Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2E1_LEIMU

TriTrypDb:

LmxM.31.0200

Length:

361

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2E1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2E1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	308	312	PF00656	0.586
CLV_C14_Caspase3-7	356	360	PF00656	0.549
CLV_NRD_NRD_1	142	144	PF00675	0.429
CLV_NRD_NRD_1	175	177	PF00675	0.436
CLV_NRD_NRD_1	272	274	PF00675	0.443
CLV_NRD_NRD_1	57	59	PF00675	0.394
CLV_PCSK_KEX2_1	142	144	PF00082	0.429
CLV_PCSK_KEX2_1	149	151	PF00082	0.428
CLV_PCSK_KEX2_1	175	177	PF00082	0.436
CLV_PCSK_KEX2_1	272	274	PF00082	0.443
CLV_PCSK_KEX2_1	57	59	PF00082	0.394
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.428
CLV_PCSK_SKI1_1	142	146	PF00082	0.434
CLV_PCSK_SKI1_1	175	179	PF00082	0.442
CLV_PCSK_SKI1_1	222	226	PF00082	0.514
CLV_PCSK_SKI1_1	282	286	PF00082	0.516
CLV_PCSK_SKI1_1	85	89	PF00082	0.442
DEG_APCC_DBOX_1	271	279	PF00400	0.452
DEG_APCC_KENBOX_2	242	246	PF00400	0.488
DOC_CKS1_1	218	223	PF01111	0.526
DOC_CYCLIN_RxL_1	261	270	PF00134	0.541
DOC_MAPK_gen_1	149	155	PF00069	0.431
DOC_PP2B_LxvP_1	248	251	PF13499	0.513
DOC_USP7_MATH_1	133	137	PF00917	0.503
DOC_USP7_MATH_1	2	6	PF00917	0.532
DOC_USP7_MATH_1	200	204	PF00917	0.581
DOC_USP7_MATH_1	253	257	PF00917	0.586
DOC_USP7_MATH_1	334	338	PF00917	0.549
DOC_WW_Pin1_4	202	207	PF00397	0.589
DOC_WW_Pin1_4	217	222	PF00397	0.586
DOC_WW_Pin1_4	249	254	PF00397	0.563
DOC_WW_Pin1_4	28	33	PF00397	0.479
DOC_WW_Pin1_4	296	301	PF00397	0.638
DOC_WW_Pin1_4	315	320	PF00397	0.710
LIG_14-3-3_CanoR_1	212	221	PF00244	0.572
LIG_14-3-3_CanoR_1	272	276	PF00244	0.442
LIG_14-3-3_CanoR_1	332	341	PF00244	0.518
LIG_14-3-3_CanoR_1	66	71	PF00244	0.433
LIG_Actin_WH2_2	70	87	PF00022	0.424
LIG_APCC_ABBAyCdc20_2	243	249	PF00400	0.445
LIG_deltaCOP1_diTrp_1	119	126	PF00928	0.669
LIG_DLG_GKlike_1	66	73	PF00625	0.436
LIG_EH1_1	17	25	PF00400	0.447
LIG_FHA_1	157	163	PF00498	0.455
LIG_FHA_1	272	278	PF00498	0.488
LIG_FHA_1	343	349	PF00498	0.439
LIG_FHA_1	350	356	PF00498	0.434
LIG_FHA_1	47	53	PF00498	0.432
LIG_FHA_2	260	266	PF00498	0.566
LIG_FHA_2	283	289	PF00498	0.550
LIG_FHA_2	306	312	PF00498	0.586
LIG_GBD_Chelix_1	169	177	PF00786	0.434
LIG_LIR_Gen_1	182	191	PF02991	0.423
LIG_LIR_Nem_3	182	188	PF02991	0.424
LIG_SH2_CRK	185	189	PF00017	0.424
LIG_SH2_NCK_1	185	189	PF00017	0.424
LIG_SH2_STAP1	185	189	PF00017	0.424
LIG_SH3_3	247	253	PF00018	0.593
LIG_SH3_3	299	305	PF00018	0.693
LIG_SH3_3	313	319	PF00018	0.534
LIG_SH3_3	322	328	PF00018	0.547
