Armadillo/beta-catenin-like repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum attachment zone protein 9

Species:

Leishmania mexicana

UniProt:

E9B2D4_LEIMU

TriTrypDb:

LmxM.31.0140

Length:

1042

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9B2D4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2D4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.635
CLV_C14_Caspase3-7	481	485	PF00656	0.485
CLV_C14_Caspase3-7	894	898	PF00656	0.532
CLV_NRD_NRD_1	1026	1028	PF00675	0.431
CLV_NRD_NRD_1	170	172	PF00675	0.622
CLV_NRD_NRD_1	350	352	PF00675	0.411
CLV_NRD_NRD_1	485	487	PF00675	0.444
CLV_NRD_NRD_1	581	583	PF00675	0.412
CLV_NRD_NRD_1	596	598	PF00675	0.522
CLV_NRD_NRD_1	93	95	PF00675	0.558
CLV_PCSK_FUR_1	168	172	PF00082	0.672
CLV_PCSK_KEX2_1	1026	1028	PF00082	0.431
CLV_PCSK_KEX2_1	140	142	PF00082	0.779
CLV_PCSK_KEX2_1	170	172	PF00082	0.597
CLV_PCSK_KEX2_1	661	663	PF00082	0.756
CLV_PCSK_KEX2_1	93	95	PF00082	0.558
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.779
CLV_PCSK_PC1ET2_1	661	663	PF00082	0.756
CLV_PCSK_PC7_1	89	95	PF00082	0.634
CLV_PCSK_SKI1_1	1038	1042	PF00082	0.502
CLV_PCSK_SKI1_1	106	110	PF00082	0.617
CLV_PCSK_SKI1_1	352	356	PF00082	0.488
CLV_PCSK_SKI1_1	414	418	PF00082	0.371
CLV_PCSK_SKI1_1	578	582	PF00082	0.554
CLV_PCSK_SKI1_1	965	969	PF00082	0.520
CLV_Separin_Metazoa	500	504	PF03568	0.444
DEG_APCC_DBOX_1	193	201	PF00400	0.634
DEG_APCC_DBOX_1	413	421	PF00400	0.390
DEG_APCC_DBOX_1	485	493	PF00400	0.344
DEG_APCC_KENBOX_2	214	218	PF00400	0.400
DEG_Nend_UBRbox_3	1	3	PF02207	0.599
DEG_SPOP_SBC_1	14	18	PF00917	0.488
DEG_SPOP_SBC_1	551	555	PF00917	0.351
DOC_CDC14_PxL_1	492	500	PF14671	0.344
DOC_CDC14_PxL_1	542	550	PF14671	0.444
DOC_CKS1_1	762	767	PF01111	0.592
DOC_CYCLIN_yCln2_LP_2	730	736	PF00134	0.576
DOC_CYCLIN_yCln2_LP_2	767	773	PF00134	0.508
DOC_MAPK_gen_1	102	113	PF00069	0.621
DOC_MAPK_gen_1	582	589	PF00069	0.401
DOC_MAPK_MEF2A_6	102	111	PF00069	0.556
DOC_MAPK_MEF2A_6	582	591	PF00069	0.396
DOC_MAPK_MEF2A_6	640	649	PF00069	0.411
DOC_MAPK_MEF2A_6	801	808	PF00069	0.503
DOC_MAPK_NFAT4_5	106	114	PF00069	0.541
DOC_PP1_RVXF_1	376	383	PF00149	0.473
DOC_PP1_RVXF_1	757	763	PF00149	0.292
DOC_PP1_RVXF_1	990	997	PF00149	0.451
DOC_PP2B_LxvP_1	209	212	PF13499	0.487
DOC_PP2B_LxvP_1	734	737	PF13499	0.556
DOC_PP2B_LxvP_1	767	770	PF13499	0.516
DOC_PP4_FxxP_1	326	329	PF00568	0.466
DOC_PP4_FxxP_1	762	765	PF00568	0.551
DOC_PP4_FxxP_1	829	832	PF00568	0.619
DOC_USP7_MATH_1	199	203	PF00917	0.554
DOC_USP7_MATH_1	25	29	PF00917	0.640
DOC_USP7_MATH_1	275	279	PF00917	0.615
