C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B2C3_LEIMU

TriTrypDb:

LmxM.31.0030

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2C3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2C3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.465
CLV_C14_Caspase3-7	345	349	PF00656	0.582
CLV_NRD_NRD_1	117	119	PF00675	0.454
CLV_NRD_NRD_1	151	153	PF00675	0.399
CLV_NRD_NRD_1	189	191	PF00675	0.530
CLV_PCSK_KEX2_1	110	112	PF00082	0.507
CLV_PCSK_KEX2_1	150	152	PF00082	0.428
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.489
CLV_PCSK_SKI1_1	111	115	PF00082	0.479
CLV_PCSK_SKI1_1	131	135	PF00082	0.395
CLV_PCSK_SKI1_1	152	156	PF00082	0.396
CLV_PCSK_SKI1_1	235	239	PF00082	0.426
CLV_PCSK_SKI1_1	241	245	PF00082	0.428
CLV_PCSK_SKI1_1	352	356	PF00082	0.599
DEG_APCC_DBOX_1	110	118	PF00400	0.452
DEG_APCC_DBOX_1	151	159	PF00400	0.401
DEG_Nend_UBRbox_3	1	3	PF02207	0.597
DOC_CKS1_1	336	341	PF01111	0.503
DOC_MAPK_gen_1	99	109	PF00069	0.514
DOC_MAPK_HePTP_8	73	85	PF00069	0.489
DOC_MAPK_MEF2A_6	76	85	PF00069	0.484
DOC_PP4_FxxP_1	282	285	PF00568	0.613
DOC_USP7_MATH_1	274	278	PF00917	0.692
DOC_USP7_MATH_1	361	365	PF00917	0.558
DOC_USP7_MATH_1	39	43	PF00917	0.468
DOC_USP7_UBL2_3	191	195	PF12436	0.579
DOC_USP7_UBL2_3	235	239	PF12436	0.429
DOC_USP7_UBL2_3	91	95	PF12436	0.520
DOC_WW_Pin1_4	265	270	PF00397	0.638
DOC_WW_Pin1_4	272	277	PF00397	0.667
DOC_WW_Pin1_4	296	301	PF00397	0.592
DOC_WW_Pin1_4	305	310	PF00397	0.545
DOC_WW_Pin1_4	317	322	PF00397	0.738
DOC_WW_Pin1_4	335	340	PF00397	0.513
LIG_14-3-3_CanoR_1	222	227	PF00244	0.371
LIG_14-3-3_CanoR_1	352	361	PF00244	0.603
LIG_14-3-3_CanoR_1	76	82	PF00244	0.502
LIG_BRCT_BRCA1_1	55	59	PF00533	0.544
LIG_CtBP_PxDLS_1	329	333	PF00389	0.592
LIG_eIF4E_1	22	28	PF01652	0.568
LIG_EVH1_1	282	286	PF00568	0.609
LIG_EVH1_2	303	307	PF00568	0.605
LIG_FHA_1	160	166	PF00498	0.406
LIG_FHA_1	22	28	PF00498	0.492
LIG_FHA_1	56	62	PF00498	0.551
LIG_FHA_2	170	176	PF00498	0.484
LIG_LIR_Gen_1	138	149	PF02991	0.391
LIG_LIR_Nem_3	138	144	PF02991	0.401
LIG_LIR_Nem_3	348	354	PF02991	0.550
LIG_LIR_Nem_3	357	362	PF02991	0.561
LIG_PDZ_Class_3	362	367	PF00595	0.583
LIG_Pex14_2	85	89	PF04695	0.468
LIG_SH2_CRK	121	125	PF00017	0.511
LIG_SH2_CRK	93	97	PF00017	0.619
LIG_SH2_GRB2like	121	124	PF00017	0.536
