Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2C9_LEIMU

TriTrypDb:

LmxM.31.0090

Length:

304

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9B2C9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2C9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.507
CLV_NRD_NRD_1	215	217	PF00675	0.388
CLV_NRD_NRD_1	22	24	PF00675	0.608
CLV_NRD_NRD_1	274	276	PF00675	0.337
CLV_NRD_NRD_1	87	89	PF00675	0.392
CLV_NRD_NRD_1	94	96	PF00675	0.399
CLV_PCSK_FUR_1	272	276	PF00082	0.396
CLV_PCSK_FUR_1	85	89	PF00082	0.393
CLV_PCSK_KEX2_1	169	171	PF00082	0.507
CLV_PCSK_KEX2_1	215	217	PF00082	0.388
CLV_PCSK_KEX2_1	272	274	PF00082	0.363
CLV_PCSK_KEX2_1	87	89	PF00082	0.390
CLV_PCSK_KEX2_1	94	96	PF00082	0.401
CLV_PCSK_SKI1_1	28	32	PF00082	0.557
CLV_PCSK_SKI1_1	95	99	PF00082	0.405
DEG_APCC_DBOX_1	169	177	PF00400	0.495
DEG_APCC_KENBOX_2	30	34	PF00400	0.437
DEG_MDM2_SWIB_1	276	284	PF02201	0.625
DOC_ANK_TNKS_1	254	261	PF00023	0.650
DOC_CYCLIN_RxL_1	92	101	PF00134	0.702
DOC_MAPK_gen_1	108	116	PF00069	0.540
DOC_MAPK_gen_1	169	176	PF00069	0.597
DOC_MAPK_gen_1	85	93	PF00069	0.615
DOC_PP4_FxxP_1	209	212	PF00568	0.650
DOC_PP4_FxxP_1	217	220	PF00568	0.624
DOC_USP7_MATH_1	126	130	PF00917	0.785
DOC_USP7_MATH_1	144	148	PF00917	0.730
DOC_USP7_MATH_1	178	182	PF00917	0.585
DOC_USP7_MATH_1	36	40	PF00917	0.339
DOC_USP7_MATH_1	71	75	PF00917	0.362
DOC_WW_Pin1_4	130	135	PF00397	0.722
LIG_14-3-3_CanoR_1	180	186	PF00244	0.616
LIG_14-3-3_CanoR_1	85	93	PF00244	0.661
LIG_14-3-3_CanoR_1	95	104	PF00244	0.687
LIG_Actin_WH2_2	33	48	PF00022	0.308
LIG_BRCT_BRCA1_1	213	217	PF00533	0.699
LIG_deltaCOP1_diTrp_1	259	265	PF00928	0.621
LIG_EH_1	34	38	PF12763	0.397
LIG_FHA_1	144	150	PF00498	0.777
LIG_FHA_1	225	231	PF00498	0.700
LIG_FHA_1	5	11	PF00498	0.453
LIG_FHA_2	10	16	PF00498	0.414
LIG_LIR_Apic_2	208	212	PF02991	0.643
LIG_LIR_Apic_2	214	220	PF02991	0.698
LIG_LIR_Gen_1	168	178	PF02991	0.679
LIG_LIR_Gen_1	74	83	PF02991	0.508
LIG_LIR_Nem_3	49	55	PF02991	0.414
LIG_LIR_Nem_3	74	78	PF02991	0.504
LIG_Pex14_2	276	280	PF04695	0.650
LIG_SH2_CRK	218	222	PF00017	0.582
LIG_SH2_SRC	55	58	PF00017	0.355
LIG_SH2_STAT5	50	53	PF00017	0.363
LIG_SH2_STAT5	55	58	PF00017	0.275
LIG_SH3_3	112	118	PF00018	0.573
LIG_SH3_3	131	137	PF00018	0.598
LIG_SH3_3	263	269	PF00018	0.568
LIG_SH3_3	294	300	PF00018	0.592
LIG_SUMO_SIM_anti_2	146	153	PF11976	0.601
LIG_SUMO_SIM_par_1	243	249	PF11976	0.533
LIG_TRAF2_1	220	223	PF00917	0.681
LIG_UBA3_1	25	31	PF00899	0.418
LIG_WRC_WIRS_1	63	68	PF05994	0.370
LIG_WRC_WIRS_1	72	77	PF05994	0.423
LIG_WW_2	117	120	PF00397	0.653
MOD_CK1_1	143	149	PF00069	0.726
MOD_CK1_1	182	188	PF00069	0.684
MOD_CK1_1	4	10	PF00069	0.453
MOD_CK2_1	253	259	PF00069	0.611
MOD_CK2_1	264	270	PF00069	0.486
MOD_CMANNOS	261	264	PF00535	0.412
MOD_GlcNHglycan	128	131	PF01048	0.468
MOD_GlcNHglycan	142	145	PF01048	0.558
MOD_GlcNHglycan	175	179	PF01048	0.423
MOD_GlcNHglycan	58	61	PF01048	0.301
MOD_GSK3_1	126	133	PF00069	0.719
MOD_GSK3_1	135	142	PF00069	0.646
MOD_GSK3_1	143	150	PF00069	0.727
MOD_GSK3_1	174	181	PF00069	0.577
MOD_GSK3_1	249	256	PF00069	0.573
MOD_GSK3_1	51	58	PF00069	0.341
MOD_N-GLC_1	147	152	PF02516	0.445
MOD_N-GLC_1	249	254	PF02516	0.359
MOD_NEK2_1	139	144	PF00069	0.703
MOD_NEK2_1	174	179	PF00069	0.687
MOD_NEK2_1	56	61	PF00069	0.281
MOD_NEK2_1	62	67	PF00069	0.272
MOD_PIKK_1	86	92	PF00454	0.686
MOD_PKA_2	179	185	PF00069	0.607
MOD_PKA_2	86	92	PF00069	0.689
MOD_Plk_1	147	153	PF00069	0.644
MOD_Plk_1	249	255	PF00069	0.576
MOD_Plk_4	135	141	PF00069	0.672
MOD_Plk_4	147	153	PF00069	0.768
MOD_Plk_4	36	42	PF00069	0.486
MOD_Plk_4	46	52	PF00069	0.374
MOD_Plk_4	71	77	PF00069	0.379
MOD_ProDKin_1	130	136	PF00069	0.722
MOD_SUMO_rev_2	17	26	PF00179	0.405
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.438
TRG_ENDOCYTIC_2	218	221	PF00928	0.582
TRG_ENDOCYTIC_2	72	75	PF00928	0.292
TRG_ER_diArg_1	10	13	PF00400	0.347
TRG_ER_diArg_1	169	171	PF00400	0.637
TRG_ER_diArg_1	215	217	PF00400	0.631
TRG_ER_diArg_1	272	275	PF00400	0.538
TRG_ER_diArg_1	86	88	PF00400	0.593
TRG_ER_diArg_1	93	95	PF00400	0.602
TRG_Pf-PMV_PEXEL_1	196	201	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.624
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P876	Leptomonas seymouri	58%	97%
A0A1X0P6T9	Trypanosomatidae	39%	100%
A0A3Q8IF74	Leishmania donovani	90%	100%
A0A422NPR8	Trypanosoma rangeli	41%	100%
A4HJY9	Leishmania braziliensis	73%	100%
A4I7H2	Leishmania infantum	88%	100%
D0A004	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q4Q5S7	Leishmania major	89%	100%
V5BWT8	Trypanosoma cruzi	38%	69%