Putative U2 small nuclear ribonucleoprotein 40K

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U2 small nuclear ribonucleoprotein 40K, putative

Species:

Leishmania mexicana

UniProt:

E9B2D8_LEIMU

TriTrypDb:

LmxM.31.0170

Length:

308

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0032991	protein-containing complex	1	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

E9B2D8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2D8

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	12
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	12
GO:0000398	mRNA splicing, via spliceosome	8	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008380	RNA splicing	7	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0017069	snRNA binding	5	12
GO:0030620	U2 snRNA binding	6	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.739
CLV_NRD_NRD_1	216	218	PF00675	0.624
CLV_NRD_NRD_1	302	304	PF00675	0.558
CLV_PCSK_KEX2_1	218	220	PF00082	0.621
CLV_PCSK_KEX2_1	304	306	PF00082	0.560
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.618
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.590
CLV_PCSK_SKI1_1	153	157	PF00082	0.273
DEG_APCC_DBOX_1	110	118	PF00400	0.557
DEG_APCC_DBOX_1	152	160	PF00400	0.473
DEG_MDM2_SWIB_1	122	129	PF02201	0.463
DEG_Nend_UBRbox_1	1	4	PF02207	0.304
DOC_CKS1_1	193	198	PF01111	0.330
DOC_MAPK_gen_1	124	134	PF00069	0.499
DOC_MAPK_gen_1	151	159	PF00069	0.440
DOC_MIT_MIM_1	261	271	PF04212	0.566
DOC_PP1_RVXF_1	116	123	PF00149	0.477
DOC_PP4_FxxP_1	158	161	PF00568	0.477
DOC_USP7_MATH_1	230	234	PF00917	0.681
DOC_USP7_MATH_1	62	66	PF00917	0.505
DOC_USP7_MATH_1	67	71	PF00917	0.520
DOC_USP7_UBL2_3	124	128	PF12436	0.538
DOC_USP7_UBL2_3	183	187	PF12436	0.521
DOC_USP7_UBL2_3	214	218	PF12436	0.660
DOC_WW_Pin1_4	192	197	PF00397	0.437
DOC_WW_Pin1_4	247	252	PF00397	0.750
LIG_14-3-3_CanoR_1	2	6	PF00244	0.460
LIG_14-3-3_CanoR_1	204	211	PF00244	0.743
LIG_14-3-3_CanoR_1	29	34	PF00244	0.538
LIG_14-3-3_CanoR_1	78	83	PF00244	0.458
LIG_14-3-3_CanoR_1	91	95	PF00244	0.435
LIG_Actin_WH2_2	149	166	PF00022	0.444
LIG_Actin_WH2_2	16	31	PF00022	0.538
LIG_BRCT_BRCA1_1	143	147	PF00533	0.557
LIG_Clathr_ClatBox_1	38	42	PF01394	0.503
LIG_FHA_1	2	8	PF00498	0.478
LIG_FHA_1	78	84	PF00498	0.482
LIG_FHA_2	170	176	PF00498	0.477
LIG_FHA_2	235	241	PF00498	0.710
LIG_FHA_2	279	285	PF00498	0.501
LIG_FHA_2	54	60	PF00498	0.513
LIG_IRF3_LxIS_1	25	31	PF10401	0.538
LIG_LIR_Apic_2	192	196	PF02991	0.558
LIG_LIR_Gen_1	42	50	PF02991	0.454
LIG_LIR_Nem_3	184	189	PF02991	0.419
LIG_LIR_Nem_3	42	48	PF02991	0.466
LIG_Pex14_2	122	126	PF04695	0.463
LIG_SH2_CRK	168	172	PF00017	0.463
LIG_SH2_STAT5	121	124	PF00017	0.557
LIG_SH2_STAT5	60	63	PF00017	0.452
