Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2C6_LEIMU

TriTrypDb:

LmxM.31.0060

Length:

383

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B2C6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2C6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.598
CLV_NRD_NRD_1	128	130	PF00675	0.568
CLV_NRD_NRD_1	216	218	PF00675	0.499
CLV_NRD_NRD_1	268	270	PF00675	0.622
CLV_NRD_NRD_1	319	321	PF00675	0.616
CLV_PCSK_KEX2_1	108	110	PF00082	0.596
CLV_PCSK_KEX2_1	128	130	PF00082	0.568
CLV_PCSK_KEX2_1	216	218	PF00082	0.438
CLV_PCSK_KEX2_1	267	269	PF00082	0.600
CLV_PCSK_KEX2_1	280	282	PF00082	0.595
CLV_PCSK_KEX2_1	319	321	PF00082	0.616
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.595
CLV_PCSK_PC7_1	315	321	PF00082	0.537
CLV_PCSK_SKI1_1	129	133	PF00082	0.587
CLV_PCSK_SKI1_1	187	191	PF00082	0.573
CLV_PCSK_SKI1_1	193	197	PF00082	0.498
CLV_PCSK_SKI1_1	315	319	PF00082	0.551
DOC_ANK_TNKS_1	268	275	PF00023	0.449
DOC_CDC14_PxL_1	224	232	PF14671	0.687
DOC_CYCLIN_yCln2_LP_2	242	248	PF00134	0.484
DOC_CYCLIN_yCln2_LP_2	368	371	PF00134	0.501
DOC_MAPK_gen_1	108	114	PF00069	0.664
DOC_MAPK_gen_1	128	134	PF00069	0.600
DOC_MAPK_gen_1	256	264	PF00069	0.664
DOC_PP2B_LxvP_1	368	371	PF13499	0.501
DOC_USP7_MATH_1	26	30	PF00917	0.674
DOC_USP7_MATH_1	288	292	PF00917	0.691
DOC_USP7_MATH_1	69	73	PF00917	0.619
DOC_WW_Pin1_4	21	26	PF00397	0.662
DOC_WW_Pin1_4	268	273	PF00397	0.745
DOC_WW_Pin1_4	284	289	PF00397	0.701
DOC_WW_Pin1_4	33	38	PF00397	0.545
DOC_WW_Pin1_4	39	44	PF00397	0.587
DOC_WW_Pin1_4	57	62	PF00397	0.692
LIG_14-3-3_CanoR_1	324	333	PF00244	0.568
LIG_Actin_WH2_2	202	218	PF00022	0.567
LIG_Actin_WH2_2	323	341	PF00022	0.571
LIG_Clathr_ClatBox_1	88	92	PF01394	0.584
LIG_FHA_1	161	167	PF00498	0.486
LIG_FHA_1	218	224	PF00498	0.591
LIG_FHA_1	25	31	PF00498	0.668
LIG_FHA_1	321	327	PF00498	0.567
LIG_FHA_2	169	175	PF00498	0.407
LIG_FHA_2	231	237	PF00498	0.638
LIG_FHA_2	329	335	PF00498	0.514
LIG_Integrin_RGD_1	135	137	PF01839	0.524
LIG_LIR_Apic_2	259	263	PF02991	0.683
LIG_LIR_Gen_1	167	177	PF02991	0.442
LIG_LIR_Nem_3	167	173	PF02991	0.448
LIG_LIR_Nem_3	259	264	PF02991	0.625
LIG_LIR_Nem_3	291	296	PF02991	0.537
LIG_MYND_1	5	9	PF01753	0.644
LIG_NRBOX	295	301	PF00104	0.316
LIG_SH2_CRK	191	195	PF00017	0.584
LIG_SH2_NCK_1	191	195	PF00017	0.586
LIG_SH2_NCK_1	333	337	PF00017	0.614
LIG_SH2_PTP2	261	264	PF00017	0.685
LIG_SH2_SRC	261	264	PF00017	0.685
LIG_SH2_STAP1	102	106	PF00017	0.611
LIG_SH2_STAT5	102	105	PF00017	0.619
LIG_SH2_STAT5	116	119	PF00017	0.360
LIG_SH2_STAT5	261	264	PF00017	0.653
LIG_SH3_3	178	184	PF00018	0.468
LIG_SH3_3	222	228	PF00018	0.538
LIG_SH3_3	34	40	PF00018	0.620
LIG_SH3_3	52	58	PF00018	0.719
LIG_SH3_3	92	98	PF00018	0.630
LIG_SUMO_SIM_anti_2	295	301	PF11976	0.316
LIG_SUMO_SIM_par_1	355	362	PF11976	0.438
LIG_SUMO_SIM_par_1	85	92	PF11976	0.649
