Leucine-rich_repeat_protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2F1_LEIMU

TriTrypDb:

LmxM.31.0300

Length:

761

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7
GO:0005634	nucleus	5	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9B2F1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2F1

Function

Biological processes
Term	Name	Level	Count
GO:0009314	response to radiation	3	7
GO:0009628	response to abiotic stimulus	2	7
GO:0010165	response to X-ray	5	7
GO:0010212	response to ionizing radiation	4	7
GO:0050896	response to stimulus	1	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.338
CLV_C14_Caspase3-7	34	38	PF00656	0.693
CLV_C14_Caspase3-7	652	656	PF00656	0.647
CLV_C14_Caspase3-7	662	666	PF00656	0.577
CLV_NRD_NRD_1	10	12	PF00675	0.526
CLV_NRD_NRD_1	138	140	PF00675	0.538
CLV_NRD_NRD_1	141	143	PF00675	0.533
CLV_NRD_NRD_1	390	392	PF00675	0.612
CLV_NRD_NRD_1	402	404	PF00675	0.500
CLV_NRD_NRD_1	511	513	PF00675	0.549
CLV_NRD_NRD_1	599	601	PF00675	0.665
CLV_NRD_NRD_1	605	607	PF00675	0.581
CLV_NRD_NRD_1	682	684	PF00675	0.684
CLV_NRD_NRD_1	742	744	PF00675	0.555
CLV_PCSK_FUR_1	139	143	PF00082	0.571
CLV_PCSK_KEX2_1	10	12	PF00082	0.526
CLV_PCSK_KEX2_1	137	139	PF00082	0.590
CLV_PCSK_KEX2_1	141	143	PF00082	0.531
CLV_PCSK_KEX2_1	390	392	PF00082	0.612
CLV_PCSK_KEX2_1	402	404	PF00082	0.500
CLV_PCSK_KEX2_1	511	513	PF00082	0.564
CLV_PCSK_KEX2_1	599	601	PF00082	0.727
CLV_PCSK_KEX2_1	605	607	PF00082	0.658
CLV_PCSK_PC7_1	134	140	PF00082	0.586
CLV_PCSK_SKI1_1	107	111	PF00082	0.558
CLV_PCSK_SKI1_1	657	661	PF00082	0.655
CLV_PCSK_SKI1_1	683	687	PF00082	0.686
CLV_PCSK_SKI1_1	739	743	PF00082	0.711
DEG_APCC_DBOX_1	140	148	PF00400	0.557
DEG_APCC_DBOX_1	334	342	PF00400	0.406
DEG_APCC_DBOX_1	742	750	PF00400	0.570
DEG_Nend_UBRbox_2	1	3	PF02207	0.653
DEG_SCF_FBW7_1	533	539	PF00400	0.565
DEG_SCF_FBW7_1	627	632	PF00400	0.636
DOC_CDC14_PxL_1	338	346	PF14671	0.571
DOC_CKS1_1	533	538	PF01111	0.549
DOC_CYCLIN_yCln2_LP_2	618	624	PF00134	0.529
DOC_CYCLIN_yCln2_LP_2	94	97	PF00134	0.639
DOC_MAPK_gen_1	47	57	PF00069	0.614
DOC_MAPK_MEF2A_6	253	261	PF00069	0.271
DOC_MAPK_MEF2A_6	356	365	PF00069	0.521
DOC_MAPK_MEF2A_6	50	57	PF00069	0.510
DOC_PP2B_LxvP_1	224	227	PF13499	0.374
DOC_PP2B_LxvP_1	426	429	PF13499	0.511
DOC_PP2B_LxvP_1	618	621	PF13499	0.536
DOC_PP2B_LxvP_1	94	97	PF13499	0.639
DOC_PP4_FxxP_1	123	126	PF00568	0.576
