Nuclear segregation protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear segregation protein, putative

Species:

Leishmania mexicana

UniProt:

E9B2C2_LEIMU

TriTrypDb:

LmxM.31.0020

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0016020	membrane	2	1
GO:0032991	protein-containing complex	1	1
GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9B2C2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2C2

Function

Biological processes
Term	Name	Level	Count
GO:0006403	RNA localization	3	1
GO:0008298	intracellular mRNA localization	4	1
GO:0009987	cellular process	1	1
GO:0033036	macromolecule localization	2	1
GO:0051179	localization	1	1
GO:0051641	cellular localization	2	1
GO:0070727	cellular macromolecule localization	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.365
CLV_MEL_PAP_1	237	243	PF00089	0.514
CLV_NRD_NRD_1	103	105	PF00675	0.381
CLV_NRD_NRD_1	106	108	PF00675	0.398
CLV_NRD_NRD_1	138	140	PF00675	0.476
CLV_NRD_NRD_1	152	154	PF00675	0.487
CLV_NRD_NRD_1	269	271	PF00675	0.487
CLV_NRD_NRD_1	284	286	PF00675	0.388
CLV_NRD_NRD_1	291	293	PF00675	0.507
CLV_NRD_NRD_1	338	340	PF00675	0.515
CLV_NRD_NRD_1	341	343	PF00675	0.529
CLV_NRD_NRD_1	45	47	PF00675	0.517
CLV_NRD_NRD_1	85	87	PF00675	0.432
CLV_NRD_NRD_1	92	94	PF00675	0.433
CLV_PCSK_FUR_1	104	108	PF00082	0.455
CLV_PCSK_FUR_1	281	285	PF00082	0.458
CLV_PCSK_FUR_1	339	343	PF00082	0.569
CLV_PCSK_FUR_1	90	94	PF00082	0.551
CLV_PCSK_KEX2_1	105	107	PF00082	0.391
CLV_PCSK_KEX2_1	152	154	PF00082	0.488
CLV_PCSK_KEX2_1	213	215	PF00082	0.585
CLV_PCSK_KEX2_1	226	228	PF00082	0.599
CLV_PCSK_KEX2_1	283	285	PF00082	0.480
CLV_PCSK_KEX2_1	291	293	PF00082	0.469
CLV_PCSK_KEX2_1	300	302	PF00082	0.449
CLV_PCSK_KEX2_1	306	308	PF00082	0.481
CLV_PCSK_KEX2_1	340	342	PF00082	0.551
CLV_PCSK_KEX2_1	45	47	PF00082	0.462
CLV_PCSK_KEX2_1	85	87	PF00082	0.456
CLV_PCSK_KEX2_1	92	94	PF00082	0.497
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.382
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.585
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.599
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.616
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.428
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.489
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.542
CLV_PCSK_SKI1_1	179	183	PF00082	0.508
CLV_PCSK_SKI1_1	213	217	PF00082	0.530
CLV_PCSK_SKI1_1	303	307	PF00082	0.537
CLV_PCSK_SKI1_1	374	378	PF00082	0.705
CLV_PCSK_SKI1_1	45	49	PF00082	0.352
CLV_PCSK_SKI1_1	72	76	PF00082	0.587
DOC_MAPK_gen_1	326	334	PF00069	0.563
DOC_MAPK_gen_1	413	422	PF00069	0.538
DOC_MAPK_MEF2A_6	232	241	PF00069	0.403
DOC_MAPK_MEF2A_6	326	334	PF00069	0.480
DOC_USP7_MATH_1	18	22	PF00917	0.616
DOC_USP7_UBL2_3	209	213	PF12436	0.586
DOC_USP7_UBL2_3	267	271	PF12436	0.445
DOC_USP7_UBL2_3	296	300	PF12436	0.490
DOC_USP7_UBL2_3	370	374	PF12436	0.692
DOC_USP7_UBL2_3	377	381	PF12436	0.676
DOC_WW_Pin1_4	387	392	PF00397	0.573
DOC_WW_Pin1_4	470	475	PF00397	0.663
DOC_WW_Pin1_4	481	486	PF00397	0.489
LIG_14-3-3_CanoR_1	238	248	PF00244	0.515
LIG_BIR_II_1	1	5	PF00653	0.598
LIG_deltaCOP1_diTrp_1	261	265	PF00928	0.432
LIG_FHA_1	164	170	PF00498	0.503
LIG_FHA_1	388	394	PF00498	0.577
LIG_FHA_1	449	455	PF00498	0.571
LIG_FHA_2	180	186	PF00498	0.492
LIG_FHA_2	218	224	PF00498	0.423