LIG_SUMO_SIM_anti_2	274	281	PF11976	0.507
LIG_SUMO_SIM_par_1	12	17	PF11976	0.436
LIG_SUMO_SIM_par_1	280	288	PF11976	0.560
LIG_TRAF2_1	285	288	PF00917	0.659
MOD_CDC14_SPxK_1	205	208	PF00782	0.588
MOD_CDK_SPK_2	217	222	PF00069	0.542
MOD_CDK_SPxK_1	202	208	PF00069	0.591
MOD_CDK_SPxxK_3	296	303	PF00069	0.548
MOD_CK1_1	199	205	PF00069	0.654
MOD_CK1_1	46	52	PF00069	0.478
MOD_CK2_1	122	128	PF00069	0.637
MOD_CK2_1	133	139	PF00069	0.423
MOD_CK2_1	158	164	PF00069	0.505
MOD_CK2_1	259	265	PF00069	0.574
MOD_CK2_1	282	288	PF00069	0.689
MOD_CK2_1	334	340	PF00069	0.510
MOD_CK2_1	73	79	PF00069	0.440
MOD_GlcNHglycan	105	109	PF01048	0.464
MOD_GlcNHglycan	198	201	PF01048	0.565
MOD_GlcNHglycan	202	205	PF01048	0.612
MOD_GlcNHglycan	336	339	PF01048	0.626
MOD_GlcNHglycan	36	39	PF01048	0.536
MOD_GSK3_1	122	129	PF00069	0.579
MOD_GSK3_1	156	163	PF00069	0.426
MOD_GSK3_1	196	203	PF00069	0.594
MOD_GSK3_1	207	214	PF00069	0.593
MOD_GSK3_1	249	256	PF00069	0.583
MOD_GSK3_1	278	285	PF00069	0.590
MOD_GSK3_1	30	37	PF00069	0.581
MOD_N-GLC_1	349	354	PF02516	0.430
MOD_N-GLC_1	73	78	PF02516	0.423
MOD_NEK2_1	16	21	PF00069	0.432
MOD_NEK2_1	277	282	PF00069	0.528
MOD_NEK2_1	73	78	PF00069	0.589
MOD_NEK2_2	2	7	PF00069	0.477
MOD_PIKK_1	156	162	PF00454	0.447
MOD_PIKK_1	232	238	PF00454	0.466
MOD_PIKK_1	320	326	PF00454	0.650
MOD_PIKK_1	46	52	PF00454	0.458
MOD_PIKK_1	87	93	PF00454	0.520
MOD_PKA_2	207	213	PF00069	0.611
MOD_PKA_2	271	277	PF00069	0.459
MOD_PKA_2	278	284	PF00069	0.543
MOD_Plk_1	342	348	PF00069	0.441
MOD_Plk_1	43	49	PF00069	0.460
MOD_Plk_1	73	79	PF00069	0.420
MOD_Plk_2-3	114	120	PF00069	0.556
MOD_Plk_2-3	122	128	PF00069	0.565
MOD_Plk_2-3	354	360	PF00069	0.468
MOD_ProDKin_1	202	208	PF00069	0.591
MOD_ProDKin_1	217	223	PF00069	0.580
MOD_ProDKin_1	249	255	PF00069	0.559
MOD_ProDKin_1	28	34	PF00069	0.479
MOD_ProDKin_1	296	302	PF00069	0.640
MOD_ProDKin_1	315	321	PF00069	0.710
MOD_SUMO_rev_2	109	118	PF00179	0.554
TRG_DiLeu_BaEn_2	342	348	PF01217	0.441
TRG_DiLeu_BaEn_4	79	85	PF01217	0.442
TRG_ENDOCYTIC_2	185	188	PF00928	0.430
TRG_ER_diArg_1	141	143	PF00400	0.432
TRG_ER_diArg_1	150	153	PF00400	0.430
TRG_ER_diArg_1	175	177	PF00400	0.436
TRG_ER_diArg_1	271	273	PF00400	0.441
TRG_ER_diArg_1	56	58	PF00400	0.405
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	222	227	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IME2	Leptomonas seymouri	63%	83%
A0A3S7X529	Leishmania donovani	93%	100%
A4HK01	Leishmania braziliensis	69%	100%
A4I7I4	Leishmania infantum	92%	100%
Q4Q5R5	Leishmania major	91%	100%