Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2E0_LEIMU

TriTrypDb:

LmxM.31.0190

Length:

768

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9B2E0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2E0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0044183	protein folding chaperone	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140657	ATP-dependent activity	1	6
GO:0140662	ATP-dependent protein folding chaperone	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	331	335	PF00656	0.478
CLV_C14_Caspase3-7	590	594	PF00656	0.741
CLV_C14_Caspase3-7	678	682	PF00656	0.444
CLV_C14_Caspase3-7	88	92	PF00656	0.538
CLV_NRD_NRD_1	264	266	PF00675	0.667
CLV_NRD_NRD_1	353	355	PF00675	0.494
CLV_NRD_NRD_1	557	559	PF00675	0.622
CLV_PCSK_KEX2_1	264	266	PF00082	0.667
CLV_PCSK_KEX2_1	353	355	PF00082	0.494
CLV_PCSK_SKI1_1	197	201	PF00082	0.390
CLV_PCSK_SKI1_1	206	210	PF00082	0.408
CLV_PCSK_SKI1_1	311	315	PF00082	0.571
CLV_PCSK_SKI1_1	353	357	PF00082	0.514
CLV_PCSK_SKI1_1	398	402	PF00082	0.386
CLV_PCSK_SKI1_1	506	510	PF00082	0.535
CLV_PCSK_SKI1_1	550	554	PF00082	0.519
CLV_PCSK_SKI1_1	640	644	PF00082	0.555
CLV_PCSK_SKI1_1	665	669	PF00082	0.547
DEG_Nend_Nbox_1	1	3	PF02207	0.452
DEG_SPOP_SBC_1	19	23	PF00917	0.594
DEG_SPOP_SBC_1	191	195	PF00917	0.683
DOC_CKS1_1	753	758	PF01111	0.620
DOC_CYCLIN_RxL_1	350	360	PF00134	0.606
DOC_MAPK_MEF2A_6	197	204	PF00069	0.378
DOC_MAPK_MEF2A_6	394	403	PF00069	0.486
DOC_MAPK_MEF2A_6	730	738	PF00069	0.466
DOC_MAPK_NFAT4_5	197	205	PF00069	0.483
DOC_PP1_RVXF_1	137	144	PF00149	0.548
DOC_PP1_RVXF_1	221	228	PF00149	0.587
DOC_PP2B_LxvP_1	202	205	PF13499	0.442
DOC_PP4_FxxP_1	356	359	PF00568	0.643
DOC_USP7_MATH_1	10	14	PF00917	0.470
DOC_USP7_MATH_1	19	23	PF00917	0.558
DOC_USP7_MATH_1	191	195	PF00917	0.611
DOC_USP7_MATH_1	231	235	PF00917	0.516
DOC_USP7_MATH_1	27	31	PF00917	0.540
DOC_USP7_MATH_1	357	361	PF00917	0.675
DOC_USP7_MATH_1	390	394	PF00917	0.490
DOC_USP7_MATH_1	446	450	PF00917	0.555
DOC_USP7_MATH_1	575	579	PF00917	0.448
DOC_USP7_MATH_1	635	639	PF00917	0.468
DOC_USP7_MATH_1	691	695	PF00917	0.516
DOC_USP7_MATH_1	710	714	PF00917	0.292
DOC_USP7_MATH_1	85	89	PF00917	0.481
DOC_USP7_MATH_2	599	605	PF00917	0.474
DOC_USP7_UBL2_3	559	563	PF12436	0.631
DOC_WW_Pin1_4	355	360	PF00397	0.644
DOC_WW_Pin1_4	44	49	PF00397	0.453
DOC_WW_Pin1_4	499	504	PF00397	0.554
DOC_WW_Pin1_4	655	660	PF00397	0.574
DOC_WW_Pin1_4	752	757	PF00397	0.599
LIG_14-3-3_CanoR_1	268	274	PF00244	0.670
LIG_14-3-3_CanoR_1	558	564	PF00244	0.673
LIG_14-3-3_CanoR_1	690	699	PF00244	0.495
LIG_APCC_ABBA_1	668	673	PF00400	0.504
LIG_BIR_III_2	31	35	PF00653	0.577
LIG_BIR_III_4	673	677	PF00653	0.577
LIG_BRCT_BRCA1_1	244	248	PF00533	0.391
LIG_BRCT_BRCA1_1	359	363	PF00533	0.650
LIG_BRCT_BRCA1_1	761	765	PF00533	0.558
LIG_CSL_BTD_1	656	659	PF09270	0.583
LIG_deltaCOP1_diTrp_1	450	457	PF00928	0.424
LIG_deltaCOP1_diTrp_1	470	476	PF00928	0.561
LIG_eIF4E_1	427	433	PF01652	0.543
LIG_FHA_1	108	114	PF00498	0.575
LIG_FHA_1	136	142	PF00498	0.598
LIG_FHA_1	199	205	PF00498	0.364
LIG_FHA_1	24	30	PF00498	0.700
LIG_FHA_1	242	248	PF00498	0.463
LIG_FHA_1	382	388	PF00498	0.577
LIG_FHA_1	433	439	PF00498	0.492
LIG_FHA_1	45	51	PF00498	0.517
LIG_FHA_1	491	497	PF00498	0.505
LIG_FHA_1	621	627	PF00498	0.603
LIG_FHA_1	629	635	PF00498	0.434
LIG_FHA_1	753	759	PF00498	0.562
LIG_FHA_2	184	190	PF00498	0.690
LIG_FHA_2	461	467	PF00498	0.543
LIG_FHA_2	469	475	PF00498	0.591
LIG_FHA_2	52	58	PF00498	0.491
LIG_FHA_2	582	588	PF00498	0.575
LIG_FHA_2	658	664	PF00498	0.589
LIG_FHA_2	96	102	PF00498	0.711
LIG_LIR_Gen_1	11	20	PF02991	0.504
LIG_LIR_Gen_1	161	171	PF02991	0.410
LIG_LIR_Gen_1	196	207	PF02991	0.434
LIG_LIR_Gen_1	360	369	PF02991	0.582
LIG_LIR_Gen_1	473	483	PF02991	0.344
LIG_LIR_Gen_1	577	587	PF02991	0.618
LIG_LIR_LC3C_4	201	204	PF02991	0.470
LIG_LIR_Nem_3	11	17	PF02991	0.491
LIG_LIR_Nem_3	161	167	PF02991	0.435
LIG_LIR_Nem_3	196	202	PF02991	0.431
LIG_LIR_Nem_3	322	327	PF02991	0.620
LIG_LIR_Nem_3	360	366	PF02991	0.589
LIG_LIR_Nem_3	449	454	PF02991	0.465
LIG_LIR_Nem_3	577	583	PF02991	0.604
LIG_LIR_Nem_3	761	766	PF02991	0.487
LIG_NRBOX	491	497	PF00104	0.505
LIG_NRBOX	638	644	PF00104	0.538
LIG_Pex14_1	472	476	PF04695	0.549
LIG_SH2_CRK	207	211	PF00017	0.491
LIG_SH2_CRK	763	767	PF00017	0.270
LIG_SH2_NCK_1	257	261	PF00017	0.574
LIG_SH2_NCK_1	82	86	PF00017	0.497
LIG_SH2_PTP2	14	17	PF00017	0.489
LIG_SH2_SRC	617	620	PF00017	0.513
LIG_SH2_STAP1	2	6	PF00017	0.410
LIG_SH2_STAP1	82	86	PF00017	0.507
LIG_SH2_STAT3	348	351	PF00017	0.528
LIG_SH2_STAT3	546	549	PF00017	0.509
LIG_SH2_STAT3	68	71	PF00017	0.495
LIG_SH2_STAT5	14	17	PF00017	0.489
LIG_SH2_STAT5	145	148	PF00017	0.525
