Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2E5_LEIMU

TriTrypDb:

LmxM.31.0240

Length:

1086

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	6
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

E9B2E5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2E5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.537
CLV_C14_Caspase3-7	192	196	PF00656	0.444
CLV_C14_Caspase3-7	888	892	PF00656	0.504
CLV_C14_Caspase3-7	954	958	PF00656	0.810
CLV_NRD_NRD_1	1006	1008	PF00675	0.454
CLV_NRD_NRD_1	1043	1045	PF00675	0.672
CLV_NRD_NRD_1	697	699	PF00675	0.480
CLV_NRD_NRD_1	724	726	PF00675	0.564
CLV_NRD_NRD_1	738	740	PF00675	0.511
CLV_NRD_NRD_1	763	765	PF00675	0.634
CLV_NRD_NRD_1	768	770	PF00675	0.664
CLV_NRD_NRD_1	838	840	PF00675	0.679
CLV_NRD_NRD_1	846	848	PF00675	0.653
CLV_NRD_NRD_1	911	913	PF00675	0.559
CLV_PCSK_KEX2_1	1006	1008	PF00082	0.454
CLV_PCSK_KEX2_1	1043	1045	PF00082	0.672
CLV_PCSK_KEX2_1	660	662	PF00082	0.465
CLV_PCSK_KEX2_1	697	699	PF00082	0.480
CLV_PCSK_KEX2_1	740	742	PF00082	0.525
CLV_PCSK_KEX2_1	763	765	PF00082	0.634
CLV_PCSK_KEX2_1	768	770	PF00082	0.664
CLV_PCSK_KEX2_1	846	848	PF00082	0.660
CLV_PCSK_KEX2_1	911	913	PF00082	0.559
CLV_PCSK_PC1ET2_1	660	662	PF00082	0.465
CLV_PCSK_PC1ET2_1	740	742	PF00082	0.525
CLV_PCSK_PC7_1	1002	1008	PF00082	0.453
CLV_PCSK_PC7_1	764	770	PF00082	0.671
CLV_PCSK_SKI1_1	1019	1023	PF00082	0.525
CLV_PCSK_SKI1_1	1082	1086	PF00082	0.644
CLV_PCSK_SKI1_1	425	429	PF00082	0.460
CLV_PCSK_SKI1_1	663	667	PF00082	0.636
CLV_Separin_Metazoa	731	735	PF03568	0.502
DEG_APCC_KENBOX_2	643	647	PF00400	0.366
DEG_Nend_UBRbox_2	1	3	PF02207	0.414
DEG_SCF_TRCP1_1	954	959	PF00400	0.536
DEG_SPOP_SBC_1	342	346	PF00917	0.446
DOC_CKS1_1	574	579	PF01111	0.543
DOC_CKS1_1	67	72	PF01111	0.478
DOC_CKS1_1	794	799	PF01111	0.510
DOC_CKS1_1	961	966	PF01111	0.597
DOC_CYCLIN_RxL_1	169	179	PF00134	0.350
DOC_CYCLIN_RxL_1	422	430	PF00134	0.453
DOC_CYCLIN_yClb5_NLxxxL_5	108	117	PF00134	0.374
DOC_MAPK_gen_1	154	163	PF00069	0.459
DOC_MAPK_gen_1	411	420	PF00069	0.405
DOC_MAPK_gen_1	6	15	PF00069	0.405
DOC_MAPK_gen_1	705	714	PF00069	0.535
DOC_MAPK_HePTP_8	153	165	PF00069	0.367
DOC_MAPK_MEF2A_6	156	165	PF00069	0.364
DOC_PP1_RVXF_1	10	16	PF00149	0.482
DOC_PP2B_LxvP_1	236	239	PF13499	0.445
DOC_PP2B_LxvP_1	823	826	PF13499	0.678
DOC_PP2B_LxvP_1	914	917	PF13499	0.600
DOC_PP4_FxxP_1	159	162	PF00568	0.341
DOC_USP7_MATH_1	140	144	PF00917	0.554
DOC_USP7_MATH_1	145	149	PF00917	0.408
DOC_USP7_MATH_1	205	209	PF00917	0.353
DOC_USP7_MATH_1	253	257	PF00917	0.578
DOC_USP7_MATH_1	262	266	PF00917	0.388
DOC_USP7_MATH_1	307	311	PF00917	0.423