DOC_USP7_MATH_1	282	286	PF00917	0.574
DOC_USP7_MATH_1	464	468	PF00917	0.441
DOC_USP7_MATH_1	50	54	PF00917	0.534
DOC_USP7_MATH_1	607	611	PF00917	0.697
DOC_USP7_MATH_1	672	676	PF00917	0.488
DOC_USP7_MATH_1	705	709	PF00917	0.456
DOC_USP7_MATH_1	718	722	PF00917	0.531
DOC_USP7_MATH_1	738	742	PF00917	0.343
DOC_USP7_MATH_1	884	888	PF00917	0.392
DOC_USP7_MATH_1	924	928	PF00917	0.717
DOC_USP7_MATH_1	967	971	PF00917	0.443
DOC_USP7_MATH_1	999	1003	PF00917	0.456
DOC_USP7_UBL2_3	102	106	PF12436	0.529
DOC_USP7_UBL2_3	1038	1042	PF12436	0.577
DOC_USP7_UBL2_3	58	62	PF12436	0.613
DOC_USP7_UBL2_3	722	726	PF12436	0.648
DOC_WW_Pin1_4	129	134	PF00397	0.685
DOC_WW_Pin1_4	161	166	PF00397	0.654
DOC_WW_Pin1_4	180	185	PF00397	0.730
DOC_WW_Pin1_4	189	194	PF00397	0.673
DOC_WW_Pin1_4	276	281	PF00397	0.593
DOC_WW_Pin1_4	665	670	PF00397	0.736
DOC_WW_Pin1_4	687	692	PF00397	0.411
DOC_WW_Pin1_4	711	716	PF00397	0.510
DOC_WW_Pin1_4	729	734	PF00397	0.565
DOC_WW_Pin1_4	750	755	PF00397	0.417
DOC_WW_Pin1_4	761	766	PF00397	0.583
DOC_WW_Pin1_4	851	856	PF00397	0.575
DOC_WW_Pin1_4	867	872	PF00397	0.457
LIG_14-3-3_CanoR_1	1019	1025	PF00244	0.534
LIG_14-3-3_CanoR_1	662	669	PF00244	0.683
LIG_14-3-3_CanoR_1	742	746	PF00244	0.417
LIG_14-3-3_CanoR_1	782	788	PF00244	0.415
LIG_14-3-3_CanoR_1	944	949	PF00244	0.411
LIG_BIR_III_4	122	126	PF00653	0.671
LIG_FHA_1	307	313	PF00498	0.397
LIG_FHA_1	332	338	PF00498	0.519
LIG_FHA_1	40	46	PF00498	0.397
LIG_FHA_1	420	426	PF00498	0.415
LIG_FHA_1	456	462	PF00498	0.434
LIG_FHA_1	535	541	PF00498	0.331
LIG_FHA_1	609	615	PF00498	0.551
LIG_FHA_1	681	687	PF00498	0.392
LIG_FHA_1	705	711	PF00498	0.433
LIG_FHA_1	738	744	PF00498	0.639
LIG_FHA_1	762	768	PF00498	0.527
LIG_FHA_1	798	804	PF00498	0.396
LIG_FHA_1	852	858	PF00498	0.358
LIG_FHA_2	386	392	PF00498	0.532
LIG_FHA_2	437	443	PF00498	0.415
LIG_FHA_2	687	693	PF00498	0.549
LIG_FHA_2	784	790	PF00498	0.419
LIG_FHA_2	80	86	PF00498	0.657
LIG_LIR_Apic_2	325	329	PF02991	0.475
LIG_LIR_Apic_2	827	832	PF02991	0.650
LIG_LIR_Gen_1	514	523	PF02991	0.405
LIG_LIR_Gen_1	704	712	PF02991	0.499
LIG_LIR_Gen_1	71	81	PF02991	0.545
LIG_LIR_Gen_1	931	941	PF02991	0.416
LIG_LIR_Nem_3	242	246	PF02991	0.532
LIG_LIR_Nem_3	289	295	PF02991	0.443
LIG_LIR_Nem_3	514	518	PF02991	0.405
LIG_LIR_Nem_3	541	545	PF02991	0.344
LIG_LIR_Nem_3	704	709	PF02991	0.494
LIG_LIR_Nem_3	71	77	PF02991	0.543
LIG_LIR_Nem_3	729	734	PF02991	0.553
LIG_LIR_Nem_3	901	905	PF02991	0.270
LIG_LIR_Nem_3	931	937	PF02991	0.436
LIG_LYPXL_yS_3	243	246	PF13949	0.574
LIG_MYND_3	425	429	PF01753	0.492
LIG_NRBOX	204	210	PF00104	0.546
LIG_NRBOX	307	313	PF00104	0.473