DOC_USP7_MATH_1	243	247	PF00917	0.363
DOC_USP7_MATH_1	307	311	PF00917	0.351
DOC_USP7_MATH_1	359	363	PF00917	0.393
DOC_USP7_MATH_1	462	466	PF00917	0.571
DOC_USP7_MATH_1	477	481	PF00917	0.603
DOC_USP7_MATH_1	490	494	PF00917	0.567
DOC_USP7_MATH_1	56	60	PF00917	0.575
DOC_USP7_MATH_1	672	676	PF00917	0.792
DOC_USP7_MATH_1	745	749	PF00917	0.577
DOC_USP7_MATH_1	750	754	PF00917	0.597
DOC_WW_Pin1_4	312	317	PF00397	0.350
DOC_WW_Pin1_4	513	518	PF00397	0.612
DOC_WW_Pin1_4	532	537	PF00397	0.401
DOC_WW_Pin1_4	625	630	PF00397	0.676
DOC_WW_Pin1_4	634	639	PF00397	0.632
DOC_WW_Pin1_4	722	727	PF00397	0.587
LIG_14-3-3_CanoR_1	117	123	PF00244	0.609
LIG_14-3-3_CanoR_1	139	145	PF00244	0.485
LIG_14-3-3_CanoR_1	335	344	PF00244	0.417
LIG_14-3-3_CanoR_1	448	452	PF00244	0.496
LIG_14-3-3_CanoR_1	605	609	PF00244	0.790
LIG_14-3-3_CanoR_1	683	690	PF00244	0.716
LIG_14-3-3_CanoR_1	701	706	PF00244	0.511
LIG_14-3-3_CanoR_1	718	724	PF00244	0.684
LIG_Actin_WH2_2	204	221	PF00022	0.351
LIG_APCC_ABBA_1	572	577	PF00400	0.544
LIG_BRCT_BRCA1_1	552	556	PF00533	0.661
LIG_deltaCOP1_diTrp_1	444	451	PF00928	0.583
LIG_EVH1_1	125	129	PF00568	0.529
LIG_FHA_1	183	189	PF00498	0.333
LIG_FHA_1	208	214	PF00498	0.404
LIG_FHA_1	429	435	PF00498	0.509
LIG_FHA_1	564	570	PF00498	0.603
LIG_FHA_1	726	732	PF00498	0.646
LIG_FHA_2	131	137	PF00498	0.522
LIG_FHA_2	207	213	PF00498	0.312
LIG_FHA_2	436	442	PF00498	0.686
LIG_FHA_2	519	525	PF00498	0.453
LIG_FHA_2	660	666	PF00498	0.649
LIG_FHA_2	707	713	PF00498	0.707
LIG_LIR_Apic_2	121	126	PF02991	0.634
LIG_LIR_Gen_1	168	178	PF02991	0.394
LIG_LIR_Gen_1	260	271	PF02991	0.390
LIG_LIR_Gen_1	420	429	PF02991	0.535
LIG_LIR_Gen_1	576	584	PF02991	0.537
LIG_LIR_Gen_1	67	78	PF02991	0.644
LIG_LIR_Gen_1	748	756	PF02991	0.538
LIG_LIR_Nem_3	121	125	PF02991	0.631
LIG_LIR_Nem_3	168	173	PF02991	0.378
LIG_LIR_Nem_3	260	266	PF02991	0.338
LIG_LIR_Nem_3	317	322	PF02991	0.432
LIG_LIR_Nem_3	420	426	PF02991	0.507
LIG_LIR_Nem_3	450	454	PF02991	0.557
LIG_LIR_Nem_3	523	529	PF02991	0.417
LIG_LIR_Nem_3	576	581	PF02991	0.540
LIG_LIR_Nem_3	67	73	PF02991	0.643
LIG_LIR_Nem_3	748	754	PF02991	0.543
LIG_MYND_3	226	230	PF01753	0.378
LIG_PTAP_UEV_1	484	489	PF05743	0.620
LIG_PTB_Apo_2	234	241	PF02174	0.381
LIG_SH2_CRK	423	427	PF00017	0.538
LIG_SH2_NCK_1	263	267	PF00017	0.364
LIG_SH2_NCK_1	552	556	PF00017	0.576
LIG_SH2_STAP1	552	556	PF00017	0.597
LIG_SH2_STAP1	575	579	PF00017	0.460