DOC_USP7_MATH_1	374	378	PF00917	0.543
DOC_USP7_MATH_1	436	440	PF00917	0.689
DOC_USP7_MATH_1	455	459	PF00917	0.550
DOC_USP7_MATH_1	524	528	PF00917	0.783
DOC_USP7_MATH_1	557	561	PF00917	0.718
DOC_USP7_MATH_1	567	571	PF00917	0.598
DOC_USP7_MATH_1	671	675	PF00917	0.508
DOC_USP7_MATH_1	706	710	PF00917	0.586
DOC_USP7_MATH_1	83	87	PF00917	0.532
DOC_USP7_MATH_1	841	845	PF00917	0.683
DOC_USP7_MATH_1	980	984	PF00917	0.589
DOC_USP7_MATH_1	988	992	PF00917	0.647
DOC_WW_Pin1_4	1042	1047	PF00397	0.752
DOC_WW_Pin1_4	295	300	PF00397	0.373
DOC_WW_Pin1_4	573	578	PF00397	0.573
DOC_WW_Pin1_4	66	71	PF00397	0.402
DOC_WW_Pin1_4	751	756	PF00397	0.600
DOC_WW_Pin1_4	763	768	PF00397	0.639
DOC_WW_Pin1_4	793	798	PF00397	0.672
DOC_WW_Pin1_4	846	851	PF00397	0.639
DOC_WW_Pin1_4	869	874	PF00397	0.737
DOC_WW_Pin1_4	917	922	PF00397	0.618
DOC_WW_Pin1_4	960	965	PF00397	0.777
DOC_WW_Pin1_4	976	981	PF00397	0.658
LIG_14-3-3_CanoR_1	1006	1015	PF00244	0.562
LIG_14-3-3_CanoR_1	1028	1036	PF00244	0.650
LIG_14-3-3_CanoR_1	351	356	PF00244	0.558
LIG_14-3-3_CanoR_1	435	444	PF00244	0.676
LIG_14-3-3_CanoR_1	523	533	PF00244	0.723
LIG_14-3-3_CanoR_1	58	64	PF00244	0.353
LIG_14-3-3_CanoR_1	66	70	PF00244	0.406
LIG_14-3-3_CanoR_1	973	981	PF00244	0.619
LIG_Actin_WH2_2	383	399	PF00022	0.391
LIG_Actin_WH2_2	43	60	PF00022	0.345
LIG_Actin_WH2_2	787	802	PF00022	0.648
LIG_Actin_WH2_2	803	821	PF00022	0.501
LIG_BIR_III_4	1048	1052	PF00653	0.729
LIG_BRCT_BRCA1_1	1062	1066	PF00533	0.589
LIG_BRCT_BRCA1_1	827	831	PF00533	0.661
LIG_DLG_GKlike_1	351	358	PF00625	0.346
LIG_FHA_1	100	106	PF00498	0.350
LIG_FHA_1	1027	1033	PF00498	0.657
LIG_FHA_1	1056	1062	PF00498	0.711
LIG_FHA_1	144	150	PF00498	0.536
LIG_FHA_1	208	214	PF00498	0.331
LIG_FHA_1	314	320	PF00498	0.579
LIG_FHA_1	337	343	PF00498	0.593
LIG_FHA_1	344	350	PF00498	0.527
LIG_FHA_1	47	53	PF00498	0.325
LIG_FHA_1	614	620	PF00498	0.475
LIG_FHA_1	664	670	PF00498	0.537
LIG_FHA_1	794	800	PF00498	0.584
LIG_FHA_1	925	931	PF00498	0.630
LIG_FHA_2	1055	1061	PF00498	0.630
LIG_FHA_2	18	24	PF00498	0.383
LIG_FHA_2	269	275	PF00498	0.395
LIG_FHA_2	579	585	PF00498	0.549
LIG_FHA_2	777	783	PF00498	0.649
LIG_FHA_2	849	855	PF00498	0.731
LIG_FHA_2	934	940	PF00498	0.641
LIG_HCF-1_HBM_1	784	787	PF13415	0.608
LIG_LIR_Apic_2	571	577	PF02991	0.583
LIG_LIR_Gen_1	107	117	PF02991	0.325
LIG_LIR_Gen_1	389	400	PF02991	0.360
LIG_LIR_Gen_1	49	59	PF02991	0.525
LIG_LIR_Gen_1	68	79	PF02991	0.400
LIG_LIR_Nem_3	107	113	PF02991	0.345
LIG_LIR_Nem_3	389	395	PF02991	0.348
LIG_LIR_Nem_3	49	54	PF02991	0.535
LIG_LIR_Nem_3	632	637	PF02991	0.625
LIG_LIR_Nem_3	68	74	PF02991	0.373