LIG_SH2_NCK_1	121	125	PF00017	0.490
LIG_SH2_STAP1	174	178	PF00017	0.411
LIG_SH2_STAP1	23	27	PF00017	0.524
LIG_SH2_STAT3	174	177	PF00017	0.530
LIG_SH2_STAT5	121	124	PF00017	0.490
LIG_SH2_STAT5	128	131	PF00017	0.589
LIG_SH2_STAT5	157	160	PF00017	0.373
LIG_SH2_STAT5	23	26	PF00017	0.472
LIG_SH2_STAT5	305	308	PF00017	0.574
LIG_SH3_3	273	279	PF00018	0.640
LIG_SH3_3	280	286	PF00018	0.621
LIG_SH3_3	294	300	PF00018	0.572
LIG_SH3_3	306	312	PF00018	0.488
LIG_WRC_WIRS_1	86	91	PF05994	0.489
LIG_WW_1	302	305	PF00397	0.530
MOD_CDK_SPK_2	265	270	PF00069	0.654
MOD_CK1_1	344	350	PF00069	0.525
MOD_CK1_1	41	47	PF00069	0.500
MOD_CK1_1	9	15	PF00069	0.476
MOD_CK2_1	169	175	PF00069	0.482
MOD_CK2_1	181	187	PF00069	0.450
MOD_Cter_Amidation	250	253	PF01082	0.435
MOD_GlcNHglycan	8	11	PF01048	0.667
MOD_GSK3_1	165	172	PF00069	0.538
MOD_GSK3_1	26	33	PF00069	0.488
MOD_GSK3_1	317	324	PF00069	0.702
MOD_GSK3_1	331	338	PF00069	0.576
MOD_GSK3_1	55	62	PF00069	0.564
MOD_N-GLC_1	135	140	PF02516	0.394
MOD_N-GLC_1	76	81	PF02516	0.504
MOD_N-GLC_2	209	211	PF02516	0.358
MOD_NEK2_1	129	134	PF00069	0.435
MOD_NEK2_1	204	209	PF00069	0.404
MOD_NEK2_1	214	219	PF00069	0.401
MOD_NEK2_1	295	300	PF00069	0.580
MOD_NEK2_1	330	335	PF00069	0.525
MOD_NEK2_1	6	11	PF00069	0.627
MOD_NEK2_1	85	90	PF00069	0.512
MOD_OFUCOSY	220	226	PF10250	0.380
MOD_PIKK_1	352	358	PF00454	0.541
MOD_PKA_1	252	258	PF00069	0.592
MOD_Plk_1	330	336	PF00069	0.742
MOD_Plk_1	76	82	PF00069	0.503
MOD_Plk_2-3	159	165	PF00069	0.401
MOD_Plk_4	143	149	PF00069	0.384
MOD_Plk_4	252	258	PF00069	0.592
MOD_Plk_4	30	36	PF00069	0.474
MOD_ProDKin_1	265	271	PF00069	0.638
MOD_ProDKin_1	272	278	PF00069	0.667
MOD_ProDKin_1	296	302	PF00069	0.591
MOD_ProDKin_1	305	311	PF00069	0.543
MOD_ProDKin_1	317	323	PF00069	0.738
MOD_ProDKin_1	335	341	PF00069	0.514
MOD_SUMO_for_1	109	112	PF00179	0.420
TRG_DiLeu_BaLyEn_6	349	354	PF01217	0.601
TRG_ENDOCYTIC_2	157	160	PF00928	0.373
TRG_ENDOCYTIC_2	93	96	PF00928	0.614
TRG_ER_diArg_1	150	152	PF00400	0.435
TRG_NLS_MonoExtN_4	188	194	PF00514	0.558
TRG_Pf-PMV_PEXEL_1	25	30	PF00026	0.705
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2H1	Leptomonas seymouri	59%	100%
A0A3S7X500	Leishmania donovani	93%	100%
A4HJY2	Leishmania braziliensis	73%	100%
A4I7G6	Leishmania infantum	93%	100%
Q4Q5T3	Leishmania major	90%	100%