LIG_IBAR_NPY_1	309	311	PF08397	0.482
LIG_LIR_Gen_1	191	199	PF02991	0.418
LIG_LIR_Gen_1	414	425	PF02991	0.322
LIG_LIR_Nem_3	191	195	PF02991	0.396
LIG_LIR_Nem_3	414	420	PF02991	0.411
LIG_PDZ_Class_3	489	494	PF00595	0.799
LIG_PTB_Apo_2	200	207	PF02174	0.533
LIG_PTB_Phospho_1	200	206	PF10480	0.529
LIG_SH2_CRK	192	196	PF00017	0.491
LIG_SH2_STAP1	206	210	PF00017	0.503
LIG_SH2_STAP1	311	315	PF00017	0.440
LIG_SH2_STAP1	445	449	PF00017	0.463
LIG_SH2_STAT3	273	276	PF00017	0.474
LIG_SH2_STAT3	324	327	PF00017	0.543
LIG_SH2_STAT5	273	276	PF00017	0.482
LIG_SH2_STAT5	324	327	PF00017	0.429
LIG_SH3_2	23	28	PF14604	0.596
LIG_SH3_3	20	26	PF00018	0.444
LIG_SH3_3	395	401	PF00018	0.525
LIG_SH3_3	473	479	PF00018	0.587
LIG_SH3_4	370	377	PF00018	0.678
LIG_SUMO_SIM_par_1	418	423	PF11976	0.525
LIG_SUMO_SIM_par_1	424	430	PF11976	0.509
LIG_TRAF2_1	182	185	PF00917	0.507
LIG_TRAF2_1	2	5	PF00917	0.714
LIG_TRAF2_1	489	492	PF00917	0.727
LIG_UBA3_1	321	329	PF00899	0.465
LIG_UBA3_1	48	54	PF00899	0.494
MOD_CDK_SPK_2	472	477	PF00069	0.507
MOD_CDK_SPxxK_3	387	394	PF00069	0.576
MOD_CDK_SPxxK_3	470	477	PF00069	0.663
MOD_CDK_SPxxK_3	481	488	PF00069	0.491
MOD_CK1_1	242	248	PF00069	0.430
MOD_CK1_1	316	322	PF00069	0.475
MOD_CK1_1	364	370	PF00069	0.734
MOD_CK1_1	427	433	PF00069	0.570
MOD_CK2_1	179	185	PF00069	0.531
MOD_CK2_1	440	446	PF00069	0.541
MOD_CMANNOS	262	265	PF00535	0.421
MOD_GlcNHglycan	142	146	PF01048	0.493
MOD_GlcNHglycan	314	318	PF01048	0.432
MOD_GlcNHglycan	457	460	PF01048	0.693
MOD_GSK3_1	313	320	PF00069	0.372
MOD_GSK3_1	389	396	PF00069	0.528
MOD_GSK3_1	440	447	PF00069	0.471
MOD_NEK2_1	141	146	PF00069	0.482
MOD_NEK2_1	454	459	PF00069	0.702
MOD_NEK2_1	55	60	PF00069	0.472
MOD_PIKK_1	217	223	PF00454	0.365
MOD_PIKK_1	242	248	PF00454	0.430
MOD_PIKK_1	348	354	PF00454	0.649
MOD_PIKK_1	440	446	PF00454	0.476
MOD_PIKK_1	62	68	PF00454	0.578
MOD_PK_1	394	400	PF00069	0.509
MOD_PKA_2	239	245	PF00069	0.585
MOD_Plk_1	411	417	PF00069	0.525
MOD_Plk_4	317	323	PF00069	0.410
MOD_ProDKin_1	387	393	PF00069	0.575
MOD_ProDKin_1	470	476	PF00069	0.661
MOD_ProDKin_1	481	487	PF00069	0.490
MOD_SUMO_rev_2	162	166	PF00179	0.500
MOD_SUMO_rev_2	205	210	PF00179	0.562
MOD_SUMO_rev_2	362	372	PF00179	0.691
MOD_SUMO_rev_2	427	435	PF00179	0.583
MOD_SUMO_rev_2	50	55	PF00179	0.455
TRG_ENDOCYTIC_2	192	195	PF00928	0.512
TRG_ER_diArg_1	103	106	PF00400	0.504
TRG_ER_diArg_1	237	240	PF00400	0.515
TRG_ER_diArg_1	339	342	PF00400	0.603
TRG_ER_diArg_1	45	47	PF00400	0.361
TRG_NLS_Bipartite_1	283	304	PF00514	0.599
TRG_NLS_Bipartite_1	86	108	PF00514	0.544
TRG_NLS_MonoCore_2	103	108	PF00514	0.493
TRG_NLS_MonoExtC_3	103	109	PF00514	0.550
TRG_NLS_MonoExtC_3	211	216	PF00514	0.564
TRG_NLS_MonoExtC_3	269	275	PF00514	0.380
TRG_NLS_MonoExtN_4	102	108	PF00514	0.553
TRG_NLS_MonoExtN_4	209	216	PF00514	0.470
TRG_NLS_MonoExtN_4	267	274	PF00514	0.466
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD36	Leptomonas seymouri	55%	98%
A0A0S4J925	Bodo saltans	39%	100%
A0A1X0P6U5	Trypanosomatidae	42%	100%
A0A3R7KQ83	Trypanosoma rangeli	40%	98%
A0A3S7X525	Leishmania donovani	89%	100%
A4HJX8	Leishmania braziliensis	74%	99%
A4HJY1	Leishmania braziliensis	73%	99%
A4I7G5	Leishmania infantum	89%	100%
C9ZZZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4Q5T4	Leishmania major	88%	100%
V5BS50	Trypanosoma cruzi	41%	98%