LIG_LIR_Nem_3	784	790	PF02991	0.581
LIG_MYND_1	448	452	PF01753	0.584
LIG_MYND_1	917	921	PF01753	0.606
LIG_NRBOX	148	154	PF00104	0.457
LIG_NRBOX	422	428	PF00104	0.404
LIG_NRBOX	885	891	PF00104	0.512
LIG_PDZ_Class_2	1081	1086	PF00595	0.500
LIG_PTAP_UEV_1	451	456	PF05743	0.690
LIG_SH2_CRK	392	396	PF00017	0.349
LIG_SH2_CRK	71	75	PF00017	0.424
LIG_SH2_CRK	791	795	PF00017	0.467
LIG_SH2_NCK_1	753	757	PF00017	0.585
LIG_SH2_STAP1	392	396	PF00017	0.352
LIG_SH2_STAT5	575	578	PF00017	0.567
LIG_SH2_STAT5	787	790	PF00017	0.583
LIG_SH2_STAT5	806	809	PF00017	0.543
LIG_SH3_3	446	452	PF00018	0.620
LIG_SH3_3	506	512	PF00018	0.669
LIG_SH3_3	527	533	PF00018	0.602
LIG_SH3_3	791	797	PF00018	0.518
LIG_SH3_3	910	916	PF00018	0.620
LIG_SH3_3	958	964	PF00018	0.603
LIG_SH3_3	982	988	PF00018	0.527
LIG_SH3_5	858	862	PF00018	0.645
LIG_SUMO_SIM_anti_2	1012	1018	PF11976	0.468
LIG_SUMO_SIM_anti_2	256	263	PF11976	0.384
LIG_SUMO_SIM_anti_2	29	35	PF11976	0.354
LIG_SUMO_SIM_anti_2	298	304	PF11976	0.405
LIG_TRAF2_1	552	555	PF00917	0.583
LIG_TRAF2_1	743	746	PF00917	0.539
LIG_TRAF2_1	780	783	PF00917	0.604
LIG_TYR_ITIM	390	395	PF00017	0.346
LIG_TYR_ITSM	67	74	PF00017	0.338
LIG_WRC_WIRS_1	113	118	PF05994	0.384
MOD_CDC14_SPxK_1	766	769	PF00782	0.633
MOD_CDK_SPK_2	763	768	PF00069	0.655
MOD_CDK_SPxK_1	763	769	PF00069	0.633
MOD_CDK_SPxxK_3	66	73	PF00069	0.442
MOD_CDK_SPxxK_3	767	774	PF00069	0.618
MOD_CDK_SPxxK_3	793	800	PF00069	0.585
MOD_CK1_1	1009	1015	PF00069	0.535
MOD_CK1_1	1035	1041	PF00069	0.595
MOD_CK1_1	143	149	PF00069	0.466
MOD_CK1_1	256	262	PF00069	0.605
MOD_CK1_1	298	304	PF00069	0.379
MOD_CK1_1	402	408	PF00069	0.388
MOD_CK1_1	525	531	PF00069	0.565
MOD_CK1_1	544	550	PF00069	0.773
MOD_CK1_1	560	566	PF00069	0.655
MOD_CK1_1	578	584	PF00069	0.516
MOD_CK1_1	719	725	PF00069	0.595
MOD_CK1_1	776	782	PF00069	0.639
MOD_CK1_1	793	799	PF00069	0.548
MOD_CK1_1	827	833	PF00069	0.600
MOD_CK1_1	849	855	PF00069	0.698
MOD_CK1_1	882	888	PF00069	0.560
MOD_CK1_1	976	982	PF00069	0.642
MOD_CK2_1	1054	1060	PF00069	0.664
MOD_CK2_1	112	118	PF00069	0.361
MOD_CK2_1	17	23	PF00069	0.401
MOD_CK2_1	183	189	PF00069	0.394
MOD_CK2_1	268	274	PF00069	0.458
MOD_CK2_1	549	555	PF00069	0.615
MOD_CK2_1	578	584	PF00069	0.648
MOD_CK2_1	776	782	PF00069	0.657
MOD_CK2_1	827	833	PF00069	0.726
MOD_CK2_1	848	854	PF00069	0.657
MOD_CK2_1	882	888	PF00069	0.537
MOD_CK2_1	933	939	PF00069	0.683
MOD_GlcNHglycan	1008	1011	PF01048	0.453
MOD_GlcNHglycan	1019	1022	PF01048	0.565
MOD_GlcNHglycan	1024	1027	PF01048	0.603
MOD_GlcNHglycan	165	168	PF01048	0.459
MOD_GlcNHglycan	244	247	PF01048	0.547
MOD_GlcNHglycan	28	31	PF01048	0.486