LIG_NRBOX	382	388	PF00104	0.399
LIG_NRBOX	497	503	PF00104	0.369
LIG_NRBOX	589	595	PF00104	0.497
LIG_NRBOX	936	942	PF00104	0.382
LIG_PCNA_PIPBox_1	250	259	PF02747	0.576
LIG_PCNA_yPIPBox_3	283	295	PF02747	0.527
LIG_PTB_Apo_2	509	516	PF02174	0.408
LIG_PTB_Phospho_1	509	515	PF10480	0.408
LIG_SH2_CRK	542	546	PF00017	0.344
LIG_SH2_CRK	74	78	PF00017	0.483
LIG_SH2_CRK	902	906	PF00017	0.285
LIG_SH2_CRK	934	938	PF00017	0.403
LIG_SH2_NCK_1	811	815	PF00017	0.495
LIG_SH2_STAP1	421	425	PF00017	0.425
LIG_SH2_STAT3	1003	1006	PF00017	0.499
LIG_SH2_STAT3	226	229	PF00017	0.480
LIG_SH2_STAT3	274	277	PF00017	0.593
LIG_SH2_STAT5	1003	1006	PF00017	0.506
LIG_SH2_STAT5	112	115	PF00017	0.599
LIG_SH2_STAT5	226	229	PF00017	0.519
LIG_SH2_STAT5	421	424	PF00017	0.425
LIG_SH2_STAT5	437	440	PF00017	0.405
LIG_SH2_STAT5	656	659	PF00017	0.583
LIG_SH3_2	599	604	PF14604	0.657
LIG_SH3_3	130	136	PF00018	0.716
LIG_SH3_3	166	172	PF00018	0.718
LIG_SH3_3	257	263	PF00018	0.457
LIG_SH3_3	596	602	PF00018	0.620
LIG_SH3_3	666	672	PF00018	0.677
LIG_SH3_3	868	874	PF00018	0.451
LIG_SUMO_SIM_anti_2	10	20	PF11976	0.591
LIG_SUMO_SIM_anti_2	245	251	PF11976	0.517
LIG_SUMO_SIM_anti_2	557	562	PF11976	0.351
LIG_SUMO_SIM_par_1	10	20	PF11976	0.530
LIG_SUMO_SIM_par_1	365	373	PF11976	0.502
LIG_SUMO_SIM_par_1	545	550	PF11976	0.444
LIG_SUMO_SIM_par_1	587	592	PF11976	0.306
LIG_SUMO_SIM_par_1	68	73	PF11976	0.604
LIG_SUMO_SIM_par_1	865	870	PF11976	0.486
LIG_SUMO_SIM_par_1	906	914	PF11976	0.256
LIG_TRAF2_1	17	20	PF00917	0.596
LIG_TYR_ITIM	540	545	PF00017	0.344
LIG_TYR_ITIM	72	77	PF00017	0.480
LIG_UBA3_1	1032	1041	PF00899	0.526
LIG_UBA3_1	208	215	PF00899	0.481
LIG_UBA3_1	590	598	PF00899	0.440
LIG_UBA3_1	767	776	PF00899	0.266
LIG_WRC_WIRS_1	26	31	PF05994	0.585
MOD_CDC14_SPxK_1	732	735	PF00782	0.360
MOD_CDK_SPK_2	180	185	PF00069	0.702
MOD_CDK_SPK_2	189	194	PF00069	0.739
MOD_CDK_SPK_2	851	856	PF00069	0.495
MOD_CDK_SPxK_1	729	735	PF00069	0.411
MOD_CDK_SPxxK_3	161	168	PF00069	0.763
MOD_CDK_SPxxK_3	276	283	PF00069	0.663
MOD_CDK_SPxxK_3	687	694	PF00069	0.406
MOD_CK1_1	1021	1027	PF00069	0.465
MOD_CK1_1	164	170	PF00069	0.685
MOD_CK1_1	192	198	PF00069	0.634
MOD_CK1_1	255	261	PF00069	0.606
MOD_CK1_1	402	408	PF00069	0.511
MOD_CK1_1	467	473	PF00069	0.410
MOD_CK1_1	530	536	PF00069	0.502
MOD_CK1_1	554	560	PF00069	0.408
MOD_CK1_1	670	676	PF00069	0.620
MOD_CK1_1	713	719	PF00069	0.447
MOD_CK1_1	729	735	PF00069	0.500
MOD_CK1_1	741	747	PF00069	0.427
MOD_CK1_1	785	791	PF00069	0.269
MOD_CK1_1	886	892	PF00069	0.433
MOD_CK1_1	910	916	PF00069	0.285
MOD_CK1_1	927	933	PF00069	0.601