LIG_SUMO_SIM_anti_2	34	42	PF11976	0.495
LIG_SUMO_SIM_par_1	130	136	PF11976	0.463
LIG_SUMO_SIM_par_1	233	241	PF11976	0.682
LIG_SUMO_SIM_par_1	34	42	PF11976	0.498
LIG_TRAF2_1	281	284	PF00917	0.494
LIG_TYR_ITIM	166	171	PF00017	0.463
MOD_CK1_1	192	198	PF00069	0.588
MOD_CK1_1	205	211	PF00069	0.621
MOD_CK1_1	77	83	PF00069	0.518
MOD_CK1_1	93	99	PF00069	0.411
MOD_CK2_1	278	284	PF00069	0.501
MOD_CK2_1	29	35	PF00069	0.508
MOD_CK2_1	53	59	PF00069	0.513
MOD_Cter_Amidation	212	215	PF01082	0.645
MOD_GlcNHglycan	247	250	PF01048	0.688
MOD_GlcNHglycan	300	303	PF01048	0.607
MOD_GlcNHglycan	64	67	PF01048	0.251
MOD_GlcNHglycan	98	101	PF01048	0.314
MOD_GSK3_1	200	207	PF00069	0.667
MOD_GSK3_1	222	229	PF00069	0.723
MOD_GSK3_1	230	237	PF00069	0.671
MOD_GSK3_1	274	281	PF00069	0.596
MOD_GSK3_1	49	56	PF00069	0.526
MOD_GSK3_1	62	69	PF00069	0.483
MOD_GSK3_1	74	81	PF00069	0.569
MOD_N-GLC_1	48	53	PF02516	0.283
MOD_NEK2_1	14	19	PF00069	0.472
MOD_NEK2_1	28	33	PF00069	0.439
MOD_PIKK_1	169	175	PF00454	0.460
MOD_PIKK_1	202	208	PF00454	0.565
MOD_PKA_2	1	7	PF00069	0.320
MOD_PKA_2	169	175	PF00069	0.459
MOD_PKA_2	28	34	PF00069	0.538
MOD_PKA_2	74	80	PF00069	0.510
MOD_PKA_2	90	96	PF00069	0.384
MOD_Plk_2-3	130	136	PF00069	0.463
MOD_Plk_4	14	20	PF00069	0.480
MOD_Plk_4	78	84	PF00069	0.452
MOD_ProDKin_1	192	198	PF00069	0.449
MOD_ProDKin_1	247	253	PF00069	0.750
MOD_SUMO_for_1	182	185	PF00179	0.570
MOD_SUMO_rev_2	184	189	PF00179	0.552
MOD_SUMO_rev_2	207	216	PF00179	0.695
TRG_DiLeu_BaEn_1	185	190	PF01217	0.440
TRG_DiLeu_BaEn_4	283	289	PF01217	0.536
TRG_DiLeu_BaLyEn_6	271	276	PF01217	0.578
TRG_ENDOCYTIC_2	168	171	PF00928	0.470
TRG_ENDOCYTIC_2	60	63	PF00928	0.430
TRG_ER_diArg_1	111	114	PF00400	0.538
TRG_ER_diLys_1	304	308	PF00400	0.695
TRG_NLS_MonoCore_2	302	307	PF00514	0.637
TRG_NLS_MonoExtC_3	213	218	PF00514	0.629
TRG_NLS_MonoExtC_3	302	307	PF00514	0.637
TRG_NLS_MonoExtN_4	214	221	PF00514	0.623
TRG_NLS_MonoExtN_4	303	308	PF00514	0.586
TRG_Pf-PMV_PEXEL_1	274	278	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P873	Leptomonas seymouri	67%	100%
A0A0S4IPQ0	Bodo saltans	33%	100%
A0A1X0P6L0	Trypanosomatidae	45%	89%
A0A3R7N1N5	Trypanosoma rangeli	43%	90%
A0A3S7X552	Leishmania donovani	94%	100%
A4HJZ8	Leishmania braziliensis	87%	100%
A4I7I1	Leishmania infantum	93%	100%
D0A084	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	94%
P43333	Arabidopsis thaliana	26%	100%
Q4Q5R8	Leishmania major	95%	100%
Q4WV66	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	100%
Q6BT60	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	25%	100%
Q6C417	Yarrowia lipolytica (strain CLIB 122 / E 150)	24%	100%
Q7S9P4	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	27%	100%
V5BWU6	Trypanosoma cruzi	47%	90%