Skp1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2D3_LEIMU

TriTrypDb:

LmxM.31.0130

Length:

239

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B2D3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2D3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	66	70	PF00656	0.357
CLV_NRD_NRD_1	76	78	PF00675	0.537
CLV_PCSK_KEX2_1	162	164	PF00082	0.612
CLV_PCSK_KEX2_1	76	78	PF00082	0.533
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.612
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.558
CLV_PCSK_SKI1_1	187	191	PF00082	0.307
CLV_PCSK_SKI1_1	205	209	PF00082	0.354
CLV_Separin_Metazoa	184	188	PF03568	0.316
DEG_APCC_DBOX_1	121	129	PF00400	0.415
DOC_CDC14_PxL_1	226	234	PF14671	0.502
DOC_CYCLIN_RxL_1	101	111	PF00134	0.376
DOC_CYCLIN_yCln2_LP_2	117	123	PF00134	0.398
DOC_CYCLIN_yCln2_LP_2	85	88	PF00134	0.435
DOC_MAPK_MEF2A_6	12	19	PF00069	0.447
DOC_PP2B_LxvP_1	121	124	PF13499	0.367
DOC_PP2B_LxvP_1	85	88	PF13499	0.459
DOC_PP4_FxxP_1	231	234	PF00568	0.384
DOC_USP7_MATH_1	37	41	PF00917	0.494
LIG_FHA_1	133	139	PF00498	0.280
LIG_FHA_1	188	194	PF00498	0.413
LIG_FHA_1	4	10	PF00498	0.607
LIG_FHA_2	216	222	PF00498	0.409
LIG_FHA_2	3	9	PF00498	0.597
LIG_LIR_Gen_1	179	186	PF02991	0.320
LIG_LIR_Gen_1	223	234	PF02991	0.453
LIG_LIR_Gen_1	29	37	PF02991	0.365
LIG_LIR_Nem_3	100	106	PF02991	0.386
LIG_LIR_Nem_3	179	183	PF02991	0.319
LIG_LIR_Nem_3	223	229	PF02991	0.404
LIG_LIR_Nem_3	29	35	PF02991	0.375
LIG_MAD2	34	42	PF02301	0.317
LIG_MYND_1	230	234	PF01753	0.358
LIG_NRBOX	59	65	PF00104	0.410
LIG_Pex14_1	132	136	PF04695	0.305
LIG_SH2_CRK	226	230	PF00017	0.465
LIG_SH2_PTP2	32	35	PF00017	0.369
LIG_SH2_STAT5	105	108	PF00017	0.303
LIG_SH2_STAT5	136	139	PF00017	0.460
LIG_SH2_STAT5	18	21	PF00017	0.461
LIG_SH2_STAT5	32	35	PF00017	0.326
LIG_SH3_3	86	92	PF00018	0.390
LIG_TRAF2_1	124	127	PF00917	0.383
LIG_TRAF2_1	218	221	PF00917	0.414
MOD_CK1_1	200	206	PF00069	0.422
MOD_CK2_1	200	206	PF00069	0.360
MOD_CK2_1	215	221	PF00069	0.388
MOD_GlcNHglycan	152	155	PF01048	0.502
MOD_GlcNHglycan	199	202	PF01048	0.543
MOD_GlcNHglycan	39	42	PF01048	0.473
MOD_GlcNHglycan	8	12	PF01048	0.587
MOD_GSK3_1	108	115	PF00069	0.358
MOD_GSK3_1	152	159	PF00069	0.292
MOD_GSK3_1	193	200	PF00069	0.477
MOD_GSK3_1	3	10	PF00069	0.441
MOD_GSK3_1	63	70	PF00069	0.429
MOD_NEK2_1	108	113	PF00069	0.364
MOD_NEK2_1	156	161	PF00069	0.456
MOD_NEK2_1	193	198	PF00069	0.341
MOD_NEK2_1	63	68	PF00069	0.336
MOD_PKA_1	150	156	PF00069	0.292
MOD_PKB_1	24	32	PF00069	0.409
MOD_Plk_1	132	138	PF00069	0.279
MOD_Plk_1	42	48	PF00069	0.453
MOD_Plk_4	112	118	PF00069	0.402
MOD_Plk_4	132	138	PF00069	0.271
MOD_Plk_4	63	69	PF00069	0.343
MOD_SUMO_rev_2	148	153	PF00179	0.361
TRG_DiLeu_BaEn_1	133	138	PF01217	0.300
TRG_DiLeu_BaEn_4	220	226	PF01217	0.400
TRG_DiLeu_BaLyEn_6	59	64	PF01217	0.331
TRG_ENDOCYTIC_2	105	108	PF00928	0.303
TRG_ENDOCYTIC_2	226	229	PF00928	0.422
TRG_ENDOCYTIC_2	32	35	PF00928	0.337
TRG_NES_CRM1_1	166	179	PF08389	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7P1	Leptomonas seymouri	82%	100%
A0A1X0P7H5	Trypanosomatidae	43%	77%
A0A3S7X513	Leishmania donovani	97%	100%
A0A422P0X4	Trypanosoma rangeli	41%	75%
A4HJZ3	Leishmania braziliensis	87%	100%
A4I7H6	Leishmania infantum	97%	100%
D0A078	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	71%
Q4Q5S3	Leishmania major	93%	100%
V5DTE4	Trypanosoma cruzi	44%	75%