MOD_GlcNHglycan	309	312	PF01048	0.478
MOD_GlcNHglycan	346	349	PF01048	0.473
MOD_GlcNHglycan	44	47	PF01048	0.357
MOD_GlcNHglycan	452	455	PF01048	0.704
MOD_GlcNHglycan	501	505	PF01048	0.760
MOD_GlcNHglycan	534	537	PF01048	0.620
MOD_GlcNHglycan	546	549	PF01048	0.804
MOD_GlcNHglycan	551	554	PF01048	0.675
MOD_GlcNHglycan	559	562	PF01048	0.674
MOD_GlcNHglycan	577	580	PF01048	0.576
MOD_GlcNHglycan	708	711	PF01048	0.608
MOD_GlcNHglycan	718	721	PF01048	0.615
MOD_GlcNHglycan	827	830	PF01048	0.635
MOD_GlcNHglycan	851	854	PF01048	0.719
MOD_GlcNHglycan	945	948	PF01048	0.790
MOD_GlcNHglycan	949	952	PF01048	0.651
MOD_GlcNHglycan	954	957	PF01048	0.675
MOD_GlcNHglycan	958	961	PF01048	0.682
MOD_GlcNHglycan	982	985	PF01048	0.640
MOD_GlcNHglycan	989	993	PF01048	0.619
MOD_GlcNHglycan	994	997	PF01048	0.684
MOD_GSK3_1	1022	1029	PF00069	0.590
MOD_GSK3_1	1055	1062	PF00069	0.643
MOD_GSK3_1	183	190	PF00069	0.467
MOD_GSK3_1	205	212	PF00069	0.528
MOD_GSK3_1	216	223	PF00069	0.380
MOD_GSK3_1	256	263	PF00069	0.482
MOD_GSK3_1	264	271	PF00069	0.363
MOD_GSK3_1	382	389	PF00069	0.507
MOD_GSK3_1	42	49	PF00069	0.264
MOD_GSK3_1	532	539	PF00069	0.619
MOD_GSK3_1	542	549	PF00069	0.505
MOD_GSK3_1	663	670	PF00069	0.481
MOD_GSK3_1	715	722	PF00069	0.585
MOD_GSK3_1	763	770	PF00069	0.646
MOD_GSK3_1	774	781	PF00069	0.630
MOD_GSK3_1	827	834	PF00069	0.626
MOD_GSK3_1	835	842	PF00069	0.637
MOD_GSK3_1	880	887	PF00069	0.681
MOD_GSK3_1	929	936	PF00069	0.646
MOD_GSK3_1	939	946	PF00069	0.718
MOD_GSK3_1	952	959	PF00069	0.616
MOD_GSK3_1	972	979	PF00069	0.593
MOD_GSK3_1	988	995	PF00069	0.594
MOD_N-GLC_1	1017	1022	PF02516	0.579
MOD_N-GLC_1	176	181	PF02516	0.362
MOD_N-GLC_1	869	874	PF02516	0.597
MOD_NEK2_1	163	168	PF00069	0.386
MOD_NEK2_1	176	181	PF00069	0.365
MOD_NEK2_1	183	188	PF00069	0.474
MOD_NEK2_1	234	239	PF00069	0.530
MOD_NEK2_1	268	273	PF00069	0.454
MOD_NEK2_1	313	318	PF00069	0.531
MOD_NEK2_1	418	423	PF00069	0.430
MOD_NEK2_1	546	551	PF00069	0.698
MOD_NEK2_1	57	62	PF00069	0.334
MOD_NEK2_1	647	652	PF00069	0.545
MOD_NEK2_1	790	795	PF00069	0.468
MOD_NEK2_1	831	836	PF00069	0.758
MOD_NEK2_1	972	977	PF00069	0.648
MOD_NEK2_2	46	51	PF00069	0.313
MOD_PIKK_1	534	540	PF00454	0.503
MOD_PIKK_1	841	847	PF00454	0.685
MOD_PKA_1	1006	1012	PF00069	0.447
MOD_PKA_1	839	845	PF00069	0.548
MOD_PKA_2	1006	1012	PF00069	0.580
MOD_PKA_2	1027	1033	PF00069	0.643
MOD_PKA_2	187	193	PF00069	0.398
MOD_PKA_2	434	440	PF00069	0.670
MOD_PKA_2	522	528	PF00069	0.581
MOD_PKA_2	57	63	PF00069	0.362
MOD_PKA_2	65	71	PF00069	0.397
MOD_PKA_2	74	80	PF00069	0.466
MOD_PKA_2	773	779	PF00069	0.691