MOD_CK2_1	1012	1018	PF00069	0.568
MOD_CK2_1	14	20	PF00069	0.526
MOD_CK2_1	367	373	PF00069	0.517
MOD_CK2_1	385	391	PF00069	0.487
MOD_CK2_1	441	447	PF00069	0.434
MOD_CK2_1	556	562	PF00069	0.210
MOD_CK2_1	686	692	PF00069	0.569
MOD_CK2_1	7	13	PF00069	0.564
MOD_CK2_1	705	711	PF00069	0.268
MOD_CK2_1	783	789	PF00069	0.437
MOD_CK2_1	79	85	PF00069	0.666
MOD_GlcNHglycan	179	183	PF01048	0.628
MOD_GlcNHglycan	284	287	PF01048	0.665
MOD_GlcNHglycan	346	349	PF01048	0.413
MOD_GlcNHglycan	506	509	PF01048	0.194
MOD_GlcNHglycan	52	55	PF01048	0.607
MOD_GlcNHglycan	564	567	PF01048	0.344
MOD_GlcNHglycan	571	574	PF01048	0.344
MOD_GlcNHglycan	663	666	PF01048	0.771
MOD_GlcNHglycan	754	757	PF01048	0.544
MOD_GlcNHglycan	812	815	PF01048	0.575
MOD_GlcNHglycan	841	844	PF01048	0.397
MOD_GlcNHglycan	905	908	PF01048	0.514
MOD_GlcNHglycan	965	968	PF01048	0.533
MOD_GlcNHglycan	969	972	PF01048	0.490
MOD_GSK3_1	1014	1021	PF00069	0.539
MOD_GSK3_1	232	239	PF00069	0.448
MOD_GSK3_1	32	39	PF00069	0.597
MOD_GSK3_1	395	402	PF00069	0.703
MOD_GSK3_1	530	537	PF00069	0.461
MOD_GSK3_1	550	557	PF00069	0.329
MOD_GSK3_1	608	615	PF00069	0.565
MOD_GSK3_1	661	668	PF00069	0.724
MOD_GSK3_1	737	744	PF00069	0.524
MOD_GSK3_1	820	827	PF00069	0.638
MOD_GSK3_1	903	910	PF00069	0.348
MOD_GSK3_1	924	931	PF00069	0.636
MOD_GSK3_1	959	966	PF00069	0.503
MOD_N-GLC_1	429	434	PF02516	0.474
MOD_N-GLC_1	511	516	PF02516	0.445
MOD_N-GLC_1	527	532	PF02516	0.265
MOD_N-GLC_1	562	567	PF02516	0.344
MOD_N-GLC_1	569	574	PF02516	0.344
MOD_N-GLC_1	63	68	PF02516	0.592
MOD_N-GLC_1	726	731	PF02516	0.505
MOD_N-GLC_1	782	787	PF02516	0.408
MOD_N-GLC_1	944	949	PF02516	0.411
MOD_N-GLC_2	993	995	PF02516	0.393
MOD_NEK2_1	1012	1017	PF00069	0.540
MOD_NEK2_1	311	316	PF00069	0.411
MOD_NEK2_1	36	41	PF00069	0.580
MOD_NEK2_1	552	557	PF00069	0.444
MOD_NEK2_1	680	685	PF00069	0.417
MOD_NEK2_1	710	715	PF00069	0.405
MOD_NEK2_1	836	841	PF00069	0.404
MOD_NEK2_2	464	469	PF00069	0.537
MOD_NEK2_2	812	817	PF00069	0.514
MOD_NEK2_2	939	944	PF00069	0.481
MOD_PIKK_1	224	230	PF00454	0.545
MOD_PIKK_1	402	408	PF00454	0.511
MOD_PIKK_1	534	540	PF00454	0.331
MOD_PIKK_1	831	837	PF00454	0.547
MOD_PIKK_1	87	93	PF00454	0.637
MOD_PIKK_1	96	102	PF00454	0.622
MOD_PKA_1	661	667	PF00069	0.769
MOD_PKA_2	1018	1024	PF00069	0.475
MOD_PKA_2	282	288	PF00069	0.631
MOD_PKA_2	661	667	PF00069	0.769
MOD_PKA_2	741	747	PF00069	0.419
MOD_PKA_2	790	796	PF00069	0.390
MOD_Plk_1	399	405	PF00069	0.575
MOD_Plk_1	429	435	PF00069	0.472
MOD_Plk_1	511	517	PF00069	0.417
MOD_Plk_1	527	533	PF00069	0.227
MOD_Plk_1	726	732	PF00069	0.485
