DNA glycosylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA glycosylase

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B2F3_LEIMU

TriTrypDb:

LmxM.31.0320

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2F3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2F3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	7
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	4	7
GO:0019104	DNA N-glycosylase activity	4	7
GO:0140097	catalytic activity, acting on DNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	51	55	PF00656	0.704
CLV_NRD_NRD_1	104	106	PF00675	0.745
CLV_NRD_NRD_1	107	109	PF00675	0.775
CLV_NRD_NRD_1	179	181	PF00675	0.696
CLV_NRD_NRD_1	26	28	PF00675	0.757
CLV_PCSK_FUR_1	105	109	PF00082	0.757
CLV_PCSK_KEX2_1	104	106	PF00082	0.656
CLV_PCSK_KEX2_1	107	109	PF00082	0.664
CLV_PCSK_KEX2_1	179	181	PF00082	0.696
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.696
CLV_PCSK_SKI1_1	128	132	PF00082	0.665
CLV_PCSK_SKI1_1	16	20	PF00082	0.737
DEG_Nend_UBRbox_2	1	3	PF02207	0.716
DOC_CYCLIN_RxL_1	209	223	PF00134	0.665
DOC_CYCLIN_yCln2_LP_2	241	247	PF00134	0.473
DOC_MAPK_FxFP_2	32	35	PF00069	0.661
DOC_MAPK_gen_1	224	232	PF00069	0.704
DOC_PP1_RVXF_1	14	20	PF00149	0.642
DOC_PP1_RVXF_1	26	33	PF00149	0.663
DOC_PP1_RVXF_1	85	92	PF00149	0.739
DOC_PP2B_LxvP_1	236	239	PF13499	0.654
DOC_PP2B_LxvP_1	241	244	PF13499	0.658
DOC_PP4_FxxP_1	32	35	PF00568	0.661
DOC_PP4_FxxP_1	67	70	PF00568	0.669
DOC_USP7_MATH_1	211	215	PF00917	0.644
DOC_USP7_MATH_1	68	72	PF00917	0.515
DOC_USP7_UBL2_3	220	224	PF12436	0.618
DOC_WW_Pin1_4	131	136	PF00397	0.667
DOC_WW_Pin1_4	164	169	PF00397	0.503
DOC_WW_Pin1_4	66	71	PF00397	0.602
LIG_14-3-3_CanoR_1	209	219	PF00244	0.669
LIG_BRCT_BRCA1_1	28	32	PF00533	0.761
LIG_BRCT_BRCA1_1	63	67	PF00533	0.671
LIG_deltaCOP1_diTrp_1	40	49	PF00928	0.619
LIG_eIF4E_1	61	67	PF01652	0.487
LIG_FHA_1	122	128	PF00498	0.702
LIG_FHA_1	141	147	PF00498	0.624
LIG_FHA_1	78	84	PF00498	0.748
LIG_FHA_2	110	116	PF00498	0.786
LIG_FHA_2	161	167	PF00498	0.782
LIG_LIR_Apic_2	29	35	PF02991	0.640
LIG_LIR_Apic_2	64	70	PF02991	0.668
LIG_LIR_Nem_3	22	26	PF02991	0.656
LIG_LIR_Nem_3	40	45	PF02991	0.396
LIG_MAD2	16	24	PF02301	0.741
LIG_NRBOX	147	153	PF00104	0.621
LIG_PCNA_yPIPBox_3	31	45	PF02747	0.648
LIG_Pex14_2	19	23	PF04695	0.644
LIG_SH2_CRK	182	186	PF00017	0.688
LIG_SH2_CRK	208	212	PF00017	0.665
LIG_SH2_NCK_1	182	186	PF00017	0.787
LIG_SH2_NCK_1	50	54	PF00017	0.664
LIG_SH2_SRC	50	53	PF00017	0.623
LIG_SH2_STAP1	57	61	PF00017	0.507
LIG_SH2_STAT5	57	60	PF00017	0.730
LIG_SH3_3	3	9	PF00018	0.683
LIG_SUMO_SIM_par_1	142	149	PF11976	0.625
MOD_CDC14_SPxK_1	69	72	PF00782	0.529
MOD_CDK_SPxK_1	66	72	PF00069	0.532
MOD_CK1_1	164	170	PF00069	0.560
MOD_CK1_1	71	77	PF00069	0.661
MOD_CK2_1	160	166	PF00069	0.782
MOD_Cter_Amidation	177	180	PF01082	0.700
MOD_GlcNHglycan	112	115	PF01048	0.754
MOD_GlcNHglycan	153	158	PF01048	0.661
MOD_GlcNHglycan	202	205	PF01048	0.715
MOD_GlcNHglycan	241	244	PF01048	0.756
MOD_GlcNHglycan	73	76	PF01048	0.613
MOD_GSK3_1	142	149	PF00069	0.626
MOD_GSK3_1	153	160	PF00069	0.665
MOD_GSK3_1	239	246	PF00069	0.647
MOD_GSK3_1	57	64	PF00069	0.697
MOD_NEK2_1	146	151	PF00069	0.572
MOD_NEK2_1	19	24	PF00069	0.611
MOD_NEK2_1	56	61	PF00069	0.661
MOD_NEK2_1	91	96	PF00069	0.570
MOD_NEK2_2	62	67	PF00069	0.531
MOD_PIKK_1	91	97	PF00454	0.747
MOD_PK_1	180	186	PF00069	0.553
MOD_PKA_1	180	186	PF00069	0.553
MOD_PKA_2	26	32	PF00069	0.729
MOD_Plk_4	146	152	PF00069	0.619
MOD_Plk_4	157	163	PF00069	0.683
MOD_Plk_4	62	68	PF00069	0.672
MOD_ProDKin_1	131	137	PF00069	0.667
MOD_ProDKin_1	164	170	PF00069	0.505
MOD_ProDKin_1	66	72	PF00069	0.602
MOD_SUMO_for_1	219	222	PF00179	0.636
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.476
TRG_ER_diArg_1	104	107	PF00400	0.659
TRG_NLS_MonoExtN_4	176	183	PF00514	0.698
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.740

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAV6	Leptomonas seymouri	56%	90%
A0A3S7X534	Leishmania donovani	91%	100%
A4HK12	Leishmania braziliensis	81%	100%
A4I7J6	Leishmania infantum	92%	100%
Q4Q5Q3	Leishmania major	90%	100%