF2_1	404	407	PF00917	0.611
LIG_WRC_WIRS_1	348	353	PF05994	0.354
MOD_CDK_SPK_2	613	618	PF00069	0.521
MOD_CDK_SPxxK_3	560	567	PF00069	0.751
MOD_CK1_1	286	292	PF00069	0.504
MOD_CK1_1	332	338	PF00069	0.446
MOD_CK1_1	46	52	PF00069	0.673
MOD_CK1_1	479	485	PF00069	0.653
MOD_CK1_1	551	557	PF00069	0.664
MOD_CK1_1	628	634	PF00069	0.672
MOD_CK1_1	90	96	PF00069	0.646
MOD_CK2_1	148	154	PF00069	0.533
MOD_CK2_1	263	269	PF00069	0.520
MOD_CK2_1	343	349	PF00069	0.394
MOD_CK2_1	364	370	PF00069	0.687
MOD_CK2_1	400	406	PF00069	0.610
MOD_CK2_1	483	489	PF00069	0.487
MOD_CK2_1	546	552	PF00069	0.788
MOD_GlcNHglycan	115	118	PF01048	0.593
MOD_GlcNHglycan	120	123	PF01048	0.622
MOD_GlcNHglycan	133	136	PF01048	0.606
MOD_GlcNHglycan	168	171	PF01048	0.694
MOD_GlcNHglycan	24	27	PF01048	0.739
MOD_GlcNHglycan	280	283	PF01048	0.460
MOD_GlcNHglycan	345	348	PF01048	0.535
MOD_GlcNHglycan	366	369	PF01048	0.634
MOD_GlcNHglycan	39	42	PF01048	0.713
MOD_GlcNHglycan	398	401	PF01048	0.698
MOD_GlcNHglycan	410	413	PF01048	0.505
MOD_GlcNHglycan	436	439	PF01048	0.788
MOD_GlcNHglycan	482	485	PF01048	0.654
MOD_GlcNHglycan	486	489	PF01048	0.659
MOD_GlcNHglycan	540	543	PF01048	0.776
MOD_GlcNHglycan	555	558	PF01048	0.623
MOD_GlcNHglycan	580	583	PF01048	0.583
MOD_GlcNHglycan	83	87	PF01048	0.765
MOD_GlcNHglycan	89	92	PF01048	0.713
MOD_GSK3_1	109	116	PF00069	0.506
MOD_GSK3_1	118	125	PF00069	0.650
MOD_GSK3_1	127	134	PF00069	0.650
MOD_GSK3_1	158	165	PF00069	0.706
MOD_GSK3_1	307	314	PF00069	0.460
MOD_GSK3_1	343	350	PF00069	0.389
MOD_GSK3_1	35	42	PF00069	0.661
MOD_GSK3_1	396	403	PF00069	0.618
MOD_GSK3_1	453	460	PF00069	0.786
MOD_GSK3_1	476	483	PF00069	0.650
MOD_GSK3_1	538	545	PF00069	0.654
MOD_GSK3_1	548	555	PF00069	0.621
MOD_GSK3_1	602	609	PF00069	0.695
MOD_GSK3_1	625	632	PF00069	0.671
MOD_GSK3_1	633	640	PF00069	0.633
MOD_N-GLC_1	434	439	PF02516	0.654
MOD_N-GLC_1	509	514	PF02516	0.624
MOD_N-GLC_1	636	641	PF02516	0.639
MOD_NEK2_1	212	217	PF00069	0.523
MOD_NEK2_1	343	348	PF00069	0.389
MOD_NEK2_1	387	392	PF00069	0.504
MOD_NEK2_1	480	485	PF00069	0.628
MOD_NEK2_1	509	514	PF00069	0.714
MOD_NEK2_1	540	545	PF00069	0.683
MOD_NEK2_1	546	551	PF00069	0.626
MOD_NEK2_1	553	558	PF00069	0.647
MOD_NEK2_1	630	635	PF00069	0.758
MOD_NEK2_2	347	352	PF00069	0.410
MOD_PK_1	141	147	PF00069	0.455
MOD_PKA_1	162	168	PF00069	0.631
MOD_PKA_1	519	525	PF00069	0.688
MOD_PKA_2	162	168	PF00069	0.637
MOD_PKA_2	278	284	PF00069	0.411
MOD_PKA_2	329	335	PF00069	0.331
MOD_PKA_2	388	394	PF00069	0.592
MOD_PKA_2	408	414	PF00069	0.788
MOD_PKA_2	460	466	PF00069	0.671
MOD_PKA_2	476	482	PF00069	0.781
MOD_PKA_2	484	490	PF00069	0.649
MOD_PKA_2	519	525	PF00069	0.688
MOD_PKA_2	566	572	PF00069	0.819
MOD_PKA_2	628	634	PF00069	0.764
MOD_PKB_1	518	526	PF00069	0.643
MOD_Plk_1	636	642	PF00069	0.589
MOD_Plk_2-3	366	372	PF00069	0.536
MOD_Plk_2-3	402	408	PF00069	0.483
MOD_Plk_4	283	289	PF00069	0.511
MOD_Plk_4	329	335	PF00069	0.469
MOD_Plk_4	347	353	PF00069	0.289
MOD_Plk_4	420	426	PF00069	0.642
MOD_Plk_4	476	482	PF00069	0.762
MOD_ProDKin_1	304	310	PF00069	0.529
MOD_ProDKin_1	453	459	PF00069	0.646
MOD_ProDKin_1	462	468	PF00069	0.636
MOD_ProDKin_1	494	500	PF00069	0.631
MOD_ProDKin_1	560	566	PF00069	0.749
MOD_ProDKin_1	607	613	PF00069	0.699
MOD_ProDKin_1	642	648	PF00069	0.526
MOD_SUMO_rev_2	251	259	PF00179	0.433
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.335
TRG_DiLeu_BaLyEn_6	454	459	PF01217	0.643
TRG_ENDOCYTIC_2	273	276	PF00928	0.476
TRG_ER_diArg_1	191	193	PF00400	0.583
TRG_ER_diArg_1	207	210	PF00400	0.412
TRG_ER_diArg_1	517	520	PF00400	0.600
TRG_NLS_MonoCore_2	517	522	PF00514	0.600
TRG_NLS_MonoExtN_4	516	523	PF00514	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P7Z7	Trypanosomatidae	30%	69%
A0A3Q8IT10	Leishmania donovani	85%	73%
A0A3R7N1Q3	Trypanosoma rangeli	28%	76%
A4HK14	Leishmania braziliensis	69%	100%
A4I7J8	Leishmania infantum	85%	82%
D0A0A0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	75%
Q4Q5Q1	Leishmania major	86%	100%
V5C1Q2	Trypanosoma cruzi	30%	77%