LIG_SH2_STAT5	122	125	PF00017	0.573
LIG_SH2_STAT5	204	207	PF00017	0.461
LIG_SH2_STAT5	454	457	PF00017	0.534
LIG_SH2_STAT5	525	528	PF00017	0.432
LIG_SH2_STAT5	550	553	PF00017	0.590
LIG_SH2_STAT5	575	578	PF00017	0.432
LIG_SH3_1	11	17	PF00018	0.508
LIG_SH3_1	482	488	PF00018	0.506
LIG_SH3_1	744	750	PF00018	0.575
LIG_SH3_2	544	549	PF14604	0.613
LIG_SH3_2	614	619	PF14604	0.578
LIG_SH3_3	11	17	PF00018	0.510
LIG_SH3_3	123	129	PF00018	0.532
LIG_SH3_3	482	488	PF00018	0.617
LIG_SH3_3	498	504	PF00018	0.495
LIG_SH3_3	50	56	PF00018	0.509
LIG_SH3_3	512	518	PF00018	0.671
LIG_SH3_3	530	536	PF00018	0.331
LIG_SH3_3	538	544	PF00018	0.575
LIG_SH3_3	567	573	PF00018	0.592
LIG_SH3_3	611	617	PF00018	0.640
LIG_SH3_3	618	624	PF00018	0.595
LIG_SH3_3	70	76	PF00018	0.578
LIG_SH3_3	707	713	PF00018	0.650
LIG_SH3_3	720	726	PF00018	0.597
LIG_SH3_3	744	750	PF00018	0.575
LIG_SUMO_SIM_par_1	209	215	PF11976	0.308
LIG_SUMO_SIM_par_1	255	260	PF11976	0.343
LIG_TRAF2_1	133	136	PF00917	0.583
LIG_TRAF2_1	521	524	PF00917	0.347
LIG_TRAF2_1	642	645	PF00917	0.742
LIG_TRAF2_1	646	649	PF00917	0.690
LIG_TRAF2_1	709	712	PF00917	0.631
LIG_TRAF2_2	638	643	PF00917	0.533
LIG_TYR_ITIM	261	266	PF00017	0.352
LIG_TYR_ITIM	749	754	PF00017	0.538
LIG_WW_2	517	520	PF00397	0.473
LIG_WW_2	541	544	PF00397	0.675
MOD_CDK_SPK_2	532	537	PF00069	0.525
MOD_CDK_SPxK_1	625	631	PF00069	0.644
MOD_CK1_1	192	198	PF00069	0.392
MOD_CK1_1	246	252	PF00069	0.470
MOD_CK1_1	480	486	PF00069	0.590
MOD_CK1_1	506	512	PF00069	0.633
MOD_CK1_1	722	728	PF00069	0.597
MOD_CK2_1	110	116	PF00069	0.519
MOD_CK2_1	130	136	PF00069	0.399
MOD_CK2_1	171	177	PF00069	0.399
MOD_CK2_1	194	200	PF00069	0.392
MOD_CK2_1	238	244	PF00069	0.437
MOD_CK2_1	435	441	PF00069	0.646
MOD_CK2_1	462	468	PF00069	0.630
MOD_CK2_1	518	524	PF00069	0.539
MOD_CK2_1	639	645	PF00069	0.689
MOD_CK2_1	706	712	PF00069	0.708
MOD_DYRK1A_RPxSP_1	625	629	PF00069	0.576
MOD_GlcNHglycan	112	115	PF01048	0.668
MOD_GlcNHglycan	173	176	PF01048	0.405
MOD_GlcNHglycan	21	24	PF01048	0.582
MOD_GlcNHglycan	297	300	PF01048	0.532
MOD_GlcNHglycan	352	355	PF01048	0.608
MOD_GlcNHglycan	485	488	PF01048	0.659
MOD_GlcNHglycan	553	556	PF01048	0.574
MOD_GlcNHglycan	560	564	PF01048	0.575
MOD_GlcNHglycan	600	603	PF01048	0.596
MOD_GlcNHglycan	703	706	PF01048	0.669
MOD_GSK3_1	188	195	PF00069	0.424
MOD_GSK3_1	203	210	PF00069	0.450
MOD_GSK3_1	243	250	PF00069	0.420
MOD_GSK3_1	307	314	PF00069	0.421
