C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B2C4_LEIMU

TriTrypDb:

LmxM.31.0040

Length:

342

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2C4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2C4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	313	317	PF00656	0.502
CLV_MEL_PAP_1	100	106	PF00089	0.422
CLV_NRD_NRD_1	121	123	PF00675	0.451
CLV_NRD_NRD_1	164	166	PF00675	0.544
CLV_NRD_NRD_1	253	255	PF00675	0.785
CLV_NRD_NRD_1	59	61	PF00675	0.466
CLV_NRD_NRD_1	68	70	PF00675	0.481
CLV_NRD_NRD_1	84	86	PF00675	0.403
CLV_PCSK_KEX2_1	121	123	PF00082	0.486
CLV_PCSK_KEX2_1	253	255	PF00082	0.622
CLV_PCSK_KEX2_1	68	70	PF00082	0.522
CLV_PCSK_KEX2_1	84	86	PF00082	0.405
CLV_PCSK_SKI1_1	122	126	PF00082	0.488
CLV_PCSK_SKI1_1	21	25	PF00082	0.529
CLV_PCSK_SKI1_1	233	237	PF00082	0.723
CLV_PCSK_SKI1_1	68	72	PF00082	0.495
CLV_PCSK_SKI1_1	73	77	PF00082	0.451
CLV_PCSK_SKI1_1	84	88	PF00082	0.389
CLV_PCSK_SKI1_1	93	97	PF00082	0.261
DEG_COP1_1	190	198	PF00400	0.559
DEG_Nend_Nbox_1	1	3	PF02207	0.556
DEG_SCF_TRCP1_1	316	322	PF00400	0.502
DOC_CYCLIN_RxL_1	119	129	PF00134	0.495
DOC_CYCLIN_yCln2_LP_2	198	201	PF00134	0.474
DOC_MAPK_gen_1	18	28	PF00069	0.518
DOC_MAPK_MEF2A_6	18	26	PF00069	0.484
DOC_PP2B_LxvP_1	198	201	PF13499	0.549
DOC_USP7_MATH_1	189	193	PF00917	0.668
DOC_USP7_MATH_1	301	305	PF00917	0.591
DOC_WW_Pin1_4	77	82	PF00397	0.448
LIG_14-3-3_CanoR_1	103	109	PF00244	0.585
LIG_14-3-3_CanoR_1	60	66	PF00244	0.379
LIG_APCC_ABBAyCdc20_2	121	127	PF00400	0.476
LIG_BRCT_BRCA1_1	104	108	PF00533	0.446
LIG_FHA_1	134	140	PF00498	0.455
LIG_FHA_1	183	189	PF00498	0.618
LIG_FHA_1	274	280	PF00498	0.759
LIG_FHA_1	300	306	PF00498	0.584
LIG_FHA_1	70	76	PF00498	0.461
LIG_FHA_2	127	133	PF00498	0.544
LIG_FHA_2	307	313	PF00498	0.507
LIG_LIR_Nem_3	211	217	PF02991	0.701
LIG_MYND_1	196	200	PF01753	0.636
LIG_NRBOX	82	88	PF00104	0.492
LIG_Pex14_2	28	32	PF04695	0.471
LIG_REV1ctd_RIR_1	68	77	PF16727	0.480
LIG_SH2_CRK	214	218	PF00017	0.769
LIG_SH2_NCK_1	116	120	PF00017	0.437
LIG_SH2_NCK_1	63	67	PF00017	0.496
LIG_SH2_SRC	159	162	PF00017	0.448
LIG_SH2_STAP1	116	120	PF00017	0.395
LIG_SH2_STAT5	159	162	PF00017	0.448
LIG_SH2_STAT5	63	66	PF00017	0.530
LIG_SH2_STAT5	99	102	PF00017	0.387
LIG_SH3_2	228	233	PF14604	0.573
LIG_SH3_3	198	204	PF00018	0.685
LIG_SH3_3	225	231	PF00018	0.576
LIG_SUMO_SIM_anti_2	135	141	PF11976	0.440
LIG_SUMO_SIM_par_1	208	213	PF11976	0.479
LIG_TYR_ITIM	212	217	PF00017	0.613
LIG_UBA3_1	86	93	PF00899	0.509