LIG_SH2_STAT5	170	173	PF00017	0.477
LIG_SH2_STAT5	324	327	PF00017	0.580
LIG_SH2_STAT5	617	620	PF00017	0.434
LIG_SH2_STAT5	669	672	PF00017	0.432
LIG_SH2_STAT5	78	81	PF00017	0.378
LIG_SH3_3	297	303	PF00018	0.580
LIG_SH3_3	650	656	PF00018	0.507
LIG_SH3_3	736	742	PF00018	0.564
LIG_SH3_3	750	756	PF00018	0.463
LIG_Sin3_3	695	702	PF02671	0.489
LIG_SUMO_SIM_par_1	238	245	PF11976	0.253
LIG_SUMO_SIM_par_1	276	281	PF11976	0.416
LIG_TRAF2_1	159	162	PF00917	0.323
LIG_TRAF2_1	260	263	PF00917	0.625
LIG_TRAF2_1	54	57	PF00917	0.516
LIG_WRC_WIRS_1	461	466	PF05994	0.371
MOD_CDC14_SPxK_1	358	361	PF00782	0.679
MOD_CDK_SPxK_1	355	361	PF00069	0.649
MOD_CDK_SPxxK_3	499	506	PF00069	0.553
MOD_CDK_SPxxK_3	658	665	PF00069	0.539
MOD_CK1_1	135	141	PF00069	0.552
MOD_CK1_1	156	162	PF00069	0.490
MOD_CK1_1	193	199	PF00069	0.522
MOD_CK1_1	21	27	PF00069	0.623
MOD_CK1_1	39	45	PF00069	0.264
MOD_CK1_1	409	415	PF00069	0.542
MOD_CK1_1	499	505	PF00069	0.481
MOD_CK1_1	554	560	PF00069	0.657
MOD_CK1_1	658	664	PF00069	0.576
MOD_CK1_1	679	685	PF00069	0.666
MOD_CK2_1	146	152	PF00069	0.447
MOD_CK2_1	156	162	PF00069	0.317
MOD_CK2_1	460	466	PF00069	0.401
MOD_CK2_1	468	474	PF00069	0.519
MOD_CK2_1	51	57	PF00069	0.532
MOD_CK2_1	589	595	PF00069	0.748
MOD_CK2_1	657	663	PF00069	0.591
MOD_CK2_1	725	731	PF00069	0.556
MOD_CK2_1	95	101	PF00069	0.658
MOD_GlcNHglycan	135	138	PF01048	0.640
MOD_GlcNHglycan	148	151	PF01048	0.509
MOD_GlcNHglycan	158	161	PF01048	0.450
MOD_GlcNHglycan	316	319	PF01048	0.646
MOD_GlcNHglycan	330	333	PF01048	0.475
MOD_GlcNHglycan	41	44	PF01048	0.489
MOD_GlcNHglycan	522	525	PF01048	0.342
MOD_GlcNHglycan	559	562	PF01048	0.629
MOD_GlcNHglycan	645	648	PF01048	0.534
MOD_GlcNHglycan	681	684	PF01048	0.690
MOD_GlcNHglycan	693	696	PF01048	0.492
MOD_GSK3_1	129	136	PF00069	0.571
MOD_GSK3_1	19	26	PF00069	0.542
MOD_GSK3_1	242	249	PF00069	0.423
MOD_GSK3_1	287	294	PF00069	0.465
MOD_GSK3_1	372	379	PF00069	0.613
MOD_GSK3_1	4	11	PF00069	0.374
MOD_GSK3_1	432	439	PF00069	0.475
MOD_GSK3_1	456	463	PF00069	0.259
MOD_GSK3_1	516	523	PF00069	0.307
MOD_GSK3_1	550	557	PF00069	0.605
MOD_GSK3_1	620	627	PF00069	0.457
MOD_GSK3_1	675	682	PF00069	0.620
MOD_GSK3_1	710	717	PF00069	0.377
MOD_GSK3_1	748	755	PF00069	0.616
MOD_N-GLC_1	242	247	PF02516	0.463
MOD_N-GLC_1	39	44	PF02516	0.568
MOD_NEK2_1	153	158	PF00069	0.584
MOD_NEK2_1	192	197	PF00069	0.574