MOD_GSK3_1	471	478	PF00069	0.630
MOD_GSK3_1	532	539	PF00069	0.557
MOD_GSK3_1	559	566	PF00069	0.536
MOD_GSK3_1	625	632	PF00069	0.745
MOD_GSK3_1	85	92	PF00069	0.610
MOD_LATS_1	585	591	PF00433	0.493
MOD_N-GLC_1	110	115	PF02516	0.525
MOD_N-GLC_1	295	300	PF02516	0.306
MOD_N-GLC_1	331	336	PF02516	0.354
MOD_NEK2_1	140	145	PF00069	0.482
MOD_NEK2_1	171	176	PF00069	0.392
MOD_NEK2_1	189	194	PF00069	0.412
MOD_NEK2_1	283	288	PF00069	0.429
MOD_NEK2_1	366	371	PF00069	0.371
MOD_NEK2_1	385	390	PF00069	0.410
MOD_NEK2_1	442	447	PF00069	0.599
MOD_NEK2_1	551	556	PF00069	0.595
MOD_NEK2_1	659	664	PF00069	0.755
MOD_NEK2_1	86	91	PF00069	0.610
MOD_NEK2_2	750	755	PF00069	0.501
MOD_PIKK_1	189	195	PF00454	0.402
MOD_PIKK_1	243	249	PF00454	0.377
MOD_PIKK_1	672	678	PF00454	0.638
MOD_PIKK_1	691	697	PF00454	0.695
MOD_PK_1	337	343	PF00069	0.465
MOD_PKA_1	683	689	PF00069	0.716
MOD_PKA_2	140	146	PF00069	0.622
MOD_PKA_2	252	258	PF00069	0.328
MOD_PKA_2	336	342	PF00069	0.392
MOD_PKA_2	447	453	PF00069	0.531
MOD_PKA_2	556	562	PF00069	0.603
MOD_PKA_2	598	604	PF00069	0.791
MOD_PKB_1	335	343	PF00069	0.462
MOD_PKB_1	587	595	PF00069	0.560
MOD_PKB_1	681	689	PF00069	0.639
MOD_Plk_1	110	116	PF00069	0.519
MOD_Plk_1	182	188	PF00069	0.422
MOD_Plk_2-3	435	441	PF00069	0.527
MOD_Plk_2-3	649	655	PF00069	0.554
MOD_Plk_4	252	258	PF00069	0.379
MOD_Plk_4	90	96	PF00069	0.655
MOD_ProDKin_1	312	318	PF00069	0.346
MOD_ProDKin_1	513	519	PF00069	0.599
MOD_ProDKin_1	532	538	PF00069	0.417
MOD_ProDKin_1	625	631	PF00069	0.677
MOD_ProDKin_1	634	640	PF00069	0.632
MOD_ProDKin_1	722	728	PF00069	0.584
MOD_SUMO_rev_2	649	659	PF00179	0.538
TRG_DiLeu_BaEn_1	230	235	PF01217	0.330
TRG_DiLeu_BaEn_4	135	141	PF01217	0.586
TRG_ENDOCYTIC_2	122	125	PF00928	0.573
TRG_ENDOCYTIC_2	263	266	PF00928	0.360
TRG_ENDOCYTIC_2	423	426	PF00928	0.525
TRG_ENDOCYTIC_2	575	578	PF00928	0.531
TRG_ENDOCYTIC_2	751	754	PF00928	0.583
TRG_ER_diArg_1	137	139	PF00400	0.590
TRG_ER_diArg_1	140	142	PF00400	0.544
TRG_ER_diArg_1	335	338	PF00400	0.446
TRG_ER_diArg_1	389	391	PF00400	0.479
TRG_ER_diArg_1	402	404	PF00400	0.492
TRG_ER_diArg_1	598	600	PF00400	0.607
TRG_NES_CRM1_1	215	230	PF08389	0.460
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2F9	Leptomonas seymouri	43%	96%
A0A3Q8IIZ4	Leishmania donovani	85%	100%
A4HK10	Leishmania braziliensis	68%	100%
A4I7J4	Leishmania infantum	85%	100%
Q4Q5Q5	Leishmania major	86%	100%