LIG_WRC_WIRS_1	29	34	PF05994	0.480
MOD_CDK_SPxxK_3	77	84	PF00069	0.447
MOD_CK1_1	126	132	PF00069	0.535
MOD_CK1_1	135	141	PF00069	0.467
MOD_CK1_1	150	156	PF00069	0.494
MOD_CK1_1	182	188	PF00069	0.530
MOD_CK1_1	264	270	PF00069	0.774
MOD_CK1_1	283	289	PF00069	0.504
MOD_CK1_1	292	298	PF00069	0.702
MOD_CK1_1	310	316	PF00069	0.622
MOD_CK1_1	336	342	PF00069	0.744
MOD_CK2_1	126	132	PF00069	0.609
MOD_CK2_1	301	307	PF00069	0.737
MOD_CK2_1	319	325	PF00069	0.640
MOD_Cter_Amidation	251	254	PF01082	0.605
MOD_GlcNHglycan	109	112	PF01048	0.257
MOD_GlcNHglycan	127	132	PF01048	0.464
MOD_GlcNHglycan	224	227	PF01048	0.807
MOD_GlcNHglycan	228	231	PF01048	0.638
MOD_GlcNHglycan	249	252	PF01048	0.735
MOD_GlcNHglycan	267	270	PF01048	0.543
MOD_GlcNHglycan	316	319	PF01048	0.586
MOD_GlcNHglycan	338	341	PF01048	0.702
MOD_GSK3_1	123	130	PF00069	0.367
MOD_GSK3_1	143	150	PF00069	0.483
MOD_GSK3_1	222	229	PF00069	0.732
MOD_GSK3_1	261	268	PF00069	0.713
MOD_GSK3_1	292	299	PF00069	0.754
MOD_GSK3_1	306	313	PF00069	0.566
MOD_GSK3_1	327	334	PF00069	0.640
MOD_GSK3_1	38	45	PF00069	0.523
MOD_LATS_1	260	266	PF00433	0.699
MOD_N-GLC_1	273	278	PF02516	0.693
MOD_N-GLC_1	320	325	PF02516	0.807
MOD_N-GLC_1	331	336	PF02516	0.572
MOD_NEK2_1	143	148	PF00069	0.436
MOD_NEK2_1	28	33	PF00069	0.477
MOD_NEK2_1	71	76	PF00069	0.423
MOD_NEK2_2	189	194	PF00069	0.553
MOD_PIKK_1	182	188	PF00454	0.530
MOD_PIKK_1	283	289	PF00454	0.641
MOD_PIKK_1	296	302	PF00454	0.797
MOD_PKA_2	102	108	PF00069	0.508
MOD_PKA_2	261	267	PF00069	0.698
MOD_PKA_2	37	43	PF00069	0.521
MOD_Plk_1	210	216	PF00069	0.653
MOD_Plk_1	273	279	PF00069	0.619
MOD_Plk_1	306	312	PF00069	0.702
MOD_Plk_2-3	307	313	PF00069	0.796
MOD_Plk_4	280	286	PF00069	0.667
MOD_ProDKin_1	77	83	PF00069	0.443
MOD_SUMO_rev_2	17	23	PF00179	0.347
MOD_SUMO_rev_2	307	315	PF00179	0.620
TRG_DiLeu_BaEn_1	82	87	PF01217	0.513
TRG_DiLeu_LyEn_5	19	24	PF01217	0.539
TRG_DiLeu_LyEn_5	82	87	PF01217	0.450
TRG_ENDOCYTIC_2	214	217	PF00928	0.758
TRG_ER_diArg_1	120	122	PF00400	0.482
TRG_ER_diArg_1	253	255	PF00400	0.802
TRG_ER_diArg_1	68	70	PF00400	0.536
TRG_ER_diArg_1	83	85	PF00400	0.405
TRG_Pf-PMV_PEXEL_1	122	127	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	253	258	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2H1	Leptomonas seymouri	38%	95%
A0A0N1I963	Leptomonas seymouri	56%	90%
A0A3S7X526	Leishmania donovani	86%	100%
A4HJY4	Leishmania braziliensis	68%	100%
A4I7G7	Leishmania infantum	87%	100%
Q4Q5T2	Leishmania major	86%	100%