MOD_NEK2_1	198	203	PF00069	0.510
MOD_NEK2_1	242	247	PF00069	0.483
MOD_NEK2_1	287	292	PF00069	0.354
MOD_NEK2_1	432	437	PF00069	0.464
MOD_NEK2_1	456	461	PF00069	0.516
MOD_NEK2_1	496	501	PF00069	0.409
MOD_NEK2_1	516	521	PF00069	0.477
MOD_NEK2_1	551	556	PF00069	0.595
MOD_NEK2_1	643	648	PF00069	0.518
MOD_NEK2_1	714	719	PF00069	0.489
MOD_NEK2_1	759	764	PF00069	0.391
MOD_NEK2_1	8	13	PF00069	0.386
MOD_NEK2_2	536	541	PF00069	0.543
MOD_NEK2_2	635	640	PF00069	0.567
MOD_PIKK_1	129	135	PF00454	0.589
MOD_PIKK_1	258	264	PF00454	0.540
MOD_PIKK_1	347	353	PF00454	0.508
MOD_PIKK_1	432	438	PF00454	0.562
MOD_PIKK_1	628	634	PF00454	0.501
MOD_PK_1	172	178	PF00069	0.489
MOD_PK_1	740	746	PF00069	0.649
MOD_PKA_1	406	412	PF00069	0.542
MOD_PKA_2	129	135	PF00069	0.533
MOD_PKA_2	554	560	PF00069	0.663
MOD_Plk_1	172	178	PF00069	0.507
MOD_Plk_1	242	248	PF00069	0.462
MOD_Plk_1	516	522	PF00069	0.536
MOD_Plk_1	621	627	PF00069	0.596
MOD_Plk_1	747	753	PF00069	0.393
MOD_Plk_4	10	16	PF00069	0.428
MOD_Plk_4	153	159	PF00069	0.486
MOD_Plk_4	198	204	PF00069	0.368
MOD_Plk_4	242	248	PF00069	0.414
MOD_Plk_4	287	293	PF00069	0.466
MOD_Plk_4	516	522	PF00069	0.483
MOD_Plk_4	575	581	PF00069	0.622
MOD_Plk_4	748	754	PF00069	0.592
MOD_ProDKin_1	355	361	PF00069	0.649
MOD_ProDKin_1	44	50	PF00069	0.449
MOD_ProDKin_1	499	505	PF00069	0.549
MOD_ProDKin_1	655	661	PF00069	0.571
MOD_ProDKin_1	752	758	PF00069	0.591
MOD_SUMO_rev_2	590	599	PF00179	0.516
TRG_DiLeu_BaEn_1	428	433	PF01217	0.549
TRG_DiLeu_BaLyEn_6	491	496	PF01217	0.482
TRG_ENDOCYTIC_2	14	17	PF00928	0.489
TRG_ENDOCYTIC_2	310	313	PF00928	0.628
TRG_ENDOCYTIC_2	324	327	PF00928	0.616
TRG_ENDOCYTIC_2	427	430	PF00928	0.551
TRG_ENDOCYTIC_2	617	620	PF00928	0.540
TRG_ENDOCYTIC_2	763	766	PF00928	0.488
TRG_ER_diArg_1	264	266	PF00400	0.667
TRG_ER_diArg_1	353	355	PF00400	0.494
TRG_ER_FFAT_2	152	162	PF00635	0.532
TRG_Pf-PMV_PEXEL_1	139	144	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAW3	Leptomonas seymouri	66%	98%
A0A0S4IR51	Bodo saltans	26%	100%
A0A1X0P6L7	Trypanosomatidae	32%	89%
A0A3R7RRJ4	Trypanosoma rangeli	31%	93%
A0A3S7X511	Leishmania donovani	89%	100%
A4HK00	Leishmania braziliensis	78%	100%
A4I7I3	Leishmania infantum	89%	100%
D0A086	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	89%
Q4Q5R6	Leishmania major	90%	100%
V5C1N9	Trypanosoma cruzi	33%	100%