MOD_Plk_1	738	744	PF00069	0.547
MOD_Plk_1	782	788	PF00069	0.415
MOD_Plk_1	79	85	PF00069	0.654
MOD_Plk_1	944	950	PF00069	0.482
MOD_Plk_2-3	116	122	PF00069	0.620
MOD_Plk_2-3	32	38	PF00069	0.565
MOD_Plk_2-3	511	517	PF00069	0.444
MOD_Plk_2-3	7	13	PF00069	0.580
MOD_Plk_2-3	977	983	PF00069	0.512
MOD_Plk_4	116	122	PF00069	0.620
MOD_Plk_4	294	300	PF00069	0.464
MOD_Plk_4	429	435	PF00069	0.472
MOD_Plk_4	556	562	PF00069	0.316
MOD_Plk_4	564	570	PF00069	0.371
MOD_Plk_4	589	595	PF00069	0.285
MOD_Plk_4	680	686	PF00069	0.409
MOD_Plk_4	7	13	PF00069	0.550
MOD_Plk_4	705	711	PF00069	0.490
MOD_Plk_4	726	732	PF00069	0.571
MOD_Plk_4	763	769	PF00069	0.372
MOD_Plk_4	790	796	PF00069	0.368
MOD_Plk_4	812	818	PF00069	0.598
MOD_Plk_4	872	878	PF00069	0.430
MOD_Plk_4	999	1005	PF00069	0.396
MOD_ProDKin_1	129	135	PF00069	0.687
MOD_ProDKin_1	161	167	PF00069	0.653
MOD_ProDKin_1	180	186	PF00069	0.732
MOD_ProDKin_1	189	195	PF00069	0.667
MOD_ProDKin_1	276	282	PF00069	0.605
MOD_ProDKin_1	665	671	PF00069	0.728
MOD_ProDKin_1	687	693	PF00069	0.405
MOD_ProDKin_1	711	717	PF00069	0.512
MOD_ProDKin_1	729	735	PF00069	0.575
MOD_ProDKin_1	750	756	PF00069	0.414
MOD_ProDKin_1	761	767	PF00069	0.576
MOD_ProDKin_1	851	857	PF00069	0.576
MOD_ProDKin_1	867	873	PF00069	0.455
MOD_SUMO_for_1	319	322	PF00179	0.380
MOD_SUMO_for_1	57	60	PF00179	0.627
MOD_SUMO_rev_2	530	537	PF00179	0.419
MOD_SUMO_rev_2	55	63	PF00179	0.609
MOD_SUMO_rev_2	690	696	PF00179	0.412
MOD_SUMO_rev_2	848	854	PF00179	0.469
MOD_SUMO_rev_2	959	967	PF00179	0.547
TRG_DiLeu_BaEn_1	116	121	PF01217	0.642
TRG_DiLeu_BaEn_1	333	338	PF01217	0.525
TRG_DiLeu_BaEn_1	7	12	PF01217	0.578
TRG_DiLeu_BaEn_2	321	327	PF01217	0.466
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.508
TRG_ENDOCYTIC_2	243	246	PF00928	0.532
TRG_ENDOCYTIC_2	515	518	PF00928	0.369
TRG_ENDOCYTIC_2	542	545	PF00928	0.344
TRG_ENDOCYTIC_2	74	77	PF00928	0.483
TRG_ENDOCYTIC_2	902	905	PF00928	0.286
TRG_ENDOCYTIC_2	934	937	PF00928	0.407
TRG_ENDOCYTIC_2	958	961	PF00928	0.561
TRG_ER_diArg_1	1025	1027	PF00400	0.431
TRG_ER_diArg_1	168	171	PF00400	0.593
TRG_ER_diArg_1	93	95	PF00400	0.590
TRG_NES_CRM1_1	409	423	PF08389	0.502
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	487	491	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEV7	Leptomonas seymouri	76%	98%
A0A1X0P6M1	Trypanosomatidae	44%	91%
A0A3Q8IFW8	Leishmania donovani	95%	100%
A0A3R7KX09	Trypanosoma rangeli	46%	96%
A4HJZ4	Leishmania braziliensis	85%	100%
A4I7H7	Leishmania infantum	95%	100%
D0A079	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	92%
Q4Q5S2	Leishmania major	93%	100%