MOD_PKA_2	943	949	PF00069	0.592
MOD_PKA_2	972	978	PF00069	0.666
MOD_Plk_1	143	149	PF00069	0.514
MOD_Plk_1	183	189	PF00069	0.476
MOD_Plk_1	205	211	PF00069	0.416
MOD_Plk_1	220	226	PF00069	0.376
MOD_Plk_1	23	29	PF00069	0.428
MOD_Plk_1	625	631	PF00069	0.469
MOD_Plk_1	647	653	PF00069	0.503
MOD_Plk_1	663	669	PF00069	0.539
MOD_Plk_1	819	825	PF00069	0.520
MOD_Plk_1	879	885	PF00069	0.571
MOD_Plk_1	956	962	PF00069	0.605
MOD_Plk_4	112	118	PF00069	0.356
MOD_Plk_4	253	259	PF00069	0.413
MOD_Plk_4	298	304	PF00069	0.443
MOD_Plk_4	382	388	PF00069	0.441
MOD_Plk_4	46	52	PF00069	0.320
MOD_Plk_4	525	531	PF00069	0.534
MOD_Plk_4	91	97	PF00069	0.355
MOD_Plk_4	929	935	PF00069	0.646
MOD_ProDKin_1	1042	1048	PF00069	0.755
MOD_ProDKin_1	295	301	PF00069	0.369
MOD_ProDKin_1	573	579	PF00069	0.570
MOD_ProDKin_1	66	72	PF00069	0.408
MOD_ProDKin_1	751	757	PF00069	0.601
MOD_ProDKin_1	763	769	PF00069	0.642
MOD_ProDKin_1	793	799	PF00069	0.671
MOD_ProDKin_1	846	852	PF00069	0.639
MOD_ProDKin_1	869	875	PF00069	0.737
MOD_ProDKin_1	917	923	PF00069	0.619
MOD_ProDKin_1	960	966	PF00069	0.774
MOD_ProDKin_1	976	982	PF00069	0.660
MOD_SUMO_for_1	758	761	PF00179	0.699
MOD_SUMO_rev_2	134	141	PF00179	0.542
MOD_SUMO_rev_2	589	598	PF00179	0.532
MOD_SUMO_rev_2	744	750	PF00179	0.563
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.457
TRG_DiLeu_BaLyEn_6	422	427	PF01217	0.526
TRG_ENDOCYTIC_2	114	117	PF00928	0.245
TRG_ENDOCYTIC_2	392	395	PF00928	0.352
TRG_ENDOCYTIC_2	588	591	PF00928	0.487
TRG_ENDOCYTIC_2	71	74	PF00928	0.419
TRG_ENDOCYTIC_2	787	790	PF00928	0.583
TRG_ENDOCYTIC_2	791	794	PF00928	0.574
TRG_ER_diArg_1	153	156	PF00400	0.540
TRG_ER_diArg_1	702	705	PF00400	0.523
TRG_ER_diArg_1	738	741	PF00400	0.516
TRG_ER_diArg_1	762	764	PF00400	0.690
TRG_ER_diArg_1	767	769	PF00400	0.686
TRG_ER_diArg_1	910	912	PF00400	0.552
TRG_NES_CRM1_1	314	327	PF08389	0.470
TRG_NES_CRM1_1	417	430	PF08389	0.434
TRG_NES_CRM1_1	42	56	PF08389	0.397
TRG_NLS_Bipartite_1	725	743	PF00514	0.520
TRG_NLS_MonoExtC_3	724	729	PF00514	0.555
TRG_NLS_MonoExtC_3	738	744	PF00514	0.518
TRG_NLS_MonoExtN_4	725	730	PF00514	0.538
TRG_Pf-PMV_PEXEL_1	425	430	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	596	600	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	627	632	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	700	704	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	740	744	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P868	Leptomonas seymouri	48%	100%
A0A3S7X576	Leishmania donovani	90%	100%
A4HK05	Leishmania braziliensis	75%	100%
A4I7I8	Leishmania infantum	90%	100%
Q4Q5R1	Leishmania major	88%	100%