LIG_TRAF2_1	9	12	PF00917	0.598
LIG_TRFH_1	94	98	PF08558	0.625
LIG_WRC_WIRS_1	20	25	PF05994	0.698
MOD_CK1_1	150	156	PF00069	0.474
MOD_CK1_1	159	165	PF00069	0.500
MOD_CK1_1	19	25	PF00069	0.672
MOD_CK1_1	292	298	PF00069	0.575
MOD_CK1_1	359	365	PF00069	0.611
MOD_CK1_1	42	48	PF00069	0.722
MOD_CK1_1	53	59	PF00069	0.650
MOD_CK2_1	161	167	PF00069	0.421
MOD_CK2_1	168	174	PF00069	0.386
MOD_CK2_1	230	236	PF00069	0.667
MOD_CK2_1	328	334	PF00069	0.513
MOD_GlcNHglycan	141	144	PF01048	0.742
MOD_GlcNHglycan	149	152	PF01048	0.685
MOD_GlcNHglycan	217	220	PF01048	0.612
MOD_GlcNHglycan	277	280	PF01048	0.679
MOD_GlcNHglycan	47	50	PF01048	0.661
MOD_GlcNHglycan	52	55	PF01048	0.677
MOD_GSK3_1	156	163	PF00069	0.510
MOD_GSK3_1	284	291	PF00069	0.709
MOD_GSK3_1	352	359	PF00069	0.651
MOD_GSK3_1	53	60	PF00069	0.640
MOD_N-GLC_1	159	164	PF02516	0.577
MOD_N-GLC_1	45	50	PF02516	0.603
MOD_N-GLC_1	62	67	PF02516	0.638
MOD_NEK2_1	101	106	PF00069	0.592
MOD_NEK2_1	161	166	PF00069	0.519
MOD_NEK2_1	215	220	PF00069	0.594
MOD_NEK2_1	230	235	PF00069	0.540
MOD_NEK2_1	44	49	PF00069	0.633
MOD_NEK2_1	62	67	PF00069	0.697
MOD_NEK2_2	289	294	PF00069	0.400
MOD_PIKK_1	325	331	PF00454	0.533
MOD_PIKK_1	7	13	PF00454	0.623
MOD_PKA_2	215	221	PF00069	0.610
MOD_PKA_2	230	236	PF00069	0.589
MOD_Plk_1	166	172	PF00069	0.521
MOD_Plk_1	63	69	PF00069	0.738
MOD_Plk_1	84	90	PF00069	0.580
MOD_Plk_4	161	167	PF00069	0.473
MOD_Plk_4	26	32	PF00069	0.702
MOD_Plk_4	328	334	PF00069	0.529
MOD_Plk_4	356	362	PF00069	0.625
MOD_Plk_4	69	75	PF00069	0.664
MOD_Plk_4	84	90	PF00069	0.631
MOD_ProDKin_1	21	27	PF00069	0.665
MOD_ProDKin_1	268	274	PF00069	0.746
MOD_ProDKin_1	284	290	PF00069	0.698
MOD_ProDKin_1	33	39	PF00069	0.547
MOD_ProDKin_1	57	63	PF00069	0.703
TRG_DiLeu_BaEn_1	236	241	PF01217	0.390
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.544
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.690
TRG_ENDOCYTIC_2	212	215	PF00928	0.530
TRG_ENDOCYTIC_2	261	264	PF00928	0.627
TRG_ER_diArg_1	128	130	PF00400	0.637
TRG_ER_diArg_1	215	217	PF00400	0.524
TRG_ER_diArg_1	267	269	PF00400	0.619
TRG_ER_diArg_1	318	320	PF00400	0.622
TRG_ER_diArg_1	78	81	PF00400	0.549
TRG_NLS_Bipartite_1	267	284	PF00514	0.671
TRG_NLS_MonoCore_2	279	284	PF00514	0.597
TRG_NLS_MonoExtC_3	279	285	PF00514	0.629
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	339	343	PF00026	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P875	Leptomonas seymouri	60%	100%
A0A0S4JFY4	Bodo saltans	31%	100%
A0A1X0P6X1	Trypanosomatidae	34%	87%
A0A3R7M1V0	Trypanosoma rangeli	32%	83%
A0A3S7X519	Leishmania donovani	91%	86%
A4HJY6	Leishmania braziliensis	77%	100%
A4I7G9	Leishmania infantum	91%	100%
C9ZZZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	83%
Q4Q5T0	Leishmania major	91%	100%
V5DTD7	Trypanosoma cruzi	30%	82%