LeishMANIAdb
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Transmembrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B2C1_LEIMU
TriTrypDb:
LmxM.31.0010
Length:
134

Annotations

LeishMANIAdb annotations

A protein with unclear topology, conserved but entirely restricted to Kinetoplastida.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

E9B2C1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2C1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 107 109 PF00675 0.621
CLV_NRD_NRD_1 36 38 PF00675 0.429
CLV_NRD_NRD_1 8 10 PF00675 0.495
CLV_PCSK_KEX2_1 107 109 PF00082 0.632
CLV_PCSK_KEX2_1 36 38 PF00082 0.429
CLV_PCSK_KEX2_1 8 10 PF00082 0.492
CLV_PCSK_PC7_1 103 109 PF00082 0.597
DEG_Nend_Nbox_1 1 3 PF02207 0.645
DOC_USP7_MATH_1 126 130 PF00917 0.368
DOC_USP7_MATH_1 19 23 PF00917 0.698
DOC_USP7_UBL2_3 121 125 PF12436 0.427
DOC_USP7_UBL2_3 23 27 PF12436 0.563
DOC_WW_Pin1_4 9 14 PF00397 0.684
LIG_14-3-3_CanoR_1 3 7 PF00244 0.631
LIG_14-3-3_CanoR_1 71 76 PF00244 0.399
LIG_BRCT_BRCA1_1 128 132 PF00533 0.377
LIG_FHA_2 110 116 PF00498 0.382
LIG_LIR_Apic_2 17 21 PF02991 0.696
LIG_LIR_Gen_1 44 55 PF02991 0.498
LIG_LIR_Nem_3 29 34 PF02991 0.659
LIG_LIR_Nem_3 44 50 PF02991 0.457
LIG_LIR_Nem_3 52 56 PF02991 0.347
LIG_LIR_Nem_3 60 64 PF02991 0.422
LIG_Pex14_2 53 57 PF04695 0.337
LIG_SH2_CRK 47 51 PF00017 0.391
LIG_SH2_STAT5 67 70 PF00017 0.357
LIG_SH3_3 80 86 PF00018 0.510
LIG_WRC_WIRS_1 58 63 PF05994 0.323
MOD_CK1_1 74 80 PF00069 0.503
MOD_CK2_1 109 115 PF00069 0.534
MOD_CK2_1 32 38 PF00069 0.500
MOD_GlcNHglycan 122 125 PF01048 0.553
MOD_GSK3_1 116 123 PF00069 0.471
MOD_GSK3_1 32 39 PF00069 0.516
MOD_N-GLC_1 71 76 PF02516 0.560
MOD_NEK2_1 1 6 PF00069 0.517
MOD_NEK2_1 26 31 PF00069 0.377
MOD_NEK2_1 57 62 PF00069 0.333
MOD_PK_1 36 42 PF00069 0.480
MOD_PKA_1 36 42 PF00069 0.540
MOD_PKA_2 2 8 PF00069 0.601
MOD_PKA_2 32 38 PF00069 0.560
MOD_Plk_1 71 77 PF00069 0.477
MOD_Plk_2-3 109 115 PF00069 0.517
MOD_Plk_4 126 132 PF00069 0.454
MOD_Plk_4 2 8 PF00069 0.547
MOD_Plk_4 26 32 PF00069 0.666
MOD_ProDKin_1 9 15 PF00069 0.618
MOD_SUMO_rev_2 93 99 PF00179 0.489
TRG_ENDOCYTIC_2 31 34 PF00928 0.591
TRG_ENDOCYTIC_2 47 50 PF00928 0.267
TRG_ER_diArg_1 7 9 PF00400 0.636

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I7P8 Leptomonas seymouri 78% 100%
A0A0S4J967 Bodo saltans 43% 100%
A0A1X0PA05 Trypanosomatidae 61% 99%
A0A3S7X509 Leishmania donovani 93% 100%
A4HJY0 Leishmania braziliensis 81% 100%
A4I7G4 Leishmania infantum 92% 100%
D0A202 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 99%
Q4Q5T5 Leishmania major 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS